JP2019500315A5 - - Google Patents
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- Publication number
- JP2019500315A5 JP2019500315A5 JP2018514282A JP2018514282A JP2019500315A5 JP 2019500315 A5 JP2019500315 A5 JP 2019500315A5 JP 2018514282 A JP2018514282 A JP 2018514282A JP 2018514282 A JP2018514282 A JP 2018514282A JP 2019500315 A5 JP2019500315 A5 JP 2019500315A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- compound according
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 40
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000004404 heteroalkyl group Chemical group 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- -1 1-isoquinolinyl Chemical group 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021172158A JP7399925B2 (ja) | 2015-09-17 | 2021-10-21 | Ｐｃｎａ阻害剤 |
| JP2023205089A JP7690553B2 (ja) | 2015-09-17 | 2023-12-05 | Ｐｃｎａ阻害剤 |
| JP2025088605A JP2025128193A (ja) | 2015-09-17 | 2025-05-28 | Ｐｃｎａ阻害剤 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220014P | 2015-09-17 | 2015-09-17 | |
| US62/220,014 | 2015-09-17 | ||
| US201662313592P | 2016-03-25 | 2016-03-25 | |
| US62/313,592 | 2016-03-25 | ||
| US201662340964P | 2016-05-24 | 2016-05-24 | |
| US62/340,964 | 2016-05-24 | ||
| PCT/US2016/052310 WO2017049206A1 (en) | 2015-09-17 | 2016-09-16 | Pcna inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172158A Division JP7399925B2 (ja) | 2015-09-17 | 2021-10-21 | Ｐｃｎａ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500315A JP2019500315A (ja) | 2019-01-10 |
| JP2019500315A5 true JP2019500315A5 (OSRAM) | 2019-10-31 |
| JP6966996B2 JP6966996B2 (ja) | 2021-11-17 |
Family
ID=58289682
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514282A Active JP6966996B2 (ja) | 2015-09-17 | 2016-09-16 | Ｐｃｎａ阻害剤 |
| JP2021172158A Active JP7399925B2 (ja) | 2015-09-17 | 2021-10-21 | Ｐｃｎａ阻害剤 |
| JP2023205089A Active JP7690553B2 (ja) | 2015-09-17 | 2023-12-05 | Ｐｃｎａ阻害剤 |
| JP2025088605A Pending JP2025128193A (ja) | 2015-09-17 | 2025-05-28 | Ｐｃｎａ阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172158A Active JP7399925B2 (ja) | 2015-09-17 | 2021-10-21 | Ｐｃｎａ阻害剤 |
| JP2023205089A Active JP7690553B2 (ja) | 2015-09-17 | 2023-12-05 | Ｐｃｎａ阻害剤 |
| JP2025088605A Pending JP2025128193A (ja) | 2015-09-17 | 2025-05-28 | Ｐｃｎａ阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US10550070B2 (OSRAM) |
| EP (2) | EP4616910A3 (OSRAM) |
| JP (4) | JP6966996B2 (OSRAM) |
| KR (2) | KR102768838B1 (OSRAM) |
| CN (2) | CN108348512B (OSRAM) |
| AU (3) | AU2016324158B2 (OSRAM) |
| CA (1) | CA2999080C (OSRAM) |
| ES (1) | ES3040726T3 (OSRAM) |
| IL (4) | IL282400B (OSRAM) |
| MX (2) | MX2021006326A (OSRAM) |
| WO (1) | WO2017049206A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10420840B2 (en) * | 2015-04-10 | 2019-09-24 | Rll, Llc | Anticancer therapeutic agents |
| CN108348512B (zh) | 2015-09-17 | 2021-09-03 | 希望之城 | Pcna抑制剂 |
| US11551247B1 (en) | 2017-12-29 | 2023-01-10 | Groupon, Inc. | Methods and systems for determining a travel propensity configured for use in the generation of a supply index indicative of a quality of available supply |
| US11392971B1 (en) * | 2017-12-29 | 2022-07-19 | Groupon, Inc. | Methods and systems for generating a supply index indicative of a quality of available supply of merchant promotions |
| KR20240004548A (ko) * | 2021-04-30 | 2024-01-11 | 시티 오브 호프 | 암 치료를 위한 pcna 억제제 및 egfr 억제제 |
| AU2023231620A1 (en) * | 2022-03-07 | 2024-09-12 | City Of Hope | Pcna inhibitors and uses thereof |
| WO2025054318A1 (en) * | 2023-09-06 | 2025-03-13 | City Of Hope | Pcna inhibitors and uses thereof |
| CN117603081A (zh) * | 2023-11-28 | 2024-02-27 | 沈阳药科大学 | N-(2-((2-(3-甲氧基苯氧基)苯基)氨基)-2-乙酰氧基)-1-萘胺的制备方法 |
| CN120097860A (zh) * | 2023-12-05 | 2025-06-06 | 杜心赟 | 增殖细胞核抗原抑制剂、其制备方法、其中间体、其药物组合物和用途 |
| WO2025184571A1 (en) * | 2024-03-01 | 2025-09-04 | City Of Hope | Pcna inhibitors for the treatment of myc family associated cancers |
| CN118459363B (zh) * | 2024-05-27 | 2024-12-17 | 安徽贝克制药股份有限公司 | 一种氟取代增殖细胞核抗原抑制剂及其制备方法和其应用 |
| CN118546074B (zh) * | 2024-05-27 | 2025-06-06 | 安徽贝克制药股份有限公司 | 一种氘代增殖细胞核抗原抑制剂及其制备方法和其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1295611A (en) * | 1916-07-29 | 1919-02-25 | Moritz D Schwartz | Metatarsal support. |
| US1298989A (en) * | 1918-11-14 | 1919-04-01 | Reed Foundry & Machine Co | Tractor-plow. |
| US4030910A (en) * | 1974-01-22 | 1977-06-21 | The Dow Chemical Company | Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives, herbicidal compositions and methods containing same |
| US4269829A (en) | 1979-06-18 | 1981-05-26 | Rohm And Haas Company | Method and composition for treating helminths containing O,O-dialkyl-N-(substituted phenyl)aminothiocarbonyl phosphoramidates |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| FR2723739B1 (fr) * | 1994-08-19 | 1997-02-14 | Sanofi Sa | Derives de glycinamide, procedes pour leur preparation et medicaments les contenant. |
| US5783597A (en) * | 1997-03-04 | 1998-07-21 | Ortho Pharmaceutical Corporation | 2,5-disubstituted thiophenes: inhibitors of 5-lipoxygenase and inducible cyclooxygenase (COX-2) enzymes, composition and use |
| US6258822B1 (en) | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
| BRPI9909660B8 (pt) | 1998-03-19 | 2021-05-25 | Vertex Pharma | compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos |
| AU2333099A (en) * | 1998-03-20 | 1999-10-18 | Bristol-Myers Squibb Company | Aryloxyanilides and related compounds |
| JP3966816B2 (ja) | 2000-05-30 | 2007-08-29 | 中外製薬株式会社 | トロンボポエチン様活性を有する化合物 |
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| GB0319126D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
| JP2007527412A (ja) * | 2003-10-24 | 2007-09-27 | エグゼリクシス， インコーポレイテッド | Ｔａｏキナーゼモジュレーターおよび使用方法 |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200745025A (en) * | 2005-12-29 | 2007-12-16 | Schering Ag | Amide inhibitors of leukotriene A4 hydrolase |
| JP2012505923A (ja) | 2008-10-17 | 2012-03-08 | エグゼリクシス， インコーポレイテッド | スフィンゴシン−１−リン酸受容体拮抗剤と抗微小管剤との間の相乗効果 |
| MX2011003991A (es) * | 2008-10-17 | 2011-06-24 | Exelixis Inc | Antagonistas del receptor esfingosina-1-fosfato. |
| GB201011411D0 (en) | 2010-07-06 | 2010-08-18 | St Georges Hosp Medical School | Therapeutic compounds and their use |
| MX358682B (es) | 2010-07-13 | 2018-08-31 | Hoffmann La Roche | Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4). |
| CN103189063B (zh) | 2010-11-01 | 2016-10-19 | 宾夕法尼亚州研究基金会 | 治疗组合物和方法 |
| EP2688566A4 (en) * | 2011-03-23 | 2014-09-10 | Univ Indiana Res & Tech Corp | THERAPEUTIC AGENTS AGAINST CANCER |
| JP6513076B2 (ja) * | 2014-02-28 | 2019-05-15 | 国立大学法人東北大学 | アミド誘導体 |
| CN108348512B (zh) | 2015-09-17 | 2021-09-03 | 希望之城 | Pcna抑制剂 |
-
2016
- 2016-09-16 CN CN201680066579.9A patent/CN108348512B/zh active Active
- 2016-09-16 EP EP25181629.4A patent/EP4616910A3/en active Pending
- 2016-09-16 CA CA2999080A patent/CA2999080C/en active Active
- 2016-09-16 KR KR1020187010753A patent/KR102768838B1/ko active Active
- 2016-09-16 AU AU2016324158A patent/AU2016324158B2/en active Active
- 2016-09-16 IL IL282400A patent/IL282400B/en unknown
- 2016-09-16 WO PCT/US2016/052310 patent/WO2017049206A1/en not_active Ceased
- 2016-09-16 CN CN202110922191.7A patent/CN113620833A/zh active Pending
- 2016-09-16 KR KR1020257004433A patent/KR20250026875A/ko active Pending
- 2016-09-16 ES ES16847479T patent/ES3040726T3/es active Active
- 2016-09-16 MX MX2021006326A patent/MX2021006326A/es unknown
- 2016-09-16 MX MX2018003301A patent/MX382996B/es unknown
- 2016-09-16 JP JP2018514282A patent/JP6966996B2/ja active Active
- 2016-09-16 EP EP16847479.9A patent/EP3349754B9/en active Active
- 2016-09-16 US US15/760,959 patent/US10550070B2/en active Active
-
2018
- 2018-03-16 IL IL258174A patent/IL258174B/en active IP Right Grant
-
2019
- 2019-12-13 US US16/714,062 patent/US10913706B2/en active Active
-
2020
- 2020-07-16 IL IL276115A patent/IL276115B/en active IP Right Grant
- 2020-11-17 AU AU2020270487A patent/AU2020270487B2/en active Active
- 2020-12-01 US US17/108,739 patent/US11345656B2/en active Active
-
2021
- 2021-10-21 JP JP2021172158A patent/JP7399925B2/ja active Active
-
2022
- 2022-04-27 US US17/730,948 patent/US12054447B2/en active Active
- 2022-06-28 IL IL294381A patent/IL294381B2/en unknown
-
2023
- 2023-03-10 AU AU2023201501A patent/AU2023201501B2/en active Active
- 2023-12-05 JP JP2023205089A patent/JP7690553B2/ja active Active
-
2024
- 2024-06-26 US US18/755,058 patent/US12435030B2/en active Active
-
2025
- 2025-05-28 JP JP2025088605A patent/JP2025128193A/ja active Pending
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