JP2008501000A5 - - Google Patents

Info

Publication number

JP2008501000A5

JP2008501000A5 JP2007513942A JP2007513942A JP2008501000A5 JP 2008501000 A5 JP2008501000 A5 JP 2008501000A5 JP 2007513942 A JP2007513942 A JP 2007513942A JP 2007513942 A JP2007513942 A JP 2007513942A JP 2008501000 A5 JP2008501000 A5 JP 2008501000A5

Authority

JP

Japan

Prior art keywords

alkyl

compound

aryl

hydrogen

general formula

Prior art date

2005-05-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 15
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 239000001257 hydrogen Substances 0.000 claims 8
• 125000003118 aryl group Chemical group 0.000 claims 7
• 229910052736 halogen Inorganic materials 0.000 claims 7
• 150000002367 halogens Chemical class 0.000 claims 7
• 125000000623 heterocyclic group Chemical group 0.000 claims 6
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 3
• 206010020571 Hyperaldosteronism Diseases 0.000 claims 2
• 229960000890 hydrocortisone Drugs 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000004043 oxo group Chemical group O=* 0.000 claims 2
• 230000007170 pathology Effects 0.000 claims 2
• 201000009395 primary hyperaldosteronism Diseases 0.000 claims 2
• 150000003254 radicals Chemical class 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000005103 alkyl silyl group Chemical group 0.000 claims 1
• 230000003276 anti-hypertensive effect Effects 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
• 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• RMBPEFMHABBEKP-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2C3=C[CH]C=CC3=CC2=C1 RMBPEFMHABBEKP-UHFFFAOYSA-N 0.000 claims 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 230000000297 inotrophic effect Effects 0.000 claims 1
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 1
• 230000002503 metabolic effect Effects 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims 1
• 125000002971 oxazolyl group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 125000000168 pyrrolyl group Chemical group 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 230000001603 reducing effect Effects 0.000 claims 1
• 125000000335 thiazolyl group Chemical group 0.000 claims 1
• 125000001544 thienyl group Chemical group 0.000 claims 1
• -1 trimethylsilanyl Chemical group 0.000 claims 1
• 0 C*1C*(**(*)*C2)C2C(*)(*)CC1 Chemical compound C*1C*(**(*)*C2)C2C(*)(*)CC1 0.000 description 2