ATE255899T1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents

Isophosphoramide-senfgasanalogen und deren verwendung

Info

Publication number
ATE255899T1
ATE255899T1 AT00939331T AT00939331T ATE255899T1 AT E255899 T1 ATE255899 T1 AT E255899T1 AT 00939331 T AT00939331 T AT 00939331T AT 00939331 T AT00939331 T AT 00939331T AT E255899 T1 ATE255899 T1 AT E255899T1
Authority
AT
Austria
Prior art keywords
analogues
isophosphoramide mustard
mustard gas
isophosphoramide
gas
Prior art date
Application number
AT00939331T
Other languages
English (en)
Inventor
Robert F Struck
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE255899T1 publication Critical patent/ATE255899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Artificial Filaments (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
AT00939331T 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung ATE255899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13583099P 1999-05-24 1999-05-24
PCT/US2000/014275 WO2000071134A1 (en) 1999-05-24 2000-05-24 Isophosphoramide mustard analogs and use thereof

Publications (1)

Publication Number Publication Date
ATE255899T1 true ATE255899T1 (de) 2003-12-15

Family

ID=22469903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00939331T ATE255899T1 (de) 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung

Country Status (9)

Country Link
US (1) US6197760B1 (de)
EP (1) EP1185276B1 (de)
JP (1) JP4629238B2 (de)
AT (1) ATE255899T1 (de)
AU (1) AU773061B2 (de)
CA (1) CA2373634C (de)
DE (1) DE60007120T2 (de)
HK (1) HK1043058A1 (de)
WO (1) WO2000071134A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1287794C (zh) * 2002-05-31 2006-12-06 R·P·谢勒技术有限公司 用于软胶囊的含有长春瑞滨的口服医药组合物及治疗方法
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
RU2279873C2 (ru) * 2002-05-31 2006-07-20 Ар.Пи.ШЕРЕР ТЕКНОЛОДЖИЗ, ИНК. Пероральная фармацевтическая композиция для мягких капсул, содержащая винорелбин, и способ лечения
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
AU2011221388B2 (en) * 2004-10-25 2014-08-21 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
EP2336139A3 (de) * 2004-10-25 2012-01-04 Dekk-Tec, Inc. Salze aus Isophosphoramid-Mustard und Analoge davon als Antitumormittel
CN102746336B (zh) 2005-06-29 2015-08-19 施瑞修德制药公司 氨基磷酸酯烷化剂前体药物
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
EP2114157B1 (de) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidatalkylator-prodrug für die krebstherapie
KR101505415B1 (ko) 2007-04-06 2015-03-25 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
KR20110038696A (ko) 2008-07-31 2011-04-14 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 유사체의 합성 및 제형
WO2013116281A1 (en) 2012-01-31 2013-08-08 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities

Also Published As

Publication number Publication date
DE60007120T2 (de) 2004-09-16
JP4629238B2 (ja) 2011-02-09
AU5443000A (en) 2000-12-12
AU773061B2 (en) 2004-05-13
US6197760B1 (en) 2001-03-06
CA2373634C (en) 2010-04-13
JP2004515448A (ja) 2004-05-27
CA2373634A1 (en) 2000-11-30
EP1185276B1 (de) 2003-12-10
EP1185276A4 (de) 2002-12-04
WO2000071134A1 (en) 2000-11-30
DE60007120D1 (de) 2004-01-22
EP1185276A1 (de) 2002-03-13
HK1043058A1 (zh) 2002-09-06

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Legal Events

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