JP2019513778A5 - - Google Patents
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- JP2019513778A5 JP2019513778A5 JP2018553876A JP2018553876A JP2019513778A5 JP 2019513778 A5 JP2019513778 A5 JP 2019513778A5 JP 2018553876 A JP2018553876 A JP 2018553876A JP 2018553876 A JP2018553876 A JP 2018553876A JP 2019513778 A5 JP2019513778 A5 JP 2019513778A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- alkyl
- optionally substituted
- halo
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022036728A JP7420847B2 (ja) | 2016-04-15 | 2022-03-10 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
| JP2024002232A JP2024045202A (ja) | 2016-04-15 | 2024-01-11 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662323602P | 2016-04-15 | 2016-04-15 | |
| US62/323,602 | 2016-04-15 | ||
| US201662348837P | 2016-06-10 | 2016-06-10 | |
| US62/348,837 | 2016-06-10 | ||
| US201662402997P | 2016-09-30 | 2016-09-30 | |
| US62/402,997 | 2016-09-30 | ||
| PCT/US2017/027918 WO2017181177A1 (en) | 2016-04-15 | 2017-04-17 | Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036728A Division JP7420847B2 (ja) | 2016-04-15 | 2022-03-10 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513778A JP2019513778A (ja) | 2019-05-30 |
| JP2019513778A5 true JP2019513778A5 (OSRAM) | 2020-05-28 |
| JP7041070B2 JP7041070B2 (ja) | 2022-03-23 |
Family
ID=58664786
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553876A Expired - Fee Related JP7041070B2 (ja) | 2016-04-15 | 2017-04-17 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
| JP2022036728A Active JP7420847B2 (ja) | 2016-04-15 | 2022-03-10 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
| JP2024002232A Pending JP2024045202A (ja) | 2016-04-15 | 2024-01-11 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022036728A Active JP7420847B2 (ja) | 2016-04-15 | 2022-03-10 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
| JP2024002232A Pending JP2024045202A (ja) | 2016-04-15 | 2024-01-11 | Ｅｈｍｔ１およびｅｈｍｔ２阻害剤としてのアミン置換アリールまたはヘテロアリール化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20170355712A1 (OSRAM) |
| EP (1) | EP3442947B1 (OSRAM) |
| JP (3) | JP7041070B2 (OSRAM) |
| KR (2) | KR20230130747A (OSRAM) |
| CN (1) | CN109153650A (OSRAM) |
| AU (3) | AU2017250369A1 (OSRAM) |
| BR (1) | BR112018071093A2 (OSRAM) |
| CA (1) | CA3021062A1 (OSRAM) |
| CL (2) | CL2018002928A1 (OSRAM) |
| CO (1) | CO2018012181A2 (OSRAM) |
| DK (1) | DK3442947T3 (OSRAM) |
| ES (1) | ES2953512T3 (OSRAM) |
| FI (1) | FI3442947T3 (OSRAM) |
| HU (1) | HUE064145T2 (OSRAM) |
| IL (3) | IL307931A (OSRAM) |
| LT (1) | LT3442947T (OSRAM) |
| MA (1) | MA44666A (OSRAM) |
| MX (2) | MX395342B (OSRAM) |
| PL (1) | PL3442947T3 (OSRAM) |
| PT (1) | PT3442947T (OSRAM) |
| SG (2) | SG10201913471VA (OSRAM) |
| SI (1) | SI3442947T1 (OSRAM) |
| TW (1) | TWI751155B (OSRAM) |
| WO (1) | WO2017181177A1 (OSRAM) |
Families Citing this family (54)
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| CA2983927A1 (en) | 2015-05-06 | 2016-11-10 | The Regents Of The University Of California | K-ras modulators |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| SG11201807543YA (en) | 2016-03-07 | 2018-09-27 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| EP3693369A3 (en) | 2016-04-15 | 2020-09-09 | AbbVie Inc. | Bromodomain inhibitors |
| WO2017201199A1 (en) | 2016-05-17 | 2017-11-23 | Duke University | Compositions and methods for the treatment of prader-willi syndrome |
| KR102693367B1 (ko) * | 2016-12-19 | 2024-08-12 | 에피자임, 인코포레이티드 | Ehmt2 저해제로서의 아민-치환된 헤테로사이클릭 화합물 및 이의 사용 방법 |
| AU2018243749A1 (en) * | 2017-03-31 | 2019-11-21 | Epizyme, Inc. | Methods of using EHMT2 inhibitors |
| SG11201909570PA (en) * | 2017-04-20 | 2019-11-28 | Univ California | K-ras modulators |
| CN110621316B (zh) * | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| AU2018326474B2 (en) | 2017-08-28 | 2024-07-25 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| CN111343988A (zh) * | 2017-10-17 | 2020-06-26 | Epizyme股份有限公司 | 作为ehmt2抑制剂的胺取代的杂环化合物及其衍生物 |
| JP2021500334A (ja) * | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法 |
| KR20200101332A (ko) * | 2017-10-18 | 2020-08-27 | 에피자임, 인코포레이티드 | 혈액 장애 예방 또는 치료에 있어서의 ehmt2 저해제의 사용 방법 |
| CN111343989A (zh) * | 2017-10-18 | 2020-06-26 | Epizyme股份有限公司 | 使用ehmt2抑制剂用于免疫疗法的方法 |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| AU2019220746A1 (en) | 2018-02-15 | 2020-08-27 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| CN108822103A (zh) * | 2018-07-28 | 2018-11-16 | 刘凤娟 | 一种咪唑并[4,5-b]吡啶化合物及其制备方法和应用 |
| CN112955142A (zh) | 2018-09-21 | 2021-06-11 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11071730B2 (en) | 2018-10-31 | 2021-07-27 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| PL3873903T3 (pl) | 2018-10-31 | 2024-05-20 | Gilead Sciences, Inc. | Podstawione związki 6-azabenzimidazolu jako inhibitory hpk1 |
| CN113271946A (zh) | 2018-11-21 | 2021-08-17 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CA3138973A1 (en) * | 2019-05-05 | 2020-11-12 | Qilu Regor Therapeutics Inc. | Cdk inhibitors |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| GB201910608D0 (en) * | 2019-07-24 | 2019-09-04 | Enterprise Therapeutics Ltd | Compounds |
| TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN119930610A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US20230127046A1 (en) * | 2019-11-27 | 2023-04-27 | Riken | G9a INHIBITOR |
| JOP20220160A1 (ar) | 2019-12-20 | 2023-01-30 | Nuevolution As | مركبات فعّالة نحو مستقبلات نووية |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| PH12022552933A1 (en) | 2020-05-04 | 2024-02-12 | Amgen Inc | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
| CN111518015A (zh) * | 2020-05-20 | 2020-08-11 | 上海合全药物研发有限公司 | 一种叔丁基-8-氧亚基-2-氮杂螺[4.5]癸烷-2-甲酸基酯的制备方法 |
| JP2024508794A (ja) | 2021-02-19 | 2024-02-28 | スドー バイオサイエンシーズ リミテッド | Ｔｙｋ２阻害剤およびその使用 |
| CA3207819A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| CA3234693A1 (en) * | 2021-10-15 | 2023-04-20 | Tango Therapeutics, Inc. | Novel modulators of ehmt1 and ehmt2 and therapeutic use thereof |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| EP4559908A1 (en) * | 2022-07-20 | 2025-05-28 | S2CBio Inc. | Heteroaryl derivative compound and use thereof |
| CN115947692B (zh) * | 2022-12-28 | 2024-12-27 | 上海再启生物技术有限公司 | 一种制备2-氯-4-(甲氧基甲基)嘧啶的方法 |
| WO2024216164A1 (en) | 2023-04-13 | 2024-10-17 | Tango Therapeutics, Inc. | N2-((5-hydroxy)-2-pyridyl)-pyridine-2,4-diamine derivatives as ehmt1/2 modulators for the treatment of cancer |
| WO2025045203A1 (zh) * | 2023-09-01 | 2025-03-06 | 葆元生物医药科技(杭州)有限公司 | 杂环化合物及其中间体和应用 |
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-
2017
- 2017-04-17 JP JP2018553876A patent/JP7041070B2/ja not_active Expired - Fee Related
- 2017-04-17 SG SG10201913471VA patent/SG10201913471VA/en unknown
- 2017-04-17 CA CA3021062A patent/CA3021062A1/en active Pending
- 2017-04-17 PT PT177209210T patent/PT3442947T/pt unknown
- 2017-04-17 PL PL17720921.0T patent/PL3442947T3/pl unknown
- 2017-04-17 SI SI201731402T patent/SI3442947T1/sl unknown
- 2017-04-17 AU AU2017250369A patent/AU2017250369A1/en not_active Abandoned
- 2017-04-17 IL IL307931A patent/IL307931A/en unknown
- 2017-04-17 MA MA044666A patent/MA44666A/fr unknown
- 2017-04-17 BR BR112018071093A patent/BR112018071093A2/pt active Search and Examination
- 2017-04-17 KR KR1020237028695A patent/KR20230130747A/ko not_active Ceased
- 2017-04-17 TW TW106112816A patent/TWI751155B/zh not_active IP Right Cessation
- 2017-04-17 LT LTEPPCT/US2017/027918T patent/LT3442947T/lt unknown
- 2017-04-17 WO PCT/US2017/027918 patent/WO2017181177A1/en not_active Ceased
- 2017-04-17 FI FIEP17720921.0T patent/FI3442947T3/fi active
- 2017-04-17 SG SG11201808799SA patent/SG11201808799SA/en unknown
- 2017-04-17 EP EP17720921.0A patent/EP3442947B1/en active Active
- 2017-04-17 KR KR1020187032892A patent/KR102571679B1/ko active Active
- 2017-04-17 IL IL281319A patent/IL281319B2/en unknown
- 2017-04-17 ES ES17720921T patent/ES2953512T3/es active Active
- 2017-04-17 MX MX2018012622A patent/MX395342B/es unknown
- 2017-04-17 DK DK17720921.0T patent/DK3442947T3/da active
- 2017-04-17 HU HUE17720921A patent/HUE064145T2/hu unknown
- 2017-04-17 CN CN201780030129.9A patent/CN109153650A/zh active Pending
- 2017-05-22 US US15/601,888 patent/US20170355712A1/en not_active Abandoned
-
2018
- 2018-10-04 IL IL262140A patent/IL262140A/en unknown
- 2018-10-12 CL CL2018002928A patent/CL2018002928A1/es unknown
- 2018-10-15 MX MX2022010947A patent/MX2022010947A/es unknown
- 2018-11-13 CO CONC2018/0012181A patent/CO2018012181A2/es unknown
-
2019
- 2019-03-28 CL CL2019000815A patent/CL2019000815A1/es unknown
-
2020
- 2020-11-20 US US17/100,489 patent/US20210198277A1/en not_active Abandoned
-
2021
- 2021-10-07 AU AU2021245168A patent/AU2021245168B2/en not_active Ceased
-
2022
- 2022-03-10 JP JP2022036728A patent/JP7420847B2/ja active Active
-
2024
- 2024-01-11 JP JP2024002232A patent/JP2024045202A/ja active Pending
- 2024-01-25 AU AU2024200464A patent/AU2024200464A1/en not_active Abandoned
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