MA30421B1 - Pyrrolidinones substituees par un piperidinyle en tant qu'inhibiteurs de la 11-bêta-hydroxysteroïde deshydrogenase 1 - Google Patents
Pyrrolidinones substituees par un piperidinyle en tant qu'inhibiteurs de la 11-bêta-hydroxysteroïde deshydrogenase 1Info
- Publication number
- MA30421B1 MA30421B1 MA31397A MA31397A MA30421B1 MA 30421 B1 MA30421 B1 MA 30421B1 MA 31397 A MA31397 A MA 31397A MA 31397 A MA31397 A MA 31397A MA 30421 B1 MA30421 B1 MA 30421B1
- Authority
- MA
- Morocco
- Prior art keywords
- beta
- piperidinyl
- inhibitors
- compounds
- hydroxysteroid dehydrogenase
- Prior art date
Links
- 102100036506 11-beta-hydroxysteroid dehydrogenase 1 Human genes 0.000 title 1
- 101710186107 11-beta-hydroxysteroid dehydrogenase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004040 pyrrolidinones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention a pour objet de nouveaux composés de Formule I : ( I ) d'activité antagoniste vis-à-vis de la 11-Bêta-HSD de type 1, ainsi que des méthodes de synthèse de tels composés. Dans un autre mode d'application, la présente invention concerne des compositions pharmaceutiques comprenant des composés de Formule I, ainsi que des méthodes d'utilisation des composés et des compositions dans le traitement du diabète, de l'hyperglycémie, de l'obésité, de l'hypertension, de l'hyperlipidémie, du syndrome métabolique et d'autres états pathologiques associés à l'activité de la 11-Bêta-HSD de type 1. X-17433 PCT -1-
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79611206P | 2006-04-28 | 2006-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30421B1 true MA30421B1 (fr) | 2009-05-04 |
Family
ID=38421166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31397A MA30421B1 (fr) | 2006-04-28 | 2008-11-20 | Pyrrolidinones substituees par un piperidinyle en tant qu'inhibiteurs de la 11-bêta-hydroxysteroïde deshydrogenase 1 |
Country Status (23)
Country | Link |
---|---|
US (1) | US7829582B2 (fr) |
EP (1) | EP2049513B1 (fr) |
JP (1) | JP5225980B2 (fr) |
KR (1) | KR101060016B1 (fr) |
CN (1) | CN101448816B (fr) |
AT (1) | ATE542811T1 (fr) |
AU (1) | AU2007244742B2 (fr) |
BR (1) | BRPI0710469A2 (fr) |
CA (1) | CA2650627C (fr) |
CY (1) | CY1112466T1 (fr) |
DK (1) | DK2049513T3 (fr) |
EA (1) | EA014719B1 (fr) |
EC (1) | ECSP088849A (fr) |
IL (1) | IL194879A0 (fr) |
MA (1) | MA30421B1 (fr) |
MX (1) | MX2008013844A (fr) |
NO (1) | NO20084874L (fr) |
PL (1) | PL2049513T3 (fr) |
PT (1) | PT2049513E (fr) |
SI (1) | SI2049513T1 (fr) |
TN (1) | TNSN08432A1 (fr) |
WO (1) | WO2007127901A1 (fr) |
ZA (1) | ZA200808816B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA015675B1 (ru) | 2006-04-21 | 2011-10-31 | Эли Лилли Энд Компани | Производные циклогексилпиразол-лактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
CN101541747B (zh) * | 2006-04-21 | 2012-11-14 | 伊莱利利公司 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物 |
BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
SI2021336T1 (sl) | 2006-04-24 | 2010-11-30 | Lilly Co Eli | Inhibitorji beta hidroksisteroid dehidrogenaze |
CA2649111C (fr) | 2006-04-24 | 2013-09-10 | Eli Lilly And Company | Pyrrolidinones substtuees a la cyclohexyle comme inhibiteurs de la 11-beta-hydroxysteroide dehydrogenase de type 1 |
EA016959B1 (ru) | 2006-04-24 | 2012-08-30 | Эли Лилли Энд Компани | Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа |
JP5324427B2 (ja) | 2006-04-25 | 2013-10-23 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
WO2007127726A2 (fr) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
EP2016071B1 (fr) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
EP2243479A3 (fr) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Nouvel amide et dérivés d'amidine et utilisations associées |
WO2011068927A2 (fr) * | 2009-12-04 | 2011-06-09 | Abbott Laboratories | Inhibiteurs de la 11-β-hydroxystéroïde déshydrogénase de type 1 (11b-hsd1) et leurs utilisations |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
WO2011157827A1 (fr) | 2010-06-18 | 2011-12-22 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
EP2683705B1 (fr) | 2011-03-08 | 2015-04-22 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
EP2683700B1 (fr) | 2011-03-08 | 2015-02-18 | Sanofi | Dérivés d'oxathiazine tétra-substitués, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
KR101593493B1 (ko) | 2014-10-28 | 2016-02-18 | 주식회사 아이에스티이 | 대면적 유리기판 열처리 장치 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050051691A (ko) * | 2002-10-11 | 2005-06-01 | 아스트라제네카 아베 | 1,4-이치환 피페리딘 유도체 및 11-베타hsd1억제제로서의 이들의 용도 |
WO2004056744A1 (fr) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase |
CN101001836B (zh) | 2004-05-07 | 2010-12-22 | 詹森药业有限公司 | 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物 |
EP1747198B1 (fr) | 2004-05-07 | 2008-06-04 | Janssen Pharmaceutica N.V. | Utilisation de derives d'adamantyle pyrrolidin-2-one comme inhibiteurs de la 11-beta-hydroxysteroide deshydrogenase |
EP1802623A1 (fr) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | Composes spiro actifs du type a- hydroxysteroide deshydrogenase de type 1 |
PL1807072T3 (pl) * | 2004-10-29 | 2009-06-30 | Lilly Co Eli | Cykloalkilowe pochodne laktamów jako inhibitory 11-ß-HSD1 |
TWI400239B (zh) | 2004-11-10 | 2013-07-01 | Incyte Corp | 內醯胺化合物及其作為醫藥品之用途 |
DE602005007934D1 (de) | 2004-12-20 | 2008-08-14 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
US7834194B2 (en) | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
JPWO2006104280A1 (ja) * | 2005-03-31 | 2008-09-11 | 武田薬品工業株式会社 | 糖尿病の予防・治療剤 |
US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
CN101541747B (zh) | 2006-04-21 | 2012-11-14 | 伊莱利利公司 | 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物 |
BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
EA015675B1 (ru) | 2006-04-21 | 2011-10-31 | Эли Лилли Энд Компани | Производные циклогексилпиразол-лактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 |
EA016959B1 (ru) | 2006-04-24 | 2012-08-30 | Эли Лилли Энд Компани | Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа |
SI2021336T1 (sl) | 2006-04-24 | 2010-11-30 | Lilly Co Eli | Inhibitorji beta hidroksisteroid dehidrogenaze |
CA2649111C (fr) | 2006-04-24 | 2013-09-10 | Eli Lilly And Company | Pyrrolidinones substtuees a la cyclohexyle comme inhibiteurs de la 11-beta-hydroxysteroide dehydrogenase de type 1 |
WO2007127726A2 (fr) | 2006-04-25 | 2007-11-08 | Eli Lilly And Company | Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
EP2016071B1 (fr) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
JP5324427B2 (ja) | 2006-04-25 | 2013-10-23 | イーライ リリー アンド カンパニー | 11−β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
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2007
- 2007-04-27 JP JP2009507978A patent/JP5225980B2/ja not_active Expired - Fee Related
- 2007-04-27 EA EA200870489A patent/EA014719B1/ru not_active IP Right Cessation
- 2007-04-27 CN CN2007800154205A patent/CN101448816B/zh not_active Expired - Fee Related
- 2007-04-27 PT PT07761424T patent/PT2049513E/pt unknown
- 2007-04-27 US US12/297,951 patent/US7829582B2/en not_active Expired - Fee Related
- 2007-04-27 MX MX2008013844A patent/MX2008013844A/es active IP Right Grant
- 2007-04-27 AU AU2007244742A patent/AU2007244742B2/en not_active Ceased
- 2007-04-27 CA CA2650627A patent/CA2650627C/fr not_active Expired - Fee Related
- 2007-04-27 DK DK07761424.6T patent/DK2049513T3/da active
- 2007-04-27 BR BRPI0710469-3A patent/BRPI0710469A2/pt not_active IP Right Cessation
- 2007-04-27 WO PCT/US2007/067597 patent/WO2007127901A1/fr active Application Filing
- 2007-04-27 AT AT07761424T patent/ATE542811T1/de active
- 2007-04-27 SI SI200730872T patent/SI2049513T1/sl unknown
- 2007-04-27 PL PL07761424T patent/PL2049513T3/pl unknown
- 2007-04-27 EP EP07761424A patent/EP2049513B1/fr active Active
- 2007-04-27 KR KR1020087026195A patent/KR101060016B1/ko not_active IP Right Cessation
-
2008
- 2008-10-15 ZA ZA200808816A patent/ZA200808816B/xx unknown
- 2008-10-23 IL IL194879A patent/IL194879A0/en unknown
- 2008-10-24 TN TNP2008000432A patent/TNSN08432A1/en unknown
- 2008-10-27 EC EC2008008849A patent/ECSP088849A/es unknown
- 2008-11-19 NO NO20084874A patent/NO20084874L/no not_active Application Discontinuation
- 2008-11-20 MA MA31397A patent/MA30421B1/fr unknown
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2012
- 2012-03-08 CY CY20121100235T patent/CY1112466T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7829582B2 (en) | 2010-11-09 |
ECSP088849A (es) | 2008-11-27 |
ATE542811T1 (de) | 2012-02-15 |
AU2007244742A1 (en) | 2007-11-08 |
KR101060016B1 (ko) | 2011-08-29 |
EP2049513B1 (fr) | 2012-01-25 |
BRPI0710469A2 (pt) | 2011-08-16 |
PT2049513E (pt) | 2012-03-20 |
CY1112466T1 (el) | 2015-12-09 |
NO20084874L (no) | 2008-11-19 |
CA2650627A1 (fr) | 2007-11-08 |
MX2008013844A (es) | 2008-11-10 |
SI2049513T1 (sl) | 2012-04-30 |
EP2049513A1 (fr) | 2009-04-22 |
CN101448816A (zh) | 2009-06-03 |
JP5225980B2 (ja) | 2013-07-03 |
CA2650627C (fr) | 2013-07-16 |
EA014719B1 (ru) | 2011-02-28 |
ZA200808816B (en) | 2009-12-30 |
IL194879A0 (en) | 2009-08-03 |
JP2009535362A (ja) | 2009-10-01 |
DK2049513T3 (da) | 2012-02-27 |
KR20090007371A (ko) | 2009-01-16 |
WO2007127901A1 (fr) | 2007-11-08 |
TNSN08432A1 (en) | 2010-04-14 |
EA200870489A1 (ru) | 2009-04-28 |
CN101448816B (zh) | 2013-08-07 |
PL2049513T3 (pl) | 2012-06-29 |
US20090088430A1 (en) | 2009-04-02 |
AU2007244742B2 (en) | 2012-03-08 |
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