FIC20240003I1 - Gadopiklenoli - Google Patents
GadopiklenoliInfo
- Publication number
- FIC20240003I1 FIC20240003I1 FIC20240003C FIC20240003C FIC20240003I1 FI C20240003 I1 FIC20240003 I1 FI C20240003I1 FI C20240003 C FIC20240003 C FI C20240003C FI C20240003 C FIC20240003 C FI C20240003C FI C20240003 I1 FIC20240003 I1 FI C20240003I1
- Authority
- FI
- Finland
- Prior art keywords
- gadopiclenol
- Prior art date
Links
- GNRQMLROZPOLDG-UHFFFAOYSA-K gadopiclenol Chemical compound [Gd+3].C1N(C(CCC(=O)NCC(O)CO)C([O-])=O)CCN(C(CCC(=O)NCC(O)CO)C([O-])=O)CCN(C(CCC(=O)NCC(O)CO)C([O-])=O)CC2=CC=CC1=N2 GNRQMLROZPOLDG-UHFFFAOYSA-K 0.000 title 1
- 229940121283 gadopiclenol Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/05—Mono-, di- or tri-ethylamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0510289A FR2891830B1 (fr) | 2005-10-07 | 2005-10-07 | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US73475605P | 2005-11-09 | 2005-11-09 | |
| PCT/EP2006/067214 WO2007042506A1 (en) | 2005-10-07 | 2006-10-09 | Compounds comprising short aminoalcohol chains and metal complexes for medical imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FIC20240003I1 true FIC20240003I1 (fi) | 2024-02-26 |
Family
ID=36636179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIC20240003C FIC20240003I1 (fi) | 2005-10-07 | 2024-02-26 | Gadopiklenoli |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8114863B2 (fi) |
| EP (2) | EP2457914B1 (fi) |
| JP (2) | JP5317270B2 (fi) |
| KR (2) | KR20080080495A (fi) |
| CN (2) | CN103224495B (fi) |
| BR (1) | BRPI0617151B8 (fi) |
| CA (1) | CA2625207C (fi) |
| DK (1) | DK1931673T3 (fi) |
| ES (2) | ES2519369T3 (fi) |
| FI (1) | FIC20240003I1 (fi) |
| FR (2) | FR2891830B1 (fi) |
| NL (1) | NL301259I2 (fi) |
| PL (1) | PL1931673T3 (fi) |
| PT (1) | PT1931673E (fi) |
| WO (1) | WO2007042506A1 (fi) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| FR2914303A1 (fr) * | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
| US8378134B2 (en) | 2009-09-30 | 2013-02-19 | General Electric Company | Hydroxylated contrast enhancement agents |
| US20110077396A1 (en) * | 2009-09-30 | 2011-03-31 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| CN103732595B (zh) * | 2011-08-17 | 2017-02-08 | 默克及其合伙人公司 | 叶酸的白蛋白‑结合实体缀合物 |
| FR2980364B1 (fr) | 2011-09-26 | 2018-08-31 | Guerbet | Nanoemulsions et leur utilisation comme agents de contraste |
| FR3001154B1 (fr) | 2013-01-23 | 2015-06-26 | Guerbet Sa | Magneto-emulsion vectorisee |
| JP6608805B2 (ja) * | 2013-04-26 | 2019-11-20 | ゲルベ | 造影製剤および関連する調製方法 |
| CN103467504B (zh) * | 2013-09-23 | 2015-06-24 | 武汉工程大学 | 18f-氟标记卟啉-异氮杂茚自由基配合物及合成方法 |
| CN104485193B (zh) * | 2014-12-29 | 2016-11-02 | 广西师范大学 | 一种以酰腙类希夫碱为配体构筑的磁性材料及其制备方法 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| FR3039767B1 (fr) | 2015-08-04 | 2017-09-08 | Guerbet Sa | Composition destinee a vectoriser un agent anticancereux |
| RU2739834C2 (ru) * | 2015-12-10 | 2020-12-28 | Бракко Имэджинг Спа | Димерные контрастные средства |
| EP3223181B1 (en) | 2016-03-24 | 2019-12-18 | Sofradim Production | System and method of generating a model and simulating an effect on a surgical repair site |
| JP6909234B2 (ja) * | 2016-04-13 | 2021-07-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | 造影剤 |
| GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| EP3544964B1 (en) | 2016-11-28 | 2020-06-17 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| AU2017382953B2 (en) * | 2016-12-21 | 2021-10-21 | Ge Healthcare As | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as MRI imaging agents |
| FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| JP7332600B2 (ja) * | 2017-12-20 | 2023-08-23 | ゼネラル・エレクトリック・カンパニイ | アニオン性キレート化合物 |
| DK3770160T3 (da) * | 2018-08-06 | 2023-02-20 | Bracco Imaging Spa | Kontrastmidler baseret på gadolinium-indeholdende pcta |
| JOP20210114A1 (ar) | 2018-11-23 | 2023-01-30 | Bayer Ag | تركيبة وسط تباين وعملية لتحضيرها |
| US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| FR3091872B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| CN111875667B (zh) * | 2020-07-16 | 2021-12-21 | 南方科技大学 | 有机金属螯合物及其制备方法与应用、探针 |
| JP2023533810A (ja) | 2020-07-16 | 2023-08-04 | ゲルベ | ２－ブロモグルタル酸ジエステルを合成するための方法 |
| US20230339945A1 (en) | 2020-07-17 | 2023-10-26 | Guerbet | Method for preparing a chelating ligand derived from pcta |
| CN114105983B (zh) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用 |
| WO2024049087A1 (ko) * | 2022-09-01 | 2024-03-07 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135748A (en) | 1960-05-27 | 1964-06-02 | Little Inc A | Heterocyclic substituted carbodhmides and method of preparation |
| US5334371A (en) | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5554748A (en) | 1989-04-07 | 1996-09-10 | Nycomed Salutar, Inc. | Adducts of macrocyclic chelants |
| DE69230970T2 (de) | 1991-12-10 | 2001-01-04 | Dow Chemical Co | Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| DE69426811T2 (de) * | 1993-12-30 | 2001-09-13 | Guerbet Villepinte | Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen |
| WO1998018496A2 (en) | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| US6071490A (en) | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| CA2376245A1 (en) | 1999-07-29 | 2001-02-08 | Dyax Corp. | Binding moieties for fibrin |
| WO2001052900A2 (en) * | 2000-01-21 | 2001-07-26 | Mallinckrodt Inc. | Novel orthogonally protected amino acid chelators for biomedical applications |
| US6450956B1 (en) | 2000-11-06 | 2002-09-17 | Siemens Corporate Research, Inc. | System and method for treatment and outcome measurement analysis |
| ITMI20011518A1 (it) * | 2001-07-17 | 2003-01-17 | Bracco Imaging Spa | Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| CN1795015A (zh) | 2003-05-23 | 2006-06-28 | 埃匹克斯医药品股份有限公司 | 螯合配位体和造影剂的光学纯和光学富集异构体 |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| WO2005009393A2 (en) | 2003-07-24 | 2005-02-03 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for preparation |
| US20050136003A1 (en) | 2003-10-31 | 2005-06-23 | Casebier David S. | Novel chemical agents comprising a cardiotonic moiety and an imaging moiety and methods of their use |
| GB0326546D0 (en) | 2003-11-14 | 2003-12-17 | Amersham Plc | Inhibitor imaging agents |
| JP2007512321A (ja) | 2003-11-24 | 2007-05-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| JP2007516288A (ja) | 2003-12-23 | 2007-06-21 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 金属キレート剤として有用な新規化合物 |
| US8540966B2 (en) | 2004-07-02 | 2013-09-24 | Bracco Imaging S.P.A. | Contrast agents endowed with high relaxivity |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
-
2005
- 2005-10-07 FR FR0510289A patent/FR2891830B1/fr active Active
-
2006
- 2006-10-09 CA CA2625207A patent/CA2625207C/en active Active
- 2006-10-09 KR KR1020087010991A patent/KR20080080495A/ko active Application Filing
- 2006-10-09 DK DK06807100.0T patent/DK1931673T3/da active
- 2006-10-09 WO PCT/EP2006/067214 patent/WO2007042506A1/en active Application Filing
- 2006-10-09 ES ES12153144.6T patent/ES2519369T3/es active Active
- 2006-10-09 BR BRPI0617151A patent/BRPI0617151B8/pt active IP Right Grant
- 2006-10-09 CN CN201310087412.9A patent/CN103224495B/zh active Active
- 2006-10-09 EP EP12153144.6A patent/EP2457914B1/en active Active
- 2006-10-09 PT PT06807100T patent/PT1931673E/pt unknown
- 2006-10-09 ES ES06807100T patent/ES2390092T3/es active Active
- 2006-10-09 CN CN2006800416152A patent/CN101305006B/zh active Active
- 2006-10-09 KR KR1020147009046A patent/KR101440761B1/ko active IP Right Grant
- 2006-10-09 PL PL06807100T patent/PL1931673T3/pl unknown
- 2006-10-09 EP EP06807100A patent/EP1931673B1/en active Active
- 2006-10-09 US US12/083,092 patent/US8114863B2/en active Active
- 2006-10-09 JP JP2008534029A patent/JP5317270B2/ja active Active
-
2013
- 2013-05-20 JP JP2013105720A patent/JP5731572B2/ja active Active
-
2024
- 2024-02-19 FR FR24C1006C patent/FR24C1006I1/fr active Active
- 2024-02-21 NL NL301259C patent/NL301259I2/nl unknown
- 2024-02-26 FI FIC20240003C patent/FIC20240003I1/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2625207C (en) | 2014-05-13 |
| US8114863B2 (en) | 2012-02-14 |
| EP1931673B1 (en) | 2012-08-29 |
| JP2013209400A (ja) | 2013-10-10 |
| EP1931673A1 (en) | 2008-06-18 |
| ES2390092T3 (es) | 2012-11-06 |
| BRPI0617151A2 (pt) | 2011-07-12 |
| CN101305006A (zh) | 2008-11-12 |
| EP2457914A1 (en) | 2012-05-30 |
| CN103224495A (zh) | 2013-07-31 |
| JP2009513574A (ja) | 2009-04-02 |
| NL301259I2 (nl) | 2024-03-25 |
| EP2457914B1 (en) | 2014-08-06 |
| FR24C1006I1 (fr) | 2024-04-19 |
| KR101440761B1 (ko) | 2014-09-17 |
| BRPI0617151B8 (pt) | 2021-07-27 |
| JP5731572B2 (ja) | 2015-06-10 |
| WO2007042506A1 (en) | 2007-04-19 |
| PT1931673E (pt) | 2012-09-24 |
| CN101305006B (zh) | 2013-04-24 |
| PL1931673T3 (pl) | 2012-11-30 |
| DK1931673T3 (da) | 2012-10-08 |
| KR20140060565A (ko) | 2014-05-20 |
| US20090169479A1 (en) | 2009-07-02 |
| FR2891830A1 (fr) | 2007-04-13 |
| CA2625207A1 (en) | 2007-04-19 |
| BRPI0617151B1 (pt) | 2020-08-11 |
| FR2891830B1 (fr) | 2011-06-24 |
| KR20080080495A (ko) | 2008-09-04 |
| ES2519369T3 (es) | 2014-11-06 |
| CN103224495B (zh) | 2015-07-15 |
| JP5317270B2 (ja) | 2013-10-16 |
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