JP2016506958A5 - - Google Patents

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Publication number
JP2016506958A5
JP2016506958A5 JP2015556098A JP2015556098A JP2016506958A5 JP 2016506958 A5 JP2016506958 A5 JP 2016506958A5 JP 2015556098 A JP2015556098 A JP 2015556098A JP 2015556098 A JP2015556098 A JP 2015556098A JP 2016506958 A5 JP2016506958 A5 JP 2016506958A5
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group
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heterocyclyl
cyano
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JP2015556098A
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JP2016506958A (ja
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Priority claimed from PCT/US2014/013619 external-priority patent/WO2014120783A1/en
Publication of JP2016506958A publication Critical patent/JP2016506958A/ja
Publication of JP2016506958A5 publication Critical patent/JP2016506958A5/ja
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JP2015556098A 2013-01-29 2014-01-29 スピロラクタム系nmda受容体モジュレーターおよびその使用 Ceased JP2016506958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757903P 2013-01-29 2013-01-29
US61/757,903 2013-01-29
PCT/US2014/013619 WO2014120783A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Related Child Applications (1)

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JP2018188429A Division JP6564513B2 (ja) 2013-01-29 2018-10-03 スピロラクタム系nmda受容体モジュレーターおよびその使用

Publications (2)

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JP2016506958A JP2016506958A (ja) 2016-03-07
JP2016506958A5 true JP2016506958A5 (OSRAM) 2017-03-09

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JP2015556098A Ceased JP2016506958A (ja) 2013-01-29 2014-01-29 スピロラクタム系nmda受容体モジュレーターおよびその使用
JP2018188429A Active JP6564513B2 (ja) 2013-01-29 2018-10-03 スピロラクタム系nmda受容体モジュレーターおよびその使用

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JP2018188429A Active JP6564513B2 (ja) 2013-01-29 2018-10-03 スピロラクタム系nmda受容体モジュレーターおよびその使用

Country Status (27)

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US (9) US9512134B2 (OSRAM)
EP (2) EP3514158B1 (OSRAM)
JP (2) JP2016506958A (OSRAM)
KR (1) KR102280616B1 (OSRAM)
CN (1) CN105229011B (OSRAM)
AU (1) AU2014212484B2 (OSRAM)
BR (1) BR112015018087B1 (OSRAM)
CA (1) CA2898861C (OSRAM)
CL (2) CL2015002121A1 (OSRAM)
CY (1) CY1121675T1 (OSRAM)
DK (1) DK2951183T3 (OSRAM)
EA (1) EA032649B1 (OSRAM)
ES (2) ES2935352T3 (OSRAM)
HR (2) HRP20190613T1 (OSRAM)
HU (1) HUE043843T2 (OSRAM)
IL (1) IL240163B (OSRAM)
LT (2) LT2951183T (OSRAM)
MX (1) MX2015009786A (OSRAM)
MY (1) MY188450A (OSRAM)
PE (1) PE20151416A1 (OSRAM)
PH (1) PH12015501601B1 (OSRAM)
PL (1) PL2951183T3 (OSRAM)
PT (2) PT2951183T (OSRAM)
SG (1) SG11201505860XA (OSRAM)
SI (2) SI2951183T1 (OSRAM)
TR (1) TR201908596T4 (OSRAM)
WO (1) WO2014120783A1 (OSRAM)

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MX2015009778A (es) 2013-01-29 2016-02-09 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
BR112015018094A2 (pt) 2013-01-29 2017-07-18 Naurex Inc moduladores de receptor nmda de espiro-lactama e usos dos mesmos
PT2951183T (pt) 2013-01-29 2019-06-17 Aptinyx Inc Moduladores espirolactamas de um recetor nmda e as suas utilizações
BR112015018092A2 (pt) 2013-01-29 2017-07-18 Naurex Inc moduladores de receptor de nmda de espiro-lactama e usos dos mesmos
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AU2017267708B2 (en) * 2016-05-19 2020-02-20 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
AU2017306152A1 (en) 2016-08-01 2019-01-31 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN109906218B (zh) 2016-08-01 2023-01-17 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CA3031539C (en) * 2016-08-01 2023-11-28 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN109661398B (zh) 2016-08-01 2022-07-05 阿普廷伊克斯股份有限公司 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途
MX388786B (es) 2016-08-01 2025-03-20 Aptinyx Inc Moduladores nmda espiro-lactam y métodos de uso de los mismos.
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
KR20200115610A (ko) * 2018-01-31 2020-10-07 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
EP3959205B1 (en) 2019-04-26 2025-11-12 Merck Sharp & Dohme LLC Process for the preparation of intermediates useful for making (2s,5r)-7-oxo-n-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
CN114269338B (zh) * 2019-06-24 2025-02-18 诺雷克斯股份有限公司 生产二氮杂螺内酰胺化合物的方法和中间体
JP7617043B2 (ja) * 2019-06-24 2025-01-17 ノーレックス インコーポレイテッド tert-ブチル(S)-2-((2S,3R)-1-アミノ-3-ヒドロキシ-1-オキソブタン-2-イル)-1-オキソ-2,5-ジアザスピロ[3.4]オクタン-5-カルボキシレートの固体形態およびそれらを調製する方法
JP2022543772A (ja) * 2019-08-01 2022-10-14 アプティニックス インコーポレイテッド Nmda受容体と相互作用する抗体のレベル上昇に関連する障害を治療する方法
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
CN113956183B (zh) * 2021-10-28 2023-06-20 成都市科隆化学品有限公司 一种Boc-Ser(Bzl)-OH及其制备方法

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CN112204031B (zh) 2018-01-31 2024-05-24 元羿生物科技(香港)有限公司 螺-内酰胺nmda受体调节剂及其用途
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WO2021112987A1 (en) 2019-12-04 2021-06-10 Aptinyx Inc. Methods of treating cognitive impairment associated with neurodegenerative disease

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