JP2018523671A5 - - Google Patents
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- JP2018523671A5 JP2018523671A5 JP2018506981A JP2018506981A JP2018523671A5 JP 2018523671 A5 JP2018523671 A5 JP 2018523671A5 JP 2018506981 A JP2018506981 A JP 2018506981A JP 2018506981 A JP2018506981 A JP 2018506981A JP 2018523671 A5 JP2018523671 A5 JP 2018523671A5
- Authority
- JP
- Japan
- Prior art keywords
- iii
- alkyl
- tbm
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 12
- -1 amino, thionyl Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000732 arylene group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000006587 (C5-C10) heteroarylene group Chemical group 0.000 claims 6
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical class [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 claims 3
- 150000004713 phosphodiesters Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000002577 pseudohalo group Chemical group 0.000 claims 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 206010060965 Arterial stenosis Diseases 0.000 claims 1
- 206010051290 Central nervous system lesion Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 0 CC(*(C1)(CC*(C[C@]2O3)(CC3=O)C(C(C3C=CC=C4)*34I)c3cc(OC)ccc3OC)C2OC1=O)(c(cc(cc1)OC)c1OC)c1c(C)ccc*1C Chemical compound CC(*(C1)(CC*(C[C@]2O3)(CC3=O)C(C(C3C=CC=C4)*34I)c3cc(OC)ccc3OC)C2OC1=O)(c(cc(cc1)OC)c1OC)c1c(C)ccc*1C 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021165864A JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204519P | 2015-08-13 | 2015-08-13 | |
| US62/204,519 | 2015-08-13 | ||
| US201662356732P | 2016-06-30 | 2016-06-30 | |
| US62/356,732 | 2016-06-30 | ||
| PCT/US2016/046874 WO2017027834A1 (en) | 2015-08-13 | 2016-08-12 | Manganese-based chelate conjugates for molecular mr imaging |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165864A Division JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Division JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523671A JP2018523671A (ja) | 2018-08-23 |
| JP2018523671A5 true JP2018523671A5 (OSRAM) | 2019-09-19 |
| JP7523883B2 JP7523883B2 (ja) | 2024-07-29 |
Family
ID=57984258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506981A Active JP7523883B2 (ja) | 2015-08-13 | 2016-08-12 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2021165864A Active JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Pending JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165864A Active JP7482099B2 (ja) | 2015-08-13 | 2021-10-08 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
| JP2023192615A Pending JP2024026077A (ja) | 2015-08-13 | 2023-11-10 | 分子ｍｒイメージング用マンガン系キレートコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10835623B2 (OSRAM) |
| EP (1) | EP3334464B1 (OSRAM) |
| JP (3) | JP7523883B2 (OSRAM) |
| CN (3) | CN108136053B (OSRAM) |
| ES (1) | ES2987778T3 (OSRAM) |
| WO (1) | WO2017027834A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2987778T3 (es) * | 2015-08-13 | 2024-11-18 | Massachusetts Gen Hospital | Conjugados de quelatos a base de manganeso para la imagenología por resonancia magnética molecular |
| CN108888781B (zh) * | 2018-06-27 | 2021-08-06 | 华东理工大学 | 一种超分子聚电解质胶束磁共振成像造影剂的制备方法 |
| US11267832B2 (en) | 2018-10-22 | 2022-03-08 | The Board Of Regents Of The University Of Texas System | Mn(II)-based sensors to detect zinc in vivo with MRI |
| CN112540095B (zh) * | 2019-09-20 | 2022-03-22 | 华中农业大学 | 酶促低场核磁共振免疫传感器检测食源性致病菌的方法 |
| KR20220114536A (ko) * | 2019-12-17 | 2022-08-17 | 더 제너럴 하스피탈 코포레이션 | 고효율적인 미엘로퍼록시다제 활성형 영상화제 |
| CN113248422B (zh) * | 2020-02-10 | 2022-07-12 | 河南工业大学 | 一种手性α-氮杂芳烃四级碳中心类化合物、其制备方法及应用 |
| US20230406873A1 (en) * | 2020-11-17 | 2023-12-21 | The General Hospital Corporation | Probes, systems, and methods for magnetic resonance ph sensing |
| WO2022235769A1 (en) | 2021-05-04 | 2022-11-10 | Sachem, Inc. | Strong binding metal-chelating resins using macrocycle molecules |
| WO2022235768A1 (en) | 2021-05-04 | 2022-11-10 | Sachem, Inc. | Strong binding metal-chelating resins |
| WO2024086331A1 (en) * | 2022-10-21 | 2024-04-25 | The General Hospital Corporation | Iron based mri probes |
| CN119499407A (zh) * | 2024-11-25 | 2025-02-25 | 中国科学院精密测量科学与技术创新研究院 | 一种Fe基T7肽靶向脑胶质瘤小分子磁共振造影剂及其制备合成方法和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622420A (en) | 1980-03-18 | 1986-11-11 | The Regents Of The University Of California | Chelating agents and method |
| US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4889931A (en) | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
| JP2772875B2 (ja) | 1991-05-14 | 1998-07-09 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法及び写真用漂白定着組成物 |
| AU4562693A (en) * | 1992-07-01 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Contrast agents for mr diagnosis |
| EP0713139B1 (en) * | 1994-10-20 | 1998-06-03 | Fuji Photo Film Co., Ltd. | Novel, iron complex, process for producing the same, photographic processing composition and processing process using the same |
| JP3437013B2 (ja) * | 1994-10-20 | 2003-08-18 | 富士写真フイルム株式会社 | 新規な鉄錯体、その製造方法、写真用処理組成物およびその処理方法 |
| TW319763B (OSRAM) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| DE19603033A1 (de) | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| BR9709798A (pt) * | 1996-06-19 | 1999-08-10 | Unilever Nv | Catalisador de alvejamento e oxidacão sistema de oxidacão catalítica e composicão de alvejamento |
| DK1154991T3 (da) | 1999-02-18 | 2004-11-22 | Univ California | Salicylamid-lanthanidkomplekser til anvendelse som luminescerende markörer |
| AU768957B2 (en) | 1999-02-18 | 2004-01-08 | Regents Of The University Of California, The | Phthalamide-lanthanide complexes for use as luminescent markers |
| BR0009457A (pt) * | 1999-04-01 | 2002-01-08 | Unilever Nv | Composição de branqueamento, ligando, complexo de metal de transição, processo para branquear um substrato, uso de um ligando que forma um complexo com um metal de transição, processo para tratamento de um produto têxtil, e, produto têxtil seco tendo um ligando |
| CZ2002343A3 (cs) | 1999-07-29 | 2002-08-14 | Epix Medical, Inc. | Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností |
| EP1203026A4 (en) | 1999-07-29 | 2005-03-16 | Dyax Corp | FRACTIONS BINDING FIBRIN |
| US6277841B1 (en) | 2000-03-02 | 2001-08-21 | Mallinckrodt Inc. | Quinoline ligands and metal complexes for diagnosis and therapy |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| US6869591B2 (en) | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
| FR2856689A1 (fr) | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| FR2890657B1 (fr) * | 2005-09-15 | 2007-11-09 | Commissariat Energie Atomique | Procede d'obtention de complexes de lanthanides hautement luminescents. |
| US8034898B2 (en) | 2005-12-29 | 2011-10-11 | Collagen Medical, LLC | Methods of collagen imaging |
| WO2008073458A2 (en) | 2006-12-11 | 2008-06-19 | Bracco Imaging S.P.A. | Fibrin-binding peptides and conjugates thereof |
| WO2011052532A1 (ja) | 2009-10-28 | 2011-05-05 | 住友化学株式会社 | 多座配位子金属錯体 |
| NO2536691T3 (OSRAM) * | 2010-02-19 | 2018-04-21 | ||
| US20150307774A1 (en) | 2012-09-24 | 2015-10-29 | Qi Wang | Chelates, chelating agents, conjugates derived thereof and their use |
| HUE054111T2 (hu) * | 2013-01-07 | 2021-08-30 | Massachusetts Gen Hospital | Mangán-bázisú mágneses rezonancia kontrasztanyagok |
| US20140350256A1 (en) | 2013-05-21 | 2014-11-27 | University Of Southern Denmark | Iron and manganese complexes comprising hexadentate monocarboxylato-containing ligands and their use for the catalysis of oxidation reactions |
| EP3077009A4 (en) | 2013-12-03 | 2017-06-14 | The General Hospital Corporation | Molecular imaging probes |
| AR104939A1 (es) | 2015-06-10 | 2017-08-23 | Chemsenti Ltd | Método oxidativo para generar dióxido de cloro |
| US10233205B2 (en) | 2015-08-07 | 2019-03-19 | Auburn University | Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species |
| ES2987778T3 (es) * | 2015-08-13 | 2024-11-18 | Massachusetts Gen Hospital | Conjugados de quelatos a base de manganeso para la imagenología por resonancia magnética molecular |
-
2016
- 2016-08-12 ES ES16835998T patent/ES2987778T3/es active Active
- 2016-08-12 JP JP2018506981A patent/JP7523883B2/ja active Active
- 2016-08-12 EP EP16835998.2A patent/EP3334464B1/en active Active
- 2016-08-12 WO PCT/US2016/046874 patent/WO2017027834A1/en not_active Ceased
- 2016-08-12 CN CN201680054836.7A patent/CN108136053B/zh active Active
- 2016-08-12 US US15/751,617 patent/US10835623B2/en active Active
- 2016-08-12 CN CN202210364662.1A patent/CN114890941A/zh active Pending
- 2016-08-12 CN CN202210363484.0A patent/CN114805196A/zh active Pending
-
2020
- 2020-08-11 US US16/990,368 patent/US11400171B2/en active Active
-
2021
- 2021-10-08 JP JP2021165864A patent/JP7482099B2/ja active Active
-
2023
- 2023-11-10 JP JP2023192615A patent/JP2024026077A/ja active Pending
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