BRPI0821274A2 - composto ou um sal, ou pró-droga farmaceuticamente aceitável do mesmo, uso do mesmo, método para tratar uma doença em um animal de sangue quente, e, composição farmacêutica - Google Patents
composto ou um sal, ou pró-droga farmaceuticamente aceitável do mesmo, uso do mesmo, método para tratar uma doença em um animal de sangue quente, e, composição farmacêuticaInfo
- Publication number
- BRPI0821274A2 BRPI0821274A2 BRPI0821274A BRPI0821274A BRPI0821274A2 BR PI0821274 A2 BRPI0821274 A2 BR PI0821274A2 BR PI0821274 A BRPI0821274 A BR PI0821274A BR PI0821274 A BRPI0821274 A BR PI0821274A BR PI0821274 A2 BRPI0821274 A2 BR PI0821274A2
- Authority
- BR
- Brazil
- Prior art keywords
- prodrug
- warm
- disease
- treating
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1539707P | 2007-12-20 | 2007-12-20 | |
PCT/GB2008/051199 WO2009081195A1 (en) | 2007-12-20 | 2008-12-18 | Carbamoyl compounds as dgat1 inhibitors 190 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0821274A2 true BRPI0821274A2 (pt) | 2017-06-13 |
Family
ID=40427160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0821274A BRPI0821274A2 (pt) | 2007-12-20 | 2008-12-18 | composto ou um sal, ou pró-droga farmaceuticamente aceitável do mesmo, uso do mesmo, método para tratar uma doença em um animal de sangue quente, e, composição farmacêutica |
Country Status (23)
Country | Link |
---|---|
US (2) | US7994179B2 (pt) |
EP (1) | EP2234978B1 (pt) |
JP (1) | JP5662803B2 (pt) |
KR (1) | KR20100099738A (pt) |
CN (1) | CN101932562B (pt) |
AR (1) | AR069802A1 (pt) |
AU (1) | AU2008339570B2 (pt) |
BR (1) | BRPI0821274A2 (pt) |
CA (1) | CA2707660A1 (pt) |
CL (1) | CL2008003847A1 (pt) |
CO (1) | CO6290685A2 (pt) |
CR (1) | CR11518A (pt) |
DO (1) | DOP2010000192A (pt) |
EA (1) | EA201001015A1 (pt) |
EC (1) | ECSP10010274A (pt) |
ES (1) | ES2535083T3 (pt) |
IL (1) | IL206045A0 (pt) |
NI (1) | NI201000108A (pt) |
NZ (1) | NZ586104A (pt) |
PE (1) | PE20091682A1 (pt) |
TW (1) | TW200932235A (pt) |
WO (1) | WO2009081195A1 (pt) |
ZA (1) | ZA201003979B (pt) |
Families Citing this family (32)
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EP1833806A1 (en) * | 2004-12-14 | 2007-09-19 | AstraZeneca AB | Oxadiazole derivatives as dgat inhibitors |
US7749997B2 (en) | 2005-12-22 | 2010-07-06 | Astrazeneca Ab | Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors |
CA2647819C (en) | 2006-03-31 | 2012-12-11 | Novartis Ag | Phenylcyclohexyl derivatives as dgat1 inhibitors |
US8003676B2 (en) * | 2006-05-30 | 2011-08-23 | Astrazeneca Ab | 1,3,4-oxadiazole derivatives as DGAT1 inhibitors |
US8084478B2 (en) | 2006-05-30 | 2011-12-27 | Asstrazeneca Ab | Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
AU2007255180B2 (en) * | 2006-06-08 | 2011-02-03 | Astrazeneca Ab | Benzimidazoles and their use for the treatment of diabetes |
AU2007260836B2 (en) | 2006-06-23 | 2012-11-15 | Abbvie Bahamas Ltd. | Cyclopropyl amine derivatives as histamin H3 receptor modulators |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
US20110092547A1 (en) * | 2007-08-17 | 2011-04-21 | Alan Martin Birch | Chemical compounds 979 |
AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
TW201024271A (en) * | 2008-12-19 | 2010-07-01 | Astrazeneca Ab | Chemical compounds 553 |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
UY32716A (es) | 2009-06-19 | 2011-01-31 | Astrazeneca Ab | Compuestos de pirazina carboxamida útiles para el tratamiento de diabetes y obesidad |
US8586776B2 (en) * | 2009-11-05 | 2013-11-19 | Fibrostatin, S.L. | GPBP inhibition using Q2 peptidomimetics |
US8431575B2 (en) * | 2010-02-18 | 2013-04-30 | Transtech Pharma, Inc. | Phenyl-heteroaryl derivatives and methods of use thereof |
US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
WO2012064569A1 (en) * | 2010-11-08 | 2012-05-18 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
DK2714647T3 (en) * | 2011-05-23 | 2015-05-26 | Janssen Pharmaceutica Nv | Biphenyl derivatives useful as Glucagon receptor antagonists |
WO2012165398A1 (ja) * | 2011-05-30 | 2012-12-06 | 第一三共株式会社 | シクロアルキルオキシビアリール型化合物 |
WO2013068328A1 (en) * | 2011-11-07 | 2013-05-16 | Intervet International B.V. | Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors |
WO2013074387A1 (en) * | 2011-11-14 | 2013-05-23 | Merck Sharp & Dohme Corp. | Imidazole derivatives |
US9271969B2 (en) | 2012-02-07 | 2016-03-01 | Kainos Medicine, Inc. | Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme |
MX357768B (es) * | 2012-04-27 | 2018-07-24 | Novartis Ag | Inhibidores de dgat1 de eter ciclico de cabeza de puente. |
CA2894399A1 (en) | 2012-12-06 | 2014-06-12 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
CN105308026B (zh) * | 2013-07-09 | 2018-12-21 | 东曹株式会社 | 具有金刚烷基的环状吖嗪化合物、制造方法、以及以该化合物作为构成成分的有机电致发光元件 |
EP3071541B1 (en) | 2013-11-21 | 2023-06-07 | Marquette University | Substituted (4'-hydroxyphenyl)cycloalkane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform |
EP3177293B1 (en) * | 2014-03-12 | 2021-05-05 | Astrazeneca AB | Method of treating skin conditions |
CA3101064A1 (en) * | 2018-06-21 | 2019-12-26 | Dermavant Sciences GmbH | Topical formulations of dgat1 inhibitors and their methods of use |
EP3590927A1 (en) | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Novel compounds for controlling arthropods |
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2008
- 2008-12-18 NZ NZ586104A patent/NZ586104A/en not_active IP Right Cessation
- 2008-12-18 PE PE2008002123A patent/PE20091682A1/es not_active Application Discontinuation
- 2008-12-18 ES ES08865783.8T patent/ES2535083T3/es active Active
- 2008-12-18 AR ARP080105523A patent/AR069802A1/es not_active Application Discontinuation
- 2008-12-18 CA CA2707660A patent/CA2707660A1/en not_active Abandoned
- 2008-12-18 TW TW097149460A patent/TW200932235A/zh unknown
- 2008-12-18 JP JP2010538918A patent/JP5662803B2/ja not_active Expired - Fee Related
- 2008-12-18 EA EA201001015A patent/EA201001015A1/ru unknown
- 2008-12-18 WO PCT/GB2008/051199 patent/WO2009081195A1/en active Application Filing
- 2008-12-18 AU AU2008339570A patent/AU2008339570B2/en not_active Expired - Fee Related
- 2008-12-18 BR BRPI0821274A patent/BRPI0821274A2/pt not_active IP Right Cessation
- 2008-12-18 EP EP08865783.8A patent/EP2234978B1/en active Active
- 2008-12-18 CN CN2008801259853A patent/CN101932562B/zh not_active Expired - Fee Related
- 2008-12-18 KR KR1020107016252A patent/KR20100099738A/ko not_active Application Discontinuation
- 2008-12-19 CL CL2008003847A patent/CL2008003847A1/es unknown
- 2008-12-19 US US12/339,349 patent/US7994179B2/en not_active Expired - Fee Related
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2010
- 2010-05-27 IL IL206045A patent/IL206045A0/en unknown
- 2010-06-03 ZA ZA2010/03979A patent/ZA201003979B/en unknown
- 2010-06-18 DO DO2010000192A patent/DOP2010000192A/es unknown
- 2010-06-18 CR CR11518A patent/CR11518A/es not_active Application Discontinuation
- 2010-06-18 EC EC2010010274A patent/ECSP10010274A/es unknown
- 2010-06-18 NI NI201000108A patent/NI201000108A/es unknown
- 2010-06-21 CO CO10074457A patent/CO6290685A2/es not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
AU2008339570A1 (en) | 2009-07-02 |
DOP2010000192A (es) | 2010-07-15 |
CN101932562B (zh) | 2013-06-12 |
IL206045A0 (en) | 2010-11-30 |
AR069802A1 (es) | 2010-02-17 |
JP5662803B2 (ja) | 2015-02-04 |
JP2011507823A (ja) | 2011-03-10 |
ZA201003979B (en) | 2011-11-30 |
WO2009081195A1 (en) | 2009-07-02 |
TW200932235A (en) | 2009-08-01 |
ES2535083T3 (es) | 2015-05-05 |
KR20100099738A (ko) | 2010-09-13 |
US20120108602A1 (en) | 2012-05-03 |
US20090298853A1 (en) | 2009-12-03 |
CN101932562A (zh) | 2010-12-29 |
US7994179B2 (en) | 2011-08-09 |
ECSP10010274A (es) | 2010-07-30 |
EP2234978A1 (en) | 2010-10-06 |
CR11518A (es) | 2010-07-15 |
NI201000108A (es) | 2012-05-14 |
AU2008339570B2 (en) | 2012-04-12 |
PE20091682A1 (es) | 2009-12-04 |
EP2234978B1 (en) | 2015-02-25 |
CO6290685A2 (es) | 2011-06-20 |
CA2707660A1 (en) | 2009-07-02 |
CL2008003847A1 (es) | 2009-11-27 |
NZ586104A (en) | 2012-02-24 |
EA201001015A1 (ru) | 2011-02-28 |
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