JP2012082227A5 - - Google Patents
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- Publication number
- JP2012082227A5 JP2012082227A5 JP2012014178A JP2012014178A JP2012082227A5 JP 2012082227 A5 JP2012082227 A5 JP 2012082227A5 JP 2012014178 A JP2012014178 A JP 2012014178A JP 2012014178 A JP2012014178 A JP 2012014178A JP 2012082227 A5 JP2012082227 A5 JP 2012082227A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- neoplastic agent
- agent
- protective
- neoplastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 19
- 239000002246 antineoplastic agent Substances 0.000 claims 19
- 230000001681 protective effect Effects 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 description 5
- HAWSQZCWOQZXHI-UHFFFAOYSA-N CPT-OH Natural products C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-UHFFFAOYSA-N 0.000 description 5
- 230000029936 alkylation Effects 0.000 description 4
- 238000005804 alkylation reaction Methods 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- HQVAVYYAPZDXHV-UHFFFAOYSA-N 2-nitro-1h-imidazole;hydrobromide Chemical compound Br.[O-][N+](=O)C1=NC=CN1 HQVAVYYAPZDXHV-UHFFFAOYSA-N 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45884503P | 2003-03-28 | 2003-03-28 | |
| US60/458,845 | 2003-03-28 | ||
| US46528103P | 2003-04-21 | 2003-04-21 | |
| US60/465,281 | 2003-04-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Division JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012082227A JP2012082227A (ja) | 2012-04-26 |
| JP2012082227A5 true JP2012082227A5 (enExample) | 2013-03-07 |
| JP5572644B2 JP5572644B2 (ja) | 2014-08-13 |
Family
ID=33135116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Ceased JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
| JP2012014178A Expired - Fee Related JP5572644B2 (ja) | 2003-03-28 | 2012-01-26 | 癌を処置するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Ceased JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7550496B2 (enExample) |
| EP (2) | EP2671581B8 (enExample) |
| JP (2) | JP2006521409A (enExample) |
| KR (2) | KR20050113670A (enExample) |
| CN (2) | CN1791403A (enExample) |
| AU (1) | AU2004226338C1 (enExample) |
| CA (1) | CA2520000C (enExample) |
| ES (1) | ES2759176T3 (enExample) |
| IL (1) | IL170970A (enExample) |
| MX (1) | MXPA05010407A (enExample) |
| NO (1) | NO336266B1 (enExample) |
| NZ (1) | NZ543223A (enExample) |
| WO (1) | WO2004087075A2 (enExample) |
| ZA (1) | ZA200507752B (enExample) |
Families Citing this family (86)
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| US7691838B2 (en) | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
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| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3652579A (en) | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
| DE2229223C3 (de) | 1971-07-30 | 1975-12-18 | Gruppo Lepetit S.P.A., Mailand (Italien) | 2-Nitro-S-imidazol-Derivate und Verfahren zu deren Herstellung |
| US4921963A (en) | 1987-04-13 | 1990-05-01 | British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
| JPH0819111B2 (ja) | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤 |
| US5403932A (en) | 1988-05-25 | 1995-04-04 | Research Corporation Technologies, Inc. | Phosphoramidates useful as antitumor agents |
| US4908356A (en) | 1988-05-25 | 1990-03-13 | Research Corporation Technologies, Inc. | Aldophosphamide derivatives useful as antitumor agents |
| US5190929A (en) | 1988-05-25 | 1993-03-02 | Research Corporation Technologies, Inc. | Cyclophosphamide analogs useful as anti-tumor agents |
| DE3835772A1 (de) | 1988-10-20 | 1990-04-26 | Deutsches Krebsforsch | Tumorhemmende saccharid-konjugate |
| KR927003539A (ko) | 1990-01-26 | 1992-12-18 | 스즈끼 쯔네시 | 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제 |
| US5233031A (en) | 1991-09-23 | 1993-08-03 | University Of Rochester | Phosphoramidate analogs of 2'-deoxyuridine |
| JP4115514B2 (ja) | 1991-10-23 | 2008-07-09 | キャンサー・リサーチ・キヤンペーン・テクノロジー・リミテツド | Ｃｂ １９５４およびその類似体を細胞障害性の形態に還元するための細菌のニトロリダクターゼ |
| US5750782A (en) | 1992-11-27 | 1998-05-12 | Cancer Research Campaign Technology Limited | Nitroaniline derivatives and their use as anti-tumour agents |
| US5306727A (en) | 1993-04-30 | 1994-04-26 | Research Corporation Technologies, Inc. | Phosphoramidates useful as antitumor agents |
| US5691371A (en) | 1993-05-25 | 1997-11-25 | Auckland Uniservices Limited | Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents |
| ES2148259T3 (es) | 1993-09-22 | 2000-10-16 | Hoechst Ag | Pro-profarmacos, su produccion y uso. |
| JPH07309761A (ja) | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | デュオカルマイシン誘導体の安定化法 |
| US5659061A (en) | 1995-04-20 | 1997-08-19 | Drug Innovation & Design, Inc. | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities |
| GB9516943D0 (en) | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
| GB9526391D0 (en) | 1995-12-22 | 1996-02-21 | Diversey Equipment Technologie | Dispenser |
| US6218519B1 (en) | 1996-04-12 | 2001-04-17 | Pro-Neuron, Inc. | Compounds and methods for the selective treatment of cancer and bacterial infections |
| US6130237A (en) | 1996-09-12 | 2000-10-10 | Cancer Research Campaign Technology Limited | Condensed N-aclyindoles as antitumor agents |
| US6251933B1 (en) | 1996-12-13 | 2001-06-26 | The Cancer Research Campaign Technology Limited | Seco precursors of cyclopropylindolines and their use as prodrugs |
| DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| US6240925B1 (en) | 1999-03-23 | 2001-06-05 | Cynosure, Inc. | Photothermal vascular targeting with bioreductive agents |
| GB9909612D0 (en) * | 1999-04-26 | 1999-06-23 | Cancer Res Campaign Tech | N-protected amines and their use as prodrugs |
| JP4629238B2 (ja) | 1999-05-24 | 2011-02-09 | サザン・リサーチ・インスティテュート | イソホスホアミドマスタード・アナログ及びその使用 |
| AU5935600A (en) | 1999-07-14 | 2001-01-30 | Richard F. Borch | Phosphoramide compounds |
| DE60117247D1 (de) | 2000-03-31 | 2006-04-20 | Purdue Research Foundation West Lafayette | Phosphoramidat-prodrugs |
| JP2002046334A (ja) | 2000-08-04 | 2002-02-12 | Riso Kagaku Corp | 孔版印刷装置及び該装置の印刷ドラム |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US6506739B1 (en) | 2001-05-01 | 2003-01-14 | Telik, Inc. | Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents |
| KR20030033007A (ko) | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
| FR2825926A1 (fr) * | 2001-06-14 | 2002-12-20 | Sod Conseils Rech Applic | Derives d'imidazoles modulant les canaux sodiques |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| KR20030067275A (ko) | 2002-02-07 | 2003-08-14 | 주식회사 하이폭시 | 니트로이미다졸 및 위상 이성질화 효소 저해제를유효성분으로 포함하는 항암제 |
| JP4187096B2 (ja) | 2003-01-15 | 2008-11-26 | 独立行政法人科学技術振興機構 | ３次元フォトニック結晶製造方法 |
| GB0306907D0 (en) | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Boireductively-activated prodrugs |
| GB0306908D0 (en) | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Bioreductively activated stilbene prodrugs |
| ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| US6855695B2 (en) | 2003-06-13 | 2005-02-15 | Vion Pharmaceuticals, Inc. | Water-soluble SHPs as novel alkylating agents |
| KR20120117943A (ko) | 2004-02-06 | 2012-10-24 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 항암 치료 방법 |
| JP2008520719A (ja) | 2004-11-22 | 2008-06-19 | スレショルド ファーマシューティカルズ インコーポレイティッド | チューブリン結合抗癌剤およびそれらのプロドラッグ |
| WO2008011588A2 (en) | 2006-07-20 | 2008-01-24 | Threshold Pharmaceuticals, Inc. | Glycoconjugates of phosphoramidate alkylators for treatment of cancer |
| WO2008076826A1 (en) | 2006-12-13 | 2008-06-26 | Threshold Pharmaceuticals, Inc. | Pyrophosphoramide alkylators |
| US8552048B2 (en) | 2006-12-26 | 2013-10-08 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
-
2004
- 2004-03-28 ZA ZA200507752A patent/ZA200507752B/en unknown
- 2004-03-29 EP EP13178249.2A patent/EP2671581B8/en not_active Expired - Lifetime
- 2004-03-29 ES ES13178249T patent/ES2759176T3/es not_active Expired - Lifetime
- 2004-03-29 JP JP2006509466A patent/JP2006521409A/ja not_active Ceased
- 2004-03-29 KR KR1020057018367A patent/KR20050113670A/ko not_active Withdrawn
- 2004-03-29 NZ NZ543223A patent/NZ543223A/en not_active IP Right Cessation
- 2004-03-29 CA CA2520000A patent/CA2520000C/en not_active Expired - Lifetime
- 2004-03-29 US US10/549,545 patent/US7550496B2/en not_active Expired - Lifetime
- 2004-03-29 AU AU2004226338A patent/AU2004226338C1/en not_active Expired
- 2004-03-29 CN CNA2004800132768A patent/CN1791403A/zh active Pending
- 2004-03-29 CN CN2010105956028A patent/CN102161679A/zh active Pending
- 2004-03-29 WO PCT/US2004/009667 patent/WO2004087075A2/en not_active Ceased
- 2004-03-29 EP EP04749522A patent/EP1622608A4/en not_active Withdrawn
- 2004-03-29 KR KR1020127002215A patent/KR101198526B1/ko not_active Expired - Lifetime
- 2004-03-29 MX MXPA05010407A patent/MXPA05010407A/es active IP Right Grant
-
2005
- 2005-09-19 IL IL170970A patent/IL170970A/en active IP Right Grant
- 2005-10-26 NO NO20054988A patent/NO336266B1/no not_active IP Right Cessation
-
2009
- 2009-06-12 US US12/484,104 patent/US8299088B2/en not_active Expired - Fee Related
-
2012
- 2012-01-26 JP JP2012014178A patent/JP5572644B2/ja not_active Expired - Fee Related
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