HK1126493A1 - Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1- - Google Patents

Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1-

Info

Publication number
HK1126493A1
HK1126493A1 HK09105407.7A HK09105407A HK1126493A1 HK 1126493 A1 HK1126493 A1 HK 1126493A1 HK 09105407 A HK09105407 A HK 09105407A HK 1126493 A1 HK1126493 A1 HK 1126493A1
Authority
HK
Hong Kong
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
hydroxysteroid dehydrogenase
lactam derivatives
Prior art date
Application number
HK09105407.7A
Other languages
English (en)
Chinese (zh)
Inventor
Thomas Daniel Aicher
Peter Biagio Anzeveno
Renhua Li
Alexei Pavlovych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Nancy June Snyder
Gregory Alan Stephenson
Hongqi Tian
Owen Brendan Wallace
Leonard Larry Junior Winneroski
Yanping Xu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1126493A1 publication Critical patent/HK1126493A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK09105407.7A 2006-04-21 2009-06-17 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1- HK1126493A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21
PCT/US2007/066069 WO2007124254A2 (en) 2006-04-21 2007-04-05 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
HK1126493A1 true HK1126493A1 (en) 2009-09-04

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09105407.7A HK1126493A1 (en) 2006-04-21 2009-06-17 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1-

Country Status (30)

Country Link
US (1) US7981918B2 (es)
EP (1) EP2029579B1 (es)
JP (1) JP5161869B2 (es)
KR (1) KR101055576B1 (es)
CN (1) CN101426783B (es)
AR (1) AR060618A1 (es)
AU (1) AU2007240550B2 (es)
BR (1) BRPI0710229A2 (es)
CA (1) CA2647677C (es)
CO (1) CO6140026A2 (es)
CR (1) CR10400A (es)
DO (1) DOP2007000078A (es)
EA (1) EA015675B1 (es)
EC (1) ECSP088839A (es)
ES (1) ES2533263T3 (es)
HK (1) HK1126493A1 (es)
IL (1) IL194835A (es)
JO (1) JO3042B1 (es)
MA (1) MA30476B1 (es)
MX (1) MX2008013484A (es)
MY (1) MY148128A (es)
NO (1) NO20084403L (es)
NZ (1) NZ571175A (es)
PE (1) PE20080362A1 (es)
SV (1) SV2008003070A (es)
TN (1) TNSN08405A1 (es)
TW (1) TWI347321B (es)
UA (1) UA95798C2 (es)
WO (1) WO2007124254A2 (es)
ZA (1) ZA200808686B (es)

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EA014718B1 (ru) 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
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MX2008013658A (es) 2006-04-24 2008-11-04 Lilly Co Eli Pirrolidinonas sustituidas con ciclohexilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
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CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
US8148534B2 (en) * 2006-04-25 2012-04-03 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ES2336849T3 (es) 2006-04-25 2010-04-16 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1.
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US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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CN101432275B (zh) 2006-04-24 2013-10-30 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
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US8148534B2 (en) 2006-04-25 2012-04-03 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
KR101060016B1 (ko) 2006-04-28 2011-08-29 일라이 릴리 앤드 캄파니 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 피페리디닐 치환 피롤리디논
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Also Published As

Publication number Publication date
AU2007240550B2 (en) 2012-02-23
NO20084403L (no) 2008-11-14
JO3042B1 (ar) 2016-09-05
TW200811141A (en) 2008-03-01
CA2647677C (en) 2014-03-18
ES2533263T3 (es) 2015-04-08
TNSN08405A1 (en) 2010-04-14
AR060618A1 (es) 2008-07-02
US7981918B2 (en) 2011-07-19
WO2007124254A2 (en) 2007-11-01
EP2029579A2 (en) 2009-03-04
MX2008013484A (es) 2008-10-30
US20090111800A1 (en) 2009-04-30
CN101426783A (zh) 2009-05-06
MA30476B1 (fr) 2009-06-01
DOP2007000078A (es) 2007-11-15
KR20080109867A (ko) 2008-12-17
TWI347321B (en) 2011-08-21
PE20080362A1 (es) 2008-04-25
AU2007240550A1 (en) 2007-11-01
KR101055576B1 (ko) 2011-08-08
NZ571175A (en) 2011-10-28
IL194835A0 (en) 2009-08-03
JP5161869B2 (ja) 2013-03-13
SV2008003070A (es) 2010-01-18
IL194835A (en) 2015-04-30
BRPI0710229A2 (pt) 2011-08-02
EA200870460A1 (ru) 2009-04-28
EP2029579B1 (en) 2014-12-31
WO2007124254A3 (en) 2007-12-27
ZA200808686B (en) 2009-12-30
CR10400A (es) 2009-01-14
EA015675B1 (ru) 2011-10-31
UA95798C2 (ru) 2011-09-12
MY148128A (en) 2013-02-28
CN101426783B (zh) 2013-10-30
CO6140026A2 (es) 2010-03-19
ECSP088839A (es) 2008-11-27
CA2647677A1 (en) 2007-11-01
JP2009534398A (ja) 2009-09-24

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Effective date: 20190405