JP2016503799A5 - - Google Patents

Download PDF

Info

Publication number
JP2016503799A5
JP2016503799A5 JP2015549728A JP2015549728A JP2016503799A5 JP 2016503799 A5 JP2016503799 A5 JP 2016503799A5 JP 2015549728 A JP2015549728 A JP 2015549728A JP 2015549728 A JP2015549728 A JP 2015549728A JP 2016503799 A5 JP2016503799 A5 JP 2016503799A5
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
alkyl
nhc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015549728A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016503799A (ja
JP6256772B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/076666 external-priority patent/WO2014100463A1/en
Publication of JP2016503799A publication Critical patent/JP2016503799A/ja
Publication of JP2016503799A5 publication Critical patent/JP2016503799A5/ja
Application granted granted Critical
Publication of JP6256772B2 publication Critical patent/JP6256772B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015549728A 2012-12-19 2013-12-19 ヒストンデメチラーゼ阻害剤 Expired - Fee Related JP6256772B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261739521P 2012-12-19 2012-12-19
US61/739,521 2012-12-19
US201361792930P 2013-03-15 2013-03-15
US61/792,930 2013-03-15
PCT/US2013/076666 WO2014100463A1 (en) 2012-12-19 2013-12-19 Histone demethylase inhibitors

Publications (3)

Publication Number Publication Date
JP2016503799A JP2016503799A (ja) 2016-02-08
JP2016503799A5 true JP2016503799A5 (OSRAM) 2016-12-01
JP6256772B2 JP6256772B2 (ja) 2018-01-10

Family

ID=50931614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015549728A Expired - Fee Related JP6256772B2 (ja) 2012-12-19 2013-12-19 ヒストンデメチラーゼ阻害剤

Country Status (17)

Country Link
US (4) US9617242B2 (OSRAM)
EP (1) EP2934145B1 (OSRAM)
JP (1) JP6256772B2 (OSRAM)
AU (1) AU2013361255B2 (OSRAM)
CA (1) CA2895355A1 (OSRAM)
CY (1) CY1119901T1 (OSRAM)
DK (1) DK2934145T3 (OSRAM)
ES (1) ES2658597T3 (OSRAM)
HR (1) HRP20180067T1 (OSRAM)
HU (1) HUE037312T2 (OSRAM)
LT (1) LT2934145T (OSRAM)
PL (1) PL2934145T3 (OSRAM)
PT (1) PT2934145T (OSRAM)
RS (1) RS56821B1 (OSRAM)
SI (1) SI2934145T1 (OSRAM)
SM (1) SMT201800070T1 (OSRAM)
WO (1) WO2014100463A1 (OSRAM)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2888010T3 (da) 2012-08-22 2021-06-28 Univ Cornell Fremgangsmåder til at hæmme fascin
PE20150998A1 (es) 2012-10-02 2015-06-29 Epitherapeutics Aps Inhibidores de histona demetilasas
US9617242B2 (en) 2012-12-19 2017-04-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EA028774B1 (ru) 2012-12-21 2017-12-29 Квонтисел Фармасьютикалс, Инк. Ингибиторы гистондеметилазы
PL2961736T3 (pl) 2013-02-27 2018-08-31 Gilead Sciences, Inc. Inhibitory demetylaz histonowych
US9738637B2 (en) 2013-03-12 2017-08-22 Celgene Quantical Research, Inc. Histone demethylase inhibitors
US10035801B2 (en) 2013-03-13 2018-07-31 Genentech, Inc. Pyrazolo compounds and uses thereof
DK3107902T3 (da) 2014-02-20 2021-05-03 Cornell Univ Cornell Center For Technology Enterprise & Commercialization Cctec Forbindelser og fremgangsmåder til at hæmme fascin
US10385047B2 (en) 2014-06-25 2019-08-20 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
MA40470A (fr) 2014-08-27 2016-03-03 Gilead Sciences Inc Composés et procédés d'inhibition des histones déméthylases
JP6723663B2 (ja) 2014-09-17 2020-07-15 セルジーン クオンティセル リサーチ,インク. ヒストンデメチラーゼ阻害剤
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EP3453710B1 (en) 2014-09-17 2022-09-21 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
JP6883913B2 (ja) * 2015-12-28 2021-06-09 セルジーン クオンティセル リサーチ,インク. ヒストンデメチラーゼ阻害剤
CN105601555B (zh) * 2016-03-14 2018-07-31 苏州大学 一种制备硝基吲哚衍生物的方法
JP6970681B2 (ja) * 2016-03-15 2021-11-24 セルジーン クオンティセル リサーチ,インク. ヒストンデメチラーゼ阻害剤
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EA201892375A1 (ru) 2016-05-27 2019-08-30 Джилид Сайэнс, Инк. Способы лечения инфекций, вызываемых вирусом гепатита b
BR102017010009A2 (pt) 2016-05-27 2017-12-12 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
JP6746776B2 (ja) 2016-09-02 2020-08-26 ギリアード サイエンシーズ, インコーポレイテッド Toll様受容体調節剤化合物
IL308894A (en) 2016-10-14 2024-01-01 Prec Biosciences Inc Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
WO2018073828A1 (en) * 2016-10-20 2018-04-26 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Dna primase and gyrase inhibitors
TW202510891A (zh) 2017-01-31 2025-03-16 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
JOP20180008A1 (ar) 2017-02-02 2019-01-30 Gilead Sciences Inc مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b
WO2018149986A1 (en) * 2017-02-16 2018-08-23 Oryzon Genomics, S.A. 2-(bicyclo-heteroaryl)-isonicotinic derivatives as histone demethylase inhibitors
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
WO2019123339A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
WO2019123340A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
MY196582A (en) 2018-02-13 2023-04-19 Gilead Sciences Inc PD-1/PD-L1 Inhibitors
KR102526964B1 (ko) 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Hbv 복제 억제제로서의 치환된 피롤리진 화합물
EP3774883A1 (en) 2018-04-05 2021-02-17 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2,2,─環二核苷酸
TW201945388A (zh) 2018-04-12 2019-12-01 美商精密生物科學公司 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
TW202014193A (zh) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 包含碳環核苷酸之2’3’-環二核苷酸
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
EP3870566A1 (en) 2018-10-24 2021-09-01 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11071730B2 (en) 2018-10-31 2021-07-27 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
PL3873903T3 (pl) 2018-10-31 2024-05-20 Gilead Sciences, Inc. Podstawione związki 6-azabenzimidazolu jako inhibitory hpk1
CN113543851B (zh) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 2’3’-环二核苷酸及其前药
US20220143061A1 (en) 2019-03-07 2022-05-12 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides and prodrugs thereof
WO2020178768A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
US20210009718A1 (en) 2019-06-25 2021-01-14 Gilead Sciences, Inc. FLT3L-Fc FUSION PROTEINS AND METHODS OF USE
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
EP4017476A1 (en) 2019-08-19 2022-06-29 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
US11497808B2 (en) 2019-09-30 2022-11-15 Gilead Sciences, Inc. HBV vaccines and methods treating HBV
EP4567109A3 (en) 2019-12-06 2025-09-17 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
TW202421168A (zh) 2020-03-20 2024-06-01 美商基利科學股份有限公司 4’-c-經取代-2-鹵基-2’-去氧腺苷核苷之前藥及其製造與使用方法
WO2022031894A1 (en) 2020-08-07 2022-02-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
EP4337223A1 (en) 2021-05-13 2024-03-20 Gilead Sciences, Inc. Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics
US11976072B2 (en) 2021-06-23 2024-05-07 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359411A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4624465A1 (en) 2022-11-21 2025-10-01 Nippon Shinyaku Co., Ltd. Compound serving as ddr1 kinase inhibitor, and medicine
US20250345389A1 (en) 2024-05-13 2025-11-13 Gilead Sciences, Inc. Combination therapies
WO2025240242A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies with ribavirin
WO2025240244A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection
WO2025240246A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies with ribavirin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593349B2 (en) * 2001-03-19 2003-07-15 Icagen, Inc. Bisarylamines as potassium channel openers
EP1537087B1 (fr) 2002-09-05 2012-11-28 Aventis Pharma S.A. Derives de 3-aminoindazole comme inhibiteurs de kinase et compositions pharmaceutiques les renfermant
US7442698B2 (en) 2003-07-24 2008-10-28 Amgen Inc. Substituted heterocyclic compounds and methods of use
FR2882361A1 (fr) * 2005-02-22 2006-08-25 Aventis Pharma Sa Nouveaux derives de 3-aryl-1,2-benzisoxazole, compositions les contenant et leur utilisation
DE602007004638D1 (de) * 2006-07-20 2010-03-18 Amgen Inc Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin
US8299057B2 (en) 2007-07-20 2012-10-30 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
CA2745004C (en) 2008-11-28 2014-07-15 Kowa Company, Ltd. Pyridine-3-carboxyamide derivative
ES2534804T3 (es) 2010-05-07 2015-04-28 Glaxosmithkline Llc Indazoles
EP2681216B1 (en) * 2011-02-28 2017-09-27 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US9617242B2 (en) 2012-12-19 2017-04-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors

Similar Documents

Publication Publication Date Title
JP2016503799A5 (OSRAM)
JP2013537203A5 (OSRAM)
JP2016501882A5 (OSRAM)
JP2016514159A5 (OSRAM)
SI2934145T1 (en) Histone demethylase inhibitors
JP2016540742A5 (OSRAM)
JP2014515406A5 (OSRAM)
JP2016506960A5 (OSRAM)
RU2020110780A (ru) Ингибитор fgfr и его медицинское применение
JP2014508811A5 (OSRAM)
JP2015517574A5 (OSRAM)
JP2016530259A5 (OSRAM)
JP2016505614A5 (OSRAM)
JP2014528467A5 (OSRAM)
JP2013163667A5 (OSRAM)
JP2016006118A5 (OSRAM)
JP2012515776A5 (OSRAM)
JP2017501237A5 (OSRAM)
JP2016506958A5 (OSRAM)
JP2017508782A5 (OSRAM)
JP2017538773A5 (OSRAM)
JP2014526533A5 (OSRAM)
JP2016040288A5 (OSRAM)
JP2015516427A5 (OSRAM)
JP2014507477A5 (OSRAM)