MX2008013484A - Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. - Google Patents

Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.

Info

Publication number
MX2008013484A
MX2008013484A MX2008013484A MX2008013484A MX2008013484A MX 2008013484 A MX2008013484 A MX 2008013484A MX 2008013484 A MX2008013484 A MX 2008013484A MX 2008013484 A MX2008013484 A MX 2008013484A MX 2008013484 A MX2008013484 A MX 2008013484A
Authority
MX
Mexico
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
compounds
hydroxysteroid dehydrogenase
Prior art date
Application number
MX2008013484A
Other languages
English (en)
Inventor
Nancy June Snyder
Ashraf Saeed
Owen Brendan Wallace
Thomas Daniel Aicher
Thomas Edward Mabry
Yanping Xu
Peter Biagio Anzeveno
Renhua Li
Alexei Pavlovych Krasutsky
Gregory Alan Stephenson
Hongqi Tian
Leonard Larry Winneroski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2008013484A publication Critical patent/MX2008013484A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención describe nuevos compuestos de Fórmula I: que poseen actividad antagonista de 11ß-HSD tipo 1, así como también métodos para preparar tales compuestos. En otra modalidad, la invención describe composiciones farmacéuticas que comprenden compuestos de Fórmula I, así como también métodos para usar los compuestos y composiciones para tratar diabetes, hiperglicemia, obesidad, hipertensión, hiperlipidemia, síndrome metabólico, y otras condiciones asociadas con la actividad de 11ß-HSD tipo 1. (ver fórmula (I)).
MX2008013484A 2006-04-21 2007-04-05 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. MX2008013484A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21
PCT/US2007/066069 WO2007124254A2 (en) 2006-04-21 2007-04-05 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
MX2008013484A true MX2008013484A (es) 2008-10-30

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008013484A MX2008013484A (es) 2006-04-21 2007-04-05 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.

Country Status (30)

Country Link
US (1) US7981918B2 (es)
EP (1) EP2029579B1 (es)
JP (1) JP5161869B2 (es)
KR (1) KR101055576B1 (es)
CN (1) CN101426783B (es)
AR (1) AR060618A1 (es)
AU (1) AU2007240550B2 (es)
BR (1) BRPI0710229A2 (es)
CA (1) CA2647677C (es)
CO (1) CO6140026A2 (es)
CR (1) CR10400A (es)
DO (1) DOP2007000078A (es)
EA (1) EA015675B1 (es)
EC (1) ECSP088839A (es)
ES (1) ES2533263T3 (es)
HK (1) HK1126493A1 (es)
IL (1) IL194835A (es)
JO (1) JO3042B1 (es)
MA (1) MA30476B1 (es)
MX (1) MX2008013484A (es)
MY (1) MY148128A (es)
NO (1) NO20084403L (es)
NZ (1) NZ571175A (es)
PE (1) PE20080362A1 (es)
SV (1) SV2008003070A (es)
TN (1) TNSN08405A1 (es)
TW (1) TWI347321B (es)
UA (1) UA95798C2 (es)
WO (1) WO2007124254A2 (es)
ZA (1) ZA200808686B (es)

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SI2049475T1 (sl) 2006-04-24 2012-04-30 Lilly Co Eli Pirolidinoni substituirani s cikloheksilom kot inhibitorji 11-betahidroksisteroid dehidrogenaze 1
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SI2021336T1 (sl) 2006-04-24 2010-11-30 Lilly Co Eli Inhibitorji beta hidroksisteroid dehidrogenaze
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JP5324427B2 (ja) 2006-04-25 2013-10-23 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
ATE542811T1 (de) 2006-04-28 2012-02-15 Lilly Co Eli Piperidinylsubstituierte pyrrolidinone als inhibitoren von 11-beta- hydroxysteroiddehydrogenase 1
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
EP2229368A1 (en) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8138178B2 (en) 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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EP2393813B1 (en) * 2009-02-04 2013-07-31 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 ß-hydroxysteroid dehydrogenase 1 useful for the treatment of diseases related to elevated level of cortisol
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WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011149822A1 (en) 2010-05-26 2011-12-01 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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SI2049475T1 (sl) 2006-04-24 2012-04-30 Lilly Co Eli Pirolidinoni substituirani s cikloheksilom kot inhibitorji 11-betahidroksisteroid dehidrogenaze 1
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Also Published As

Publication number Publication date
IL194835A (en) 2015-04-30
TWI347321B (en) 2011-08-21
NZ571175A (en) 2011-10-28
TNSN08405A1 (en) 2010-04-14
CA2647677C (en) 2014-03-18
US7981918B2 (en) 2011-07-19
EP2029579A2 (en) 2009-03-04
JO3042B1 (ar) 2016-09-05
AU2007240550A1 (en) 2007-11-01
IL194835A0 (en) 2009-08-03
AR060618A1 (es) 2008-07-02
WO2007124254A3 (en) 2007-12-27
MY148128A (en) 2013-02-28
CR10400A (es) 2009-01-14
AU2007240550B2 (en) 2012-02-23
CN101426783B (zh) 2013-10-30
TW200811141A (en) 2008-03-01
CN101426783A (zh) 2009-05-06
CA2647677A1 (en) 2007-11-01
NO20084403L (no) 2008-11-14
CO6140026A2 (es) 2010-03-19
ZA200808686B (en) 2009-12-30
DOP2007000078A (es) 2007-11-15
ECSP088839A (es) 2008-11-27
EA200870460A1 (ru) 2009-04-28
KR20080109867A (ko) 2008-12-17
HK1126493A1 (en) 2009-09-04
UA95798C2 (ru) 2011-09-12
US20090111800A1 (en) 2009-04-30
ES2533263T3 (es) 2015-04-08
MA30476B1 (fr) 2009-06-01
EP2029579B1 (en) 2014-12-31
PE20080362A1 (es) 2008-04-25
KR101055576B1 (ko) 2011-08-08
JP5161869B2 (ja) 2013-03-13
BRPI0710229A2 (pt) 2011-08-02
WO2007124254A2 (en) 2007-11-01
SV2008003070A (es) 2010-01-18
JP2009534398A (ja) 2009-09-24
EA015675B1 (ru) 2011-10-31

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