CN112771045A - 喹啉并吡咯烷-2-酮类衍生物及其应用 - Google Patents
喹啉并吡咯烷-2-酮类衍生物及其应用 Download PDFInfo
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- CN112771045A CN112771045A CN201980064561.9A CN201980064561A CN112771045A CN 112771045 A CN112771045 A CN 112771045A CN 201980064561 A CN201980064561 A CN 201980064561A CN 112771045 A CN112771045 A CN 112771045A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
PCT国内申请,说明书已公开。
Claims (24)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811157825 | 2018-09-30 | ||
CN2018111578259 | 2018-09-30 | ||
PCT/CN2019/108520 WO2020063855A1 (zh) | 2018-09-30 | 2019-09-27 | 喹啉并吡咯烷-2-酮类衍生物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112771045A true CN112771045A (zh) | 2021-05-07 |
CN112771045B CN112771045B (zh) | 2022-04-19 |
Family
ID=69949734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980064561.9A Active CN112771045B (zh) | 2018-09-30 | 2019-09-27 | 喹啉并吡咯烷-2-酮类衍生物及其应用 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11230549B2 (zh) |
EP (1) | EP3845532B1 (zh) |
JP (1) | JP6997358B2 (zh) |
KR (1) | KR102345208B1 (zh) |
CN (1) | CN112771045B (zh) |
AU (1) | AU2019348132B2 (zh) |
BR (1) | BR112021005989A2 (zh) |
CA (1) | CA3114646C (zh) |
MX (1) | MX2021003739A (zh) |
RU (1) | RU2771314C1 (zh) |
WO (1) | WO2020063855A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112469720A (zh) * | 2018-04-20 | 2021-03-09 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
CN115380031A (zh) * | 2020-03-30 | 2022-11-22 | 南京明德新药研发有限公司 | 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 |
CN117355528A (zh) * | 2021-05-08 | 2024-01-05 | 成都嘉葆药银医药科技有限公司 | 吡咯并三嗪类化合物的盐型、其晶型及其制备方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114746421A (zh) * | 2019-11-19 | 2022-07-12 | 南京明德新药研发有限公司 | 作为atm抑制剂的有取代的喹啉吡咯酮类合物及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药(上海)有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
CN107889488A (zh) * | 2015-04-02 | 2018-04-06 | 默克专利股份公司 | 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 |
CN108348515A (zh) * | 2015-11-05 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
CN108349971A (zh) * | 2015-11-03 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2647256A1 (en) * | 2006-04-18 | 2007-10-25 | Abbott Laboratories | Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof |
WO2019201283A1 (en) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Dual atm and dna-pk inhibitors for use in anti-tumor therapy |
-
2019
- 2019-09-27 WO PCT/CN2019/108520 patent/WO2020063855A1/zh unknown
- 2019-09-27 EP EP19865180.4A patent/EP3845532B1/en active Active
- 2019-09-27 CA CA3114646A patent/CA3114646C/en active Active
- 2019-09-27 KR KR1020217013030A patent/KR102345208B1/ko active IP Right Grant
- 2019-09-27 BR BR112021005989-0A patent/BR112021005989A2/pt unknown
- 2019-09-27 US US17/280,538 patent/US11230549B2/en active Active
- 2019-09-27 MX MX2021003739A patent/MX2021003739A/es unknown
- 2019-09-27 CN CN201980064561.9A patent/CN112771045B/zh active Active
- 2019-09-27 RU RU2021110825A patent/RU2771314C1/ru active
- 2019-09-27 JP JP2021517848A patent/JP6997358B2/ja active Active
- 2019-09-27 AU AU2019348132A patent/AU2019348132B2/en not_active Ceased
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药(上海)有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
CN107889488A (zh) * | 2015-04-02 | 2018-04-06 | 默克专利股份公司 | 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 |
CN108349971A (zh) * | 2015-11-03 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
CN108348515A (zh) * | 2015-11-05 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112469720A (zh) * | 2018-04-20 | 2021-03-09 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
CN112469720B (zh) * | 2018-04-20 | 2024-03-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
CN115380031A (zh) * | 2020-03-30 | 2022-11-22 | 南京明德新药研发有限公司 | 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 |
CN117355528A (zh) * | 2021-05-08 | 2024-01-05 | 成都嘉葆药银医药科技有限公司 | 吡咯并三嗪类化合物的盐型、其晶型及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP3845532A4 (en) | 2021-11-17 |
CN112771045B (zh) | 2022-04-19 |
BR112021005989A2 (pt) | 2021-06-29 |
CA3114646A1 (en) | 2020-04-02 |
CA3114646C (en) | 2022-03-08 |
RU2771314C1 (ru) | 2022-04-29 |
AU2019348132B2 (en) | 2022-03-31 |
EP3845532A1 (en) | 2021-07-07 |
US11230549B2 (en) | 2022-01-25 |
AU2019348132A1 (en) | 2021-05-20 |
EP3845532B1 (en) | 2022-12-21 |
JP6997358B2 (ja) | 2022-01-17 |
US20210380599A1 (en) | 2021-12-09 |
JP2021529214A (ja) | 2021-10-28 |
KR102345208B1 (ko) | 2021-12-30 |
MX2021003739A (es) | 2022-04-07 |
KR20210060613A (ko) | 2021-05-26 |
WO2020063855A1 (zh) | 2020-04-02 |
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