JP2009534398A5 - - Google Patents
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- Publication number
- JP2009534398A5 JP2009534398A5 JP2009506680A JP2009506680A JP2009534398A5 JP 2009534398 A5 JP2009534398 A5 JP 2009534398A5 JP 2009506680 A JP2009506680 A JP 2009506680A JP 2009506680 A JP2009506680 A JP 2009506680A JP 2009534398 A5 JP2009534398 A5 JP 2009534398A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogens
- acceptable salt
- optionally substituted
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 25
- 150000002367 halogens Chemical class 0.000 claims 25
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 150000002431 hydrogen Chemical class 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- -1 3,5-Dichloro-4′-fluoro-biphenyl-4-ylmethyl Chemical group 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- UCNKMJWLJXQYMZ-VIFPVBQESA-N 1-[(5s)-4,5,6,7-tetrahydro-1h-indazol-5-yl]pyrrolidin-2-one Chemical compound O=C1CCCN1[C@@H]1CC(C=NN2)=C2CC1 UCNKMJWLJXQYMZ-VIFPVBQESA-N 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74532006P | 2006-04-21 | 2006-04-21 | |
| US60/745,320 | 2006-04-21 | ||
| PCT/US2007/066069 WO2007124254A2 (en) | 2006-04-21 | 2007-04-05 | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534398A JP2009534398A (ja) | 2009-09-24 |
| JP2009534398A5 true JP2009534398A5 (OSRAM) | 2011-04-28 |
| JP5161869B2 JP5161869B2 (ja) | 2013-03-13 |
Family
ID=38595048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506680A Expired - Fee Related JP5161869B2 (ja) | 2006-04-21 | 2007-04-05 | １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7981918B2 (OSRAM) |
| EP (1) | EP2029579B1 (OSRAM) |
| JP (1) | JP5161869B2 (OSRAM) |
| KR (1) | KR101055576B1 (OSRAM) |
| CN (1) | CN101426783B (OSRAM) |
| AR (1) | AR060618A1 (OSRAM) |
| AU (1) | AU2007240550B2 (OSRAM) |
| BR (1) | BRPI0710229A2 (OSRAM) |
| CA (1) | CA2647677C (OSRAM) |
| CO (1) | CO6140026A2 (OSRAM) |
| CR (1) | CR10400A (OSRAM) |
| DO (1) | DOP2007000078A (OSRAM) |
| EA (1) | EA015675B1 (OSRAM) |
| EC (1) | ECSP088839A (OSRAM) |
| ES (1) | ES2533263T3 (OSRAM) |
| IL (1) | IL194835A (OSRAM) |
| JO (1) | JO3042B1 (OSRAM) |
| MA (1) | MA30476B1 (OSRAM) |
| MX (1) | MX2008013484A (OSRAM) |
| MY (1) | MY148128A (OSRAM) |
| NO (1) | NO20084403L (OSRAM) |
| NZ (1) | NZ571175A (OSRAM) |
| PE (1) | PE20080362A1 (OSRAM) |
| SV (1) | SV2008003070A (OSRAM) |
| TN (1) | TNSN08405A1 (OSRAM) |
| TW (1) | TWI347321B (OSRAM) |
| UA (1) | UA95798C2 (OSRAM) |
| WO (1) | WO2007124254A2 (OSRAM) |
| ZA (1) | ZA200808686B (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007240458B2 (en) * | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| BRPI0710467A2 (pt) * | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, uso de um composto, e, intermediário |
| PT2029529E (pt) | 2006-04-24 | 2010-09-02 | Lilly Co Eli | Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase |
| BRPI0710468A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, e, composição farmacêutica |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| ES2336849T3 (es) | 2006-04-25 | 2010-04-16 | Eli Lilly And Company | Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1. |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| PL2049513T3 (pl) * | 2006-04-28 | 2012-06-29 | Lilly Co Eli | Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| EP2125750B1 (en) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| PL2300461T3 (pl) | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010010150A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5379160B2 (ja) | 2008-07-25 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| EP2393807B1 (en) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
| JP5589003B2 (ja) * | 2009-02-04 | 2014-09-10 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体 |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| US8552212B2 (en) | 2009-11-05 | 2013-10-08 | Boehringer Ingelheim International Gmbh | Chiral phosphorus ligands |
| WO2011068927A2 (en) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EA024846B1 (ru) | 2011-10-18 | 2016-10-31 | Астеллас Фарма Инк. | Бициклическое гетероциклическое соединение |
| AR099936A1 (es) * | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
| US10858347B2 (en) | 2015-12-31 | 2020-12-08 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| AU2022224918B2 (en) | 2021-02-25 | 2023-04-13 | Aptabio Therapeutics Inc. | Novel pyrazole derivatives |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| EA011097B1 (ru) * | 2004-05-07 | 2008-12-30 | Янссен Фармацевтика Н.В. | Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы |
| US7687644B2 (en) | 2004-05-07 | 2010-03-30 | Janssen Pharmaceutica Nv | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| JP2008515956A (ja) | 2004-10-12 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物 |
| DK1807072T3 (da) | 2004-10-29 | 2009-03-16 | Lilly Co Eli | Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1 |
| AU2005304560C1 (en) | 2004-11-10 | 2013-05-09 | Incyte Holdings Corporation | Lactam compounds and their use as pharmaceuticals |
| US20080214621A1 (en) | 2004-12-20 | 2008-09-04 | Thomas Daniel Aicher | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 |
| ATE401073T1 (de) | 2004-12-21 | 2008-08-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| ES2322727B1 (es) | 2005-07-28 | 2010-04-22 | Universidad Del Pais Vasco | Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares. |
| WO2007084314A2 (en) | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| AU2007240458B2 (en) * | 2006-04-21 | 2012-03-15 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
| AU2007240450B2 (en) | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| PT2029529E (pt) | 2006-04-24 | 2010-09-02 | Lilly Co Eli | Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase |
| BRPI0710467A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, composição farmacêutica, uso de um composto, e, intermediário |
| BRPI0710468A2 (pt) | 2006-04-24 | 2011-08-16 | Lilly Co Eli | composto, e, composição farmacêutica |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| DK2035379T3 (da) | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| ES2336849T3 (es) | 2006-04-25 | 2010-04-16 | Eli Lilly And Company | Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1. |
| PL2049513T3 (pl) | 2006-04-28 | 2012-06-29 | Lilly Co Eli | Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-05 UA UAA200812290A patent/UA95798C2/ru unknown
- 2007-04-05 EP EP07760191.2A patent/EP2029579B1/en active Active
- 2007-04-05 JP JP2009506680A patent/JP5161869B2/ja not_active Expired - Fee Related
- 2007-04-05 BR BRPI0710229-1A patent/BRPI0710229A2/pt active Search and Examination
- 2007-04-05 NZ NZ571175A patent/NZ571175A/en not_active IP Right Cessation
- 2007-04-05 US US12/297,375 patent/US7981918B2/en not_active Expired - Fee Related
- 2007-04-05 EA EA200870460A patent/EA015675B1/ru not_active IP Right Cessation
- 2007-04-05 MX MX2008013484A patent/MX2008013484A/es active IP Right Grant
- 2007-04-05 WO PCT/US2007/066069 patent/WO2007124254A2/en not_active Ceased
- 2007-04-05 AU AU2007240550A patent/AU2007240550B2/en not_active Ceased
- 2007-04-05 CN CN2007800142829A patent/CN101426783B/zh not_active Expired - Fee Related
- 2007-04-05 CA CA2647677A patent/CA2647677C/en not_active Expired - Fee Related
- 2007-04-05 KR KR1020087025618A patent/KR101055576B1/ko not_active Expired - Fee Related
- 2007-04-05 MY MYPI20084205A patent/MY148128A/en unknown
- 2007-04-05 ES ES07760191.2T patent/ES2533263T3/es active Active
- 2007-04-18 JO JOP/2007/0149A patent/JO3042B1/ar active
- 2007-04-19 TW TW096113852A patent/TWI347321B/zh not_active IP Right Cessation
- 2007-04-19 DO DO2007000078A patent/DOP2007000078A/es unknown
- 2007-04-20 PE PE2007000491A patent/PE20080362A1/es not_active Application Discontinuation
- 2007-04-20 AR ARP070101715A patent/AR060618A1/es not_active Application Discontinuation
-
2008
- 2008-10-10 ZA ZA200808686A patent/ZA200808686B/xx unknown
- 2008-10-17 TN TNP2008000405A patent/TNSN08405A1/en unknown
- 2008-10-17 CO CO08110816A patent/CO6140026A2/es unknown
- 2008-10-20 NO NO20084403A patent/NO20084403L/no not_active Application Discontinuation
- 2008-10-21 EC EC2008008839A patent/ECSP088839A/es unknown
- 2008-10-21 SV SV2008003070A patent/SV2008003070A/es unknown
- 2008-10-22 IL IL194835A patent/IL194835A/en not_active IP Right Cessation
- 2008-10-24 CR CR10400A patent/CR10400A/es unknown
- 2008-11-20 MA MA31396A patent/MA30476B1/fr unknown
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