CN1116875C - 紫杉醇脂质组合物及其制备方法 - Google Patents
紫杉醇脂质组合物及其制备方法 Download PDFInfo
- Publication number
- CN1116875C CN1116875C CN00119039A CN00119039A CN1116875C CN 1116875 C CN1116875 C CN 1116875C CN 00119039 A CN00119039 A CN 00119039A CN 00119039 A CN00119039 A CN 00119039A CN 1116875 C CN1116875 C CN 1116875C
- Authority
- CN
- China
- Prior art keywords
- preparation
- paclitaxel
- paclitaxel liposome
- liposome preparation
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract description 3
- 239000000203 mixture Substances 0.000 title description 5
- 229930012538 Paclitaxel Natural products 0.000 claims abstract description 40
- 229960001592 paclitaxel Drugs 0.000 claims abstract description 40
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims abstract description 40
- 238000002360 preparation method Methods 0.000 claims abstract description 32
- 239000002502 liposome Substances 0.000 claims abstract description 27
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 18
- 150000001413 amino acids Chemical class 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 7
- 239000000594 mannitol Substances 0.000 claims abstract description 7
- 235000010355 mannitol Nutrition 0.000 claims abstract description 7
- 238000004108 freeze drying Methods 0.000 claims abstract description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 3
- 235000001014 amino acid Nutrition 0.000 claims description 12
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 229940067606 lecithin Drugs 0.000 claims description 11
- 239000000787 lecithin Substances 0.000 claims description 11
- 235000010445 lecithin Nutrition 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 235000001727 glucose Nutrition 0.000 claims description 8
- 150000003904 phospholipids Chemical class 0.000 claims description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
- 239000004472 Lysine Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004473 Threonine Substances 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 150000002304 glucoses Chemical class 0.000 claims description 4
- 229930182817 methionine Natural products 0.000 claims description 4
- 239000008347 soybean phospholipid Substances 0.000 claims description 4
- 125000002456 taxol group Chemical group 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 239000001307 helium Substances 0.000 claims description 2
- 229910052734 helium Inorganic materials 0.000 claims description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000002904 solvent Substances 0.000 abstract description 12
- 231100000419 toxicity Toxicity 0.000 abstract description 8
- 230000001988 toxicity Effects 0.000 abstract description 8
- 230000001093 anti-cancer Effects 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- 239000008121 dextrose Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 description 12
- 230000008025 crystallization Effects 0.000 description 12
- 229940108949 paclitaxel injection Drugs 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 229940090044 injection Drugs 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 3
- 239000008389 polyethoxylated castor oil Substances 0.000 description 3
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003708 ampul Substances 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- -1 phosphatidyl glycerol ester Chemical class 0.000 description 2
- 206010065553 Bone marrow failure Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002801 charged material Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 剂量(mg/kg) | 动物数(只) | 瘤重(g) | 抑瘤率(%) | |
药前 | 药后 | ||||
紫杉醇脂质体紫杉醇脂质体紫杉醇脂质体紫杉醇注射液紫杉醇注射液对照 | 20.014.09.814.09.8 | 101010101010 | 10101010910 | 0.826±0.204**0.896±0.293**1.114±0.4250.860±0.177**1.180±0.2991.612±0.705 | 48.7944.4430.8946.6526.80 |
批号 | 时间(月) | 外观 | 显微镜检测 |
№1 | 0 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 |
1 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 | |
6 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 | |
12 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 | |
№2 | 0 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 |
1 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 | |
6 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 | |
12 | 类白色疏松块状物 | 溶解后无结晶析出,不聚集 |
Claims (8)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00119039A CN1116875C (zh) | 2000-10-19 | 2000-10-19 | 紫杉醇脂质组合物及其制备方法 |
AU2001246338A AU2001246338A1 (en) | 2000-10-19 | 2001-02-28 | Taxol liposome composition for treatment of cancer and preparation thereof |
ES01919099T ES2353488T3 (es) | 2000-10-19 | 2001-02-28 | Composición de liposomas de paclitaxel para el tratamiento del cáncer, y su preparación. |
AT01919099T ATE482688T1 (de) | 2000-10-19 | 2001-02-28 | Liposomzusammensetzungen, paclitaxel enthaltend, zur behandlung von krebs und deren zubereitung |
DE60143168T DE60143168D1 (de) | 2000-10-19 | 2001-02-28 | Liposomzusammensetzungen, Paclitaxel enthaltend, zur Behandlung von Krebs und deren Zubereitung |
RU2003114442/15A RU2264807C2 (ru) | 2000-10-19 | 2001-02-28 | Липосомальная композиция с паклитакселом для лечения рака и способ ее получения |
JP2002535637A JP4890732B2 (ja) | 2000-10-19 | 2001-02-28 | 癌治療用パクリタキセル・リポソーム組成物およびその製造方法 |
PCT/CN2001/000309 WO2002032399A1 (fr) | 2000-10-19 | 2001-02-28 | Composition pharmaceutique pour le traitement du cancer combinant le taxol et un liposome ainsi que son procede de preparation |
EP01919099A EP1332755B1 (en) | 2000-10-19 | 2001-02-28 | Paclitaxel Liposome Composition For Treatment of Cancer and Preparation Thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN00119039A CN1116875C (zh) | 2000-10-19 | 2000-10-19 | 紫杉醇脂质组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1291474A CN1291474A (zh) | 2001-04-18 |
CN1116875C true CN1116875C (zh) | 2003-08-06 |
Family
ID=4587434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN00119039A Expired - Lifetime CN1116875C (zh) | 2000-10-19 | 2000-10-19 | 紫杉醇脂质组合物及其制备方法 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1332755B1 (zh) |
JP (1) | JP4890732B2 (zh) |
CN (1) | CN1116875C (zh) |
AT (1) | ATE482688T1 (zh) |
AU (1) | AU2001246338A1 (zh) |
DE (1) | DE60143168D1 (zh) |
ES (1) | ES2353488T3 (zh) |
RU (1) | RU2264807C2 (zh) |
WO (1) | WO2002032399A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100364525C (zh) * | 2006-04-12 | 2008-01-30 | 中国药科大学 | 含壳聚糖衍生物的多西他塞脂质体、冻干制剂及制备方法 |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1813679A (zh) * | 2005-11-30 | 2006-08-09 | 上海医药(集团)有限公司 | 一种紫杉烷脂质体冻干组合物及其制备方法 |
US8226975B2 (en) | 2005-12-08 | 2012-07-24 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof |
AR054215A1 (es) | 2006-01-20 | 2007-06-13 | Eriochem Sa | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
CN100386069C (zh) * | 2006-06-26 | 2008-05-07 | 裴泽军 | 亮菌甲素脂质体制剂及其制备方法 |
CN101015525B (zh) * | 2007-02-15 | 2012-02-22 | 沈阳药科大学 | 紫杉醇脂质体及其制备方法 |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
AR063111A1 (es) | 2007-10-03 | 2008-12-30 | Eriochem Sa | Una formulacion farmaceutica de taxano |
EP2415464B1 (en) * | 2009-03-30 | 2017-05-10 | Eisai R&D Management Co., Ltd. | Method for producing liposome composition |
CN102369008B (zh) | 2009-03-30 | 2014-10-29 | 卫材R&D管理有限公司 | 脂质体组合物 |
CN102048725B (zh) * | 2009-10-29 | 2014-07-16 | 中国医学科学院药物研究所 | 紫杉醇胆固醇复合物 |
CN103476250A (zh) | 2010-08-18 | 2013-12-25 | 德玛医药 | 改善未达最佳给药的化合物包括取代的己糖醇比如卫康醇与二乙酰二脱水卫矛醇的治疗效果的组合物和方法 |
WO2012129957A1 (zh) * | 2011-03-28 | 2012-10-04 | Zhao Wenzhi | 几种药物配方 |
AU2012389562A1 (en) | 2011-08-17 | 2014-07-24 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of subotimally administered chemical compounds including substituted hexitols such as dibromodulcitol |
EP2804602A4 (en) | 2012-01-20 | 2016-08-10 | Dennis Brown | USE OF SUBSTITUTED HEXITOLS WITH DIANHYDROGALACTITOL AND ANALOGUE FOR THE TREATMENT OF NEOPLASTIC DISEASES AND CANCER STEM CELLS INCLUDING GLIOBLASTOMA MULTFORME AND MEDULLOBLASTOMA |
EP2827869A4 (en) | 2012-03-23 | 2015-09-23 | Dennis Brown | COMPOSITIONS AND METHODS FOR IMPROVING THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ITS ANALOGUES INCLUDING MESOINDIGO |
WO2013169600A1 (en) | 2012-05-09 | 2013-11-14 | Delmar Pharmaceuticals | Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies |
WO2014004376A2 (en) | 2012-06-26 | 2014-01-03 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
ES2743039T3 (es) * | 2012-11-29 | 2020-02-18 | Insmed Inc | Formulaciones de vancomicina estabilizada |
RU2516893C1 (ru) * | 2012-12-14 | 2014-05-20 | Общество с ограниченной ответственностью "Уральский центр биофармацевтических технологий" | Липосомальная композиция и способ ее получения |
WO2015013579A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
AU2014318471B2 (en) * | 2013-09-13 | 2019-12-19 | Veiled Therapeutics, Llc | Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation |
CN103705475A (zh) * | 2013-12-27 | 2014-04-09 | 桂林南药股份有限公司 | 一种青蒿琥酯冻干粉针剂组合物及其制备方法 |
JP2015193580A (ja) * | 2014-03-31 | 2015-11-05 | テルモ株式会社 | アムホテリシンbリポソームの製造方法 |
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US5576017A (en) * | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
PT706373E (pt) * | 1992-03-23 | 2000-11-30 | Univ Georgetown | Taxol encapsulado num liposoma e um metodo |
WO1994026254A1 (en) * | 1993-05-17 | 1994-11-24 | The Liposome Company, Inc. | Incorporation of taxol into liposomes and gels |
DE4447770C2 (de) * | 1994-08-20 | 2002-12-19 | Max Delbrueck Centrum | Verfahren zur Herstellung von liposomal verkapseltem Taxol |
CN1148957A (zh) * | 1996-09-02 | 1997-05-07 | 张海茹 | 紫杉醇水溶性粉针剂及其制备方法 |
US5891467A (en) * | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
-
2000
- 2000-10-19 CN CN00119039A patent/CN1116875C/zh not_active Expired - Lifetime
-
2001
- 2001-02-28 AT AT01919099T patent/ATE482688T1/de active
- 2001-02-28 JP JP2002535637A patent/JP4890732B2/ja not_active Expired - Lifetime
- 2001-02-28 AU AU2001246338A patent/AU2001246338A1/en not_active Abandoned
- 2001-02-28 EP EP01919099A patent/EP1332755B1/en not_active Expired - Lifetime
- 2001-02-28 RU RU2003114442/15A patent/RU2264807C2/ru active
- 2001-02-28 DE DE60143168T patent/DE60143168D1/de not_active Expired - Lifetime
- 2001-02-28 WO PCT/CN2001/000309 patent/WO2002032399A1/zh active Application Filing
- 2001-02-28 ES ES01919099T patent/ES2353488T3/es not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN100364525C (zh) * | 2006-04-12 | 2008-01-30 | 中国药科大学 | 含壳聚糖衍生物的多西他塞脂质体、冻干制剂及制备方法 |
Also Published As
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ES2353488T3 (es) | 2011-03-02 |
EP1332755B1 (en) | 2010-09-29 |
WO2002032399A1 (fr) | 2002-04-25 |
DE60143168D1 (de) | 2010-11-11 |
EP1332755A1 (en) | 2003-08-06 |
AU2001246338A1 (en) | 2002-04-29 |
JP2004516247A (ja) | 2004-06-03 |
JP4890732B2 (ja) | 2012-03-07 |
RU2264807C2 (ru) | 2005-11-27 |
ATE482688T1 (de) | 2010-10-15 |
EP1332755A4 (en) | 2005-03-09 |
CN1291474A (zh) | 2001-04-18 |
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