SI1913157T2 - EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem - Google Patents
EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjemInfo
- Publication number
- SI1913157T2 SI1913157T2 SI200631512T SI200631512T SI1913157T2 SI 1913157 T2 SI1913157 T2 SI 1913157T2 SI 200631512 T SI200631512 T SI 200631512T SI 200631512 T SI200631512 T SI 200631512T SI 1913157 T2 SI1913157 T2 SI 1913157T2
- Authority
- SI
- Slovenia
- Prior art keywords
- egfr
- prediction
- patient response
- inhibitor treatment
- kras mutations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69517405P | 2005-06-28 | 2005-06-28 | |
PCT/US2006/023230 WO2007001868A1 (en) | 2005-06-28 | 2006-06-13 | Egfr and kras mutations |
EP06773201.6A EP1913157B2 (en) | 2005-06-28 | 2006-06-13 | Egfr and kras mutations for prediction of patient response to egfr inhibitor treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
SI1913157T1 SI1913157T1 (sl) | 2013-02-28 |
SI1913157T2 true SI1913157T2 (sl) | 2017-02-28 |
Family
ID=36999856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200631512T SI1913157T2 (sl) | 2005-06-28 | 2006-06-13 | EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem |
Country Status (9)
Country | Link |
---|---|
US (4) | US20090202989A1 (sl) |
EP (1) | EP1913157B2 (sl) |
JP (2) | JP2008546421A (sl) |
CA (1) | CA2612183C (sl) |
DK (1) | DK1913157T4 (sl) |
ES (1) | ES2398709T5 (sl) |
PL (1) | PL1913157T5 (sl) |
SI (1) | SI1913157T2 (sl) |
WO (1) | WO2007001868A1 (sl) |
Families Citing this family (59)
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ATE533513T1 (de) | 2002-09-06 | 2011-12-15 | Cerulean Pharma Inc | Polymere auf basis von cyclodextrin zur verabreichung von an diese kovalent gebundene arzneimittel |
CA2569520C (en) | 2004-06-04 | 2023-03-14 | Genentech, Inc. | Kras mutations for identifying colorectal tumors responsive to cetuximab or panitumumab |
JP2008535477A (ja) | 2005-02-24 | 2008-09-04 | アムジエン・インコーポレーテツド | 上皮成長因子受容体変異 |
JP2008536493A (ja) | 2005-04-01 | 2008-09-11 | アムジエン・インコーポレーテツド | 上皮増殖因子受容体遺伝子のコピー数 |
DK1913157T4 (en) * | 2005-06-28 | 2017-01-23 | Genentech Inc | EGFR and KRAS mutations for predicting patient response to EGFR inhibitor therapy. |
CA2620195A1 (en) * | 2005-08-24 | 2007-03-01 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
US7858390B2 (en) * | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway |
US7906342B2 (en) | 2006-03-31 | 2011-03-15 | Biodesix, Inc. | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples |
CN101449162B (zh) | 2006-05-18 | 2013-07-31 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
RS56422B1 (sr) † | 2007-03-13 | 2018-01-31 | Amgen Inc | K-ras mutacije i terapija anti-egfr antitelom |
PT2412828E (pt) | 2007-03-13 | 2013-08-02 | Amgen Inc | Mutações k-ras e b-raf e terapia com anticorpos anti-egfr |
EP2173370B1 (en) | 2007-06-27 | 2015-10-21 | The Board of Trustees of the Leland Stanford Junior University | Oligopeptide tyrosinase inhibitors and uses thereof |
KR101507188B1 (ko) | 2007-06-27 | 2015-03-30 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 펩티드 티로시나제 억제제 및 그의 용도 |
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BR112012003926A2 (pt) * | 2009-08-24 | 2020-08-11 | Genentech Inc | método para identificar um paciente não responsivo ao tratamento com um inibidor de b-raf, método para determinar se um tumor irá responder ao tratamento com um inibidor de b-raf, método para predizer se um paciente será não responsivo ao tratamento com um inibidor de braf específico, kit, método para classificar um tumor de mama, pulmão, cólon, ovário, tiroide, melanoma, ou pancreático e método para identificar um tumor não responsivo ao tratamento com um inibidor de b-raf |
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EP2475989A4 (en) * | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
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JP5808349B2 (ja) | 2010-03-01 | 2015-11-10 | カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー | セラノーシスのためのバイオマーカー |
AU2011223655A1 (en) | 2010-03-03 | 2012-06-28 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
CA2783656A1 (en) | 2010-03-03 | 2011-09-09 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
EP2542699A4 (en) * | 2010-03-03 | 2013-10-02 | Targeted Molecular Diagnostics Llc | METHODS FOR DETERMINING REACTIVITY TO A MEDICINE BASED ON DETERMINATION OF RAS MUTATION AND / OR RAS AMPLIFICATION |
WO2011107664A1 (en) | 2010-03-04 | 2011-09-09 | Hospital District Of Southwest Finland | Method for selecting patients for treatment with an egfr inhibitor |
US9469876B2 (en) | 2010-04-06 | 2016-10-18 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for metastatic prostate cancer |
CN102234683B (zh) * | 2010-04-23 | 2013-07-17 | 广州益善生物技术有限公司 | 一种egfr基因突变检测液相芯片 |
US20130095473A1 (en) * | 2010-06-14 | 2013-04-18 | Qiagen Gmbh | Method for determination of target cells or tissue for extraction of biomolecules from fixed biological samples |
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IN2013MN00522A (sl) | 2010-09-24 | 2015-05-29 | Univ Leland Stanford Junior | |
US9238812B2 (en) | 2010-09-30 | 2016-01-19 | Lsip, Llc | Agent for suppressing expression of dominant mutant gene |
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EP2715347A4 (en) * | 2011-05-26 | 2014-12-03 | Univ Brandeis | DETECTION OF SEQUENCE VARIANTS IN THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR GENE (EGFR-R) |
EP2748339B1 (en) * | 2011-10-18 | 2017-09-27 | Exact Sciences Corporation | Multiplexed kras mutation detection assay |
CN104039328B (zh) | 2011-11-11 | 2018-10-09 | 米伦纽姆医药公司 | 对蛋白酶体抑制剂的反应的生物标记 |
EP2823306A4 (en) * | 2012-03-09 | 2015-11-11 | Caris Life Sciences Switzerland Holdings Gmbh | BIOMARKER COMPOSITIONS AND METHODS |
EP2879712B1 (en) | 2012-07-31 | 2018-04-25 | Crown Bioscience, Inc. (Taicang) | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
SI2884979T1 (sl) | 2012-08-17 | 2019-10-30 | Hoffmann La Roche | Kombinirana zdravljenja melanoma, ki vključujejo dajanje kobimetiniba in vemurafeniba |
WO2014052613A2 (en) * | 2012-09-26 | 2014-04-03 | Insight Genetics, Inc. | Methods and compositions relating to next generation sequencing for genetic testing in alk related cancers |
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US20140199405A1 (en) * | 2013-01-11 | 2014-07-17 | Abraxis Bioscience, Llc | Method for treating cancer based on mutation status of k-ras |
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WO2015154005A1 (en) | 2014-04-04 | 2015-10-08 | Amgen Inc. | Biomarkers and use of met inhibitor for treatment of cancer |
US10406593B2 (en) | 2014-07-09 | 2019-09-10 | The Boeing Company | Method of using a tower for accessing an interior of a fuselage assembly |
CN106834484A (zh) * | 2017-02-27 | 2017-06-13 | 宁夏海诚电化信息科技有限公司 | 一种直肠癌体外检测方法 |
KR20220050143A (ko) * | 2019-08-22 | 2022-04-22 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Kras-관련 암 치료 방법 |
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US4683203A (en) * | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
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US5981725A (en) * | 1989-09-08 | 1999-11-09 | The Johns Hopkins Univiersity | Structural alterations of the EGF receptor gene in human tumors |
US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
US5869245A (en) | 1996-06-05 | 1999-02-09 | Fox Chase Cancer Center | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands |
JP2002537776A (ja) * | 1999-02-25 | 2002-11-12 | オークランド ユニサーヴィスィズ リミテッド | 早発性卵巣機能不全の診断及び治療 |
EP1170011A1 (en) * | 2000-07-06 | 2002-01-09 | Boehringer Ingelheim International GmbH | Novel use of inhibitors of the epidermal growth factor receptor |
EP2226396A1 (en) * | 2003-05-30 | 2010-09-08 | Genomic Health, Inc. | Gene expression markers for response to EGFR inhibitor drugs |
CN101501211A (zh) * | 2004-03-31 | 2009-08-05 | 综合医院公司 | 测定癌症对表皮生长因子受体靶向性治疗反应性的方法 |
CA2569520C (en) * | 2004-06-04 | 2023-03-14 | Genentech, Inc. | Kras mutations for identifying colorectal tumors responsive to cetuximab or panitumumab |
DK1913157T4 (en) * | 2005-06-28 | 2017-01-23 | Genentech Inc | EGFR and KRAS mutations for predicting patient response to EGFR inhibitor therapy. |
-
2006
- 2006-06-13 DK DK06773201.6T patent/DK1913157T4/en active
- 2006-06-13 WO PCT/US2006/023230 patent/WO2007001868A1/en active Application Filing
- 2006-06-13 US US11/915,830 patent/US20090202989A1/en not_active Abandoned
- 2006-06-13 EP EP06773201.6A patent/EP1913157B2/en active Active
- 2006-06-13 JP JP2008519347A patent/JP2008546421A/ja not_active Withdrawn
- 2006-06-13 CA CA2612183A patent/CA2612183C/en active Active
- 2006-06-13 ES ES06773201.6T patent/ES2398709T5/es active Active
- 2006-06-13 SI SI200631512T patent/SI1913157T2/sl unknown
- 2006-06-13 PL PL06773201T patent/PL1913157T5/pl unknown
-
2010
- 2010-06-15 US US12/815,978 patent/US20110081651A1/en not_active Abandoned
-
2012
- 2012-06-07 US US13/491,223 patent/US20130203788A1/en not_active Abandoned
- 2012-11-19 JP JP2012252837A patent/JP5827935B2/ja active Active
-
2014
- 2014-07-30 US US14/447,275 patent/US20150197814A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2398709T5 (es) | 2017-04-18 |
US20110081651A1 (en) | 2011-04-07 |
CA2612183A1 (en) | 2007-01-04 |
JP2008546421A (ja) | 2008-12-25 |
JP5827935B2 (ja) | 2015-12-02 |
WO2007001868A1 (en) | 2007-01-04 |
EP1913157A1 (en) | 2008-04-23 |
ES2398709T3 (es) | 2013-03-21 |
US20150197814A1 (en) | 2015-07-16 |
DK1913157T3 (da) | 2013-03-11 |
US20130203788A1 (en) | 2013-08-08 |
PL1913157T5 (pl) | 2017-09-29 |
DK1913157T4 (en) | 2017-01-23 |
PL1913157T3 (sl) | 2013-04-30 |
US20090202989A1 (en) | 2009-08-13 |
JP2013099330A (ja) | 2013-05-23 |
SI1913157T1 (sl) | 2013-02-28 |
EP1913157B1 (en) | 2012-11-28 |
EP1913157B2 (en) | 2016-10-26 |
CA2612183C (en) | 2015-08-11 |
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