JP2011510663A5 - - Google Patents

Info

Publication number

JP2011510663A5

JP2011510663A5 JP2010545256A JP2010545256A JP2011510663A5 JP 2011510663 A5 JP2011510663 A5 JP 2011510663A5 JP 2010545256 A JP2010545256 A JP 2010545256A JP 2010545256 A JP2010545256 A JP 2010545256A JP 2011510663 A5 JP2011510663 A5 JP 2011510663A5

Authority

JP

Japan

Prior art keywords

nucleic acid

subject

microvesicle

dna

biomarker

Prior art date

2009-02-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108020004707 nucleic acids Proteins 0.000 claims 22
• 150000007523 nucleic acids Chemical class 0.000 claims 22
• 102000039446 nucleic acids Human genes 0.000 claims 22
• 239000000090 biomarker Substances 0.000 claims 19
• 238000000034 method Methods 0.000 claims 19
• 201000010099 disease Diseases 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 108020004999 messenger RNA Proteins 0.000 claims 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
• 210000001124 body fluid Anatomy 0.000 claims 4
• 239000010839 body fluid Substances 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 108091033411 PCA3 Proteins 0.000 claims 3
• 102000016911 Deoxyribonucleases Human genes 0.000 claims 2
• 108010053770 Deoxyribonucleases Proteins 0.000 claims 2
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 2
• 241000192019 Human endogenous retrovirus K Species 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 102000006382 Ribonucleases Human genes 0.000 claims 2
• 108010083644 Ribonucleases Proteins 0.000 claims 2
• 108091006649 SLC9A3 Proteins 0.000 claims 2
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 2
• 102100030375 Sodium/hydrogen exchanger 3 Human genes 0.000 claims 2
• 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 2
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
• 208000005017 glioblastoma Diseases 0.000 claims 2
• 239000012139 lysis buffer Substances 0.000 claims 2
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
• 238000000746 purification Methods 0.000 claims 2
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• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 1
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• 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 1
• 102000004888 Aquaporin 1 Human genes 0.000 claims 1
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• 102100031096 Cubilin Human genes 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 102100030708 GTPase KRas Human genes 0.000 claims 1
• 102100034477 H(+)/Cl(-) exchange transporter 3 Human genes 0.000 claims 1
• 101000922080 Homo sapiens Cubilin Proteins 0.000 claims 1
• 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims 1
• 101000710223 Homo sapiens H(+)/Cl(-) exchange transporter 3 Proteins 0.000 claims 1
• 101001043562 Homo sapiens Low-density lipoprotein receptor-related protein 2 Proteins 0.000 claims 1
• 101000627854 Homo sapiens Matrix metalloproteinase-26 Proteins 0.000 claims 1
• 101000978730 Homo sapiens Nephrin Proteins 0.000 claims 1
• 101000595193 Homo sapiens Podocin Proteins 0.000 claims 1
• 101000670953 Homo sapiens V-type proton ATPase subunit B, kidney isoform Proteins 0.000 claims 1
• 101000807859 Homo sapiens Vasopressin V2 receptor Proteins 0.000 claims 1
• 102100021922 Low-density lipoprotein receptor-related protein 2 Human genes 0.000 claims 1
• 102100027998 Macrophage metalloelastase Human genes 0.000 claims 1
• 101710187853 Macrophage metalloelastase Proteins 0.000 claims 1
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 1
• 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 1
• 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
• 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
• 102100030201 Matrix metalloproteinase-15 Human genes 0.000 claims 1
• 108090000560 Matrix metalloproteinase-15 Proteins 0.000 claims 1
• 102100029693 Matrix metalloproteinase-20 Human genes 0.000 claims 1
• 108090000609 Matrix metalloproteinase-20 Proteins 0.000 claims 1
• 101710082411 Matrix metalloproteinase-21 Proteins 0.000 claims 1
• 102100024130 Matrix metalloproteinase-23 Human genes 0.000 claims 1
• 102100024129 Matrix metalloproteinase-24 Human genes 0.000 claims 1
• 108050005214 Matrix metalloproteinase-24 Proteins 0.000 claims 1
• 102100024128 Matrix metalloproteinase-26 Human genes 0.000 claims 1
• 102100024132 Matrix metalloproteinase-27 Human genes 0.000 claims 1
• 108050005201 Matrix metalloproteinase-27 Proteins 0.000 claims 1
• 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
• 102100023195 Nephrin Human genes 0.000 claims 1
• 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
• 101710118230 Neutrophil collagenase Proteins 0.000 claims 1
• 102100036037 Podocin Human genes 0.000 claims 1
• 108091027967 Small hairpin RNA Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 102000007000 Tenascin Human genes 0.000 claims 1
• 108010008125 Tenascin Proteins 0.000 claims 1
• 102100039468 V-type proton ATPase subunit B, kidney isoform Human genes 0.000 claims 1
• 102100037108 Vasopressin V2 receptor Human genes 0.000 claims 1
• 230000005856 abnormality Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 238000000605 extraction Methods 0.000 claims 1
• 230000004077 genetic alteration Effects 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 claims 1
• 102000018511 hepcidin Human genes 0.000 claims 1
• 229940066919 hepcidin Drugs 0.000 claims 1
• 108060003558 hepcidin Proteins 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1
• 239000004055 small Interfering RNA Substances 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1