TWI347321B - Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 - Google Patents

Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Info

Publication number
TWI347321B
TWI347321B TW096113852A TW96113852A TWI347321B TW I347321 B TWI347321 B TW I347321B TW 096113852 A TW096113852 A TW 096113852A TW 96113852 A TW96113852 A TW 96113852A TW I347321 B TWI347321 B TW I347321B
Authority
TW
Taiwan
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
hydroxysteroid dehydrogenase
lactam derivatives
Prior art date
Application number
TW096113852A
Other languages
English (en)
Other versions
TW200811141A (en
Inventor
Thomas Daniel Aicher
Alexei Pavlovych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Nancy June Snyder
Hongqi Tian
Owen Brendan Wallace
Leonard Larry Junior Winneroski
Yanping Xu
Peter Biagio Anzeveno
Renhua Li
Gregory Alan Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of TW200811141A publication Critical patent/TW200811141A/zh
Application granted granted Critical
Publication of TWI347321B publication Critical patent/TWI347321B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW096113852A 2006-04-21 2007-04-19 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 TWI347321B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (2)

Publication Number Publication Date
TW200811141A TW200811141A (en) 2008-03-01
TWI347321B true TWI347321B (en) 2011-08-21

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096113852A TWI347321B (en) 2006-04-21 2007-04-19 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Country Status (30)

Country Link
US (1) US7981918B2 (zh)
EP (1) EP2029579B1 (zh)
JP (1) JP5161869B2 (zh)
KR (1) KR101055576B1 (zh)
CN (1) CN101426783B (zh)
AR (1) AR060618A1 (zh)
AU (1) AU2007240550B2 (zh)
BR (1) BRPI0710229A2 (zh)
CA (1) CA2647677C (zh)
CO (1) CO6140026A2 (zh)
CR (1) CR10400A (zh)
DO (1) DOP2007000078A (zh)
EA (1) EA015675B1 (zh)
EC (1) ECSP088839A (zh)
ES (1) ES2533263T3 (zh)
HK (1) HK1126493A1 (zh)
IL (1) IL194835A (zh)
JO (1) JO3042B1 (zh)
MA (1) MA30476B1 (zh)
MX (1) MX2008013484A (zh)
MY (1) MY148128A (zh)
NO (1) NO20084403L (zh)
NZ (1) NZ571175A (zh)
PE (1) PE20080362A1 (zh)
SV (1) SV2008003070A (zh)
TN (1) TNSN08405A1 (zh)
TW (1) TWI347321B (zh)
UA (1) UA95798C2 (zh)
WO (1) WO2007124254A2 (zh)
ZA (1) ZA200808686B (zh)

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CA2646678C (en) 2006-04-21 2014-02-11 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014718B1 (ru) 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
BRPI0710262A2 (pt) 2006-04-24 2011-08-09 Lilly Co Eli composto, composição farmacêutica, e, intermediário
MX2008013658A (es) 2006-04-24 2008-11-04 Lilly Co Eli Pirrolidinonas sustituidas con ciclohexilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
CN101432275B (zh) * 2006-04-24 2013-10-30 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
US8148534B2 (en) * 2006-04-25 2012-04-03 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ES2336849T3 (es) 2006-04-25 2010-04-16 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1.
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EA014718B1 (ru) 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
BRPI0710262A2 (pt) 2006-04-24 2011-08-09 Lilly Co Eli composto, composição farmacêutica, e, intermediário
MX2008013658A (es) 2006-04-24 2008-11-04 Lilly Co Eli Pirrolidinonas sustituidas con ciclohexilo como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
CN101432275B (zh) 2006-04-24 2013-10-30 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
ES2336849T3 (es) 2006-04-25 2010-04-16 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1.
US8148534B2 (en) 2006-04-25 2012-04-03 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
KR101060016B1 (ko) 2006-04-28 2011-08-29 일라이 릴리 앤드 캄파니 11-베타-히드록시스테로이드 데히드로게나제 1의 억제제로서의 피페리디닐 치환 피롤리디논
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
AU2007240550B2 (en) 2012-02-23
NO20084403L (no) 2008-11-14
JO3042B1 (ar) 2016-09-05
TW200811141A (en) 2008-03-01
CA2647677C (en) 2014-03-18
ES2533263T3 (es) 2015-04-08
TNSN08405A1 (en) 2010-04-14
AR060618A1 (es) 2008-07-02
US7981918B2 (en) 2011-07-19
WO2007124254A2 (en) 2007-11-01
EP2029579A2 (en) 2009-03-04
MX2008013484A (es) 2008-10-30
US20090111800A1 (en) 2009-04-30
HK1126493A1 (zh) 2009-09-04
CN101426783A (zh) 2009-05-06
MA30476B1 (fr) 2009-06-01
DOP2007000078A (es) 2007-11-15
KR20080109867A (ko) 2008-12-17
PE20080362A1 (es) 2008-04-25
AU2007240550A1 (en) 2007-11-01
KR101055576B1 (ko) 2011-08-08
NZ571175A (en) 2011-10-28
IL194835A0 (en) 2009-08-03
JP5161869B2 (ja) 2013-03-13
SV2008003070A (es) 2010-01-18
IL194835A (en) 2015-04-30
BRPI0710229A2 (pt) 2011-08-02
EA200870460A1 (ru) 2009-04-28
EP2029579B1 (en) 2014-12-31
WO2007124254A3 (en) 2007-12-27
ZA200808686B (en) 2009-12-30
CR10400A (es) 2009-01-14
EA015675B1 (ru) 2011-10-31
UA95798C2 (ru) 2011-09-12
MY148128A (en) 2013-02-28
CN101426783B (zh) 2013-10-30
CO6140026A2 (es) 2010-03-19
ECSP088839A (es) 2008-11-27
CA2647677A1 (en) 2007-11-01
JP2009534398A (ja) 2009-09-24

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