JP2016512520A5 - - Google Patents

Download PDF

Info

Publication number
JP2016512520A5
JP2016512520A5 JP2016501185A JP2016501185A JP2016512520A5 JP 2016512520 A5 JP2016512520 A5 JP 2016512520A5 JP 2016501185 A JP2016501185 A JP 2016501185A JP 2016501185 A JP2016501185 A JP 2016501185A JP 2016512520 A5 JP2016512520 A5 JP 2016512520A5
Authority
JP
Japan
Prior art keywords
alkyl
optionally substituted
aryl
pharmaceutically acceptable
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016501185A
Other languages
English (en)
Japanese (ja)
Other versions
JP6511430B2 (ja
JP2016512520A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/023263 external-priority patent/WO2014164704A2/en
Publication of JP2016512520A publication Critical patent/JP2016512520A/ja
Publication of JP2016512520A5 publication Critical patent/JP2016512520A5/ja
Application granted granted Critical
Publication of JP6511430B2 publication Critical patent/JP6511430B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016501185A 2013-03-11 2014-03-11 がんの治療のための化合物および組成物 Active JP6511430B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361776520P 2013-03-11 2013-03-11
US61/776,520 2013-03-11
PCT/US2014/023263 WO2014164704A2 (en) 2013-03-11 2014-03-11 Compounds and compositions for the treatment of cancer

Publications (3)

Publication Number Publication Date
JP2016512520A JP2016512520A (ja) 2016-04-28
JP2016512520A5 true JP2016512520A5 (OSRAM) 2017-04-13
JP6511430B2 JP6511430B2 (ja) 2019-05-15

Family

ID=50729763

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016501185A Active JP6511430B2 (ja) 2013-03-11 2014-03-11 がんの治療のための化合物および組成物

Country Status (4)

Country Link
US (2) US9890127B2 (OSRAM)
EP (1) EP2970145B1 (OSRAM)
JP (1) JP6511430B2 (OSRAM)
WO (1) WO2014164704A2 (OSRAM)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016062277A1 (zh) * 2014-10-24 2016-04-28 朗齐生物医学股份有限公司 驱虫药用于制备抗癌医药组合物中的应用
CN104478809B (zh) * 2014-11-14 2016-08-17 成都新恒创药业有限公司 一种左西孟旦杂质及其制备和检测方法
EP3236967B1 (en) 2014-12-22 2019-10-16 SUDA Pharmaceuticals Ltd Prevention and treatment of metastatic disease in thrombocytotic cancer patients
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
RS62639B1 (sr) 2015-07-06 2021-12-31 Alkermes Inc Hetero-halo inhibitori histonskih deacetilaza
CN108366947B (zh) * 2015-08-13 2022-03-29 布罗德研究所股份有限公司 用于表达pde3a或slfn12的癌症的组合物和方法
CA3013402C (en) * 2016-02-05 2024-05-28 Bayer Pharma Aktiengesellschaft Compounds, compositions and methods for cancer patient stratification and cancer treatment
WO2017137048A1 (en) * 2016-02-08 2017-08-17 H. Lundbeck A/S Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
JP6596595B2 (ja) 2016-03-04 2019-10-23 大塚製薬株式会社 ５−メチル−６−フェニル−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体
MX2022008085A (es) * 2016-03-16 2022-07-11 H Lee Moffitt Cancer Ct & Res Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t.
CN105968054B (zh) * 2016-05-12 2018-09-14 海门慧聚药业有限公司 匹莫苯丹关键中间体的制备
MD3570834T2 (ro) 2017-01-11 2022-04-30 Alkermes Inc Inhibitori biciclici ai histon deacetilazei
CA3052220A1 (en) * 2017-02-03 2018-08-09 Dana-Farber Cancer Institute, Inc. Compounds, compositions and methods for cancer treatment
US11897867B2 (en) * 2017-08-04 2024-02-13 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer
JOP20200024A1 (ar) * 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
JP7152471B2 (ja) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド ヒストン脱アセチル化酵素の二環阻害剤
JP7104588B2 (ja) * 2017-09-01 2022-07-21 大塚製薬株式会社 ５－メチル－６－フェニル－４，５－ジヒドロ－２ｈ－ピリダジン－３－オン誘導体を含有する悪性腫瘍治療剤
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
CN108997349B (zh) * 2018-06-20 2021-03-16 合肥华方医药科技有限公司 一种依匹斯汀有关物质的制备方法
SG11202012464WA (en) 2018-07-11 2021-01-28 H Lee Moffitt Cancer Center And Research Institute Inc Dimeric immuno-modulatory compounds against cereblon-based mechanisms
WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
WO2020157201A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Oxadiazinone compounds for the treatment of hyperproliferative diseases
CN113348165B (zh) * 2019-02-01 2024-06-25 拜耳股份有限公司 用于治疗过度增殖性疾病的1,2,4-三嗪-3(2h)-酮化合物
WO2020157199A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Annulated dihydropyridazinone compounds as anti-cancer compounds
CN113582974B (zh) * 2020-04-30 2022-05-17 江西济民可信集团有限公司 一类作为蛋白降解剂的化合物及其制备方法和医药用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624730A (en) * 1950-08-16 1953-01-06 Sterling Drug Inc 6-haloaryl-3-pyridazones
SE352811B (OSRAM) 1971-06-04 1973-01-15 Pharmacia Ab
US3960150A (en) 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3867519A (en) 1972-04-27 1975-02-18 Alza Corp Bioerodible drug delivery device
US3824271A (en) * 1972-07-20 1974-07-16 American Cyanamid Co 3-alkyl-3-(benzoyl)propionitriles
SE375007B (OSRAM) 1972-11-30 1975-04-07 Pharmacia Ab
US3963025A (en) 1974-09-16 1976-06-15 Alza Corporation Ocular drug delivery device
US4052395A (en) * 1975-09-11 1977-10-04 Sankyo Company Limited Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones
US4092311A (en) 1976-06-03 1978-05-30 American Cyanamid Company Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates
US4186184A (en) 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
US4303637A (en) 1980-04-04 1981-12-01 Alza Corporation Medication indicated for ocular hypertension
FI72718C (fi) * 1981-03-04 1987-07-10 Ciba Geigy Ag Foerfarande foer framstaellning av terapeutiskt verkande, substituerade 6-(4-morfolino-fenyl)-4,5-dihydro- 3(2h)-pyridazinoner och deras syraadditionssalter.
US4717730A (en) * 1982-12-03 1988-01-05 Warner-Lambert Company 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
JPS6061570A (ja) 1983-09-16 1985-04-09 Sankyo Co Ltd ピリダジノン誘導体及び農業用殺菌剤
JPS6153270A (ja) 1984-08-17 1986-03-17 チバ・ガイギー・アクチエンゲゼルシヤフト 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤
GB8426804D0 (en) * 1984-10-23 1984-11-28 Ciba Geigy Ag Pyridazinones preparations
DE3531658A1 (de) 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5053338A (en) * 1989-09-01 1991-10-01 Glaxo Inc. Kinetic resolution of pyridazinones using lipase
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
JPH05140116A (ja) 1991-11-21 1993-06-08 Nippon Soda Co Ltd 光学活性な化合物
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2204915A1 (en) 1994-11-11 1996-05-23 Seiichi Uchida Optically active compound
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6525053B1 (en) * 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
NZ574873A (en) * 2006-07-25 2012-03-30 Cephalon Inc Pyridazinone derivatives as h3 inhibitors
JP2010013354A (ja) * 2006-09-07 2010-01-21 Kyorin Pharmaceut Co Ltd ２−アルキル−６−（ピラゾロピリジン−４−イル）ピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
CN101538245B (zh) * 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途

Similar Documents

Publication Publication Date Title
JP2016512520A5 (OSRAM)
JP2016506960A5 (OSRAM)
JP2016506962A5 (OSRAM)
MY187617A (en) Bridged ring compounds as hepatitis c virus (hcv) inhibitors and pharmaceutical applications thereof
JP2012111770A5 (OSRAM)
MX2019002212A (es) Compuestos de amino-pirrolo-pirimidinona y metodos de uso de los mismos.
IL244787B (en) Polymorph c of n-((4,6-dimethyl-2 oxo-1,2-dihydropyridine-3-yl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl)amino)-4-methyl -4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide monohydrochloride, methods for its preparation, medical preparations containing it and its use
MY194405A (en) Dihydropyrimidine compounds and uses thereof in medicine
JP2016503799A5 (OSRAM)
JP2016514159A5 (OSRAM)
MX2017007748A (es) Compuestos de heteroarilo anulares fusionados y su uso como inhibidores del receptor de la tirocina cinasa (trk).
MX2016006564A (es) Compuestos dihidropirimidina y su aplicacion en productos farmaceuticos.
JP2015504091A5 (OSRAM)
MX2015011984A (es) Inhibidores de bromodominio de dihidro-pirrolopiridinona.
EA201390884A1 (ru) Азабензимидазолы в качестве противовирусных средств в отношении респираторного синцитиального вируса
MX2015002511A (es) Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
JP2013537203A5 (OSRAM)
JP2016505614A5 (OSRAM)
JP2016506961A5 (OSRAM)
JP2017504635A5 (OSRAM)
JO3811B1 (ar) مركبات غير متجانسة حلقياً ثلاثية الحلقات ملتحمة تعمل في صورة مثبطات انزيم إنتيجراز hiv
MX341341B (es) Derivados de benzamida y su uso como inhibidores de proteina de choque termico 90 kda (hsp90).
RU2015143843A (ru) Ингибиторы гистондеацетилазы
JP2017517538A5 (OSRAM)
SI3102573T1 (en) SUBSTITUTED TIAZOL OR OXASOL AS ANTAGONISTS OF THE RECEPTOR P2X7