BRPI0617151B8 - composto, multímero, composto vetorizado, complexo do referido composto, bem como composições farmacêutica, farmacêutica lipídica e de diagnóstico para imagiologia por ressonância magnética e processo para a preparação de um complexo metálico - Google Patents
composto, multímero, composto vetorizado, complexo do referido composto, bem como composições farmacêutica, farmacêutica lipídica e de diagnóstico para imagiologia por ressonância magnética e processo para a preparação de um complexo metálicoInfo
- Publication number
- BRPI0617151B8 BRPI0617151B8 BRPI0617151A BRPI0617151A BRPI0617151B8 BR PI0617151 B8 BRPI0617151 B8 BR PI0617151B8 BR PI0617151 A BRPI0617151 A BR PI0617151A BR PI0617151 A BRPI0617151 A BR PI0617151A BR PI0617151 B8 BRPI0617151 B8 BR PI0617151B8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical
- complex
- compounds
- vectored
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000004696 coordination complex Chemical class 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 238000002595 magnetic resonance imaging Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002184 metal Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/05—Mono-, di- or tri-ethylamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
compostos compreendendo cadeias curtas de amino-álcoois e complexos metálicos para imagiologia médica. a presente invenção refere-se a compostos de fórmula (il) escolhidos de (lia) e (llb) ou de fórmula (vi) escolhidos de (via) e (vlb) das seguintes fórmulas gerais: (iia) (iib) (via) (vib) em que: x1, x2, x3, x4 e x5 representam, independentemente um do outro, l-y em que l representa um grupo alquila c1-c3, preferencialmente (ch2)n com n = 1 a 3, y representa -conh2, -co-nr7r8 ou -nr7-co-r8, ou um isômero, um enantiômero ou um diastereoisômero dos mesmos ou das suas misturas ou um sal farmaceuticamente aceitável dos compostos de fórmula (via) e (vib). também refere-se a um complexo destes compostos com um metal paramagnético ou radionuclídeo e a sua utilização em métodos de diagnóstico.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0510289 | 2005-10-07 | ||
FR0510289A FR2891830B1 (fr) | 2005-10-07 | 2005-10-07 | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
US73475605P | 2005-11-09 | 2005-11-09 | |
US60/734,756 | 2005-11-09 | ||
PCT/EP2006/067214 WO2007042506A1 (en) | 2005-10-07 | 2006-10-09 | Compounds comprising short aminoalcohol chains and metal complexes for medical imaging |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0617151A2 BRPI0617151A2 (pt) | 2011-07-12 |
BRPI0617151B1 BRPI0617151B1 (pt) | 2020-08-11 |
BRPI0617151B8 true BRPI0617151B8 (pt) | 2021-07-27 |
Family
ID=36636179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0617151A BRPI0617151B8 (pt) | 2005-10-07 | 2006-10-09 | composto, multímero, composto vetorizado, complexo do referido composto, bem como composições farmacêutica, farmacêutica lipídica e de diagnóstico para imagiologia por ressonância magnética e processo para a preparação de um complexo metálico |
Country Status (15)
Country | Link |
---|---|
US (1) | US8114863B2 (pt) |
EP (2) | EP1931673B1 (pt) |
JP (2) | JP5317270B2 (pt) |
KR (2) | KR101440761B1 (pt) |
CN (2) | CN103224495B (pt) |
BR (1) | BRPI0617151B8 (pt) |
CA (1) | CA2625207C (pt) |
DK (1) | DK1931673T3 (pt) |
ES (2) | ES2390092T3 (pt) |
FI (1) | FIC20240003I1 (pt) |
FR (2) | FR2891830B1 (pt) |
NL (1) | NL301259I2 (pt) |
PL (1) | PL1931673T3 (pt) |
PT (1) | PT1931673E (pt) |
WO (1) | WO2007042506A1 (pt) |
Families Citing this family (32)
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FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
US8378134B2 (en) | 2009-09-30 | 2013-02-19 | General Electric Company | Hydroxylated contrast enhancement agents |
US20110077396A1 (en) * | 2009-09-30 | 2011-03-31 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
US9295739B2 (en) * | 2011-08-17 | 2016-03-29 | Merck & Cie | Folate conjugates of albumin-binding entities |
FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
EP2988756B2 (fr) | 2013-04-26 | 2022-05-18 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
CN103467504B (zh) * | 2013-09-23 | 2015-06-24 | 武汉工程大学 | 18f-氟标记卟啉-异氮杂茚自由基配合物及合成方法 |
CN104485193B (zh) * | 2014-12-29 | 2016-11-02 | 广西师范大学 | 一种以酰腙类希夫碱为配体构筑的磁性材料及其制备方法 |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
FR3039767B1 (fr) | 2015-08-04 | 2017-09-08 | Guerbet Sa | Composition destinee a vectoriser un agent anticancereux |
ES2932302T3 (es) * | 2015-12-10 | 2023-01-17 | Bracco Imaging Spa | Agentes de contraste diméricos |
EP3223181B1 (en) | 2016-03-24 | 2019-12-18 | Sofradim Production | System and method of generating a model and simulating an effect on a surgical repair site |
US11007283B2 (en) * | 2016-04-13 | 2021-05-18 | Bracco Imaging S.P.A. | Contrast agents |
GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
EP3544964B1 (en) | 2016-11-28 | 2020-06-17 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
US10730897B2 (en) * | 2016-12-21 | 2020-08-04 | Ge Healthcare As | Manganese chelate compounds |
FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
JP7332600B2 (ja) * | 2017-12-20 | 2023-08-23 | ゼネラル・エレクトリック・カンパニイ | アニオン性キレート化合物 |
KR20210041566A (ko) | 2018-08-06 | 2021-04-15 | 브라코 이미징 에스.피.에이. | 가돌리늄 함유 pcta-기반 조영제 |
AU2019382881A1 (en) | 2018-11-23 | 2021-05-20 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
CN111875667B (zh) * | 2020-07-16 | 2021-12-21 | 南方科技大学 | 有机金属螯合物及其制备方法与应用、探针 |
AU2021309717A1 (en) | 2020-07-16 | 2023-02-09 | Guerbet | Method for synthesising 2-bromoglutaric acid diesters |
WO2022013454A1 (fr) | 2020-07-17 | 2022-01-20 | Guerbet | Procede de preparation d'un ligand chelateur derive de pcta |
CN114105983B (zh) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用 |
WO2024049087A1 (ko) * | 2022-09-01 | 2024-03-07 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
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CN1795015A (zh) | 2003-05-23 | 2006-06-28 | 埃匹克斯医药品股份有限公司 | 螯合配位体和造影剂的光学纯和光学富集异构体 |
FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
CA2526556C (en) | 2003-07-24 | 2012-09-25 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for their preparation |
US20050136003A1 (en) | 2003-10-31 | 2005-06-23 | Casebier David S. | Novel chemical agents comprising a cardiotonic moiety and an imaging moiety and methods of their use |
GB0326546D0 (en) | 2003-11-14 | 2003-12-17 | Amersham Plc | Inhibitor imaging agents |
JP2007512321A (ja) | 2003-11-24 | 2007-05-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
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CN1993357B (zh) | 2004-07-02 | 2011-10-19 | 伯拉考成像股份公司 | 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂 |
FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
-
2005
- 2005-10-07 FR FR0510289A patent/FR2891830B1/fr active Active
-
2006
- 2006-10-09 US US12/083,092 patent/US8114863B2/en active Active
- 2006-10-09 CN CN201310087412.9A patent/CN103224495B/zh active Active
- 2006-10-09 EP EP06807100A patent/EP1931673B1/en active Active
- 2006-10-09 ES ES06807100T patent/ES2390092T3/es active Active
- 2006-10-09 CA CA2625207A patent/CA2625207C/en active Active
- 2006-10-09 ES ES12153144.6T patent/ES2519369T3/es active Active
- 2006-10-09 DK DK06807100.0T patent/DK1931673T3/da active
- 2006-10-09 KR KR1020147009046A patent/KR101440761B1/ko active IP Right Grant
- 2006-10-09 WO PCT/EP2006/067214 patent/WO2007042506A1/en active Application Filing
- 2006-10-09 EP EP12153144.6A patent/EP2457914B1/en active Active
- 2006-10-09 CN CN2006800416152A patent/CN101305006B/zh active Active
- 2006-10-09 PL PL06807100T patent/PL1931673T3/pl unknown
- 2006-10-09 BR BRPI0617151A patent/BRPI0617151B8/pt active IP Right Grant
- 2006-10-09 PT PT06807100T patent/PT1931673E/pt unknown
- 2006-10-09 JP JP2008534029A patent/JP5317270B2/ja active Active
- 2006-10-09 KR KR1020087010991A patent/KR20080080495A/ko active Application Filing
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2013
- 2013-05-20 JP JP2013105720A patent/JP5731572B2/ja active Active
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2024
- 2024-02-19 FR FR24C1006C patent/FR24C1006I1/fr active Active
- 2024-02-21 NL NL301259C patent/NL301259I2/nl unknown
- 2024-02-26 FI FIC20240003C patent/FIC20240003I1/fi unknown
Also Published As
Publication number | Publication date |
---|---|
DK1931673T3 (da) | 2012-10-08 |
KR20140060565A (ko) | 2014-05-20 |
EP1931673A1 (en) | 2008-06-18 |
PL1931673T3 (pl) | 2012-11-30 |
FR24C1006I1 (fr) | 2024-04-19 |
KR101440761B1 (ko) | 2014-09-17 |
JP5731572B2 (ja) | 2015-06-10 |
PT1931673E (pt) | 2012-09-24 |
KR20080080495A (ko) | 2008-09-04 |
CN103224495B (zh) | 2015-07-15 |
JP5317270B2 (ja) | 2013-10-16 |
CA2625207A1 (en) | 2007-04-19 |
US8114863B2 (en) | 2012-02-14 |
FIC20240003I1 (fi) | 2024-02-26 |
WO2007042506A1 (en) | 2007-04-19 |
FR2891830B1 (fr) | 2011-06-24 |
BRPI0617151A2 (pt) | 2011-07-12 |
CA2625207C (en) | 2014-05-13 |
US20090169479A1 (en) | 2009-07-02 |
BRPI0617151B1 (pt) | 2020-08-11 |
JP2009513574A (ja) | 2009-04-02 |
ES2519369T3 (es) | 2014-11-06 |
CN103224495A (zh) | 2013-07-31 |
EP2457914A1 (en) | 2012-05-30 |
EP2457914B1 (en) | 2014-08-06 |
FR2891830A1 (fr) | 2007-04-13 |
CN101305006B (zh) | 2013-04-24 |
NL301259I2 (nl) | 2024-03-25 |
CN101305006A (zh) | 2008-11-12 |
JP2013209400A (ja) | 2013-10-10 |
ES2390092T3 (es) | 2012-11-06 |
EP1931673B1 (en) | 2012-08-29 |
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