JP2011500638A5 - - Google Patents
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- JP2011500638A5 JP2011500638A5 JP2010529385A JP2010529385A JP2011500638A5 JP 2011500638 A5 JP2011500638 A5 JP 2011500638A5 JP 2010529385 A JP2010529385 A JP 2010529385A JP 2010529385 A JP2010529385 A JP 2010529385A JP 2011500638 A5 JP2011500638 A5 JP 2011500638A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- het
- alkyl
- aryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07118906.2 | 2007-10-19 | ||
| EP07118906 | 2007-10-19 | ||
| PCT/EP2008/063970 WO2009050236A1 (de) | 2007-10-19 | 2008-10-16 | Neue piperazino-dihydrothienopyrimidin-derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500638A JP2011500638A (ja) | 2011-01-06 |
| JP2011500638A5 true JP2011500638A5 (OSRAM) | 2011-12-01 |
| JP5563466B2 JP5563466B2 (ja) | 2014-07-30 |
Family
ID=39154598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529385A Active JP5563466B2 (ja) | 2007-10-19 | 2008-10-16 | 新規ピペラジノ−ジヒドロチエノピリミジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8486948B2 (OSRAM) |
| EP (1) | EP2215093B1 (OSRAM) |
| JP (1) | JP5563466B2 (OSRAM) |
| AT (1) | ATE537175T1 (OSRAM) |
| CA (1) | CA2702518A1 (OSRAM) |
| WO (1) | WO2009050236A1 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| JP5563466B2 (ja) | 2007-10-19 | 2014-07-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピペラジノ−ジヒドロチエノピリミジン誘導体 |
| EP2205609B1 (de) | 2007-10-19 | 2017-03-29 | Boehringer Ingelheim International GmbH | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
| BRPI0818006B8 (pt) | 2007-10-19 | 2021-05-25 | Boehringer Ingelheim Int | compostos de piperidino-di-hidrotienopirimidinas substituídas, uso dos mesmos e formulações farmacêuticas |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| JP5822911B2 (ja) | 2010-04-02 | 2015-11-25 | ユーロスクリーン エス．エー． | 新規のｎｋ−３受容体選択的アンタゴニスト化合物、医薬組成物、及びｎｋ−３受容体媒介疾患における使用方法 |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| KR102049534B1 (ko) * | 2011-10-03 | 2019-11-27 | 오게다 에스.에이. | 선택적 NK-3 수용체 길항제로서의 신규한 키랄 N-아실-5,6,7,(8-치환된)-테트라히드로-[1,2,4]트리아졸로[4,3-a]피라진, 의약 조성물, NK-3 수용체 매개 질환에 사용하는 방법 및 그의 키랄 합성법 |
| EP2802590B1 (en) * | 2012-01-10 | 2017-03-01 | F. Hoffmann-La Roche AG | Thienopyrimidine compounds |
| US9499519B2 (en) | 2012-12-26 | 2016-11-22 | Medivation Technologies, Inc. | Fused pyrimidine compounds and use thereof |
| WO2014119695A1 (ja) | 2013-01-31 | 2014-08-07 | 帝人株式会社 | 圧電振動体 |
| TW201512189A (zh) | 2013-04-16 | 2015-04-01 | Gruenenthal Chemie | 新型被取代之嘧啶縮合化合物 |
| PT3560925T (pt) * | 2016-12-26 | 2021-07-28 | Meiji Seika Pharma Co Ltd | Novo composto e sal farmaceuticamente aceitável deste |
| EP3684775B1 (en) * | 2017-09-20 | 2024-11-20 | UNION therapeutics A/S | Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| US11299497B2 (en) | 2017-12-15 | 2022-04-12 | UNION therapeutics A/S | Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| ES2935615T3 (es) * | 2017-12-15 | 2023-03-08 | Union Therapeutics As | Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| ES2968822T3 (es) | 2017-12-15 | 2024-05-14 | Union Therapeutics As | Azetidina dihidrotienopirimidinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| CN111961034A (zh) * | 2019-05-20 | 2020-11-20 | 浙江同源康医药股份有限公司 | 用作ret激酶抑制剂的化合物及其应用 |
| AU2021309876B2 (en) * | 2020-07-14 | 2024-06-27 | Wuhan Ll Science And Technology Development Co., Ltd. | Rock inhibitor, and preparation method therefor and use thereof |
| EP4534540A1 (en) * | 2022-06-02 | 2025-04-09 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| CN119630673A (zh) * | 2022-08-09 | 2025-03-14 | 西藏海思科制药有限公司 | Pde4b抑制剂及其用途 |
| JP2025534418A (ja) * | 2022-09-29 | 2025-10-15 | 蘇州愛科百発生物医薬技術有限公司 | 含窒素縮合複素環化合物、その調製方法、および医薬におけるその使用 |
| WO2024213089A1 (zh) * | 2023-04-13 | 2024-10-17 | 上海壹迪生物技术有限公司 | 取代的二氢噻吩并嘧啶类化合物、其制备方法和应用 |
| WO2025038987A2 (en) * | 2023-08-17 | 2025-02-20 | Katalytic Therapeutics, Inc. | Pde4 protein degraders, pharmaceutical compositions, and therapeutic applications |
| WO2025067168A1 (zh) * | 2023-09-25 | 2025-04-03 | 苏州爱科百发生物医药技术有限公司 | 氮杂稠环类化合物及其制备方法和用途 |
| WO2025162431A1 (zh) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | 一种pde4b抑制剂化合物的口服药物组合物及其制备方法 |
| WO2025162289A2 (zh) * | 2024-02-04 | 2025-08-07 | 西藏海思科制药有限公司 | 一种pde4b抑制剂的晶型及其在医药上的用途 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470336A1 (de) | 1962-07-04 | 1969-03-20 | Thomae Gmbh Dr K | Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung |
| NL124131C (OSRAM) | 1963-06-17 | |||
| DE1470356A1 (de) | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE754606A (fr) | 1969-08-08 | 1971-02-08 | Thomae Gmbh Dr K | Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication |
| DE2032687A1 (en) | 1970-07-02 | 1972-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Cardiovascular 2-aminoalkylamino-thienopyrimidines - and 4-morpholino derivatives from 4-diethanolamino-compounds by intramolecular cyclisa |
| DE1940572A1 (de) | 1969-08-08 | 1971-02-11 | Thomae Gmbh Dr K | Neue 2-Aminoalkylamino-thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| US3763156A (en) | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| FR2082496A5 (OSRAM) | 1970-03-18 | 1971-12-10 | Westinghouse Freins & Signaux | |
| DE2121950A1 (en) | 1971-05-04 | 1972-11-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Thieno(3,2-d)pyrimidine derivs - with thrombocyte aggregation inhibiting activity |
| DE2750288A1 (de) | 1977-11-10 | 1979-05-17 | Thomae Gmbh Dr K | Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4256737A (en) | 1979-06-11 | 1981-03-17 | Syntex (U.S.A.) Inc. | Long acting depot injectable formulations for LH-RH analogues |
| US5187168A (en) | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
| JPH07330777A (ja) | 1994-06-08 | 1995-12-19 | Taisho Pharmaceut Co Ltd | チエノ［３，２−ｄ］ピリミジン−４−オン誘導体 |
| JPH09301958A (ja) | 1996-05-09 | 1997-11-25 | Nippon Shoji Kk | 新規ピリミジン化合物及び抗ロタウイルス剤 |
| US6339089B2 (en) | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
| DE10064994A1 (de) | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
| WO2002088138A1 (en) | 2001-04-30 | 2002-11-07 | Bayer Corporation | Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines |
| US6587548B2 (en) | 2001-07-17 | 2003-07-01 | Hewlett-Packard Development Co., L.P. | Method and system of using a single telephone number for multiple services |
| AU2002364211A1 (en) | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| WO2003059913A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
| CA2523831C (en) | 2003-04-29 | 2008-11-18 | Pfizer Inc. | 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension |
| JP2005003345A (ja) | 2003-05-21 | 2005-01-06 | Showa Denko Kk | 換気兼熱交換装置および空調システム |
| CA2540617A1 (en) | 2003-10-02 | 2005-04-21 | Martek Biosciences Corporation | Production of high levels of dha in microalgae using modified amounts of chloride and potassium |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
| CN101163706A (zh) | 2005-04-21 | 2008-04-16 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的二氢噻吩并嘧啶 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| WO2008128942A1 (en) | 2007-04-20 | 2008-10-30 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| CA2702500A1 (en) | 2007-10-18 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein |
| CA2702922C (en) | 2007-10-19 | 2018-01-16 | Schering Corporation | Spiro-condensed 1,3,4-thiadiazole derivatives for inhibiting ksp kinesin activity |
| TW200934771A (en) | 2007-10-19 | 2009-08-16 | Astrazeneca Ab | New compounds |
| BRPI0818006B8 (pt) | 2007-10-19 | 2021-05-25 | Boehringer Ingelheim Int | compostos de piperidino-di-hidrotienopirimidinas substituídas, uso dos mesmos e formulações farmacêuticas |
| JP5563466B2 (ja) | 2007-10-19 | 2014-07-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピペラジノ−ジヒドロチエノピリミジン誘導体 |
| EP2205609B1 (de) | 2007-10-19 | 2017-03-29 | Boehringer Ingelheim International GmbH | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
| FR2922550B1 (fr) | 2007-10-19 | 2009-11-27 | Sanofi Aventis | Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet |
| WO2009053268A1 (de) | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | Neue phenyl-substituierte piperazino-dihydrothienopyrimidine |
| CA2753597A1 (en) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Drug combinations containing pde4-inhibitors and nsaids |
| WO2010097334A1 (de) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
-
2008
- 2008-10-16 JP JP2010529385A patent/JP5563466B2/ja active Active
- 2008-10-16 AT AT08840365T patent/ATE537175T1/de active
- 2008-10-16 US US12/738,425 patent/US8486948B2/en active Active
- 2008-10-16 WO PCT/EP2008/063970 patent/WO2009050236A1/de not_active Ceased
- 2008-10-16 EP EP08840365A patent/EP2215093B1/de active Active
- 2008-10-16 CA CA2702518A patent/CA2702518A1/en not_active Abandoned
-
2013
- 2013-06-06 US US13/911,712 patent/US9090626B2/en active Active
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