EA200870461A1 - Производные лактама циклогексилимидазола в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1 - Google Patents
Производные лактама циклогексилимидазола в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1Info
- Publication number
- EA200870461A1 EA200870461A1 EA200870461A EA200870461A EA200870461A1 EA 200870461 A1 EA200870461 A1 EA 200870461A1 EA 200870461 A EA200870461 A EA 200870461A EA 200870461 A EA200870461 A EA 200870461A EA 200870461 A1 EA200870461 A1 EA 200870461A1
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- Eurasian Patent Office
- Prior art keywords
- cyclohexylimidazole
- inhibitors
- beta
- compounds
- hydroxysteroid dehydrogenase
- Prior art date
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/00—Drugs for disorders of the metabolism
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract
Настоящее изобретение относится к новым соединениям, отвечающим формуле I, обладающим антагонистической активностью по отношению к 11β-HSD первого типа, а также к способу приготовления таких соединений. В другом примере реализации настоящее изобретение относится к фармацевтическим композициям, включающим соединения, отвечающие формуле I, а также к способам применения соединений и композиций для лечения диабета, гипергликемии, ожирения, гипертонии, гиперлипидемии, синдрома нарушения обмена веществ и других состояний, связанных с активностью 11β-HSD первого типа.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74532106P | 2006-04-21 | 2006-04-21 | |
PCT/US2007/066907 WO2007124329A1 (en) | 2006-04-21 | 2007-04-19 | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200870461A1 true EA200870461A1 (ru) | 2009-04-28 |
EA014717B1 EA014717B1 (ru) | 2011-02-28 |
Family
ID=38380722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870461A EA014717B1 (ru) | 2006-04-21 | 2007-04-19 | ПРОИЗВОДНЫЕ ЛАКТАМА ЦИКЛОГЕКСИЛИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИД ДЕГИДРОГЕНАЗЫ 1 |
Country Status (11)
Country | Link |
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US (1) | US7820659B2 (ru) |
EP (1) | EP2029576B1 (ru) |
JP (1) | JP5236628B2 (ru) |
CN (1) | CN101426780B (ru) |
AU (1) | AU2007240450B2 (ru) |
BR (1) | BRPI0710273A2 (ru) |
CA (1) | CA2646678C (ru) |
EA (1) | EA014717B1 (ru) |
ES (1) | ES2422165T3 (ru) |
MX (1) | MX2008013328A (ru) |
WO (1) | WO2007124329A1 (ru) |
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EP2029579B1 (en) | 2006-04-21 | 2014-12-31 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
WO2007124337A1 (en) | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
MX2008013644A (es) | 2006-04-24 | 2009-03-06 | Lilly Co Eli | Pirrolidinonas sustituidas como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
ES2378574T3 (es) | 2006-04-24 | 2012-04-16 | Eli Lilly & Company | Pirrolidinonas ciclohexilo substituidas como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 |
CA2646624C (en) | 2006-04-24 | 2013-08-06 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
DE602007007211D1 (de) | 2006-04-25 | 2010-07-29 | Lilly Co Eli | Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 |
DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
US8148534B2 (en) * | 2006-04-25 | 2012-04-03 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
PT2049513E (pt) * | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
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JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の環状尿素阻害剤 |
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MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
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EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
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WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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CN1980889B (zh) | 2004-05-07 | 2010-11-10 | 詹森药业有限公司 | 11-β羟基类固醇脱氢酶抑制剂的金刚烷基吡咯烷-2-酮衍生物 |
WO2005108360A1 (en) * | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
WO2006040329A1 (en) | 2004-10-12 | 2006-04-20 | Novo Nordisk A/S | 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds |
WO2006049952A1 (en) | 2004-10-29 | 2006-05-11 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
MX2007005527A (es) | 2004-11-10 | 2007-07-09 | Incyte Corp | Compuestos de lactama y sus usos como farmaceuticos. |
ATE399546T1 (de) | 2004-12-20 | 2008-07-15 | Lilly Co Eli | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
US7834194B2 (en) | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
WO2007124337A1 (en) | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 |
EP2029579B1 (en) | 2006-04-21 | 2014-12-31 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
ES2378574T3 (es) | 2006-04-24 | 2012-04-16 | Eli Lilly & Company | Pirrolidinonas ciclohexilo substituidas como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1 |
MX2008013644A (es) | 2006-04-24 | 2009-03-06 | Lilly Co Eli | Pirrolidinonas sustituidas como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
CA2646624C (en) | 2006-04-24 | 2013-08-06 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
US8148534B2 (en) | 2006-04-25 | 2012-04-03 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
DE602007007211D1 (de) | 2006-04-25 | 2010-07-29 | Lilly Co Eli | Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 |
PT2049513E (pt) | 2006-04-28 | 2012-03-20 | Lilly Co Eli | Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i |
CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-19 AU AU2007240450A patent/AU2007240450B2/en not_active Ceased
- 2007-04-19 EA EA200870461A patent/EA014717B1/ru not_active IP Right Cessation
- 2007-04-19 EP EP07760869.3A patent/EP2029576B1/en active Active
- 2007-04-19 US US12/297,361 patent/US7820659B2/en not_active Expired - Fee Related
- 2007-04-19 JP JP2009506760A patent/JP5236628B2/ja not_active Expired - Fee Related
- 2007-04-19 WO PCT/US2007/066907 patent/WO2007124329A1/en active Application Filing
- 2007-04-19 MX MX2008013328A patent/MX2008013328A/es active IP Right Grant
- 2007-04-19 ES ES07760869T patent/ES2422165T3/es active Active
- 2007-04-19 CA CA2646678A patent/CA2646678C/en not_active Expired - Fee Related
- 2007-04-19 BR BRPI0710273-9A patent/BRPI0710273A2/pt not_active IP Right Cessation
- 2007-04-19 CN CN2007800142250A patent/CN101426780B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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CN101426780A (zh) | 2009-05-06 |
EP2029576B1 (en) | 2013-06-19 |
EA014717B1 (ru) | 2011-02-28 |
BRPI0710273A2 (pt) | 2011-08-09 |
JP2009534412A (ja) | 2009-09-24 |
ES2422165T3 (es) | 2013-09-09 |
MX2008013328A (es) | 2008-10-27 |
US7820659B2 (en) | 2010-10-26 |
CN101426780B (zh) | 2013-06-26 |
CA2646678A1 (en) | 2007-11-01 |
AU2007240450A1 (en) | 2007-11-01 |
AU2007240450B2 (en) | 2011-12-22 |
CA2646678C (en) | 2014-02-11 |
JP5236628B2 (ja) | 2013-07-17 |
US20090088428A1 (en) | 2009-04-02 |
WO2007124329A1 (en) | 2007-11-01 |
EP2029576A1 (en) | 2009-03-04 |
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