MX367614B - Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma. - Google Patents

Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.

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Publication number
MX367614B
MX367614B MX2014008751A MX2014008751A MX367614B MX 367614 B MX367614 B MX 367614B MX 2014008751 A MX2014008751 A MX 2014008751A MX 2014008751 A MX2014008751 A MX 2014008751A MX 367614 B MX367614 B MX 367614B
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MX
Mexico
Prior art keywords
dianhydrogalactitol
medulloblastoma
stem cells
cancer stem
multforme
Prior art date
Application number
MX2014008751A
Other languages
English (en)
Other versions
MX2014008751A (es
Inventor
Bacha Jeffrey
Dunn Sandra
Brown Dennis
Original Assignee
Del Mar Pharmaceuticals
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48799821&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX367614(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Del Mar Pharmaceuticals filed Critical Del Mar Pharmaceuticals
Publication of MX2014008751A publication Critical patent/MX2014008751A/es
Publication of MX367614B publication Critical patent/MX367614B/es

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
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    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

El uso de dianhidrogalactitol proporciona una modalidad terapéutica novedosa para el tratamiento de glioblastoma multiforme y meduloblastoma. El dianhidrogalactitol actúa como un agente alquilante en el ADN que crea la metilación en N7. El dianhidrogalactitol es efectivo en suprimir el crecimiento de células madre de cáncer y es activo en contra de tumores que son refractarios a temozolomida; el fármaco actúa independientemente del mecanismo de reparación de MGMT.
MX2014008751A 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma. MX367614B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261589029P 2012-01-20 2012-01-20
PCT/US2013/022505 WO2013110058A2 (en) 2012-01-20 2013-01-22 Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma

Publications (2)

Publication Number Publication Date
MX2014008751A MX2014008751A (es) 2016-01-08
MX367614B true MX367614B (es) 2019-08-28

Family

ID=48799821

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014008751A MX367614B (es) 2012-01-20 2013-01-22 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.
MX2019002917A MX2019002917A (es) 2012-01-20 2014-07-18 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.

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MX2019002917A MX2019002917A (es) 2012-01-20 2014-07-18 Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.

Country Status (14)

Country Link
US (6) US10201521B2 (es)
EP (1) EP2804602A4 (es)
JP (4) JP2015511936A (es)
KR (3) KR20220137154A (es)
CN (4) CN110711188A (es)
AU (3) AU2013209394A1 (es)
BR (1) BR112014017833A2 (es)
CA (1) CA2862706C (es)
CL (1) CL2014001917A1 (es)
HK (1) HK1208365A1 (es)
IL (2) IL233722B (es)
MX (2) MX367614B (es)
SG (1) SG11201404216TA (es)
WO (1) WO2013110058A2 (es)

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