CY1109842T1 - Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i - Google Patents

Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i

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Publication number
CY1109842T1
CY1109842T1 CY20101100164T CY101100164T CY1109842T1 CY 1109842 T1 CY1109842 T1 CY 1109842T1 CY 20101100164 T CY20101100164 T CY 20101100164T CY 101100164 T CY101100164 T CY 101100164T CY 1109842 T1 CY1109842 T1 CY 1109842T1
Authority
CY
Cyprus
Prior art keywords
compounds
hydroxysteroids
dehydrogenation
inhibitors
beta
Prior art date
Application number
CY20101100164T
Other languages
English (en)
Inventor
Owen Brendan Wallace
Renhua Li
Thomas Edward Mabry
Leonard Larry Winneroski Jr
Yanping Xu
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1109842T1 publication Critical patent/CY1109842T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αποκαλύπτει νέες ενώσεις Τύπου I: έχουσες δράση συναγωνιστή 11 β-HSD τύπου 1, καθώς και μεθόδους παρασκευής αυτών των ενώσεων. Σε μία άλλη πραγματοποίηση, η εφεύρεση αποκαλύπτει φαρμακευτικές συνθέσεις περιλαμβάνουσες ενώσεις Τύπου I, καθώς και μεθόδους χρήσεως των ενώσεων και συνθέσεων για την αγωγή του διαβήτη, της υπεργλυκαιμίας, της παχυσαρκίας, της υπερτάσεως, της υπερλιπιδαιμίας, του μεταβολικού συνδρόμου και άλλων καταστάσεων σχετιζόμενων με τη δράση της 11 β-HSD τύπου 1. Χ-17377.
CY20101100164T 2006-04-25 2010-02-19 Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i CY1109842T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74556906P 2006-04-25 2006-04-25
EP07761186A EP2021337B1 (en) 2006-04-25 2007-04-24 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
CY1109842T1 true CY1109842T1 (el) 2014-09-10

Family

ID=38564372

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100164T CY1109842T1 (el) 2006-04-25 2010-02-19 Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i

Country Status (18)

Country Link
US (1) US7994176B2 (el)
EP (1) EP2021337B1 (el)
JP (1) JP5189079B2 (el)
CN (1) CN101454310B (el)
AT (1) ATE455110T1 (el)
AU (1) AU2007244904B2 (el)
BR (1) BRPI0710050A2 (el)
CA (1) CA2648236C (el)
CY (1) CY1109842T1 (el)
DE (1) DE602007004324D1 (el)
DK (1) DK2021337T3 (el)
EA (1) EA015516B1 (el)
ES (1) ES2336849T3 (el)
MX (1) MX2008013651A (el)
PL (1) PL2021337T3 (el)
PT (1) PT2021337E (el)
SI (1) SI2021337T1 (el)
WO (1) WO2007127726A2 (el)

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WO2007124337A1 (en) 2006-04-21 2007-11-01 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5161869B2 (ja) * 2006-04-21 2013-03-13 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体
PL2021336T3 (pl) * 2006-04-24 2010-11-30 Lilly Co Eli Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1
DK2049475T3 (da) 2006-04-24 2012-03-05 Lilly Co Eli Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1
PL2029529T3 (pl) 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
PT2035379E (pt) 2006-04-25 2010-07-13 Lilly Co Eli Inibidores da 11-beta-hidroxiesterëide desidrogenase 1
AU2007244863B2 (en) * 2006-04-25 2012-01-19 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014719B1 (ru) 2006-04-28 2011-02-28 Эли Лилли Энд Компани Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US8440710B2 (en) * 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US9181266B2 (en) 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
EP2731951B1 (en) 2011-07-13 2015-08-19 Novartis AG 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors
US9163003B2 (en) 2011-07-13 2015-10-20 Novartis Ag 4-piperidinyl compounds for use as tankyrase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
ME02733B (me) 2011-10-18 2017-10-20 Astellas Pharma Inc Biciklično heterociklično jedinjenje
CN105793264B (zh) * 2014-03-10 2017-09-01 四川海思科制药有限公司 取代的二氢苯并呋喃‑哌啶‑甲酮衍生物、其制备及用途
CN108046988B (zh) * 2017-12-25 2021-04-16 云南民族大学 一种高效制备碘代醇的方法

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JP5161869B2 (ja) 2006-04-21 2013-03-13 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体
WO2007124337A1 (en) 2006-04-21 2007-11-01 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
DK2049475T3 (da) 2006-04-24 2012-03-05 Lilly Co Eli Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1
PL2029529T3 (pl) 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
PL2021336T3 (pl) 2006-04-24 2010-11-30 Lilly Co Eli Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1
PT2035379E (pt) 2006-04-25 2010-07-13 Lilly Co Eli Inibidores da 11-beta-hidroxiesterëide desidrogenase 1
AU2007244863B2 (en) 2006-04-25 2012-01-19 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014719B1 (ru) 2006-04-28 2011-02-28 Эли Лилли Энд Компани Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
CA2648236A1 (en) 2007-11-08
JP5189079B2 (ja) 2013-04-24
PT2021337E (pt) 2010-02-22
PL2021337T3 (pl) 2010-06-30
ATE455110T1 (de) 2010-01-15
AU2007244904A1 (en) 2007-11-08
EP2021337A2 (en) 2009-02-11
MX2008013651A (es) 2008-11-04
SI2021337T1 (sl) 2010-05-31
BRPI0710050A2 (pt) 2011-08-02
WO2007127726A3 (en) 2008-01-03
JP2009535356A (ja) 2009-10-01
DE602007004324D1 (en) 2010-03-04
WO2007127726A2 (en) 2007-11-08
US7994176B2 (en) 2011-08-09
EA200870474A1 (ru) 2009-04-28
US20090099182A1 (en) 2009-04-16
DK2021337T3 (da) 2010-03-29
AU2007244904B2 (en) 2012-05-31
CN101454310B (zh) 2013-07-17
EP2021337B1 (en) 2010-01-13
CN101454310A (zh) 2009-06-10
CA2648236C (en) 2013-05-28
EA015516B1 (ru) 2011-08-30
ES2336849T3 (es) 2010-04-16

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