KR101145252B1 - 항균제 - Google Patents

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KR101145252B1
KR101145252B1 KR1020117003175A KR20117003175A KR101145252B1 KR 101145252 B1 KR101145252 B1 KR 101145252B1 KR 1020117003175 A KR1020117003175 A KR 1020117003175A KR 20117003175 A KR20117003175 A KR 20117003175A KR 101145252 B1 KR101145252 B1 KR 101145252B1
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substituted
alkyl
phenyl
mmol
compound
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KR20110022732A (ko
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닐스 에이치. 앤더슨
제이슨 보우맨
앨리스 어윈
에릭 하우드
토니 클라인
키시무지 음들루리
사이먼 응
키스 비. 피스터
리비 샤와
앨런 와그맨
아샤 야바나바
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유니버시티 오브 워싱톤
노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023128033A1 (ko) * 2021-12-31 2023-07-06 (주)앰틱스바이오 감염성 진균의 바이오필름 생성을 억제하는 신규한 항진균용 조성물

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
WO2004007444A2 (en) * 2002-07-11 2004-01-22 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
SG2012000667A (en) * 2003-01-08 2015-03-30 Univ Washington Antibacterial agents
NZ544756A (en) 2003-07-22 2009-09-25 Astex Therapeutics Ltd 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
EP1680109A4 (en) * 2003-10-07 2009-05-06 Renovis Inc AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE DERIVATIVES
KR20060123344A (ko) * 2003-12-19 2006-12-01 바스프 악티엔게젤샤프트 벤조일-치환된 페닐알라닌아미드
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
WO2006022442A1 (ja) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
ES2436612T3 (es) 2005-01-26 2014-01-03 Allergan, Inc. 3-heteroaril-3-hidroxi-2-amino-propilaminas y compuestos relacionados que tienen actividad analgésica y/o inmunoestimulante
BRPI0606365A2 (pt) * 2005-02-28 2017-06-27 Renovis Inc composto ou um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo e estereoisômeros e tautômeros do mesmo, composição farmacêutica, métodos para prevenir, tratar, melhorar ou controlar uma doença ou condição e para preparar um composto, uso de um composto ou um sal, solvato ou composição farmaceuticamente aceitável do mesmo, método de tratamento de um mamífero, e, combinação
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
PE20100809A1 (es) * 2005-07-11 2011-01-07 Wyeth Llc Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas
JP4961773B2 (ja) * 2005-07-29 2012-06-27 住友ベークライト株式会社 芳香族カルボン酸及びその酸ハロゲン化物
EP2338878A3 (en) * 2005-12-15 2011-11-16 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
US8222423B2 (en) * 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
AU2007248656B2 (en) 2006-05-03 2013-04-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase and tubulin deacetylase inhibitors
KR20090010092A (ko) 2006-05-30 2009-01-28 아스트라제네카 아베 Ｄｇａｔ1 억제제로서의 1,3,4-옥사디아졸 유도체
DE102006033321A1 (de) * 2006-07-17 2008-01-24 Westfälische Wilhelms-Universität Münster Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
EP2049124A4 (en) 2006-07-20 2010-02-10 Merck & Co Inc PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER
CA2658877C (en) * 2006-07-24 2013-02-19 University Of Maryland, Baltimore Heme oxygenase inhibitors for the treatment of a microbial infection
TW200821276A (en) * 2006-08-18 2008-05-16 Leo Pharma As Substituted acetylenic compounds useful for the treatment of diseases
JP2010502617A (ja) 2006-08-31 2010-01-28 シェーリング コーポレイション 抗菌物質として有用なヒダントイン誘導体
EA200970375A1 (ru) * 2006-10-13 2009-10-30 Президио Фармасьютикалз, Инк. Соединения и способы лечения вируса гепатита с
CA2668070A1 (en) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates as inhibitors of histone deacetylase
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5227304B2 (ja) * 2007-02-28 2013-07-03 大正製薬株式会社 新規なヒドロキサム酸誘導体
CN101686680B (zh) 2007-03-09 2015-12-09 伊沃泰克美国股份有限公司 作为p2x7调节剂的双环杂芳基化合物及其用途
TW201716375A (zh) * 2007-06-12 2017-05-16 Achaogen Inc 抗菌劑
CN101417937B (zh) * 2007-10-23 2013-05-29 中山大学 β-醛酮类抗菌化合物及其应用
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
BRPI0821274A2 (pt) 2007-12-20 2017-06-13 Astrazeneca Ab composto ou um sal, ou pró-droga farmaceuticamente aceitável do mesmo, uso do mesmo, método para tratar uma doença em um animal de sangue quente, e, composição farmacêutica
WO2009158369A1 (en) 2008-06-25 2009-12-30 Schering Corporation Synthesis and use of heterocyclic antibacterial agents
KR101708946B1 (ko) 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. 탈아세틸화제 억제제 및 그것의 용도
US8580859B2 (en) 2008-08-01 2013-11-12 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same
CA2732045A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Urea derivatives as antibacterial agents
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
US8372885B2 (en) * 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
EP2177502A1 (en) * 2008-10-17 2010-04-21 Oryzon Genomics, S.A. Compounds and their use
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
MX2011012531A (es) * 2009-05-25 2011-12-16 Chiesi Farma Spa Combinacion terapeutica que comprende un tensioactivo pulmonar y un esteroide.
UY32716A (es) 2009-06-19 2011-01-31 Astrazeneca Ab Compuestos de pirazina carboxamida útiles para el tratamiento de diabetes y obesidad
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
FR2950056B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950057B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
BR112012006572A2 (pt) 2009-09-25 2016-04-26 Oryzon Genomics Sa inibidores de demetilase-1 de lisina específicos e seu uso
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
WO2011106106A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
JP5868948B2 (ja) 2010-04-19 2016-02-24 オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． リジン特異的脱メチル化酵素１阻害薬およびその使用
HUE044575T2 (hu) 2010-04-20 2019-11-28 Fujifilm Toyama Chemical Co Ltd Hidroxámsav-származék
CA2797118C (en) 2010-04-22 2021-03-30 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
ES2674747T3 (es) 2010-07-29 2018-07-03 Oryzon Genomics, S.A. Inhibidores de demetilasa LSD1 basados en arilciclopropilamina y sus usos médicos
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
US9738604B2 (en) 2010-09-03 2017-08-22 Duke University Ethynylbenzene derivatives
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
AR083760A1 (es) * 2010-11-10 2013-03-20 Achaogen Inc Agentes antibacterianos y composiciones farmaceuticas
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
WO2012093101A1 (en) 2011-01-04 2012-07-12 Novartis Ag Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP2678319B1 (en) 2011-02-22 2019-04-17 The General Hospital Corporation Antibiotic tolerance inhibitors
AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
JP2014514299A (ja) 2011-04-08 2014-06-19 ファイザー・インク 抗菌剤として有用なイミダゾール、ピラゾールおよびトリアゾール誘導体
CN103717582B (zh) 2011-04-08 2015-09-30 辉瑞大药厂 用作抗菌剂的异*唑衍生物
US20150203444A1 (en) 2011-09-12 2015-07-23 Achaogen, Inc. Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide
JP6006609B2 (ja) * 2011-10-19 2016-10-12 大正製薬株式会社 新規なヒドロキサム酸誘導体を含有する医薬
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
RU2668952C2 (ru) 2011-10-20 2018-10-05 Оризон Дженомикс, С.А. (гетеро)арилциклопропиламины в качестве ингибиторов lsd1
MX357561B (es) * 2012-02-16 2018-07-13 Rqx Pharmaceuticals Inc Antibióticos peptídicos lineales.
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014002058A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
CN104603126B (zh) 2012-06-28 2017-05-31 诺华股份有限公司 吡咯烷衍生物及其作为补体途径调节剂的用途
WO2014002054A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
WO2014002051A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
CN104379579B (zh) 2012-06-28 2017-03-08 诺华股份有限公司 吡咯烷衍生物及其作为补体途径调节剂的用途
KR20150036481A (ko) 2012-07-12 2015-04-07 노파르티스 아게 보체 경로 조절제 및 그의 용도
CN103012207B (zh) * 2012-12-29 2015-05-27 吉首大学 二芳基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
CA2905248A1 (en) 2013-03-15 2014-09-18 Muneo Shoji Novel hydroxamic acid derivative or salt thereof
WO2014160649A1 (en) * 2013-03-29 2014-10-02 Novartis Ag Hydroxamic acid derivatives as lpxc inhibitors for the treatment of bacterial infections
WO2015024021A2 (en) * 2013-08-16 2015-02-19 Duke University Antibacterial compounds
AU2014306451B2 (en) * 2013-08-16 2019-01-17 Duke University Substituted hydroxamic acid compounds
WO2015024016A2 (en) 2013-08-16 2015-02-19 Duke University 2-piperidinyl substituted n,3-dihydroxybutanamides
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
CA2944140C (en) 2014-04-15 2022-10-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
JP6514716B2 (ja) 2014-04-22 2019-05-15 ノバルティス アーゲー ＬｐｘＣ阻害剤としてのイソオキサゾリンヒドロキサム酸誘導体
CN106794160A (zh) 2014-09-12 2017-05-31 富山化学工业株式会社 含有新的氧肟酸衍生物或其盐的药物组合物
MX2017003011A (es) 2014-09-12 2017-05-30 Toyama Chemical Co Ltd Metodo para usar derivado de acido hidroxamico novedoso y sustancia antibacterial en combinacion.
CN104341475A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-腺苷型多靶点抗菌化合物及其制法和用途
CN104327140B (zh) * 2014-10-11 2016-06-15 吉首大学 噁唑烷酮-腺苷型多靶点抗菌化合物及其制法和用途
CN104262433B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-腺苷型化合物作为TyrRS抑制剂及其制法和用途
CN104231024B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-肌苷型化合物作为TyrRS抑制剂及其制法和用途
CN104341476A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-肌苷型多靶点抗菌化合物及其制法和用途
SI3233843T1 (sl) 2014-12-16 2019-12-31 Novartis Ag Spojine izoksazol hidroksamične kisline kot LPXC inhibitorji
CN105777464B (zh) * 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
AU2016275764B8 (en) 2015-06-11 2021-03-04 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017042099A1 (en) * 2015-09-09 2017-03-16 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
EP3374355A4 (en) 2015-11-09 2019-04-17 Forge Therapeutics, Inc. COMPOUNDS BASED ON PYRONE AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS
EP3374350B1 (en) 2015-11-09 2022-01-05 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
EP3386950A1 (en) * 2015-12-08 2018-10-17 GlaxoSmithKline Intellectual Property Development Limited Substituted benzazinones as antibacterial compounds
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
ES2903079T3 (es) * 2016-04-18 2022-03-31 Vivoryon Therapeutics N V Novedosos inhibidores de meprina alfa y beta
WO2017189586A1 (en) * 2016-04-25 2017-11-02 Duke University Benzoylglycine derivatives and methods of making and using same
SG11201810656WA (en) 2016-06-14 2018-12-28 Novartis Ag Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
EP3472149B1 (en) 2016-06-21 2023-08-30 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
JP7076438B2 (ja) 2016-06-21 2022-05-27 オリオン・オフサルモロジー・エルエルシー 脂肪族プロリンアミド誘導体
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
MX2019003425A (es) 2016-09-28 2019-08-16 Blade Therapeutics Inc Moduladores de calpainas y usos terapeuticos de los mismos.
US11406617B2 (en) * 2016-12-23 2022-08-09 Intervet Inc. Compounds for the treatment of bovine or swine respiratory disease
JP7471820B2 (ja) * 2016-12-23 2024-04-22 インターベット インターナショナル ベー． フェー． マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物
EP3621962A4 (en) 2017-05-10 2020-12-09 Forge Therapeutics, Inc. ANTIBACTERIAL COMPOUNDS
US11666555B2 (en) 2017-05-17 2023-06-06 Drexel University RelA inhibitors for biofilm disruption
CN111065383A (zh) 2017-07-11 2020-04-24 沃泰克斯药物股份有限公司 用作钠通道调节剂的羧酰胺
CN111526873B (zh) 2017-07-27 2025-03-04 生物曼迪克斯有限责任公司 用于调节微生物定殖的经取代的二苯乙炔
CN112074507B (zh) * 2018-02-10 2023-09-05 山东亨利医药科技有限责任公司 作为抗菌素的化合物
IL281614B2 (en) * 2018-09-20 2024-12-01 Blacksmith Medicines Inc Antibacterial compounds
KR102630416B1 (ko) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ， インコーポレイテッド アルファ４ベータ７インテグリンの阻害のための化合物
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
US12440481B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
US20220117893A1 (en) * 2019-02-22 2022-04-21 The Blue Group Llc Inhalable therapeutic agent
CN114222730B (zh) 2019-08-14 2024-09-10 吉利德科学公司 用于抑制α4β7整合素的化合物
CN110563611B (zh) 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
LT4069691T (lt) 2019-12-06 2024-12-10 Vertex Pharmaceuticals Incorporated Pakeistieji tetrahidrofuranai kaip natrio kanalų moduliatoriai
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用
US11731962B2 (en) 2020-03-25 2023-08-22 Blacksmith Medicines, Inc. LpxC inhibitor and methods of making
AU2021289665A1 (en) 2020-06-10 2022-12-15 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
DK4347031T3 (da) 2021-06-04 2025-12-01 Vertex Pharma N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
IL311588A (en) 2021-09-28 2024-05-01 Blacksmith Medicines Inc LPXC inhibitors and their uses
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法
CN119350185A (zh) * 2024-10-08 2025-01-24 聊城大学 一种联苯羟肟类衍生物及其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022494A2 (en) * 1996-11-22 1998-05-28 Elan Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US628988A (en) * 1898-11-21 1899-07-18 F B Fargo & Company Combined churn and butter-worker.
US2772281A (en) * 1954-12-23 1956-11-27 Merck & Co Inc Synthesis of 4-amino-3-isoxazolidone and its derivatives
GB9503749D0 (en) 1995-02-24 1995-04-12 British Biotech Pharm Synthesis of hydroxamic acid derivatives
PT850215E (pt) * 1995-07-26 2001-03-30 Pfizer Derivados de acidos n-(aroil)glicina-hidroxamicos e compostos relacionados
US5925659A (en) * 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
JPH10265452A (ja) * 1996-05-24 1998-10-06 Ono Pharmaceut Co Ltd フェニルスルホンアミド誘導体
WO1998015525A1 (en) * 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Hydroxamic acids
US6281245B1 (en) 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
GB9715030D0 (en) * 1997-07-18 1997-09-24 British Biotech Pharm Metalloproteinase inhibitors
AU746877B2 (en) 1997-07-31 2002-05-02 Procter & Gamble Company, The Acyclic metalloprotease inhibitors
CA2320476A1 (en) 1998-02-07 1999-08-12 British Biotech Pharmaceuticals Limited Antibacterial agents
AU5034699A (en) * 1998-07-08 2000-02-01 Dirk Krumme Matrix metalloproteinase inhibitors containing aminomalonic acid derivatives andpeptide backbone modified derivatives thereof
GB9901863D0 (en) 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
EP1165500A1 (en) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
JP2002541197A (ja) 1999-04-09 2002-12-03 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 抗菌剤
WO2002030873A1 (en) * 2000-10-10 2002-04-18 Fujisawa Pharmaceutical Co., Ltd. Mmp inhibitor
WO2002050081A2 (en) * 2000-12-21 2002-06-27 De Novo Pharmaceuticals Ltd Antimicrobial agents
GB0115195D0 (en) 2001-06-21 2001-08-15 Bae Systems Plc Split-pin drill jig
WO2003004488A1 (en) * 2001-07-03 2003-01-16 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
WO2004007444A2 (en) 2002-07-11 2004-01-22 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
SG2012000667A (en) * 2003-01-08 2015-03-30 Univ Washington Antibacterial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022494A2 (en) * 1996-11-22 1998-05-28 Elan Pharmaceuticals, Inc. METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023128033A1 (ko) * 2021-12-31 2023-07-06 (주)앰틱스바이오 감염성 진균의 바이오필름 생성을 억제하는 신규한 항진균용 조성물

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