DE60007120D1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents

Isophosphoramide-senfgasanalogen und deren verwendung

Info

Publication number
DE60007120D1
DE60007120D1 DE60007120T DE60007120T DE60007120D1 DE 60007120 D1 DE60007120 D1 DE 60007120D1 DE 60007120 T DE60007120 T DE 60007120T DE 60007120 T DE60007120 T DE 60007120T DE 60007120 D1 DE60007120 D1 DE 60007120D1
Authority
DE
Germany
Prior art keywords
isophosphoramide mustard
mustard gas
analogs
gas analogs
isophosphoramide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007120T
Other languages
English (en)
Other versions
DE60007120T2 (de
Inventor
F Struck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOUTHERN RES INST BIRMINGHAM
Southern Research Institute
Original Assignee
SOUTHERN RES INST BIRMINGHAM
Southern Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOUTHERN RES INST BIRMINGHAM, Southern Research Institute filed Critical SOUTHERN RES INST BIRMINGHAM
Application granted granted Critical
Publication of DE60007120D1 publication Critical patent/DE60007120D1/de
Publication of DE60007120T2 publication Critical patent/DE60007120T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Artificial Filaments (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
DE60007120T 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung Expired - Lifetime DE60007120T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13583099P 1999-05-24 1999-05-24
US135830P 1999-05-24
PCT/US2000/014275 WO2000071134A1 (en) 1999-05-24 2000-05-24 Isophosphoramide mustard analogs and use thereof

Publications (2)

Publication Number Publication Date
DE60007120D1 true DE60007120D1 (de) 2004-01-22
DE60007120T2 DE60007120T2 (de) 2004-09-16

Family

ID=22469903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007120T Expired - Lifetime DE60007120T2 (de) 1999-05-24 2000-05-24 Isophosphoramide-senfgasanalogen und deren verwendung

Country Status (9)

Country Link
US (1) US6197760B1 (de)
EP (1) EP1185276B1 (de)
JP (1) JP4629238B2 (de)
AT (1) ATE255899T1 (de)
AU (1) AU773061B2 (de)
CA (1) CA2373634C (de)
DE (1) DE60007120T2 (de)
HK (1) HK1043058A1 (de)
WO (1) WO2000071134A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60331920D1 (de) * 2002-05-31 2010-05-12 Rp Scherer Technologies Llc Orale pharmazeutische zusammensetzung für weichkapseln mit vinorelbin und behandlungsverfahren
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
CA2585125C (en) * 2004-10-25 2014-04-22 Lee Morgan Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
AU2011221388B2 (en) * 2004-10-25 2014-08-21 Dekk-Tec, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
US8003625B2 (en) * 2005-06-29 2011-08-23 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
ES2884044T3 (es) * 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
PT2155682E (pt) * 2007-04-06 2015-10-15 Ziopharm Oncology Inc Sais de mostarda de isofosforamida e análogos da mesma
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
NZ590995A (en) 2008-07-31 2012-12-21 Ziopharm Oncology Inc Oral formulations of salts of isophosphoramide mustard and its analogs and their use in the treatment of a condition characterised by abnormal cell growth or differentiation (such as cancer)
WO2013116281A1 (en) * 2012-01-31 2013-08-08 Ziopharm Oncology, Inc. Combination therapy including isophosphoramide mustard, analogs, or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159886A (de) * 1974-11-20 1976-05-25 Shionogi Seiyaku Kk
US5468499A (en) * 1993-11-15 1995-11-21 Ohio State University Liposomes containing the salt of phosphoramide mustard and related compounds
US5659061A (en) * 1995-04-20 1997-08-19 Drug Innovation & Design, Inc. Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities

Also Published As

Publication number Publication date
EP1185276A4 (de) 2002-12-04
EP1185276B1 (de) 2003-12-10
DE60007120T2 (de) 2004-09-16
US6197760B1 (en) 2001-03-06
AU773061B2 (en) 2004-05-13
JP2004515448A (ja) 2004-05-27
ATE255899T1 (de) 2003-12-15
AU5443000A (en) 2000-12-12
EP1185276A1 (de) 2002-03-13
HK1043058A1 (zh) 2002-09-06
CA2373634C (en) 2010-04-13
CA2373634A1 (en) 2000-11-30
JP4629238B2 (ja) 2011-02-09
WO2000071134A1 (en) 2000-11-30

Similar Documents

Publication Publication Date Title
DE60010098D1 (de) 28-epirapaloge
DE29806504U1 (de) Azidfreie, gaserzeugende Zusammensetzung
CY1105758T1 (el) Τροποποιημενη απιμιναση αργινινης
DK0912535T3 (da) Konjugater af cis-docosahexaensyre og paclitaxel
ID29883A (id) Pengolahan gas hidrokarbon
HN1996000017A (es) Isotiazolonas
ID23731A (id) Metode dan aparatus untuk menambah perolehan karbon dioksida
DE69942827D1 (de) Verwendung der epothilons zur behandlung der krebs
ATE271066T1 (de) Lösliche mutante ctla4 moleküle und deren verwendung
ATE231872T1 (de) Thiazolopyrimidinderivate
DE60007120D1 (de) Isophosphoramide-senfgasanalogen und deren verwendung
ATE348805T1 (de) 2-acyl-indolderivate und deren verwendung als antitumormittel
IT1285770B1 (it) Composti corticoidei
BRPI0112375B8 (pt) aplidinas como derivados antitumorais
DE59902827D1 (de) Azidfreie, gaserzeugende Zusammensetzung
DE19981911T1 (de) Gasbildende Zusammensetzung
DE60045330D1 (de) Wirbelsystem für einen ionisierbares Gas verwendenden Koagulator
DE60024724D1 (de) Reflektoren für eine ultraviolette Strahlungsquelle
DE50010265D1 (de) Azidfreie gaserzeugende Zusammensetzung
DE19981909T1 (de) Gasbildende Zusammensetzung
DE69915690D1 (de) Antikonvulsive derivate zur behandlung von posttraumatischen stresserkrankungen
BR0316544A (pt) Compostos calcilìticos
TR200103219T2 (tr) Nöropatik ağrının iyileştirilmesinde kullanım için aroil aminoasil piroller
ATE165594T1 (de) Triarylethylenderivate zur therapeutischen verwendung
DE60227078D1 (de) Allylmercaptocaptoprilverbindungen und deren verwendungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition