CN1791403A - 治疗癌症的组合物和方法 - Google Patents

治疗癌症的组合物和方法 Download PDF

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Publication number
CN1791403A
CN1791403A CNA2004800132768A CN200480013276A CN1791403A CN 1791403 A CN1791403 A CN 1791403A CN A2004800132768 A CNA2004800132768 A CN A2004800132768A CN 200480013276 A CN200480013276 A CN 200480013276A CN 1791403 A CN1791403 A CN 1791403A
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China
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alkyl
group
amide
protected
unsubstituted
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CNA2004800132768A
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English (en)
Chinese (zh)
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M·马泰乌奇
P·拉奥
J-X·段
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Molecular Templates Inc
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Threshold Pharmaceuticals Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Nanotechnology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2004800132768A 2003-03-28 2004-03-29 治疗癌症的组合物和方法 Pending CN1791403A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45884503P 2003-03-28 2003-03-28
US60/458,845 2003-03-28
US46528103P 2003-04-21 2003-04-21
US60/465,281 2003-04-21

Related Child Applications (1)

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CN1791403A true CN1791403A (zh) 2006-06-21

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CNA2004800132768A Pending CN1791403A (zh) 2003-03-28 2004-03-29 治疗癌症的组合物和方法
CN2010105956028A Pending CN102161679A (zh) 2003-03-28 2004-03-29 治疗癌症的组合物和方法

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US (2) US7550496B2 (enExample)
EP (2) EP2671581B8 (enExample)
JP (2) JP2006521409A (enExample)
KR (2) KR101198526B1 (enExample)
CN (2) CN1791403A (enExample)
AU (1) AU2004226338C1 (enExample)
CA (1) CA2520000C (enExample)
ES (1) ES2759176T3 (enExample)
IL (1) IL170970A (enExample)
MX (1) MXPA05010407A (enExample)
NO (1) NO336266B1 (enExample)
NZ (1) NZ543223A (enExample)
WO (1) WO2004087075A2 (enExample)
ZA (1) ZA200507752B (enExample)

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CN101538256A (zh) * 2009-04-28 2009-09-23 沈阳药科大学 3,4-二芳基呋喃-2,5-二酮类衍生物与3,4-二芳基-1h-吡咯-2,5-二酮类衍生物及其用途
CN102260273A (zh) * 2011-05-13 2011-11-30 兰州大学 脱氧鬼臼与5-氟尿嘧啶的拼合物及其制备与用途
CN104434876A (zh) * 2013-09-13 2015-03-25 布里吉·P·吉里 用于癌症疗法及成像的缺氧-标靶聚合微胞
CN105250325A (zh) * 2015-10-28 2016-01-20 淄博齐鼎立专利信息咨询有限公司 Demissine在制备治疗肾癌药物中的应用
CN106977501A (zh) * 2017-03-20 2017-07-25 华东师范大学 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药
CN107417672A (zh) * 2017-04-12 2017-12-01 华东师范大学 一种基于2,2‑二甲基‑3‑（2‑硝基咪唑基）丙酸的低氧激活前药
CN114617876A (zh) * 2022-01-28 2022-06-14 四川大学华西医院 一种抗肿瘤联合用药物
WO2023160344A1 (zh) * 2022-02-22 2023-08-31 东南大学 No供体化合物及其制备方法、药物组合物和应用

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