JP2012082227A5 - - Google Patents
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- Publication number
- JP2012082227A5 JP2012082227A5 JP2012014178A JP2012014178A JP2012082227A5 JP 2012082227 A5 JP2012082227 A5 JP 2012082227A5 JP 2012014178 A JP2012014178 A JP 2012014178A JP 2012014178 A JP2012014178 A JP 2012014178A JP 2012082227 A5 JP2012082227 A5 JP 2012082227A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- neoplastic agent
- agent
- protective
- neoplastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 19
- 239000002246 antineoplastic agent Substances 0.000 claims 19
- 230000001681 protective effect Effects 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 description 5
- HAWSQZCWOQZXHI-UHFFFAOYSA-N CPT-OH Natural products C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-UHFFFAOYSA-N 0.000 description 5
- 230000029936 alkylation Effects 0.000 description 4
- 238000005804 alkylation reaction Methods 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- HQVAVYYAPZDXHV-UHFFFAOYSA-N 2-nitro-1h-imidazole;hydrobromide Chemical compound Br.[O-][N+](=O)C1=NC=CN1 HQVAVYYAPZDXHV-UHFFFAOYSA-N 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45884503P | 2003-03-28 | 2003-03-28 | |
| US60/458,845 | 2003-03-28 | ||
| US46528103P | 2003-04-21 | 2003-04-21 | |
| US60/465,281 | 2003-04-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Division JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012082227A JP2012082227A (ja) | 2012-04-26 |
| JP2012082227A5 true JP2012082227A5 (enExample) | 2013-03-07 |
| JP5572644B2 JP5572644B2 (ja) | 2014-08-13 |
Family
ID=33135116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Ceased JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
| JP2012014178A Expired - Fee Related JP5572644B2 (ja) | 2003-03-28 | 2012-01-26 | 癌を処置するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509466A Ceased JP2006521409A (ja) | 2003-03-28 | 2004-03-29 | 癌を処置するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7550496B2 (enExample) |
| EP (2) | EP2671581B8 (enExample) |
| JP (2) | JP2006521409A (enExample) |
| KR (2) | KR101198526B1 (enExample) |
| CN (2) | CN1791403A (enExample) |
| AU (1) | AU2004226338C1 (enExample) |
| CA (1) | CA2520000C (enExample) |
| ES (1) | ES2759176T3 (enExample) |
| IL (1) | IL170970A (enExample) |
| MX (1) | MXPA05010407A (enExample) |
| NO (1) | NO336266B1 (enExample) |
| NZ (1) | NZ543223A (enExample) |
| WO (1) | WO2004087075A2 (enExample) |
| ZA (1) | ZA200507752B (enExample) |
Families Citing this family (84)
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| US7691838B2 (en) | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
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-
2004
- 2004-03-28 ZA ZA200507752A patent/ZA200507752B/en unknown
- 2004-03-29 EP EP13178249.2A patent/EP2671581B8/en not_active Expired - Lifetime
- 2004-03-29 EP EP04749522A patent/EP1622608A4/en not_active Withdrawn
- 2004-03-29 KR KR1020127002215A patent/KR101198526B1/ko not_active Expired - Lifetime
- 2004-03-29 NZ NZ543223A patent/NZ543223A/en not_active IP Right Cessation
- 2004-03-29 KR KR1020057018367A patent/KR20050113670A/ko not_active Withdrawn
- 2004-03-29 AU AU2004226338A patent/AU2004226338C1/en not_active Expired
- 2004-03-29 WO PCT/US2004/009667 patent/WO2004087075A2/en not_active Ceased
- 2004-03-29 CN CNA2004800132768A patent/CN1791403A/zh active Pending
- 2004-03-29 CA CA2520000A patent/CA2520000C/en not_active Expired - Lifetime
- 2004-03-29 MX MXPA05010407A patent/MXPA05010407A/es active IP Right Grant
- 2004-03-29 CN CN2010105956028A patent/CN102161679A/zh active Pending
- 2004-03-29 US US10/549,545 patent/US7550496B2/en not_active Expired - Lifetime
- 2004-03-29 JP JP2006509466A patent/JP2006521409A/ja not_active Ceased
- 2004-03-29 ES ES13178249T patent/ES2759176T3/es not_active Expired - Lifetime
-
2005
- 2005-09-19 IL IL170970A patent/IL170970A/en active IP Right Grant
- 2005-10-26 NO NO20054988A patent/NO336266B1/no not_active IP Right Cessation
-
2009
- 2009-06-12 US US12/484,104 patent/US8299088B2/en not_active Expired - Fee Related
-
2012
- 2012-01-26 JP JP2012014178A patent/JP5572644B2/ja not_active Expired - Fee Related
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