JP5676277B2 - 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 - Google Patents

医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 Download PDF

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JP5676277B2
JP5676277B2 JP2010545256A JP2010545256A JP5676277B2 JP 5676277 B2 JP5676277 B2 JP 5676277B2 JP 2010545256 A JP2010545256 A JP 2010545256A JP 2010545256 A JP2010545256 A JP 2010545256A JP 5676277 B2 JP5676277 B2 JP 5676277B2
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microvesicles
cells
rna
exosomes
nucleic acid
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ヨハン カール オロフ スコッグ
ヨハン カール オロフ スコッグ
サンドラ オー． ブレークフィールド
サンドラ オー． ブレークフィールド
デニス ブラウン
デニス ブラウン
ケビン シー． ミランダ
ケビン シー． ミランダ
レイルアタ エム． ルッソ
レイルアタ エム． ルッソ
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ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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JP2010545256A 2008-02-01 2009-02-02 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 Active JP5676277B2 (ja)

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US2553608P 2008-02-01 2008-02-01
US61/025,536 2008-02-01
US10029308P 2008-09-26 2008-09-26
US61/100,293 2008-09-26
PCT/US2009/032881 WO2009100029A1 (en) 2008-02-01 2009-02-02 Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions

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JP2014261849A Active JP6322132B2 (ja) 2008-02-01 2014-12-25 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用
JP2017245712A Pending JP2018088922A (ja) 2008-02-01 2017-12-22 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用

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JP2017245712A Pending JP2018088922A (ja) 2008-02-01 2017-12-22 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用

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KR (3) KR20100127768A (enExample)
CN (2) CN105734128B (enExample)
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Families Citing this family (345)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
CA2607455A1 (en) * 2005-04-22 2006-11-02 Morphotek, Inc. Antibodies with immune effector activity and that internalize in endosialin-positive cells
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
CN103866018B (zh) 2005-08-01 2016-05-25 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
CN103028120B (zh) 2005-09-12 2015-08-12 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
ES2524018T3 (es) 2006-01-05 2014-12-03 The Ohio State University Research Foundation Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares
EP2487260B1 (en) 2006-01-05 2015-07-08 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis and treatment of solid cancers
WO2007081720A2 (en) 2006-01-05 2007-07-19 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
ES2736726T3 (es) * 2006-03-09 2020-01-07 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
EP2369012A1 (en) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Micro-RNA fingerprints during human megakaryocytopoiesis
CA2657030A1 (en) 2006-07-13 2008-01-17 The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
JP5501766B2 (ja) 2006-11-01 2014-05-28 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 肝細胞癌における生存および転移を予測するためのマイクロｒｎａ発現サイン
US8034560B2 (en) 2007-01-31 2011-10-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
WO2008124570A1 (en) 2007-04-05 2008-10-16 Morphotek, Inc. Methods for inhibiting the binding of endosialin to ligands
JP5592251B2 (ja) * 2007-04-30 2014-09-17 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 膵臓癌を正常な膵臓機能および／または慢性膵炎と識別する方法
CA2690144A1 (en) 2007-06-08 2008-12-18 The Government Of The United States Of America As Represented By The Sec Retary Of Department Of Health And Human Services Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
ES2496172T3 (es) 2007-07-31 2014-09-18 The Ohio State University Research Foundation Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B
AU2008283997B2 (en) 2007-08-03 2014-04-10 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
EP2176665B1 (en) 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
CN101836112A (zh) 2007-08-22 2010-09-15 俄亥俄州立大学研究基金会 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物
CA2702241A1 (en) * 2007-10-11 2009-04-16 The Ohio State University Research Foundation Methods and compositions for the diagnosis and treatment of esophageal adenocarcinomas
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
US20120058492A1 (en) * 2008-01-25 2012-03-08 Hansabiomed Ou Method and a Kit To Detect Malignant Tumors and Provide a Prognosis
US20110195426A1 (en) * 2009-07-16 2011-08-11 The General Hospital Corporation Nucleic acids analysis
CA2716906A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of gastric cancer
WO2009108860A2 (en) * 2008-02-28 2009-09-03 The Ohio University Rasearch Foundation Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
AU2009257410B2 (en) 2008-06-11 2014-03-06 Fudan University Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy
WO2010019694A1 (en) * 2008-08-12 2010-02-18 The Ohio State University Research Foundation Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma
EP2326734B1 (en) * 2008-09-03 2016-11-09 The Johns Hopkins University Pathways underlying pancreatic tumorigenesis and an hereditary pancreatic cancer gene
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
US9487837B2 (en) 2008-10-06 2016-11-08 Morehouse School Of Medicine Exosome-mediated diagnosis of hepatitis virus infections and diseases
US20110301221A1 (en) * 2008-10-10 2011-12-08 Swedish Health Services Diagnosis, prognosis and treatment of glioblastoma multiforme
US7888035B2 (en) 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
EP2202522A1 (en) * 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP3461912B1 (en) * 2009-09-09 2022-07-13 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
EP2475989A4 (en) * 2009-09-09 2013-02-27 Gen Hospital Corp USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS
WO2011044513A1 (en) * 2009-10-08 2011-04-14 Wake Forest University Health Sciences Diagnostic and prognostic markers for cancer
WO2011063324A2 (en) * 2009-11-20 2011-05-26 The General Hospital Corporation Microfluidic systems for isolating microvesicles
JP5960060B2 (ja) 2009-11-23 2016-08-02 ジ・オハイオ・ステート・ユニバーシティ 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法
EP2507393A4 (en) * 2009-11-30 2013-05-01 Caris Life Sciences Luxembourg Holdings METHODS AND SYSTEMS FOR ISOLATING, STORING AND ANALYZING VESICLES
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
EP4074838A1 (en) * 2010-01-19 2022-10-19 Verinata Health, Inc. Novel protocol for preparing sequencing libraries
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
JP2011149859A (ja) * 2010-01-22 2011-08-04 Igaku Seibutsugaku Kenkyusho:Kk 食道癌マーカー
US20130052647A1 (en) * 2010-02-10 2013-02-28 Marianna Goldrick Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery
EP2415877A3 (en) * 2010-02-17 2012-02-15 Deutsches Krebsforschungszentrum Means and methods for diagnosing pancreatic cancer
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
EP2542895A1 (en) 2010-03-03 2013-01-09 Consiglio Nazionale Delle Ricerche Increase of myeloid microvesicles in the cerebrospinal fluid as biomarker of microglia/macrophage activation in neurological disorders
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
US20130137593A1 (en) * 2010-04-15 2013-05-30 Hadasit Medical Research Services And Development Ltd. Early detection and staging of colorectal cancer using a panel of micro rnas
EP2569418B1 (en) 2010-05-12 2016-11-02 RegenMed (Cayman) Ltd. Bioactive renal cells
WO2011140662A1 (en) * 2010-05-13 2011-11-17 The Royal Institution For The Advancement Of Learning / Mcgill University Cux1 signature for determination of cancer clinical outcome
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
CA3207599A1 (en) 2010-05-18 2011-11-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9376679B2 (en) 2010-05-26 2016-06-28 Micromedmark Biotech Co. Ltd. Microvesicles carrying small interfering RNAs, preparation methods and uses thereof
EP2578236B1 (en) 2010-05-26 2016-03-30 Micromedmark Biotech Co., Ltd PREPARATION OF MICROVESICLE-siRNA COMPLEXES AND USE THEREOF IN AIDS TREATMENT
WO2011156734A2 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
JP5755326B2 (ja) * 2010-06-11 2015-07-29 日立化成株式会社 腎機能の特徴を決定する方法
RU2570636C2 (ru) * 2010-07-01 2015-12-10 Аэон Медикс Инк Микровезикулы, происходящие из протопластов клеток, и их применение
US8980549B2 (en) 2010-08-01 2015-03-17 Ramot At Tel Aviv University Ltd. MicroRNA patterns for the diagnosis, prognosis and treatment of melanoma
JP2013537538A (ja) * 2010-08-13 2013-10-03 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ グラスゴー 微小水泡および関連するマイクロｒｎａの治療用途
WO2012024543A1 (en) * 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
EP2609219A4 (en) * 2010-08-24 2014-03-26 Bio Dx Inc DEFINITION OF DIAGNOSTIC AND THERAPEUTIC TARGETS OF FLOATING FREE FLOATING F TAL DNA PRESERVED IN MATERNAL BLOOD CIRCULATION
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
WO2012071096A2 (en) * 2010-09-03 2012-05-31 The Johns Hopkins University Arid1a and ppp2r1a mutations in cancer
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
US20140147839A1 (en) * 2010-10-15 2014-05-29 The General Hospital Corporation Microvesicle-based assays
WO2012054975A1 (en) * 2010-10-28 2012-05-03 Clinical Genomics Pty. Ltd. Method of microvesicle enrichment
KR102302069B1 (ko) 2010-11-10 2021-09-14 인리젠 장기 확대를 위한 주사가능 제제
EP2638057B1 (en) * 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
WO2012065049A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
US20130295590A1 (en) * 2010-11-15 2013-11-07 The Regents Of The University Of Colorado, A Body Corporate Foxa1 as a marker for invasive bladder cancer
CA2817982C (en) 2010-11-15 2020-06-30 The Regents Of The University Of Michigan Controlled release mucoadhesive systems
EP2643470B1 (en) 2010-11-24 2016-02-03 Yale University Compositions and methods for treating ischemic injury with d-dt
WO2012092490A1 (en) 2010-12-30 2012-07-05 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
WO2012097047A1 (en) * 2011-01-11 2012-07-19 The Ohio State University Research Foundation Methods to identify chronic lymphocytic leukemia disease progression
WO2012100023A1 (en) * 2011-01-19 2012-07-26 Thomas Jefferson University Detection of pancreatic ductal adenocarcinoma
US20120196285A1 (en) * 2011-01-31 2012-08-02 Esoterix Genetic Laboratories, Llc Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules
CA2826111A1 (en) * 2011-01-31 2012-08-09 Esoterix Genetic Laboratories, Llc Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration
EP2484779A1 (en) 2011-02-03 2012-08-08 Medizinische Hochschule Hannover Device and method for analysis of kidney failure
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
SG183579A1 (en) * 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
CN103477225A (zh) * 2011-02-17 2013-12-25 康奈尔大学 防止细胞转化和癌症转移的组合物和方法
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
US20120251619A1 (en) * 2011-03-31 2012-10-04 Gunaratne Preethi H MicroRNA-29a,b,c as a Tumor Suppressor and Sensitizing Agent for Chemotherapy
US9816998B2 (en) 2011-04-01 2017-11-14 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ）
EP3569607A1 (en) 2011-05-11 2019-11-20 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
EP2718721A4 (en) * 2011-06-07 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L CIRCULATING BIOMARKERS FOR CANCER
WO2012170037A1 (en) 2011-06-10 2012-12-13 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
CA2839896A1 (en) * 2011-06-21 2012-12-27 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
WO2013022786A2 (en) * 2011-08-05 2013-02-14 University Of Louisville Research Foundation, Inc. Microrna biomarkers
WO2013023132A1 (en) 2011-08-10 2013-02-14 Wake Forest University Health Sciences Diagnostic and prognostic markers for cancer
CA2844126C (en) * 2011-08-18 2019-06-18 Ming-Chung Jiang Microvesicle membrane protein and application thereof
EP2748335B1 (en) * 2011-08-22 2018-10-03 Exosome Diagnostics, Inc. Urine biomarkers
US9939442B2 (en) * 2011-09-08 2018-04-10 The Regents Of The University Of California Salivary biomarkers for gastric cancer detection
EP2758774A4 (en) * 2011-09-22 2015-04-29 Univ Los Andes METHOD FOR MONITORING, DIAGNOSIS AND / OR FORECASTING ACUTE CHILDIER INJURY IN AN EARLY STAGE
WO2013048734A1 (en) * 2011-09-28 2013-04-04 Tufts Medical Center, Inc. Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
EP2766500A4 (en) 2011-10-14 2015-10-14 Univ Ohio State METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER
FR2981662A1 (fr) * 2011-10-20 2013-04-26 Assist Publ Hopitaux De Paris Methode de quantification de marqueurs renaux par dosage urinaire.
AU2011320021B2 (en) * 2011-10-26 2018-02-22 Clinical Genomics Pty. Ltd. Method of microvesicle enrichment
US9493840B2 (en) 2011-10-27 2016-11-15 University Of Louisville Research Foundation, Inc. Characterizing melanoma
WO2013067048A1 (en) * 2011-10-31 2013-05-10 The Ohio State University Materials and methods related to mir-221 and hepatocellular carcinoma
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
CN104619353A (zh) 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
JP2015511121A (ja) 2012-01-20 2015-04-16 ジ・オハイオ・ステート・ユニバーシティ 浸潤性および予後に関する乳がんバイオマーカーシグネチャー
WO2013119602A1 (en) * 2012-02-06 2013-08-15 President And Fellows Of Harvard College Arrdc1-mediated microvesicles (armms) and uses thereof
WO2013134786A2 (en) * 2012-03-09 2013-09-12 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods
WO2013148147A1 (en) 2012-03-26 2013-10-03 The U.S.A., As Represented By The Secretary Dept. Of Health And Human Services Dna methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
CN103374625B (zh) * 2012-04-27 2016-04-13 中国科学院上海生命科学研究院 先天性心脏病相关基因dlc1及其应用
WO2013170146A1 (en) 2012-05-10 2013-11-14 Uab Research Foundation Methods and compositions for modulating mir-204 activity
ES2638944T3 (es) 2012-05-21 2017-10-24 The Penn State Research Foundation Composiciones y métodos relacionados con la variante 2 de dennd1a y síndrome de ovario poliquístico
WO2013184905A1 (en) 2012-06-06 2013-12-12 Myriad Genetics, Inc. Hereditary cancer genes
WO2014004424A1 (en) 2012-06-26 2014-01-03 Temple University - Of The Commonwealth System Of Higher Education Method for detecting injury to the brian
KR20150023904A (ko) 2012-06-27 2015-03-05 버그 엘엘씨 전립선암의 진단 및 치료에서의 마커의 용도
US20140018299A1 (en) * 2012-07-10 2014-01-16 Banyan Biomarkers, Inc. Method and device to detect, monitor and promote neural regeneration and improvement of cognitive function in a subject suffering from neural injury
EP2875158A4 (en) * 2012-07-18 2016-03-23 Exosome Diagnostics Inc USE OF MICROVESICLES IN THE DIAGNOSIS, FORECAST AND TREATMENT OF DISEASES AND MEDICAL SUDDEN
EP3299814A3 (en) * 2012-07-19 2018-04-11 Atlantic Cancer Research Institute Method for the isolation of microvesicles
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
WO2014028862A1 (en) 2012-08-17 2014-02-20 Cornell University Use of dna in circulating exosomes as a diagnostic marker for metastasic disease
CN104995311A (zh) 2012-08-30 2015-10-21 外来体诊断公司 用于核酸测定的对照
WO2014041087A1 (en) 2012-09-12 2014-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Muscle secretome and uses thereof
CN105025878A (zh) * 2012-10-03 2015-11-04 外来体诊断公司 微泡在医学疾病和病况的诊断、预后和治疗中的用途
DK2906717T3 (en) 2012-10-11 2019-04-01 Vin De Bona Trading Company Pte Ltd PROCEDURE FOR PAINTING MICROVESICS
TWI485159B (zh) * 2012-10-11 2015-05-21 Ming Chung Jiang 一個微泡膜蛋白及其應用
WO2014062218A1 (en) * 2012-10-16 2014-04-24 University Of Southern California Colorectal cancer dna methylation markers
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP2912182B1 (en) * 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
PL3567099T3 (pl) 2012-10-24 2021-11-29 Prokidney Populacje komórek nerkowych i ich zastosowania
EP2916853B1 (en) * 2012-11-09 2020-05-06 Velin-Pharma A/S Compositions for pulmonary delivery
US20150292030A1 (en) * 2012-11-27 2015-10-15 Board Of Regents, The University Of Texas System Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer
EP2746406B1 (en) 2012-12-18 2017-08-23 Samsung Electronics Co., Ltd. Composition and kit for diagnosing breast cancer including miRNAs within vesicle, and method of diagnosing breast cancer using the same
WO2014100434A1 (en) * 2012-12-19 2014-06-26 Caris Science, Inc. Compositions and methods for aptamer screening
BR112015016136A2 (pt) 2013-01-03 2017-07-11 Exosome Diagnostics Inc métodos para isolar microvesículas
US20160186267A1 (en) * 2013-02-21 2016-06-30 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis
EA202190075A3 (ru) * 2013-02-28 2021-07-30 Те Чайниз Юниверсити Ов Гонконг Анализ транскриптома материнской плазмы с применением массивного параллельного секвенирования рнк
US10793913B2 (en) * 2013-03-08 2020-10-06 City Of Hope Methods and compositions for treatment of breast cancer
CN105209881B (zh) 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
WO2014160032A1 (en) * 2013-03-13 2014-10-02 University Of Louisville Research Foundation, Inc. Exosome-associated rna as a diagnostic marker
EP2971162B1 (en) 2013-03-15 2019-05-08 Board Of Regents, The University Of Texas System Mirna biogenesis in exosomes for diagnosis and therapy
KR101473557B1 (ko) * 2013-03-29 2014-12-24 포항공과대학교 산학협력단 원심력을 이용한 세포유래 인공 마이크로베시클 제조 장치
CN105431552B (zh) * 2013-04-12 2020-03-03 香港中文大学 多组学标记在预测糖尿病中的用途
WO2014172390A2 (en) 2013-04-15 2014-10-23 Cedars-Sinai Medical Center Methods for detecting cancer metastasis
DE212013000295U1 (de) 2013-05-06 2016-02-02 Hitachi Chemical Co. America, Ltd. Vorrichtungen zum Einfangen von Zielmolekülen
EP2999967B1 (en) * 2013-05-21 2020-05-20 NX Pharmagen Use of tenascin-c as an extracellular marker of tumor-derived microparticles
US10071170B2 (en) 2013-06-24 2018-09-11 Ablbio Antibody-drug conjugate having improved stability and use thereof
CN103272248B (zh) * 2013-06-28 2016-03-30 上海市内分泌代谢病研究所 miR-15b在制备糖尿病诊疗制剂中的应用
WO2015005553A1 (ko) * 2013-07-12 2015-01-15 Kwon Young Ah 루테리알의 형태특성을 이용한 질병의 진단방법
US10301681B2 (en) * 2013-08-06 2019-05-28 Exosome Diagnostics, Inc. Methods of treating a subject with a high gleason score prostate cancer
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
TWI708058B (zh) * 2013-10-24 2020-10-21 美商納諾索米克斯公司 阿茲海默症及其他神經退化性疾病之生物標記及診斷方法
ES2923942T3 (es) 2013-11-06 2022-10-03 Us Health Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
EP3071231A4 (en) 2013-11-19 2017-07-26 Virginia Commonwealth University Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2
WO2015083731A1 (ja) * 2013-12-04 2015-06-11 独立行政法人産業技術総合研究所 マイクロベシクルに対する核酸アプタマー
DK3076949T3 (da) * 2013-12-04 2019-11-25 Univ Texas Fremgangsmåde til isolering af kræftcelle-afledte eksosomer
US10900083B2 (en) * 2013-12-20 2021-01-26 The General Hospital Corporation Methods and assays relating to circulating tumor cells
CN106574927A (zh) * 2014-01-14 2017-04-19 崔元哲 使用luterial的形态学特征筛选癌症预防剂或抗癌剂的方法
JP6862182B2 (ja) 2014-01-14 2021-04-21 チョイ ウォンチョルＣＨＯＩ， Ｗｏｎ Ｃｈｅｏｌ ルテリアル、並びにその分離および培養方法
US10590384B2 (en) 2014-01-14 2020-03-17 Luterion Co., Ltd. Luterial and method for isolating and culturing the same
WO2015120150A1 (en) * 2014-02-05 2015-08-13 Stc.Unm Exosomes as a therapeutic for cancer
EP3117220B1 (en) * 2014-03-12 2020-07-08 Icahn School of Medicine at Mount Sinai Method for identifying kidney allograft recipients at risk for chronic injury
EP3125907A4 (en) * 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3134541B1 (en) 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US11268085B2 (en) 2014-05-27 2022-03-08 Exosome Diagnostics, Inc. Methods for isolating microvesicles and extracting nucleic acids from biological samples
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CN119842899A (zh) 2014-06-18 2025-04-18 东丽株式会社 肝癌的检测试剂盒或装置以及检测方法
WO2015200887A2 (en) 2014-06-26 2015-12-30 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
CA2954576C (en) 2014-07-09 2020-08-11 Daniel ENDERLE Methods for isolating microvesicles and extracting nucleic acids from biological samples
ES2825708T3 (es) * 2014-07-17 2021-05-17 Univ Pennsylvania Métodos para usar exosomas para monitorizar el estado de órgano trasplantado
CA2956712A1 (en) 2014-08-05 2016-02-11 Ymir Genomics Llc Methods for the isolation of extracellular vesicles and other bioparticles from urine and other biofluids
WO2016054094A1 (en) * 2014-09-30 2016-04-07 Research Institute At Nationwide Children's Hospital Compositions and methods for treating hepatic fibrosis
WO2016054399A1 (en) * 2014-10-01 2016-04-07 The Brigham And Women's Hospital, Inc. Enhancing dermal wound healing by downregulating microrna-26a
WO2016057702A2 (en) 2014-10-07 2016-04-14 Cornell University Methods for prognosing and preventing metastatic liver disease
CN104535766B (zh) * 2014-10-30 2016-04-13 中国人民解放军总医院第一附属医院 外周血exosome来源的肝癌诊断和预后标志物及其应用
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
WO2016077537A1 (en) 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
US20170319649A1 (en) * 2014-11-19 2017-11-09 The Board of Regents of the University of Texsas System Novel peptide activator of cyclin c-dependent kinase 8 (cdk8)
CN104404044B (zh) * 2014-12-04 2018-04-27 广东医学院 与心肌梗死易感相关的anril基因外显子区单核苷酸多态位点的检测方法及其应用
CN104372004B (zh) * 2014-12-04 2018-04-27 广东医学院 一个与心肌梗死易感相关的miR-27a基因单核苷酸多态位点的检测方法及其应用
SG11201704660YA (en) 2014-12-08 2017-07-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
EP3034623A1 (en) * 2014-12-18 2016-06-22 Centro de Investigación Biomédica en Red (CIBER) Method for predicting response to continuous positive air pressure treatment
JP2018502581A (ja) 2015-01-06 2018-02-01 ルテリオン カンパニー リミテッドＬｕｔｅｒｉｏｎ Ｃｏ．， Ｌｔｄ． ルテリオンおよびその分離・培養方法
JP6498274B2 (ja) * 2015-03-12 2019-04-10 三井化学株式会社 エクソソームの破壊方法、エクソソームの破壊キットおよび正常細胞由来のエクソソームの分離方法
JP2016192906A (ja) * 2015-03-31 2016-11-17 シスメックス株式会社 乳がんに関する情報の取得方法、ならびに乳がんに関する情報を取得するためのマーカー及び乳がん検出用キット
US11971402B2 (en) 2015-04-24 2024-04-30 Cornell University Methods and reagents for determination and treatment of organotropic metastasis
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
CA2988585A1 (en) 2015-06-10 2016-12-15 Raghu Kalluri Use of exosomes for the treatment of disease
WO2017040520A1 (en) 2015-08-31 2017-03-09 Hitachi Chemical Co., Ltd. Molecular methods for assessing urothelial disease
KR102087373B1 (ko) * 2015-09-11 2020-03-10 주식회사 압타머사이언스 비소세포성 폐암 진단용 단백질 바이오마커 패널 및 이를 이용한 비소세포성 폐암 진단 방법
WO2017066390A1 (en) * 2015-10-13 2017-04-20 The Trustees Of The University Of Pennsylvania Methods for using enriched exosomes as a platform for monitoring organ status
US20180321258A1 (en) * 2015-11-06 2018-11-08 The Trustees Of Columbia University In The City Of New York Exosomal Protein Profiling for Detection of Cardiac Transplant Rejection
WO2017087866A1 (en) 2015-11-20 2017-05-26 Grand Valley State University Nato3 mutant polypeptides and uses thereof
CN105296488B (zh) * 2015-12-02 2018-05-01 中国人民解放军第三军医大学第三附属医院 超声微泡介导的siRNA干扰GRK4在靶向调节尿钠排泄及血压水平中的应用
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
CN105505918B (zh) * 2016-01-12 2018-03-02 广州赛哲生物科技股份有限公司 一种血清外泌体中rna的提取方法
JP7064665B2 (ja) * 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
US11702702B2 (en) 2016-04-15 2023-07-18 Predicine, Inc. Systems and methods for detecting genetic alterations
KR20190020649A (ko) * 2016-04-15 2019-03-04 엑소좀 디아그노스틱스, 인크. 역형성 림프종 키나아제(alk) 핵산 및 alk 융합 전사물의 혈장 기반 검출 및 암의 진단 및 치료에 있어 이의 용도
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
EP4190909B1 (en) * 2016-04-19 2024-10-30 Toppan Printing Co., Ltd. Method for assessing possibility of cancerization
WO2017197399A1 (en) 2016-05-13 2017-11-16 Exosome Diagnostics, Inc. Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free dna from biofluids
US11123372B2 (en) 2016-07-29 2021-09-21 Prokidney Bioactive renal cells for the treatment of chronic kidney disease
EP4115891A1 (en) 2016-08-05 2023-01-11 The Research Foundation for The State University of New York Keratin 17 as a biomarker for bladder cancer
US10914748B2 (en) 2016-09-08 2021-02-09 UNIVERSITé LAVAL Erythrocyte-derived extracellular vesicles as a biomarker for clinically assessing Parkinson's disease
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
EP3356522A4 (en) 2016-09-30 2019-03-27 Cellex Life Sciences, Incorporated COMPOSITIONS WITH PROTEIN-LOADED EXOSOME AND METHOD FOR THE PREPARATION AND RELEASE THEREOF
EP3518981A4 (en) 2016-10-03 2020-06-10 President and Fellows of Harvard College THERAPEUTIC RNA DELIVERY THROUGH ARRDC1 MICROVESICLES
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
CN110191962A (zh) 2016-10-21 2019-08-30 外来体诊断公司 外来体相关核酸的测序和分析
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CN107058468B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过循环microRNA-369-3p表达水平预测急性高山病发病风险的试剂盒
CN107058475B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒
CN107058471B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒
CN107058472B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒
CN107058469B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过循环microRNA-449b-3p表达水平预测急性高山病发病风险的试剂盒
US11274349B2 (en) 2016-11-08 2022-03-15 Cedars-Sinai Medical Center Methods for diagnosing cancer
WO2018089672A1 (en) 2016-11-09 2018-05-17 Laura Perin Extracellular vesicles from stem cells to treat and/or prevent disease
AU2017366813B2 (en) * 2016-11-30 2023-04-20 Exosome Diagnostics, Inc. Methods and compositions to detect mutations in plasma using exosomal RNA and cell free DNA from non-small cell lung cancer patients
US20200080997A1 (en) * 2016-12-05 2020-03-12 The Penn State Research Foundation Lipid-based probes for extracellular isolation
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
KR101942197B1 (ko) * 2016-12-28 2019-01-24 주식회사 엠디헬스케어 세균 메타게놈 분석을 통한 전립선질환 진단 방법
WO2018126278A2 (en) 2017-01-02 2018-07-05 Exosome Diagnostics, Inc. Methods to distinguish rna and dna in a combined preparation
CN108300783A (zh) * 2017-01-11 2018-07-20 上海易毕恩基因科技有限公司 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途
CN110462404B (zh) * 2017-01-12 2023-06-02 理论科学株式会社 测试受试者患有胰腺癌的可能性的方法
JP6873460B2 (ja) * 2017-01-12 2021-05-19 テオリアサイエンス株式会社 被検者が膵臓癌に罹患している可能性を試験する方法
WO2018143896A1 (en) * 2017-02-02 2018-08-09 Agency For Science, Technology And Research Ovarian cancer biomarker
KR101940446B1 (ko) * 2017-02-24 2019-01-18 주식회사 엠디헬스케어 미생물 메타게놈 분석을 통한 난소암 진단방법
EP3587596B1 (en) * 2017-02-24 2023-09-27 MD Healthcare Inc. Method for diagnosing chronic obstructive airway disease through bacterial metagenome analysis
CN106906287B (zh) * 2017-03-10 2020-10-27 北京昊源生物医学科技有限公司 Prima1基因在制备椎间盘退行性疾病诊断试剂中的应用
CN110462064A (zh) * 2017-04-18 2019-11-15 深圳华大生命科学研究院 基于外泌体核酸进行微生物检测的方法及其应用
CN110520140A (zh) * 2017-04-19 2019-11-29 菲格内有限责任公司 成纤维细胞衍生的外泌体刺激血管生成
CN110945145B (zh) 2017-05-17 2024-06-11 外来体诊断公司 微泡核酸和/或蛋白及其作为肾移植排斥的标志物的应用
ES3027661T3 (en) 2017-06-21 2025-06-16 Prokidney Immunoprivileged bioactive renal cells for the treatment of kidney disease
WO2019008414A1 (en) * 2017-07-05 2019-01-10 Datar Rajan GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
EP3652315A4 (en) 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHODS FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLE POPULATIONS DERIVED FROM BIOFLUIDS, AND ASSOCIATED METHODS OF USE
EP3655531B1 (en) * 2017-07-18 2024-09-04 Exosome Diagnostics, Inc. Sequencing of nucleic acids associated with exosomal isolation from patients with glioblastoma multiforme
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CA3073669A1 (en) 2017-08-22 2019-02-28 Cedars-Sinai Medical Center Compositions and methods for treating cancer
WO2019055337A1 (en) * 2017-09-13 2019-03-21 Children's Hospital Medical Center ROLE OF EXOSOMES, EXTRACELLULAR VESICLES IN THE REGULATION OF METABOLIC HOMÉOSTASIE
KR20210015740A (ko) * 2017-09-20 2021-02-10 몰레큘러 스테서스코프, 인크. 조직 상태를 검출하기 위한 방법 및 시스템
WO2019066501A1 (ko) * 2017-09-27 2019-04-04 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 분석 방법 및 이의 용도
KR102109921B1 (ko) * 2017-09-27 2020-05-12 ㈜로제타엑소좀 크기 배제 크로마토그래피를 이용한 세포밖 소포체의 순도 분석 방법
US11835502B2 (en) 2017-09-27 2023-12-05 Rosetta Exosome Analysis method for extracellular vesicles, using size exclusion chromatography, and use for same
US12098193B2 (en) * 2017-10-11 2024-09-24 Institute For Cancer Research Netrin G1 as a biomarker for enhancing tumor treatment efficacy
CN107858430B (zh) * 2017-11-20 2019-01-04 武汉迈特维尔生物科技有限公司 一种用于诊断预示Her-2过表达型乳腺癌骨转移的基因诊断试剂盒
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
ES2724215B2 (es) * 2018-03-01 2020-04-14 Univ Alcala Henares Microvesículas endoteliales con efecto microbicida
US12241888B2 (en) 2018-03-14 2025-03-04 Children's Medical Center Corporation Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof
EP3546946A1 (en) * 2018-03-29 2019-10-02 Rüdiger Lange Method of diagnosing heart muscle damage
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたｄｎａにおけるエピジェネティック変化の同定法
EP3775889A4 (en) * 2018-04-05 2022-08-03 Genome and Company NEW TARGET FOR ANTI-CANCER AND IMMUNE ENHANCEMENT
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
WO2019204267A1 (en) 2018-04-16 2019-10-24 Icahn School Of Medicine At Mount Sinai Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood
WO2019236123A1 (en) * 2018-06-04 2019-12-12 Memorial Sloan Kettering Cancer Center Methods of detecting cancer via assessment of extracellular vesicle- mediated horizontal transfer of dna: rna hybrids
US12378608B2 (en) 2018-06-06 2025-08-05 Exosome Diagnostics, Inc. Methods for developing urine biomarkers and for detecting bladder cancer
CN108588224A (zh) * 2018-06-14 2018-09-28 大连医科大学附属第医院 一种用于嗜铬细胞瘤/副神经节瘤早期诊断和术前评估的生物标志物及其应用
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US12203933B2 (en) 2018-08-15 2025-01-21 Mayo Foundation For Medical Education And Research Methods and materials for identifying and treating membranous nephropathy
CN110872624A (zh) * 2018-08-29 2020-03-10 深圳大学 一种结直肠癌标志物及其应用
JP2021535135A (ja) 2018-08-31 2021-12-16 ティモシー エー． ベルトラム， 細胞由来の小胞を含む組成物及びその使用
CN110885830A (zh) * 2018-09-07 2020-03-17 安徽华大医学检验所有限公司 Fn1基因突变及其应用
EP3852608A4 (en) 2018-09-21 2022-09-28 Aufbau Medical Innovations Limited COMPOSITIONS AND METHODS FOR TREATING GLAUCOMA
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
KR102178922B1 (ko) * 2018-11-26 2020-11-13 순천향대학교 산학협력단 당뇨병성 신증 진단을 위한 마이크로RNA let-7 또는 마이크로RNA-150 바이오마커 및 이의 용도
RU2709651C1 (ru) * 2018-11-29 2019-12-19 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ дифференциальной диагностики глиом на основании анализа экспрессии генов и микро-рнк
CN109402262B (zh) * 2018-12-18 2022-01-25 上海交通大学医学院附属上海儿童医学中心 辅助诊断神经母细胞瘤的PCR检测试剂盒及检测miR-199a-3p表达水平的方法
WO2020163724A1 (en) * 2019-02-08 2020-08-13 Board Of Regents, The University Of Texas System Isolation and detection of exosome-associated microbiome for diagnostic and therapeutic purposes
WO2020219699A1 (en) * 2019-04-23 2020-10-29 Children's Medical Center Corporation Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb)
CN114829941A (zh) * 2019-05-16 2022-07-29 施明哲 Lama2、plxdc2及mll4作为糖尿病前期和糖尿病的新型生物标记
WO2020247675A1 (en) * 2019-06-06 2020-12-10 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US11607428B2 (en) 2019-06-06 2023-03-21 Spiritus Therapeutics, Inc. Mesenchymal stem cell-derived extracellular vesicles and uses thereof for treating and diagnosing fibrotic diseases
US12097222B2 (en) 2019-06-06 2024-09-24 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
CN110412299B (zh) * 2019-09-05 2022-11-04 四川大学华西第二医院 Hectd3自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN112535726B (zh) * 2019-09-05 2023-09-12 南京安吉生物科技有限公司 一种肿瘤标志物aquaporin 2蛋白及其应用
CN110609141A (zh) * 2019-09-30 2019-12-24 中山大学孙逸仙纪念医院 Gltscr1前列腺癌预后检测试剂及其试剂盒
CN110791560B (zh) * 2019-11-06 2021-09-14 中国医学科学院医药生物技术研究所 一种用于阿尔茨海默病诊断和/或治疗的miRNA标志物
CN110954701B (zh) * 2019-12-18 2023-07-21 重庆医科大学 一种肝纤维化或肝硬化的诊断试剂盒
EP4117702A4 (en) * 2020-03-06 2024-03-13 Mayo Foundation for Medical Education and Research Methods and materials for identifying and treating membranous nephropathy
CA3172199A1 (en) * 2020-03-18 2021-09-23 Michael Nerenberg Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay
US20230203587A1 (en) 2020-05-29 2023-06-29 Exosome Diagnostics, Inc. Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
CN113777314A (zh) * 2020-06-09 2021-12-10 首都医科大学附属北京世纪坛医院 尿液踝蛋白1及其多肽片段在烧伤中的应用
CN113913423A (zh) * 2020-07-09 2022-01-11 上海吉凯基因医学科技股份有限公司 人cfap65基因的用途及相关产品
JPWO2022030626A1 (enExample) 2020-08-06 2022-02-10
CA3190604A1 (en) 2020-08-15 2022-02-24 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
WO2022064162A1 (en) * 2020-09-22 2022-03-31 The Secretary Of State For Defence Dstl Apparatus, kits and methods for predicting the development of sepsis
CN112415199B (zh) * 2020-11-20 2023-09-08 四川大学华西医院 Cetp检测试剂在制备肺癌筛查试剂盒中的用途
US20220073992A1 (en) * 2020-11-24 2022-03-10 Hossein Abdul Tehrani Abdul Tehrani Diagnosis of chronic kidney disease (ckd) and its subgroups
CN112458104A (zh) * 2020-12-04 2021-03-09 哈尔滨医科大学 与非综合征型唇腭裂相关的突变的n4bp2基因及其应用
CN113005146A (zh) * 2021-03-10 2021-06-22 香港理工大学深圳研究院 一种重组质粒及其构建方法、重组影像系统与应用
CN113281515B (zh) * 2021-05-14 2024-12-13 青岛大学附属医院 一种tipe3免疫组织化学检测试剂盒及其使用方法和应用
US20250075258A1 (en) * 2021-07-16 2025-03-06 Exosome Diagnostics, Inc. Methods of detecting sjogren's syndrome using salivary exosomes
CN113564252B (zh) * 2021-07-22 2022-09-02 中国医学科学院北京协和医院 甲基化酶mettl3的新用途
CN113717930A (zh) * 2021-09-07 2021-11-30 复旦大学附属华山医院 携带fbn1突变的颅颈动脉夹层特异诱导多能干细胞系
CN113866413B (zh) * 2021-09-29 2023-05-30 上海市同济医院 一种结直肠癌诊断标志物及其应用
CN113995840B (zh) * 2021-10-12 2022-07-05 武汉大学中南医院 Tifa抑制剂在制备用于治疗和/或预防脓毒症急性肾损伤的药物中的应用
EP4422598A4 (en) * 2021-10-26 2025-07-09 Ohio State Innovation Foundation DESIGNER EXTRACELLULAR VESICLES FOR TARGETED DELIVERY TO SCHWANN CELLS
CN113789388B (zh) * 2021-11-15 2022-03-25 苏州艾米森生物科技有限公司 一种食管癌基因甲基化水平检测试剂及其应用
CN113913522B (zh) * 2021-11-18 2023-03-10 武汉艾米森生命科技有限公司 子宫内膜癌检测的试剂及试剂盒
CN114231643B (zh) * 2022-01-07 2023-07-07 新疆畜牧科学院畜牧研究所 影响鄂尔多斯细毛羊羊毛纤维直径变异系数性状的分子标记、获得方法及其特异性引物对和应用
CN116656810B (zh) * 2022-02-18 2024-08-16 武汉艾米森生命科技有限公司 胰腺癌的生物标志物、核酸产品和试剂盒
KR20240161644A (ko) 2022-02-18 2024-11-12 엑소좀 디아그노스틱스, 인크. 신장 장애의 식별 및 치료에 있어서의 미세 소포 시그니처의 용도
CN115786501B (zh) * 2022-07-02 2023-06-16 武汉大学 一种与结直肠癌早期筛查和辅助诊断相关的增强子功能位点及其应用
WO2024014580A1 (ko) * 2022-07-13 2024-01-18 이왕재바이오연구소 주식회사 엑소좀에서 발현되는 바이오 마커를 이용하는 인공지능 기반 암 진단용 정보제공 방법
WO2024054572A1 (en) 2022-09-07 2024-03-14 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes
CN115927591A (zh) * 2022-11-03 2023-04-07 广州市金域转化医学研究院有限公司 用于非tsc1/tsc2突变结节性硬化症的生物标志物及其应用
US20240240256A1 (en) * 2023-01-12 2024-07-18 The General Hospital Corporation MOLECULAR ANALYSIS OF EXTRACELLULAR VESICLES (EVs) FOR THE PREDICTION AND MONITORING OF DRUG RESISTANCE IN CANCER
CN116219017B (zh) * 2023-02-17 2024-04-30 安徽同科生物科技有限公司 生物标志物在制备卵巢癌诊断和/或预后的产品中的应用
WO2024261242A1 (en) 2023-06-22 2024-12-26 Fondazione Di Religione E Di Culto "Casa Sollievo Della Sofferenza" - Opera Di San Pio Da Pietrelcina Prognostic method for non-metastatic female breast cancer
CN119570732A (zh) * 2023-09-05 2025-03-07 中国科学院基础医学与肿瘤研究所(筹) 胞质体囊泡的制备方法及其应用
CN117092354B (zh) * 2023-10-18 2023-12-29 亿航(苏州)生物医药有限公司 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物
CN120366450A (zh) * 2023-11-21 2025-07-25 首都医科大学附属北京世纪坛医院 检测slamf8的物质在制备用于筛查和诊断前列腺癌的产品中的应用和检测试剂盒
CN117965433B (zh) * 2024-03-29 2024-07-19 四川大学华西第二医院 一种提高体外精子存活率和活性的方法、产品及应用
CN119530137B (zh) * 2024-12-03 2025-08-05 复旦大学附属妇产科医院 一种精子损伤修复模型及其建立方法
CN119291204B (zh) * 2024-12-13 2025-03-25 成都市第三人民医院 一种用于胃液外泌体的标志物、检测试剂、试剂盒及应用
CN119709984B (zh) * 2024-12-27 2025-08-15 梅州市人民医院(梅州市医学科学院) Nlrc3在制备诊断、筛查或评估冠状动脉粥样硬化性心脏病产品中的应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5840867A (en) 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
CA2218875C (en) 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1994011018A1 (en) * 1992-11-12 1994-05-26 Biomeasure, Inc. Opioid peptides
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
GB9306053D0 (en) * 1993-03-24 1993-05-12 Nycomed Pharma As Method and assay
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5547859A (en) 1993-08-02 1996-08-20 Goodman; Myron F. Chain-terminating nucleotides for DNA sequencing methods
US5556773A (en) 1993-08-06 1996-09-17 Yourno; Joseph Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
US6759217B2 (en) * 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6794135B1 (en) * 1996-03-26 2004-09-21 Oncomedx, Inc. Method for detection of 5T4 RNA in plasma or serum
ES2347854T5 (es) * 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
EP0985148A4 (en) 1997-05-28 2004-03-10 Inst Medical W & E Hall DIAGNOSIS OF NUCLEIC ACIDS BY MASS SPECTROMETRY, MASS SEPARATION AND BASE-SPECIFIC CLEAVING
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
JP2002520072A (ja) 1998-07-20 2002-07-09 バリアジェニックス インコーポレーテッド 疾患の治療を決定するために有用な遺伝子配列の分散
FR2788780B1 (fr) * 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
EP1927604A1 (en) 2000-01-28 2008-06-04 MIP Technologies AB Functional monomers for molecular recognition and catalysis
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6525154B1 (en) 2000-07-20 2003-02-25 The Regents Of The University Of California Molecular imprinting for the recognition of peptides in aqueous solution
US6794447B1 (en) * 2000-07-28 2004-09-21 Taylor Made Golf Co., Inc. Golf balls incorporating nanocomposite materials
JP2004535765A (ja) * 2000-12-07 2004-12-02 カイロン コーポレイション 前立腺癌においてアップレギュレートされた内因性レトロウイルス
WO2002092763A2 (en) * 2001-05-11 2002-11-21 Regents Of The University Of Minnesota Intron associated with myotonic dystrophy type 2 and methods of use
US6696271B2 (en) 2001-08-23 2004-02-24 The Regents Of The University Of California Frozen tissue microarray technology for analysis of RNA, DNA, and proteins
WO2003023065A1 (en) 2001-09-06 2003-03-20 Syngenta Participations Ag Dna methylation patterns
US7671010B2 (en) * 2002-08-30 2010-03-02 The Board Of Regents Of The University Of Texas System Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US20030162190A1 (en) 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
US20050042272A1 (en) * 2002-03-14 2005-02-24 Yafei Hou Vesiles derived from t cells, production and uses
CA2489360C (en) 2002-06-26 2013-01-29 Cold Spring Harbor Laboratory Methods and compositions for determining methylation profiles
JP2005537002A (ja) 2002-09-02 2005-12-08 パムジーン ベー．ベー． 新規な一体化したマイクロアレイ分析
US7141371B2 (en) 2002-09-06 2006-11-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for detecting and localizing DNA mutations by microarray
WO2005020784A2 (en) * 2003-05-23 2005-03-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
US7332552B2 (en) * 2003-05-30 2008-02-19 Rensselaer Polytechnic Institute Low odor chain transfer agents for controlled radical polymerization
EP1498144A1 (en) * 2003-07-15 2005-01-19 Universite Pierre Et Marie Curie Paris Vi Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell
US7384589B2 (en) * 2003-08-01 2008-06-10 Lawrence Livermore National Security, Llc Nanoscale molecularly imprinted polymers and method thereof
US20050095218A1 (en) * 2003-10-29 2005-05-05 The Procter & Gamble Company Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants
CA2453198A1 (en) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes
EP2439285B1 (en) 2004-03-31 2019-05-08 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
KR20070058441A (ko) * 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
CN101437842A (zh) * 2004-10-07 2009-05-20 阿南达·查克拉博蒂 铜氧还蛋白衍生的转运制剂及其应用方法
US20060223072A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
WO2006113590A2 (en) 2005-04-15 2006-10-26 Cedars-Sinai Medical Center Flow-cytometric heteroduplex analysis for detection of genetic alterations
WO2007001868A1 (en) * 2005-06-28 2007-01-04 Genentech, Inc. Egfr and kras mutations
US20090148460A1 (en) * 2005-07-08 2009-06-11 Alain Delcayre Exosome ligands, their preparation and uses
JP2009502135A (ja) * 2005-07-19 2009-01-29 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 血液脳関門を越えるための、および脳癌細胞内への輸送因子、並びにその使用方法
ES2736726T3 (es) * 2006-03-09 2020-01-07 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
US8758991B2 (en) * 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CN101085349B (zh) * 2006-06-09 2011-05-25 项雯华 囊泡导向的免疫细胞及其在制备抗肿瘤药物上的应用
US20080287669A1 (en) * 2007-05-16 2008-11-20 Braman Jeffrey C Methods and compositions for identifying compounds useful in nucleic acid purification
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
EP2176665B1 (en) * 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
US8455199B2 (en) * 2007-09-14 2013-06-04 The Ohio State University Research Foundation MicroRNA expression in human peripheral blood microvesicles and uses thereof
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
US20120142001A1 (en) * 2008-02-01 2012-06-07 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
US20100008978A1 (en) * 2008-05-09 2010-01-14 The Regents Of The University Of California Nanoparticles effective for internalization into cells
EP2294196A1 (en) * 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
EP3181705A1 (en) * 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes

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