CN113286790A - 喹唑啉衍生物在制备治疗鼻咽癌药物中的应用 - Google Patents
喹唑啉衍生物在制备治疗鼻咽癌药物中的应用 Download PDFInfo
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- CN113286790A CN113286790A CN202080008721.0A CN202080008721A CN113286790A CN 113286790 A CN113286790 A CN 113286790A CN 202080008721 A CN202080008721 A CN 202080008721A CN 113286790 A CN113286790 A CN 113286790A
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- nasopharyngeal carcinoma
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- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000002053 thietanyl group Chemical group 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
式(I)所示喹唑啉类化合物、其异构体或其药学上可接受的盐在制备治疗鼻咽癌药物中的的应用。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910049769 | 2019-01-18 | ||
| CN2019100497695 | 2019-01-18 | ||
| PCT/CN2020/072407 WO2020147774A1 (zh) | 2019-01-18 | 2020-01-16 | 喹唑啉衍生物在制备治疗鼻咽癌药物中的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113286790A true CN113286790A (zh) | 2021-08-20 |
| CN113286790B CN113286790B (zh) | 2024-03-15 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080008721.0A Active CN113286790B (zh) | 2019-01-18 | 2020-01-16 | 喹唑啉衍生物在制备治疗鼻咽癌药物中的应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113286790B (zh) |
| WO (1) | WO2020147774A1 (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015154725A1 (zh) * | 2014-04-11 | 2015-10-15 | 四川海思科制药有限公司 | 喹唑啉衍生物及其制备方法和在医药上的应用 |
| WO2019120213A1 (zh) * | 2017-12-19 | 2019-06-27 | 南京明德新药研发股份有限公司 | 喹唑啉衍生物及其应用 |
-
2020
- 2020-01-16 WO PCT/CN2020/072407 patent/WO2020147774A1/zh active Application Filing
- 2020-01-16 CN CN202080008721.0A patent/CN113286790B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015154725A1 (zh) * | 2014-04-11 | 2015-10-15 | 四川海思科制药有限公司 | 喹唑啉衍生物及其制备方法和在医药上的应用 |
| WO2019120213A1 (zh) * | 2017-12-19 | 2019-06-27 | 南京明德新药研发股份有限公司 | 喹唑啉衍生物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113286790B (zh) | 2024-03-15 |
| WO2020147774A1 (zh) | 2020-07-23 |
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