CR10400A - Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1 - Google Patents

Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1

Info

Publication number
CR10400A
CR10400A CR10400A CR10400A CR10400A CR 10400 A CR10400 A CR 10400A CR 10400 A CR10400 A CR 10400A CR 10400 A CR10400 A CR 10400A CR 10400 A CR10400 A CR 10400A
Authority
CR
Costa Rica
Prior art keywords
cyclhexilpirazol
lactamas
inhibitors
beta
derivatives
Prior art date
Application number
CR10400A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Aicher Thomas
Pavlovych Krasutsky Alexei
Edward Mabry Thomas
Saeed Ashraf
June Snyder Nancy
Tian Hongqi
Brendan Wallace Owen
Larry Winneroski Leonard
Xu Yanping
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR10400A publication Critical patent/CR10400A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CR10400A 2006-04-21 2008-10-24 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1 CR10400A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
CR10400A true CR10400A (es) 2009-01-14

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10400A CR10400A (es) 2006-04-21 2008-10-24 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1

Country Status (29)

Country Link
US (1) US7981918B2 (OSRAM)
EP (1) EP2029579B1 (OSRAM)
JP (1) JP5161869B2 (OSRAM)
KR (1) KR101055576B1 (OSRAM)
CN (1) CN101426783B (OSRAM)
AR (1) AR060618A1 (OSRAM)
AU (1) AU2007240550B2 (OSRAM)
BR (1) BRPI0710229A2 (OSRAM)
CA (1) CA2647677C (OSRAM)
CO (1) CO6140026A2 (OSRAM)
CR (1) CR10400A (OSRAM)
DO (1) DOP2007000078A (OSRAM)
EA (1) EA015675B1 (OSRAM)
EC (1) ECSP088839A (OSRAM)
ES (1) ES2533263T3 (OSRAM)
IL (1) IL194835A (OSRAM)
JO (1) JO3042B1 (OSRAM)
MA (1) MA30476B1 (OSRAM)
MX (1) MX2008013484A (OSRAM)
MY (1) MY148128A (OSRAM)
NO (1) NO20084403L (OSRAM)
NZ (1) NZ571175A (OSRAM)
PE (1) PE20080362A1 (OSRAM)
SV (1) SV2008003070A (OSRAM)
TN (1) TNSN08405A1 (OSRAM)
TW (1) TWI347321B (OSRAM)
UA (1) UA95798C2 (OSRAM)
WO (1) WO2007124254A2 (OSRAM)
ZA (1) ZA200808686B (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007240458B2 (en) * 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
BRPI0710467A2 (pt) * 2006-04-24 2011-08-16 Lilly Co Eli composto, composição farmacêutica, uso de um composto, e, intermediário
PT2029529E (pt) 2006-04-24 2010-09-02 Lilly Co Eli Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase
BRPI0710468A2 (pt) 2006-04-24 2011-08-16 Lilly Co Eli composto, e, composição farmacêutica
MX2008013656A (es) 2006-04-25 2008-11-10 Lilly Co Eli Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa.
ES2336849T3 (es) 2006-04-25 2010-04-16 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1.
DK2035379T3 (da) 2006-04-25 2010-09-06 Lilly Co Eli Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
PL2049513T3 (pl) * 2006-04-28 2012-06-29 Lilly Co Eli Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
PL2300461T3 (pl) 2008-05-01 2013-09-30 Vitae Pharmaceuticals Inc Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010010150A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
JP5589003B2 (ja) * 2009-02-04 2014-09-10 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体
US8507493B2 (en) 2009-04-20 2013-08-13 Abbvie Inc. Amide and amidine derivatives and uses thereof
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8552212B2 (en) 2009-11-05 2013-10-08 Boehringer Ingelheim International Gmbh Chiral phosphorus ligands
WO2011068927A2 (en) * 2009-12-04 2011-06-09 Abbott Laboratories 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8648192B2 (en) 2010-05-26 2014-02-11 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EA024846B1 (ru) 2011-10-18 2016-10-31 Астеллас Фарма Инк. Бициклическое гетероциклическое соединение
AR099936A1 (es) * 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
US10858347B2 (en) 2015-12-31 2020-12-08 Karyopharm Therapeutics Inc. Multicyclic compounds and uses thereof
AU2022224918B2 (en) 2021-02-25 2023-04-13 Aptabio Therapeutics Inc. Novel pyrazole derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
EA011097B1 (ru) * 2004-05-07 2008-12-30 Янссен Фармацевтика Н.В. Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
US7687644B2 (en) 2004-05-07 2010-03-30 Janssen Pharmaceutica Nv Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
JP2008515956A (ja) 2004-10-12 2008-05-15 ノボ ノルディスク アクティーゼルスカブ １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物
DK1807072T3 (da) 2004-10-29 2009-03-16 Lilly Co Eli Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1
AU2005304560C1 (en) 2004-11-10 2013-05-09 Incyte Holdings Corporation Lactam compounds and their use as pharmaceuticals
US20080214621A1 (en) 2004-12-20 2008-09-04 Thomas Daniel Aicher Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1
ATE401073T1 (de) 2004-12-21 2008-08-15 Lilly Co Eli Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
US20090264650A1 (en) 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
ES2322727B1 (es) 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
WO2007084314A2 (en) 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
AU2007240458B2 (en) * 2006-04-21 2012-03-15 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PT2029529E (pt) 2006-04-24 2010-09-02 Lilly Co Eli Pirrolidinonas substituídas como inibidores de 11 betahidroxiesteróide desidrogenase
BRPI0710467A2 (pt) 2006-04-24 2011-08-16 Lilly Co Eli composto, composição farmacêutica, uso de um composto, e, intermediário
BRPI0710468A2 (pt) 2006-04-24 2011-08-16 Lilly Co Eli composto, e, composição farmacêutica
MX2008013656A (es) 2006-04-25 2008-11-10 Lilly Co Eli Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa.
DK2035379T3 (da) 2006-04-25 2010-09-06 Lilly Co Eli Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
ES2336849T3 (es) 2006-04-25 2010-04-16 Eli Lilly And Company Inhibidores de 11-beta-hidroxiesteroide dehidrogenasa 1.
PL2049513T3 (pl) 2006-04-28 2012-06-29 Lilly Co Eli Pirolidynony podstawione przez piperydynyl jako inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
PE20080362A1 (es) 2008-04-25
ES2533263T3 (es) 2015-04-08
SV2008003070A (es) 2010-01-18
MX2008013484A (es) 2008-10-30
TW200811141A (en) 2008-03-01
US20090111800A1 (en) 2009-04-30
US7981918B2 (en) 2011-07-19
ECSP088839A (es) 2008-11-27
CA2647677A1 (en) 2007-11-01
MA30476B1 (fr) 2009-06-01
JO3042B1 (ar) 2016-09-05
EA200870460A1 (ru) 2009-04-28
IL194835A0 (en) 2009-08-03
CN101426783B (zh) 2013-10-30
EP2029579A2 (en) 2009-03-04
AU2007240550A1 (en) 2007-11-01
AU2007240550B2 (en) 2012-02-23
CA2647677C (en) 2014-03-18
TWI347321B (en) 2011-08-21
TNSN08405A1 (en) 2010-04-14
IL194835A (en) 2015-04-30
CN101426783A (zh) 2009-05-06
UA95798C2 (ru) 2011-09-12
AR060618A1 (es) 2008-07-02
NO20084403L (no) 2008-11-14
HK1126493A1 (en) 2009-09-04
KR20080109867A (ko) 2008-12-17
NZ571175A (en) 2011-10-28
CO6140026A2 (es) 2010-03-19
ZA200808686B (en) 2009-12-30
JP2009534398A (ja) 2009-09-24
JP5161869B2 (ja) 2013-03-13
KR101055576B1 (ko) 2011-08-08
WO2007124254A2 (en) 2007-11-01
MY148128A (en) 2013-02-28
EA015675B1 (ru) 2011-10-31
EP2029579B1 (en) 2014-12-31
DOP2007000078A (es) 2007-11-15
BRPI0710229A2 (pt) 2011-08-02
WO2007124254A3 (en) 2007-12-27

Similar Documents

Publication Publication Date Title
CR10400A (es) Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta -hidroxiesteroide deshidrogenasa 1
DOP2007000084A (es) Derivados de dihidropirazolopirimidinona
BRPI0820722A2 (pt) Derivados de tiazol usados como inibidores de pi 3 cinases
CR8944A (es) Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide
CR10562A (es) Nuevos derivados de piridazina
EP2192838A4 (en) HETEROCYCLIC NEKROPTOSIS HEMMER
BRPI0719389A2 (pt) Derivados de hidantoína utilizados como inibidores de mmp
CR10369A (es) Pyrimidine derivatives as pi3k inhibitors
HRP20150003T1 (xx) Sastavi inhibitora dpp-iv
DK1989206T3 (da) E1-aktiveringsenzymhæmmere
BRPI0717460A2 (pt) Composições de inibidores de chk1
ZA200807135B (en) Azolopyridin-3-one derivatives as inhibitors of endothelial lipase
BRPI0716477A2 (pt) Derivados heteroarila como inibidores de quinase protéica
CU23828B1 (es) Derivados de dihidropiridina de utilidad como inhibodires de la proteína quinasa
BRPI0906980A2 (pt) Composição de derivados e maleatados
CR10831A (es) INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
BRPI0911764A2 (pt) inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1
CR10879A (es) Cyclized derivatives as eg-5 inhibitors
BRPI0719797A2 (pt) compostos e composições como inibidores de proteína cinase
CR10851A (es) Inhibidores de la actividad de la akt
CR10809A (es) Derivados de heteroaril-pirrolidinil-y-piperidinil-cetona
ZA201000318B (en) Inhibitors of 11b-hydroxysteroid dehydrogenase
BRPI0907061A2 (pt) Derivados de 2-aminoquinolina úteis como inibidores de beta-secretase (base)
BRPI0812825A2 (pt) Derivados ftalazinona como inibidores de parp-1
EP2272817A4 (en) PAI-1 INHIBITORS