ATE255899T1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents

Isophosphoramide-senfgasanalogen und deren verwendung

Info

Publication number
ATE255899T1
ATE255899T1 AT00939331T AT00939331T ATE255899T1 AT E255899 T1 ATE255899 T1 AT E255899T1 AT 00939331 T AT00939331 T AT 00939331T AT 00939331 T AT00939331 T AT 00939331T AT E255899 T1 ATE255899 T1 AT E255899T1
Authority
AT
Austria
Prior art keywords
analogues
isophosphoramide mustard
mustard gas
isophosphoramide
gas
Prior art date
Application number
AT00939331T
Other languages
English (en)
Inventor
Robert F Struck
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE255899T1 publication Critical patent/ATE255899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT00939331T 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung ATE255899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13583099P 1999-05-24 1999-05-24
PCT/US2000/014275 WO2000071134A1 (en) 1999-05-24 2000-05-24 Isophosphoramide mustard analogs and use thereof

Publications (1)

Publication Number Publication Date
ATE255899T1 true ATE255899T1 (de) 2003-12-15

Family

ID=22469903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00939331T ATE255899T1 (de) 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung

Country Status (9)

Country Link
US (1) US6197760B1 (de)
EP (1) EP1185276B1 (de)
JP (1) JP4629238B2 (de)
AT (1) ATE255899T1 (de)
AU (1) AU773061B2 (de)
CA (1) CA2373634C (de)
DE (1) DE60007120T2 (de)
HK (1) HK1043058A1 (de)
WO (1) WO2000071134A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462419T1 (de) * 2002-05-31 2010-04-15 Rp Scherer Technologies Llc Orale pharmazeutische zusammensetzung für weichkapseln mit vinorelbin und behandlungsverfahren
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
JP5336082B2 (ja) 2004-10-25 2013-11-06 デック−テク インコーポレイテッド 抗腫瘍剤としてのイソホスホルアミドマスタードの塩及びその類似物
AU2011221388B2 (en) * 2004-10-25 2014-08-21 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
JP5180824B2 (ja) 2005-06-29 2013-04-10 スレッシュホールド ファーマシューティカルズ， インコーポレイテッド ホスホルアミデートアルキル化剤プロドラッグ
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
WO2008083101A1 (en) 2006-12-26 2008-07-10 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
RU2527531C2 (ru) * 2007-04-06 2014-09-10 Зайофарм Онколоджи, Инк. Соли изофосфорамидного иприта и его аналогов
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
AU2009276512B2 (en) * 2008-07-31 2014-12-18 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
WO2013116281A1 (en) * 2012-01-31 2013-08-08 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities

Also Published As

Publication number Publication date
HK1043058A1 (zh) 2002-09-06
JP2004515448A (ja) 2004-05-27
EP1185276A1 (de) 2002-03-13
US6197760B1 (en) 2001-03-06
EP1185276A4 (de) 2002-12-04
DE60007120T2 (de) 2004-09-16
DE60007120D1 (de) 2004-01-22
JP4629238B2 (ja) 2011-02-09
WO2000071134A1 (en) 2000-11-30
EP1185276B1 (de) 2003-12-10
CA2373634A1 (en) 2000-11-30
AU773061B2 (en) 2004-05-13
CA2373634C (en) 2010-04-13
AU5443000A (en) 2000-12-12

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Legal Events

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