EA200870489A1 - Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 - Google Patents

Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1

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Publication number
EA200870489A1
EA200870489A1 EA200870489A EA200870489A EA200870489A1 EA 200870489 A1 EA200870489 A1 EA 200870489A1 EA 200870489 A EA200870489 A EA 200870489A EA 200870489 A EA200870489 A EA 200870489A EA 200870489 A1 EA200870489 A1 EA 200870489A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
beta
compounds
hydroxysteroid dehydrogenase
piperidinyl substituted
Prior art date
Application number
EA200870489A
Other languages
English (en)
Other versions
EA014719B1 (ru
Inventor
Оуэн Брендан Уоллэйс
Яньпин Сюй
Джереми Шуленбург Йорк
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200870489A1 publication Critical patent/EA200870489A1/ru
Publication of EA014719B1 publication Critical patent/EA014719B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Настоящее изобретение предлагает новые соединения формулы I, обладающие антагонистической активностью по отношению к 11-β-HSD типа 1, а также способы приготовления подобных соединений. Согласно другому примеру реализации изобретение предлагает фармацевтические композиции, содержащие соединения формулы I, a также способы применения данных соединений для лечения диабета, гипергликемии, ожирения, гипертензии, гиперлипидемии, метаболического синдрома и прочих состояний, связанных с нарушением активности 11-β-HSD типа 1.
EA200870489A 2006-04-28 2007-04-27 Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 EA014719B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79611206P 2006-04-28 2006-04-28
PCT/US2007/067597 WO2007127901A1 (en) 2006-04-28 2007-04-27 Pieridinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (2)

Publication Number Publication Date
EA200870489A1 true EA200870489A1 (ru) 2009-04-28
EA014719B1 EA014719B1 (ru) 2011-02-28

Family

ID=38421166

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870489A EA014719B1 (ru) 2006-04-28 2007-04-27 Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1

Country Status (23)

Country Link
US (1) US7829582B2 (ru)
EP (1) EP2049513B1 (ru)
JP (1) JP5225980B2 (ru)
KR (1) KR101060016B1 (ru)
CN (1) CN101448816B (ru)
AT (1) ATE542811T1 (ru)
AU (1) AU2007244742B2 (ru)
BR (1) BRPI0710469A2 (ru)
CA (1) CA2650627C (ru)
CY (1) CY1112466T1 (ru)
DK (1) DK2049513T3 (ru)
EA (1) EA014719B1 (ru)
EC (1) ECSP088849A (ru)
IL (1) IL194879A0 (ru)
MA (1) MA30421B1 (ru)
MX (1) MX2008013844A (ru)
NO (1) NO20084874L (ru)
PL (1) PL2049513T3 (ru)
PT (1) PT2049513E (ru)
SI (1) SI2049513T1 (ru)
TN (1) TNSN08432A1 (ru)
WO (1) WO2007127901A1 (ru)
ZA (1) ZA200808816B (ru)

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ES2422165T3 (es) 2006-04-21 2013-09-09 Lilly Co Eli Derivados de ciclohexilimidazol lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
EA014718B1 (ru) * 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
UA95798C2 (ru) * 2006-04-21 2011-09-12 Эли Лилли Энд Компани Производные циклогексилпиразоллактама как ингибиторы 11-бета-гидроксистероиддегидрогеназы 1
JP5118692B2 (ja) 2006-04-24 2013-01-16 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン
BRPI0710262A2 (pt) 2006-04-24 2011-08-09 Lilly Co Eli composto, composição farmacêutica, e, intermediário
CA2646624C (en) 2006-04-24 2013-08-06 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
DK2035379T3 (da) 2006-04-25 2010-09-06 Lilly Co Eli Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
EP2021337B1 (en) 2006-04-25 2010-01-13 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2649822C (en) * 2006-04-25 2013-08-13 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR101593493B1 (ko) 2014-10-28 2016-02-18 주식회사 아이에스티이 대면적 유리기판 열처리 장치

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ES2422165T3 (es) 2006-04-21 2013-09-09 Lilly Co Eli Derivados de ciclohexilimidazol lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
UA95798C2 (ru) 2006-04-21 2011-09-12 Эли Лилли Энд Компани Производные циклогексилпиразоллактама как ингибиторы 11-бета-гидроксистероиддегидрогеназы 1
BRPI0710262A2 (pt) 2006-04-24 2011-08-09 Lilly Co Eli composto, composição farmacêutica, e, intermediário
JP5118692B2 (ja) 2006-04-24 2013-01-16 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン
CA2646624C (en) 2006-04-24 2013-08-06 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2649822C (en) 2006-04-25 2013-08-13 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
DK2035379T3 (da) 2006-04-25 2010-09-06 Lilly Co Eli Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
EP2021337B1 (en) 2006-04-25 2010-01-13 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
PL2049513T3 (pl) 2012-06-29
US7829582B2 (en) 2010-11-09
EP2049513A1 (en) 2009-04-22
EP2049513B1 (en) 2012-01-25
CN101448816B (zh) 2013-08-07
WO2007127901A1 (en) 2007-11-08
NO20084874L (no) 2008-11-19
US20090088430A1 (en) 2009-04-02
JP5225980B2 (ja) 2013-07-03
MA30421B1 (fr) 2009-05-04
IL194879A0 (en) 2009-08-03
BRPI0710469A2 (pt) 2011-08-16
ECSP088849A (es) 2008-11-27
TNSN08432A1 (en) 2010-04-14
EA014719B1 (ru) 2011-02-28
JP2009535362A (ja) 2009-10-01
MX2008013844A (es) 2008-11-10
CA2650627A1 (en) 2007-11-08
CN101448816A (zh) 2009-06-03
SI2049513T1 (sl) 2012-04-30
KR20090007371A (ko) 2009-01-16
ATE542811T1 (de) 2012-02-15
DK2049513T3 (da) 2012-02-27
KR101060016B1 (ko) 2011-08-29
AU2007244742B2 (en) 2012-03-08
ZA200808816B (en) 2009-12-30
CY1112466T1 (el) 2015-12-09
CA2650627C (en) 2013-07-16
PT2049513E (pt) 2012-03-20
AU2007244742A1 (en) 2007-11-08

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