PE20080362A1 - Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 - Google Patents

Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1

Info

Publication number
PE20080362A1
PE20080362A1 PE2007000491A PE2007000491A PE20080362A1 PE 20080362 A1 PE20080362 A1 PE 20080362A1 PE 2007000491 A PE2007000491 A PE 2007000491A PE 2007000491 A PE2007000491 A PE 2007000491A PE 20080362 A1 PE20080362 A1 PE 20080362A1
Authority
PE
Peru
Prior art keywords
hydroxiesteroid
cyclohexylpirazole
lactam
inhibitors
halogen
Prior art date
Application number
PE2007000491A
Other languages
English (en)
Inventor
Thomas Daniel Aicher
Alexei Pavlovych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Nancy June Snyder
Hongqi Tian
Owen Brendan Wallace
Leonard Larry Winneroski Jr
Yangping Xu
Peter Biagio Anzeveno
Renhua Li
Gregory Alan Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20080362A1 publication Critical patent/PE20080362A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CICLOHEXILPIRAZOL-LACTAMA DE FORMULA (I), EN DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, HALOGENO, -O-CH3, ENTRE OTROS; R3 ES H O HALOGENO; R4 ES H, HALOGENO, CIANO, ALCOXI(C1-C6), 1-(R8)-1H-PIRAZOL-4-IL, PIRIMIDIN-5-IL, 4-(R5)-FENIL R6-SUSTITUIDO, MORFOLIN-4-IL, 4-(R8)-PIPERIDIN-1-IL, ENTRE OTROS. SON SELECCIONADOS: (3R)-3-[3,5-DICLORO-4'-FLUORO[1,1'-BIFENIL]-4-IL)METIL]-1-[(5S)-4,5,6,7-TETRAHIDRO-1H-INDAZOL-5-IL)-2-PIRROLIDINONA, (3R)-3-(3,5-DICLORO-4'-FLUORO-BIFENIL-4-ILMETIL)-1-(4,5,6,7-TETRAHIDRO-1H-INDAZOL-4-IL)-PIRROLIDIN-2-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTOS INTERMEDIOS, UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA 11-ß-HIDROXIESTEROIDE DESHIDROEGNASA TIPO 1 (11-ß-HSD1) POR LO QUE SON UTILES PARA EL TRATAMIENTO DE DIABETES, HIPERGLICEMIA, OBESIDAD, HIPERTENSION, HIPERGLICEMIA, SIDROME METABOLICO
PE2007000491A 2006-04-21 2007-04-20 Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 PE20080362A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
PE20080362A1 true PE20080362A1 (es) 2008-04-25

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000491A PE20080362A1 (es) 2006-04-21 2007-04-20 Derivados de ciclohexilpirazol-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1

Country Status (30)

Country Link
US (1) US7981918B2 (es)
EP (1) EP2029579B1 (es)
JP (1) JP5161869B2 (es)
KR (1) KR101055576B1 (es)
CN (1) CN101426783B (es)
AR (1) AR060618A1 (es)
AU (1) AU2007240550B2 (es)
BR (1) BRPI0710229A2 (es)
CA (1) CA2647677C (es)
CO (1) CO6140026A2 (es)
CR (1) CR10400A (es)
DO (1) DOP2007000078A (es)
EA (1) EA015675B1 (es)
EC (1) ECSP088839A (es)
ES (1) ES2533263T3 (es)
HK (1) HK1126493A1 (es)
IL (1) IL194835A (es)
JO (1) JO3042B1 (es)
MA (1) MA30476B1 (es)
MX (1) MX2008013484A (es)
MY (1) MY148128A (es)
NO (1) NO20084403L (es)
NZ (1) NZ571175A (es)
PE (1) PE20080362A1 (es)
SV (1) SV2008003070A (es)
TN (1) TNSN08405A1 (es)
TW (1) TWI347321B (es)
UA (1) UA95798C2 (es)
WO (1) WO2007124254A2 (es)
ZA (1) ZA200808686B (es)

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Also Published As

Publication number Publication date
SV2008003070A (es) 2010-01-18
JO3042B1 (ar) 2016-09-05
IL194835A0 (en) 2009-08-03
MY148128A (en) 2013-02-28
EP2029579A2 (en) 2009-03-04
CO6140026A2 (es) 2010-03-19
IL194835A (en) 2015-04-30
MA30476B1 (fr) 2009-06-01
TNSN08405A1 (en) 2010-04-14
TW200811141A (en) 2008-03-01
KR20080109867A (ko) 2008-12-17
NO20084403L (no) 2008-11-14
WO2007124254A3 (en) 2007-12-27
AR060618A1 (es) 2008-07-02
ES2533263T3 (es) 2015-04-08
CA2647677A1 (en) 2007-11-01
CN101426783A (zh) 2009-05-06
UA95798C2 (ru) 2011-09-12
MX2008013484A (es) 2008-10-30
AU2007240550A1 (en) 2007-11-01
CR10400A (es) 2009-01-14
EA015675B1 (ru) 2011-10-31
TWI347321B (en) 2011-08-21
US7981918B2 (en) 2011-07-19
ECSP088839A (es) 2008-11-27
CA2647677C (en) 2014-03-18
EA200870460A1 (ru) 2009-04-28
DOP2007000078A (es) 2007-11-15
JP2009534398A (ja) 2009-09-24
KR101055576B1 (ko) 2011-08-08
US20090111800A1 (en) 2009-04-30
HK1126493A1 (en) 2009-09-04
JP5161869B2 (ja) 2013-03-13
AU2007240550B2 (en) 2012-02-23
WO2007124254A2 (en) 2007-11-01
BRPI0710229A2 (pt) 2011-08-02
EP2029579B1 (en) 2014-12-31
CN101426783B (zh) 2013-10-30
NZ571175A (en) 2011-10-28
ZA200808686B (en) 2009-12-30

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