JP2010520783A - 粘土ベースの止血剤及びその供給用器具 - Google Patents
粘土ベースの止血剤及びその供給用器具 Download PDFInfo
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- JP2010520783A JP2010520783A JP2009552753A JP2009552753A JP2010520783A JP 2010520783 A JP2010520783 A JP 2010520783A JP 2009552753 A JP2009552753 A JP 2009552753A JP 2009552753 A JP2009552753 A JP 2009552753A JP 2010520783 A JP2010520783 A JP 2010520783A
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- Prior art keywords
- clay
- hemostatic
- polyol
- substrate
- glycerol
- Prior art date
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- 230000000472 traumatic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000004017 vitrification Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
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Abstract
Description
綿ガーゼのカオリン粘土保持力を評価するために、カオリン/水スラリーの温度を変化させた。カオリンがスラリー総重量の40%となるように水及びEPKのスラリーを調製した。綿ガーゼを様々な温度のスラリーに浸漬し、加圧下で浸潤したスポンジをローリングし、乾燥させることによって3種類のスポンジを作製した。以下の表は、各スラリーのパラメータ及び得られた結果を示す。
乾燥した綿ガーゼに乾燥したカオリンを適用した。その後ガーゼを巻いた。ガーゼ上に保持されたカオリンの量は、サンプル3(実験例1)のガーゼ上に保持されたカオリンの量より目に見えて著しく少量であった。しかしながらこのサンプルは、ヒツジの全血凝固時間を加速されていない場合の70%に加速した。
水50g、グリセロール20g及びカオリン粉末15gのスラリーを調製し、ガーゼスポンジ(Kendall Curity 2733)に浸透させるために使用した。スラリーを浸透させたガーゼスポンジを乾燥させた。清潔なガラス表面上にスポンジを保持し、鉛筆で軽くたたいた。
12 メッシュ
14 カオリン
20 ガーゼ
30 布
32 粒子
50、150 救急絆
52、152 下地
54、154 粘着剤
56、156 穴
60、160、260、360 スポンジ
62、162、262、362 下地
64 剥離剤
266 膜
Claims (43)
- 出血している傷口に止血効果を提供することができる器具であって、
ガーゼ下地と、
前記ガーゼ下地上に堆積された粘土材料と、
前記粘土材料を接着するために前記ガーゼ下地上に堆積されたポリオールと、を備え、
出血している傷口を処置する場合に、前記器具を適用すると、前記粘土材料の少なくとも一部が血液と接触するようになることを特徴とする器具。 - 前記粘土材料が、カオリンであることを特徴とする請求項1に記載の器具。
- 前記粘土材料が、アタパルジャイトと、ベントナイトと、カオリンと、前述の材料の組み合わせと、から成る群から選択されることを特徴とする請求項1に記載の器具。
- 前記ガーゼ下地上に堆積された珪藻土をさらに備えることを特徴とする請求項1に記載の器具。
- 前記粘土材料が、硫酸マグネシウムと、メタリン酸ナトリウムと、塩化カルシウムと、デキストリンと、前述の材料の水和物と、前述の材料の組み合わせと、から成る群から選択された材料をさらに備えることを特徴とする請求項1に記載の器具。
- 前記粘土材料が、抗生物質と、抗真菌薬と、抗菌薬と、抗炎症薬と、鎮痛剤と、抗ヒスタミン剤と、銀または銅イオンを含有する化合物と、前述の組成物の組み合わせと、から成る群から選択された薬学活性組成物をさらに備えることを特徴とする請求項1に記載の器具。
- 前記ガーゼ下地が、綿と、絹と、ウールと、プラスチックと、セルロースと、レーヨンと、ポリエステルと、前述の組み合わせと、から成る群から選択された材料から製造されたことを特徴とする請求項1に記載の器具。
- 前記ガーゼ下地が、前記出血している傷口の形状を形成し、前記出血している傷口の形状を保持することができる程度に柔軟であることを特徴とする請求項1に記載の器具。
- 前記粘土材料が前記ポリオール中に分散され、前記下地上に堆積されたことを特徴とする請求項1に記載の器具。
- 前記粘土材料上に堆積された剥離剤をさらに備えることを特徴とする請求項1に記載の器具。
- 前記剥離剤が、ポリビニルアルコールと、グリセロールと、シリコーンと、カルボキシメチルセルロースと、ゼラチン化でんぷんと、から成る群から選択されることを特徴とする請求項10に記載の器具。
- 前記剥離剤が、前記粘土材料上に形成された膜であることを特徴とする請求項10に記載の器具。
- 前記粘土材料が、約0.2mmから約10mmの直径を有する粒子を含むことを特徴とする請求項1に記載の器具。
- 前記粘土材料が、約1mmから約7mmの直径を有する粒子を含むことを特徴とする請求項1に記載の器具。
- 前記粘土材料が、約2mmから約5mmの直径を有する粒子を含むことを特徴とする請求項1に記載の器具。
- 前記粘土材料が、0.2mm未満の直径を有する粒子を含むことを特徴とする請求項1に記載の器具。
- 前記ポリオールが、グリセロールと、グリセロールベースの化合物と、ソルビトールと、キシリトールと、マルトールと、高分子ポリオールと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項1に記載の器具。
- 前記高分子ポリオールが、ポリデキストロースであることを特徴とする請求項17に記載の器具。
- 前記グリセロールベースの化合物が、プロピレングリコールと、グリセリルトリアセタートと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項17に記載の器具。
- 出血している傷口に適用することができる救急絆であって、
柔軟な下地と、
前記柔軟な下地上に取り付けられたガーゼ下地と、
前記ガーゼ下地上に堆積された粘土材料と、
前記粘土材料を接着するために前記ガーゼ下地上に堆積されたポリオールと、を備え、
出血している傷口を処置する場合に、前記救急絆を適用すると、前記粘土材料の少なくとも一部が血液と接触するようになることを特徴とする救急絆。 - 前記粘土材料が、カオリンであることを特徴とする請求項20に記載の救急絆。
- 前記粘土材料が、アタパルジャイトと、ベントナイトと、カオリンと、前述の材料の組み合わせと、から成る群から選択されることを特徴とする請求項20に記載の救急絆。
- 前記粘土材料が、硫酸マグネシウムと、メタリン酸ナトリウムと、塩化カルシウムと、デキストリンと、前述の材料の水和物と、前述の材料の組み合わせと、から成る群から選択された材料をさらに備えることを特徴とする請求項20に記載の救急絆。
- 前記粘土材料が、抗生物質と、抗真菌薬と、抗菌薬と、抗炎症薬と、鎮痛剤と、抗ヒスタミン剤と、銀イオンを含有する化合物と、前述の組成物の組み合わせと、から成る群から選択された薬学活性組成物をさらに備えることを特徴とする請求項20に記載の救急絆。
- 前記下地上に粘着剤をさらに備え、前記粘着剤が使用者の皮膚上に前記救急絆を容易に保持するように構成されていることを特徴とする請求項20に記載の救急絆。
- 前記粘土材料が前記ポリオール中に分散され、前記ガーゼ下地上に堆積されたことを特徴とする請求項20に記載の救急絆。
- 前記ポリオールが、グリセロールと、グリセロールベースの化合物と、ソルビトールと、キシリトールと、マルトールと、高分子ポリオールと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項20に記載の救急絆。
- 前記グリセロールベースの化合物が、プロピレングリコールと、グリセリルトリアセタートと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項27に記載の救急絆。
- 前記ガーゼ下地上に堆積された前記ポリオール及び前記粘土材料の上に堆積された剥離剤をさらに備えることを特徴とする請求項20に記載の救急絆。
- 前記剥離剤が、ポリビニルアルコールと、グリセロールと、シリコーンと、カルボキシメチルセルロースと、ゼラチン化でんぷんと、から成る群から選択されることを特徴とする請求項29に記載の救急絆。
- 第1表面を有するガーゼ下地と、
前記ガーゼ下地の前記第1表面上に堆積されたポリオール及び止血材料の分散と、を備えた止血スポンジであって、
出血している傷口を処置する場合に、前記止血スポンジを適用すると、前記止血材料の少なくとも一部が血液と接触するようになることを特徴とする止血スポンジ。 - 前記ガーゼ下地と、止血材料及びポリオールの前記分散と、の少なくとも一方に堆積された剥離剤をさらに備えることを特徴とする請求項31に記載の止血スポンジ。
- 前記止血材料が、カオリンであることを特徴とする請求項31に記載の止血スポンジ。
- 前記止血材料が、アタパルジャイト粘土と、ベントナイト粘土と、カオリン粘土と、生物活性ガラスと、生物止血剤と、珪藻土と、前述の材料の組み合わせと、から成る群から選択されることを特徴とする請求項31に記載の止血スポンジ。
- 前記剥離剤が、ポリビニルアルコールと、グリセロールと、シリコーンと、カルボキシメチルセルロースと、ゼラチン化でんぷんと、から成る群から選択されることを特徴とする請求項32に記載の止血スポンジ。
- 前記ポリオールが、グリセロールと、グリセロールベースの化合物と、ソルビトールと、キシリトールと、マルトールと、高分子ポリオールと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項31に記載の止血スポンジ。
- 前記グリセロールベースの化合物が、プロピレングリコールと、グリセリルトリアセタートと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項36に記載の止血スポンジ。
- 第1下地と、
ポリオール中に分散され、前記第1下地上に塗布された止血材料と、
前記ポリオール中に分散された前記止血材料の上に堆積された第2下地と、を備えた止血スポンジであって、
出血している傷口を処置する場合に、前記止血スポンジを適用すると、前記第1下地及び前記第2下地の少なくとも一方を通じて前記止血材料の少なくとも一部が血液と接触するようになることを特徴とする止血スポンジ。 - 前記止血材料が、アタパルジャイト粘土と、ベントナイト粘土と、カオリン粘土と、生物活性ガラスと、生物止血剤と、珪藻土と、前述の材料の組み合わせと、から成る群から選択されることを特徴とする請求項38に記載の止血スポンジ。
- 前記ポリオール中に分散された前記止血材料の上に堆積された剥離剤をさらに備えることを特徴とする請求項38に記載の止血スポンジ。
- 前記剥離剤が、ポリビニルアルコールと、グリセロールと、シリコーンと、カルボキシメチルセルロースと、ゼラチン化でんぷんと、から成る群から選択されることを特徴とする請求項40に記載の止血スポンジ。
- 前記ポリオールが、グリセロールと、グリセロールベースの化合物と、ソルビトールと、キシリトールと、マルトールと、高分子ポリオールと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項38に記載の止血スポンジ。
- 前記グリセロールベースの化合物が、プロピレングリコールと、グリセリルトリアセタートと、前述の組み合わせと、から成る群から選択されることを特徴とする請求項42に記載の止血スポンジ。
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