EA200870461A1 - Производные лактама циклогексилимидазола в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1 - Google Patents

Производные лактама циклогексилимидазола в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы 1

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EA200870461A1
EA200870461A1 EA200870461A EA200870461A EA200870461A1 EA 200870461 A1 EA200870461 A1 EA 200870461A1 EA 200870461 A EA200870461 A EA 200870461A EA 200870461 A EA200870461 A EA 200870461A EA 200870461 A1 EA200870461 A1 EA 200870461A1
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EA
Eurasian Patent Office
Prior art keywords
cyclohexylimidazole
inhibitors
beta
compounds
hydroxysteroid dehydrogenase
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EA200870461A
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English (en)
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EA014717B1 (ru
Inventor
Ребекка Линн Гюнтер
Томас Эдвард Мэбри
Ашраф Саеед
Нэнси Джун Снайдер
Ооуэн Брендан Уоллэйс
Яньпин Сюй
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Эли Лилли Энд Компани
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Publication of EA200870461A1 publication Critical patent/EA200870461A1/ru
Publication of EA014717B1 publication Critical patent/EA014717B1/ru

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Abstract

Настоящее изобретение относится к новым соединениям, отвечающим формуле I, обладающим антагонистической активностью по отношению к 11β-HSD первого типа, а также к способу приготовления таких соединений. В другом примере реализации настоящее изобретение относится к фармацевтическим композициям, включающим соединения, отвечающие формуле I, а также к способам применения соединений и композиций для лечения диабета, гипергликемии, ожирения, гипертонии, гиперлипидемии, синдрома нарушения обмена веществ и других состояний, связанных с активностью 11β-HSD первого типа.
EA200870461A 2006-04-21 2007-04-19 ПРОИЗВОДНЫЕ ЛАКТАМА ЦИКЛОГЕКСИЛИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИД ДЕГИДРОГЕНАЗЫ 1 EA014717B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74532106P 2006-04-21 2006-04-21
PCT/US2007/066907 WO2007124329A1 (en) 2006-04-21 2007-04-19 Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (2)

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EA200870461A1 true EA200870461A1 (ru) 2009-04-28
EA014717B1 EA014717B1 (ru) 2011-02-28

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EA200870461A EA014717B1 (ru) 2006-04-21 2007-04-19 ПРОИЗВОДНЫЕ ЛАКТАМА ЦИКЛОГЕКСИЛИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИД ДЕГИДРОГЕНАЗЫ 1

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US (1) US7820659B2 (ru)
EP (1) EP2029576B1 (ru)
JP (1) JP5236628B2 (ru)
CN (1) CN101426780B (ru)
AU (1) AU2007240450B2 (ru)
BR (1) BRPI0710273A2 (ru)
CA (1) CA2646678C (ru)
EA (1) EA014717B1 (ru)
ES (1) ES2422165T3 (ru)
MX (1) MX2008013328A (ru)
WO (1) WO2007124329A1 (ru)

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US20090088428A1 (en) 2009-04-02
CA2646678A1 (en) 2007-11-01
US7820659B2 (en) 2010-10-26
EP2029576A1 (en) 2009-03-04
BRPI0710273A2 (pt) 2011-08-09
CN101426780A (zh) 2009-05-06
MX2008013328A (es) 2008-10-27
JP5236628B2 (ja) 2013-07-17
WO2007124329A1 (en) 2007-11-01
EP2029576B1 (en) 2013-06-19
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