NO20084403L - Cykloheksylpyrazol-lactamderivater som inhibitorer av II-beta-hydroksysteroid dehydrogenase I - Google Patents

Cykloheksylpyrazol-lactamderivater som inhibitorer av II-beta-hydroksysteroid dehydrogenase I

Info

Publication number
NO20084403L
NO20084403L NO20084403A NO20084403A NO20084403L NO 20084403 L NO20084403 L NO 20084403L NO 20084403 A NO20084403 A NO 20084403A NO 20084403 A NO20084403 A NO 20084403A NO 20084403 L NO20084403 L NO 20084403L
Authority
NO
Norway
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
compounds
hydroxysteroid dehydrogenase
Prior art date
Application number
NO20084403A
Other languages
English (en)
Inventor
Leonard Larry Winneroski Jr
Nancy June Snyder
Thomas Daniel Aicher
Hongqi Tian
Renhua Li
Thomas Edward Mabry
Owen Brendan Wallace
Yanping Xu
Alexei Pavlovych Krasutsky
Ashraf Saeed
Peter Biagio Anzeveno
Gregory Alan Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20084403L publication Critical patent/NO20084403L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse beskriver nye forbindelser med Formel I: som har 11ß-HSD type 1 antagonist aktivitet, såvel som fremgangsmåter for fremstilling av slike forbindelser. I en annen utførelsesform beskriver oppfinnelsen farmasøytiske sammensetninger som innbefatter forbindelser med Formel I, så vel som fremgangsmåter for anvendelse av forbindelsene og sammensetningene for behandling av diabetes, hyperglykemi, fedme, hypertensjon, hyperlipidemi, metabolittisk syndrom, og andre tilstander assosiert med 11ß -HSD type 1 aktivitet.
NO20084403A 2006-04-21 2008-10-20 Cykloheksylpyrazol-lactamderivater som inhibitorer av II-beta-hydroksysteroid dehydrogenase I NO20084403L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21
PCT/US2007/066069 WO2007124254A2 (en) 2006-04-21 2007-04-05 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
NO20084403L true NO20084403L (no) 2008-11-14

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084403A NO20084403L (no) 2006-04-21 2008-10-20 Cykloheksylpyrazol-lactamderivater som inhibitorer av II-beta-hydroksysteroid dehydrogenase I

Country Status (30)

Country Link
US (1) US7981918B2 (no)
EP (1) EP2029579B1 (no)
JP (1) JP5161869B2 (no)
KR (1) KR101055576B1 (no)
CN (1) CN101426783B (no)
AR (1) AR060618A1 (no)
AU (1) AU2007240550B2 (no)
BR (1) BRPI0710229A2 (no)
CA (1) CA2647677C (no)
CO (1) CO6140026A2 (no)
CR (1) CR10400A (no)
DO (1) DOP2007000078A (no)
EA (1) EA015675B1 (no)
EC (1) ECSP088839A (no)
ES (1) ES2533263T3 (no)
HK (1) HK1126493A1 (no)
IL (1) IL194835A (no)
JO (1) JO3042B1 (no)
MA (1) MA30476B1 (no)
MX (1) MX2008013484A (no)
MY (1) MY148128A (no)
NO (1) NO20084403L (no)
NZ (1) NZ571175A (no)
PE (1) PE20080362A1 (no)
SV (1) SV2008003070A (no)
TN (1) TNSN08405A1 (no)
TW (1) TWI347321B (no)
UA (1) UA95798C2 (no)
WO (1) WO2007124254A2 (no)
ZA (1) ZA200808686B (no)

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US7820659B2 (en) 2006-04-21 2010-10-26 Eli Lilly And Company Cyclohexylimidiazole lactam derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase 1
CN101541747B (zh) * 2006-04-21 2012-11-14 伊莱利利公司 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物
SI2049475T1 (sl) 2006-04-24 2012-04-30 Lilly Co Eli Pirolidinoni substituirani s cikloheksilom kot inhibitorji 11-betahidroksisteroid dehidrogenaze 1
PL2029529T3 (pl) 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
DK2021336T3 (da) * 2006-04-24 2010-09-13 Lilly Co Eli 11-beta-hydroxysteroid-dehydrogenase-1-inhibitorer
SI2021337T1 (sl) 2006-04-25 2010-05-31 Lilly Co Eli Inhibitorji beta hidroksisteroidne dehidrogenaze
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WO2007127763A2 (en) 2006-04-25 2007-11-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
MX2008013844A (es) 2006-04-28 2008-11-10 Lilly Co Eli Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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AR071609A1 (es) 2008-05-01 2010-06-30 Vitae Pharmaceuticals Inc Inhibidores ciclicos de 11(beta) -hidroxiesteroide deshidrogenasa 1
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MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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MX2008013844A (es) * 2006-04-28 2008-11-10 Lilly Co Eli Pirrolidinonas substituidas con pieridinilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
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Also Published As

Publication number Publication date
IL194835A (en) 2015-04-30
AU2007240550B2 (en) 2012-02-23
MX2008013484A (es) 2008-10-30
AR060618A1 (es) 2008-07-02
NZ571175A (en) 2011-10-28
CR10400A (es) 2009-01-14
WO2007124254A3 (en) 2007-12-27
BRPI0710229A2 (pt) 2011-08-02
CN101426783A (zh) 2009-05-06
UA95798C2 (ru) 2011-09-12
EP2029579A2 (en) 2009-03-04
EA015675B1 (ru) 2011-10-31
EA200870460A1 (ru) 2009-04-28
TW200811141A (en) 2008-03-01
CN101426783B (zh) 2013-10-30
EP2029579B1 (en) 2014-12-31
WO2007124254A2 (en) 2007-11-01
IL194835A0 (en) 2009-08-03
KR20080109867A (ko) 2008-12-17
DOP2007000078A (es) 2007-11-15
JP5161869B2 (ja) 2013-03-13
ECSP088839A (es) 2008-11-27
ES2533263T3 (es) 2015-04-08
AU2007240550A1 (en) 2007-11-01
PE20080362A1 (es) 2008-04-25
TNSN08405A1 (en) 2010-04-14
TWI347321B (en) 2011-08-21
HK1126493A1 (en) 2009-09-04
US20090111800A1 (en) 2009-04-30
CA2647677C (en) 2014-03-18
ZA200808686B (en) 2009-12-30
CA2647677A1 (en) 2007-11-01
MY148128A (en) 2013-02-28
KR101055576B1 (ko) 2011-08-08
JO3042B1 (ar) 2016-09-05
MA30476B1 (fr) 2009-06-01
US7981918B2 (en) 2011-07-19
SV2008003070A (es) 2010-01-18
CO6140026A2 (es) 2010-03-19
JP2009534398A (ja) 2009-09-24

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