JP2011502956A5 - - Google Patents

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Publication number
JP2011502956A5
JP2011502956A5 JP2010504681A JP2010504681A JP2011502956A5 JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5 JP 2010504681 A JP2010504681 A JP 2010504681A JP 2010504681 A JP2010504681 A JP 2010504681A JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5
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JP
Japan
Prior art keywords
alkyl
phenyl
methyl
compound
methoxy
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2010504681A
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English (en)
Japanese (ja)
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JP2011502956A (ja
JP5693951B2 (ja
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Priority claimed from PCT/EP2008/054975 external-priority patent/WO2008129070A1/en
Publication of JP2011502956A publication Critical patent/JP2011502956A/ja
Publication of JP2011502956A5 publication Critical patent/JP2011502956A5/ja
Application granted granted Critical
Publication of JP5693951B2 publication Critical patent/JP5693951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010504681A 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤 Expired - Fee Related JP5693951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2007003602 2007-04-24
EPPCT/EP2007/003602 2007-04-24
PCT/EP2008/054975 WO2008129070A1 (en) 2007-04-24 2008-04-24 Inhibitors of protein kinases

Publications (3)

Publication Number Publication Date
JP2011502956A JP2011502956A (ja) 2011-01-27
JP2011502956A5 true JP2011502956A5 (OSRAM) 2011-06-16
JP5693951B2 JP5693951B2 (ja) 2015-04-01

Family

ID=39588050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504681A Expired - Fee Related JP5693951B2 (ja) 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤

Country Status (4)

Country Link
US (1) US8436007B2 (OSRAM)
JP (1) JP5693951B2 (OSRAM)
ES (1) ES2539518T3 (OSRAM)
WO (1) WO2008129070A1 (OSRAM)

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US8507498B2 (en) * 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
US8436007B2 (en) 2007-04-24 2013-05-07 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
WO2008129069A1 (en) * 2007-04-24 2008-10-30 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
US20120177761A1 (en) 2009-07-08 2012-07-12 Chien-Wei Hou Method of making longan seed extract
JP2013107824A (ja) * 2010-03-17 2013-06-06 Dainippon Sumitomo Pharma Co Ltd 新規単環ピリミジン誘導体
EP2550257B1 (en) * 2010-03-22 2016-12-21 Lead Discovery Center GmbH Pharmaceutically active disubstituted triazine derivatives
WO2012066065A1 (en) * 2010-11-17 2012-05-24 Novartis Ag Phenyl-heteroaryl amine compounds and their uses
EP2681193B1 (en) 2011-03-02 2016-01-06 Lead Discovery Center GmbH Pharmaceutically active disubstituted pyridine derivatives
US9226929B2 (en) 2011-03-02 2016-01-05 Bayer Intellectual Property Gmbh Pharmaceutically active disubstituted triazine derivatives
ES2613103T3 (es) * 2011-04-19 2017-05-22 Bayer Intellectual Property Gmbh 4-Aril-n-fenil-1,3,5-triacin-2-aminas sustituidas
TWI555737B (zh) 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺
EP2527332A1 (en) 2011-05-24 2012-11-28 Bayer Intellectual Property GmbH 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors
US9108926B2 (en) * 2011-09-16 2015-08-18 Bayer Intellectual Property Gmbh Disubstituted 5-fluoro-pyrimidines
EP2755948B1 (en) 2011-09-16 2016-05-25 Bayer Intellectual Property GmbH Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
CN105102434A (zh) * 2012-10-18 2015-11-25 拜耳药业股份公司 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺
HK1209414A1 (en) * 2012-10-18 2016-04-01 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
ES2616441T3 (es) 2012-10-18 2017-06-13 Bayer Pharma Aktiengesellschaft Derivados de N-(piridin-2-il))pirimidin-4-amina que contienen un grupo sulfona
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物
US9499492B2 (en) * 2012-11-15 2016-11-22 Bayer Pharma Aktiengesellschaft 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
AU2013346939B2 (en) 2012-11-15 2017-06-08 Bayer Pharma Aktiengesellschaft 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
ES2630115T3 (es) 2013-07-04 2017-08-18 Bayer Pharma Aktiengesellschaft Derivados de 5-fluoro-n-(piridin-2-il)piridin-2-amina con sulfoximina sustituida y su uso como inhibidores de quinasa cdk9
EP3116869A1 (en) 2014-03-13 2017-01-18 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
CN106414412B (zh) * 2014-04-01 2019-06-21 拜耳医药股份有限公司 含有磺酰二亚胺基团的二取代的5-氟嘧啶衍生物
CR20160471A (es) 2014-04-11 2016-12-21 Bayer Pharma AG Compuestos novedosos macrocíclicos
CA2964683A1 (en) 2014-10-16 2016-04-21 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group
CA2964696C (en) 2014-10-16 2022-09-06 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
WO2016150903A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating lymphomas
EP3274338A1 (en) 2015-03-24 2018-01-31 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating multiple myeloma
WO2016150902A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating gastric cancers
PH12017502334B1 (en) 2015-06-29 2023-05-26 Astrazeneca Ab Polycyclic amide derivative as cdk9 inhibitors
CA2999931A1 (en) 2015-09-29 2017-04-06 Bayer Pharma Aktiengesellschaft Novel macrocyclic sulfondiimine compounds
JP6888000B2 (ja) 2015-10-08 2021-06-16 バイエル ファーマ アクチエンゲゼルシャフト 新規な修飾された大環状化合物
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
EP3601236A1 (en) 2017-03-28 2020-02-05 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
ES2900199T3 (es) 2017-03-28 2022-03-16 Bayer Ag Novedosos compuestos macrocíclicos inhibidores de PTEFB
US11701347B2 (en) 2018-02-13 2023-07-18 Bayer Aktiengesellschaft Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large B-cell lymphoma
CN115335058B (zh) * 2020-03-27 2024-12-06 国立大学法人京都大学 神经细胞变性抑制剂

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JP5074653B2 (ja) * 2000-03-29 2012-11-14 サイクラセル リミテッド 2−置換4−ヘテロアリール−ピリミジンおよび増殖性障害におけるその使用
WO2003066601A1 (en) * 2002-02-08 2003-08-14 Smithkline Beecham Corporation Pyrimidine compounds
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US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
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EP1678147B1 (en) 2003-09-15 2012-08-08 Lead Discovery Center GmbH Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
DE602005014382D1 (de) * 2004-12-21 2009-06-18 Smithkline Beecham Corp 2-pyrimidinyl-pyrazolopyridin-erbb-kinaseinhibitoren
EP1901747A2 (en) 2005-05-25 2008-03-26 Ingenium Pharmaceuticals AG Pyrimidine-based cdk inhibitors for treating pain
US8436007B2 (en) 2007-04-24 2013-05-07 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
US8507511B2 (en) 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
WO2008129069A1 (en) 2007-04-24 2008-10-30 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases

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