JP2010280684A5 - - Google Patents

Download PDF

Info

Publication number
JP2010280684A5
JP2010280684A5 JP2010167639A JP2010167639A JP2010280684A5 JP 2010280684 A5 JP2010280684 A5 JP 2010280684A5 JP 2010167639 A JP2010167639 A JP 2010167639A JP 2010167639 A JP2010167639 A JP 2010167639A JP 2010280684 A5 JP2010280684 A5 JP 2010280684A5
Authority
JP
Japan
Prior art keywords
substituted
alkyl
phenyl
group
och
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010167639A
Other languages
English (en)
Japanese (ja)
Other versions
JP5277213B2 (ja
JP2010280684A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2010280684A publication Critical patent/JP2010280684A/ja
Publication of JP2010280684A5 publication Critical patent/JP2010280684A5/ja
Application granted granted Critical
Publication of JP5277213B2 publication Critical patent/JP5277213B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2010167639A 2003-01-08 2010-07-26 抗菌剤 Expired - Fee Related JP5277213B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US43852303P 2003-01-08 2003-01-08
US60/438,523 2003-01-08
US46697403P 2003-04-30 2003-04-30
US60/466,974 2003-04-30
US52021103P 2003-11-13 2003-11-13
US60/520,211 2003-11-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006500858A Division JP5086635B2 (ja) 2003-01-08 2004-01-08 抗菌剤

Publications (3)

Publication Number Publication Date
JP2010280684A JP2010280684A (ja) 2010-12-16
JP2010280684A5 true JP2010280684A5 (OSRAM) 2011-11-04
JP5277213B2 JP5277213B2 (ja) 2013-08-28

Family

ID=32719190

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006500858A Expired - Fee Related JP5086635B2 (ja) 2003-01-08 2004-01-08 抗菌剤
JP2010167639A Expired - Fee Related JP5277213B2 (ja) 2003-01-08 2010-07-26 抗菌剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006500858A Expired - Fee Related JP5086635B2 (ja) 2003-01-08 2004-01-08 抗菌剤

Country Status (13)

Country Link
US (8) US20040229955A1 (OSRAM)
EP (2) EP1618087B1 (OSRAM)
JP (2) JP5086635B2 (OSRAM)
KR (2) KR101145252B1 (OSRAM)
CN (2) CN102267924A (OSRAM)
AU (2) AU2004204760C1 (OSRAM)
CA (2) CA2512582C (OSRAM)
EA (1) EA011808B1 (OSRAM)
ES (2) ES2387803T3 (OSRAM)
IL (2) IL169475A (OSRAM)
MX (1) MXPA05007394A (OSRAM)
SG (2) SG2012000667A (OSRAM)
WO (1) WO2004062601A2 (OSRAM)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
EP1539744A4 (en) * 2002-07-11 2007-06-06 Vicuron Pharm Inc N-HYDROXYAMIDE DERIVATIVES WITH ANTIBACTERIAL EFFECT
SG2012000667A (en) * 2003-01-08 2015-03-30 Univ Washington Antibacterial agents
CA2532965C (en) 2003-07-22 2013-05-14 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
JP4667384B2 (ja) * 2003-10-07 2011-04-13 レノビス, インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法
CA2548442A1 (en) * 2003-12-19 2005-07-07 Basf Aktiengesellschaft Benzoyl-substituted phenylalanine amides
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
WO2006022442A1 (ja) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
US20090088433A1 (en) 2005-01-26 2009-04-02 Bertrand Leblond Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EA200701835A1 (ru) * 2005-02-28 2008-02-28 Реновис, Инк. Амидные производные в качестве лигандов ионных каналов, их фармацевтические композиции и способы их применения
CA2601706C (en) 2005-03-22 2016-09-20 Dana-Farber Cancer Institute, Inc. Treatment of protein degradation disorders
WO2007008994A2 (en) * 2005-07-11 2007-01-18 Wyeth Glutamate aggrecanase inhibitors
JP4961773B2 (ja) * 2005-07-29 2012-06-27 住友ベークライト株式会社 芳香族カルボン酸及びその酸ハロゲン化物
US8088804B2 (en) 2005-12-15 2012-01-03 Pfizer Inc. N-hydroxyamide derivatives possessing antibacterial activity
EP1991247B1 (en) * 2006-02-14 2015-10-14 President and Fellows of Harvard College Bifunctional histone deacetylase inhibitors
AU2007248656B2 (en) 2006-05-03 2013-04-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase and tubulin deacetylase inhibitors
EP2041099A1 (en) 2006-05-30 2009-04-01 AstraZeneca AB 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors
DE102006033321A1 (de) * 2006-07-17 2008-01-24 Westfälische Wilhelms-Universität Münster Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
US7981874B2 (en) 2006-07-20 2011-07-19 Merck Sharp & Dohme Corp. Phosphorus derivatives as histone deacetylase inhibitors
WO2008014266A2 (en) * 2006-07-24 2008-01-31 University Of Maryland, Baltimore Heme oxygenase inhibitors and methods of therapeutic use
TW200821276A (en) * 2006-08-18 2008-05-16 Leo Pharma As Substituted acetylenic compounds useful for the treatment of diseases
CA2661605A1 (en) 2006-08-31 2008-03-06 Schering Corporation Hydantoin derivatives useful as antibacterial agents
AU2007313250A1 (en) * 2006-10-13 2008-04-24 Xtl Biopharmaceuticals Ltd Compounds and methods for treatment of HCV
US8962825B2 (en) 2006-10-30 2015-02-24 Glaxosmithkline Intellectual Property Development Limited Hydroxamates as inhibitors of histone deacetylase
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
WO2008105515A1 (ja) * 2007-02-28 2008-09-04 Taisho Pharmaceutical Co., Ltd. 新規なヒドロキサム酸誘導体
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
WO2008154642A2 (en) * 2007-06-12 2008-12-18 Achaogen, Inc. Antibacterial agents
CN101417937B (zh) * 2007-10-23 2013-05-29 中山大学 β-醛酮类抗菌化合物及其应用
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
WO2009081195A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Carbamoyl compounds as dgat1 inhibitors 190
WO2009158369A1 (en) 2008-06-25 2009-12-30 Schering Corporation Synthesis and use of heterocyclic antibacterial agents
EP2321264B1 (en) 2008-07-23 2016-05-04 President and Fellows of Harvard College Deacetylase inhibitors and uses thereof
AU2009276343A1 (en) * 2008-08-01 2010-02-04 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same
CA2732045A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Urea derivatives as antibacterial agents
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
US8372885B2 (en) * 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
EP2334636A2 (en) 2008-09-19 2011-06-22 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
EP2177502A1 (en) * 2008-10-17 2010-04-21 Oryzon Genomics, S.A. Compounds and their use
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
WO2011005355A1 (en) 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
BRPI1008165B1 (pt) * 2009-05-25 2020-02-27 Chiesi Farmaceutici S.P.A. Uma combinação terapêutica compreendendo um surfactante pulmonar e um esteróide
RU2011152517A (ru) 2009-06-19 2013-07-27 Астразенека Аб Пиразинкарбоксамиды в качестве ингибиторов dgat1
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
FR2950057B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950056B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
KR101736218B1 (ko) 2009-09-25 2017-05-16 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
WO2011106574A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
BR122019020471B1 (pt) 2010-04-19 2021-06-22 Oryzon Genomics S.A. Inibidores da desmetilase específica para lisina 1, seus usos e método para sua identificação, e composições farmacêuticas
PH12012502087A1 (en) 2010-04-20 2015-04-15 Taisho Pharmaceutical Co Ltd Novel hydroxamic acid derivative
RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
WO2012013728A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
US9738604B2 (en) 2010-09-03 2017-08-22 Duke University Ethynylbenzene derivatives
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
MX2013005200A (es) 2010-11-10 2013-06-28 Achaogen Inc Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
WO2012093101A1 (en) 2011-01-04 2012-07-12 Novartis Ag Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP3578548A1 (en) 2011-02-22 2019-12-11 The General Hospital Corporation Antibiotic tolerance inhibitors
AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
CN103717582B (zh) 2011-04-08 2015-09-30 辉瑞大药厂 用作抗菌剂的异*唑衍生物
SG193458A1 (en) 2011-04-08 2013-10-30 Pfizer Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2013039947A1 (en) 2011-09-12 2013-03-21 Achaogen, Inc. Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide
JP6006609B2 (ja) * 2011-10-19 2016-10-12 大正製薬株式会社 新規なヒドロキサム酸誘導体を含有する医薬
CN104203914B (zh) 2011-10-20 2017-07-11 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
UA116765C2 (uk) 2011-10-20 2018-05-10 Орізон Джіномікс, С.А. (гетеро)арилциклопропіламіни як інгібітори lsd1
CN104254518A (zh) * 2012-02-16 2014-12-31 阿奇克斯制药公司 线性肽抗生素
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
JP6209605B2 (ja) 2012-06-28 2017-10-04 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
JP6155332B2 (ja) 2012-06-28 2017-06-28 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
WO2014002052A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
ES2712190T3 (es) 2012-06-28 2019-05-09 Novartis Ag Moduladores de la vía del complemento y sus usos
JP6273274B2 (ja) 2012-06-28 2018-01-31 ノバルティス アーゲー 補体経路モジュレーターおよびその使用
EA201590200A1 (ru) 2012-07-12 2015-08-31 Новартис Аг Модуляторы пути активации комплемента и их применение
CN103012207B (zh) * 2012-12-29 2015-05-27 吉首大学 二芳基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
TR201911245T4 (tr) * 2013-03-15 2019-08-21 Fujifilm Toyama Chemical Co Ltd Yeni hidroksamik asit türevi veya bunun tuzu.
WO2014160649A1 (en) * 2013-03-29 2014-10-02 Novartis Ag Hydroxamic acid derivatives as lpxc inhibitors for the treatment of bacterial infections
US9908851B2 (en) 2013-08-16 2018-03-06 Duke University 2-piperidinyl substituted N,3-dihydroxybutanamides
CA2921427A1 (en) * 2013-08-16 2015-02-19 Duke University Substituted hydroxamic acid compounds
US10189786B2 (en) * 2013-08-16 2019-01-29 Duke University Antibacterial compounds
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
PT3131582T (pt) 2014-04-15 2018-10-08 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
CN106573924B (zh) 2014-04-22 2019-06-25 诺华股份有限公司 作为LpxC抑制剂的异噁唑啉异羟肟酸衍生物
KR20170048546A (ko) 2014-09-12 2017-05-08 토야마 케미칼 컴퍼니 리미티드 신규 히드록삼산 유도체 또는 그 염을 함유하는 의약 조성물
JPWO2016039432A1 (ja) 2014-09-12 2017-06-22 富山化学工業株式会社 新規なヒドロキサム酸誘導体および抗菌性物質を組み合わせて使用する方法
CN104341476A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-肌苷型多靶点抗菌化合物及其制法和用途
CN104327140B (zh) * 2014-10-11 2016-06-15 吉首大学 噁唑烷酮-腺苷型多靶点抗菌化合物及其制法和用途
CN104341475A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-腺苷型多靶点抗菌化合物及其制法和用途
CN104231024B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-肌苷型化合物作为TyrRS抑制剂及其制法和用途
CN104262433B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-腺苷型化合物作为TyrRS抑制剂及其制法和用途
EA032138B1 (ru) 2014-12-16 2019-04-30 Новартис Аг СОЕДИНЕНИЯ ИЗОКСАЗОЛГИДРОКСАМИНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LpxC
CN105777464B (zh) * 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
KR20180011843A (ko) 2015-06-11 2018-02-02 바실리어 파마슈티카 인터내셔널 리미티드 유출-펌프 억제제 및 이의 치료적 용도
WO2017042099A1 (en) * 2015-09-09 2017-03-16 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
EP3374350B1 (en) 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
US10611747B2 (en) 2015-11-09 2020-04-07 Forge Therapeutics, Inc. Pyrone based compounds for treating bacterial infections
RU2018124788A (ru) * 2015-12-08 2020-01-15 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Замещенные бензазиноны в качестве антибактериальных соединений
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
WO2017182433A1 (en) * 2016-04-18 2017-10-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Novel inhibitors of meprin alpha and beta
EP3448375B1 (en) 2016-04-25 2023-09-27 Duke University Benzoylglycine derivatives and methods of making and using same
CA3026356A1 (en) 2016-06-14 2017-12-21 Novartis Ag Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
CA3026505A1 (en) 2016-06-21 2017-12-28 Orion Ophthalmology LLC Aliphatic prolinamide derivatives
MX392422B (es) 2016-06-21 2025-03-24 Orion Ophthalmology LLC Derivados de prolinamida heterociclica
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
US11292801B2 (en) 2016-07-05 2022-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
AU2017336523B2 (en) 2016-09-28 2022-07-21 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
BR112019013016B1 (pt) 2016-12-23 2023-05-02 Intervet International B.V. Compostos antibacterianos, composição farmacêutica que os compreende e uso dos referidos compostos
AR110440A1 (es) 2016-12-23 2019-03-27 Intervet Int Bv Compuestos para el tratamiento de la enfermedad respiratoria bovina o porcina
US11021471B2 (en) 2017-05-10 2021-06-01 Forge Therapeutics, Inc. Antibacterial compounds
WO2018213185A1 (en) * 2017-05-17 2018-11-22 Drexel University Rela inhibitors for biofilm disruption
WO2019014352A1 (en) 2017-07-11 2019-01-17 Vertex Pharmaceuticals Incorporated CARBOXAMIDES AS INHIBITORS OF SODIUM CHANNELS
BR112020001619A2 (pt) 2017-07-27 2020-07-21 BioMendics, LLC tolanos substituídos para a modulação da colonização microbiana
CA3090833A1 (en) * 2018-02-10 2019-08-15 Kbp Biosciences Co., Ltd. Compound acting as antibiotics
AU2019345150A1 (en) * 2018-09-20 2021-05-13 Blacksmith Medicines, Inc. Antibacterial compounds
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
PL3873605T3 (pl) 2018-10-30 2025-03-03 Gilead Sciences, Inc. Związki hamujące integrynę alfa4beta7
DK3873884T3 (da) 2018-10-30 2025-02-17 Gilead Sciences Inc 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme
EP3873897B1 (en) 2018-10-30 2024-08-14 Gilead Sciences, Inc. N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases
US12440481B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
US20220117893A1 (en) * 2019-02-22 2022-04-21 The Blue Group Llc Inhalable therapeutic agent
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin
CN110563611B (zh) 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
CA3183740A1 (en) 2020-06-10 2021-12-16 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
DK4347031T3 (da) 2021-06-04 2025-12-01 Vertex Pharma N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler
WO2023283256A1 (en) 2021-07-09 2023-01-12 Aligos Therapeutics, Inc. Anti-viral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
MX2024003859A (es) 2021-09-28 2024-05-21 Blacksmith Medicines Inc Inhibidores de lpxc y usos de estos.
WO2023128033A1 (ko) * 2021-12-31 2023-07-06 (주)앰틱스바이오 감염성 진균의 바이오필름 생성을 억제하는 신규한 항진균용 조성물
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法
CN119350185A (zh) * 2024-10-08 2025-01-24 聊城大学 一种联苯羟肟类衍生物及其制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US628988A (en) * 1898-11-21 1899-07-18 F B Fargo & Company Combined churn and butter-worker.
US2772281A (en) * 1954-12-23 1956-11-27 Merck & Co Inc Synthesis of 4-amino-3-isoxazolidone and its derivatives
GB9503749D0 (en) * 1995-02-24 1995-04-12 British Biotech Pharm Synthesis of hydroxamic acid derivatives
CA2227237C (en) * 1995-07-26 2005-12-13 Pfizer Inc. N-(aroyl)glycine hydroxamic acid derivatives and related compounds
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1997045402A1 (fr) * 1996-05-24 1997-12-04 Ono Pharmaceutical Co., Ltd. Derives de phenylsulfonamide
WO1998015525A1 (en) * 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Hydroxamic acids
US6281245B1 (en) 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6541276B2 (en) * 1996-10-28 2003-04-01 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
AR016751A1 (es) * 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
GB9715030D0 (en) * 1997-07-18 1997-09-24 British Biotech Pharm Metalloproteinase inhibitors
BR9810841A (pt) * 1997-07-31 2001-07-10 Procter & Gamble Inibidores de metaloprotease alicìclicos
EP1052984B1 (en) 1998-02-07 2004-05-12 Vernalis (Oxford) Ltd Antibacterial agents
JP2002520333A (ja) * 1998-07-08 2002-07-09 ツシェシェ,ハラルト アミノマロン酸誘導体及びそのペプチド骨格を変性した誘導体である化合物又はそれを含む化合物
GB9901863D0 (en) 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
WO2000059874A1 (en) * 1999-04-02 2000-10-12 Du Pont Pharmaceuticals Company NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE
WO2000061134A1 (en) 1999-04-09 2000-10-19 British Biotech Pharmaceuticals Limited Antimicrobial agents
WO2002030873A1 (en) * 2000-10-10 2002-04-18 Fujisawa Pharmaceutical Co., Ltd. Mmp inhibitor
WO2002050081A2 (en) * 2000-12-21 2002-06-27 De Novo Pharmaceuticals Ltd Antimicrobial agents
GB0115195D0 (en) 2001-06-21 2001-08-15 Bae Systems Plc Split-pin drill jig
JP2004536113A (ja) * 2001-07-03 2004-12-02 カイロン コーポレイション チロシンキナーゼおよびセリン/スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物
EP1539744A4 (en) 2002-07-11 2007-06-06 Vicuron Pharm Inc N-HYDROXYAMIDE DERIVATIVES WITH ANTIBACTERIAL EFFECT
SG2012000667A (en) 2003-01-08 2015-03-30 Univ Washington Antibacterial agents

Similar Documents

Publication Publication Date Title
JP2010280684A5 (OSRAM)
JP2012500260A5 (OSRAM)
JP2011500638A5 (OSRAM)
JP2019504898A5 (OSRAM)
JP2012524111A5 (OSRAM)
JP2011502956A5 (OSRAM)
JP2013542218A5 (OSRAM)
JP2019518766A5 (OSRAM)
JP2009534398A5 (OSRAM)
JP2009543795A5 (OSRAM)
JP2008501000A5 (OSRAM)
JP2011520815A5 (OSRAM)
JP2012506896A5 (OSRAM)
JP2010509379A5 (OSRAM)
JP2009263394A5 (OSRAM)
JP2018523671A5 (OSRAM)
JP2015523383A5 (OSRAM)
JP2015509927A5 (OSRAM)
JP2007511546A5 (OSRAM)
JP2012510502A5 (OSRAM)
JP2014509298A5 (OSRAM)
JP2009539848A5 (OSRAM)
JP2006522824A5 (OSRAM)
JP2015522551A5 (OSRAM)
JP2019500315A5 (OSRAM)