JP2016506960A5 - - Google Patents
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- JP2016506960A5 JP2016506960A5 JP2015556100A JP2015556100A JP2016506960A5 JP 2016506960 A5 JP2016506960 A5 JP 2016506960A5 JP 2015556100 A JP2015556100 A JP 2015556100A JP 2015556100 A JP2015556100 A JP 2015556100A JP 2016506960 A5 JP2016506960 A5 JP 2016506960A5
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- 229910052799 carbon Inorganic materials 0.000 claims 17
- 150000001875 compounds Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 125000006413 ring segment Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims 1
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361757934P | 2013-01-29 | 2013-01-29 | |
| US61/757,934 | 2013-01-29 | ||
| PCT/US2014/013623 WO2014120786A1 (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506960A JP2016506960A (ja) | 2016-03-07 |
| JP2016506960A5 true JP2016506960A5 (OSRAM) | 2017-03-02 |
| JP6419087B2 JP6419087B2 (ja) | 2018-11-07 |
Family
ID=50071822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556100A Active JP6419087B2 (ja) | 2013-01-29 | 2014-01-29 | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9758525B2 (OSRAM) |
| EP (1) | EP2951184A1 (OSRAM) |
| JP (1) | JP6419087B2 (OSRAM) |
| KR (1) | KR20150110787A (OSRAM) |
| CN (1) | CN105229010A (OSRAM) |
| AU (1) | AU2014212487C1 (OSRAM) |
| BR (1) | BR112015018092A2 (OSRAM) |
| CA (1) | CA2898863A1 (OSRAM) |
| CL (1) | CL2015002123A1 (OSRAM) |
| EA (1) | EA031905B1 (OSRAM) |
| IL (1) | IL240166A0 (OSRAM) |
| MX (1) | MX2015009773A (OSRAM) |
| PE (1) | PE20151437A1 (OSRAM) |
| PH (1) | PH12015501595B1 (OSRAM) |
| SG (1) | SG11201505934XA (OSRAM) |
| WO (1) | WO2014120786A1 (OSRAM) |
Families Citing this family (39)
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| TR201908596T4 (tr) | 2013-01-29 | 2019-07-22 | Aptinyx Inc | Spiro-laktam NMDA reseptörü modülatörleri ve bunların kullanımları. |
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| KR20150110787A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
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| KR20150110586A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
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| EP3828194B1 (en) | 2015-07-06 | 2025-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| HK1255500A1 (zh) | 2015-07-06 | 2019-08-16 | Sage Therapeutics, Inc. | 氧固醇及其使用方法 |
| PL3319612T3 (pl) | 2015-07-06 | 2021-12-20 | Sage Therapeutics, Inc. | Oksysterole i sposoby ich stosowania |
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| AU2017306152A1 (en) * | 2016-08-01 | 2019-01-31 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| PE20190504A1 (es) * | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
| AU2017306136B2 (en) | 2016-08-01 | 2021-10-21 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
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| TW202444381A (zh) | 2016-10-18 | 2024-11-16 | 美商賽吉醫療公司 | 氧固醇(oxysterol)及其使用方法 |
| KR102521573B1 (ko) | 2016-10-18 | 2023-04-14 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
| CN107602436A (zh) * | 2017-09-29 | 2018-01-19 | 新发药业有限公司 | 一种n‑取代‑l‑焦谷氨酸酯的绿色制备方法 |
| WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
| WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| MX2020008107A (es) | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos. |
| JP2021512109A (ja) * | 2018-01-31 | 2021-05-13 | アプティニックス インコーポレイテッド | スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用 |
| MA56550A (fr) * | 2019-06-24 | 2022-04-27 | Naurex Inc | Formes solides de tert-butyl (s)-2-((2s,3r)-1-amino-3-hydroxy-1-oxobu tan-2-yl)-1-oxo -2, 5-diazaspiro[3,4]octane-5-carboxylate et leurs procédés de préparation |
| ES2991258T3 (es) * | 2019-06-24 | 2024-12-03 | Naurex Inc | Procedimientos y productos intermedios para producir compuestos de diazaespiro-lactama |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| KR20150110586A (ko) * | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| KR20150110787A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| SG11201505862TA (en) | 2013-01-29 | 2015-08-28 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
-
2014
- 2014-01-29 KR KR1020157023288A patent/KR20150110787A/ko not_active Withdrawn
- 2014-01-29 MX MX2015009773A patent/MX2015009773A/es unknown
- 2014-01-29 US US14/764,411 patent/US9758525B2/en active Active
- 2014-01-29 CN CN201480018641.8A patent/CN105229010A/zh active Pending
- 2014-01-29 WO PCT/US2014/013623 patent/WO2014120786A1/en not_active Ceased
- 2014-01-29 JP JP2015556100A patent/JP6419087B2/ja active Active
- 2014-01-29 EP EP14703748.5A patent/EP2951184A1/en not_active Withdrawn
- 2014-01-29 SG SG11201505934XA patent/SG11201505934XA/en unknown
- 2014-01-29 CA CA2898863A patent/CA2898863A1/en not_active Abandoned
- 2014-01-29 BR BR112015018092A patent/BR112015018092A2/pt not_active Application Discontinuation
- 2014-01-29 PE PE2015001570A patent/PE20151437A1/es not_active Application Discontinuation
- 2014-01-29 AU AU2014212487A patent/AU2014212487C1/en active Active
- 2014-01-29 EA EA201591403A patent/EA031905B1/ru not_active IP Right Cessation
-
2015
- 2015-07-20 PH PH12015501595A patent/PH12015501595B1/en unknown
- 2015-07-27 IL IL240166A patent/IL240166A0/en unknown
- 2015-07-29 CL CL2015002123A patent/CL2015002123A1/es unknown
-
2017
- 2017-08-02 US US15/667,014 patent/US10273239B2/en active Active
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