|
JP2005289809A
(ja)
*
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US9453251B2
(en)
|
2002-10-08 |
2016-09-27 |
Pfenex Inc. |
Expression of mammalian proteins in Pseudomonas fluorescens
|
|
WO2004041862A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
EP2412816B1
(en)
|
2004-07-26 |
2014-12-03 |
Pfenex Inc. |
Process for improved protein expression by strain engineering
|
|
RU2464276C2
(ru)
|
2005-05-18 |
2012-10-20 |
Аблинкс Н.В. |
Улучшенные нанотела против фактора некроза опухоли-альфа
|
|
DE102005023617A1
(de)
*
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
|
US20070269422A1
(en)
*
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
EP2069402A2
(en)
*
|
2006-09-08 |
2009-06-17 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
AU2007306340A1
(en)
|
2006-10-11 |
2008-04-17 |
Ablynx N.V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and use thereof
|
|
JP2010512734A
(ja)
*
|
2006-12-13 |
2010-04-30 |
アブリンクス エン．ヴェー． |
Ｉｌ−６／ｉｌ−６受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド
|
|
US8907065B2
(en)
*
|
2006-12-15 |
2014-12-09 |
Ablynx N.V. |
Polypeptides that modulate the interaction between cells of the immune system
|
|
US9512236B2
(en)
|
2006-12-19 |
2016-12-06 |
Ablynx N.V. |
Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
WO2012130874A1
(en)
|
2011-03-28 |
2012-10-04 |
Ablynx Nv |
Bispecific anti-cxcr7 immunoglobulin single variable domains
|
|
AU2007336242B2
(en)
|
2006-12-19 |
2012-08-30 |
Ablynx N.V. |
Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
AU2007336243B2
(en)
*
|
2006-12-19 |
2012-07-26 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
|
|
EP2101801A1
(en)
*
|
2006-12-20 |
2009-09-23 |
Ablynx N.V. |
Oral delivery of polypeptides
|
|
CA2678218A1
(en)
*
|
2007-02-21 |
2008-08-28 |
Ablynx N.V. |
Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
|
|
US9580719B2
(en)
|
2007-04-27 |
2017-02-28 |
Pfenex, Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
EP2615172A1
(en)
|
2007-04-27 |
2013-07-17 |
Pfenex Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
AU2008252853B2
(en)
*
|
2007-05-24 |
2011-12-01 |
Ablynx N.V. |
Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders
|
|
US10214588B2
(en)
|
2007-07-03 |
2019-02-26 |
Ablynx N.V. |
Providing improved immunoglobulin sequences by mutating CDR and/or FR positions
|
|
JP5592792B2
(ja)
|
2007-09-26 |
2014-09-17 |
ユセベ ファルマ ソシエテ アノニム |
二重特異性抗体の融合体
|
|
CN101970490A
(zh)
|
2007-11-27 |
2011-02-09 |
埃博灵克斯股份有限公司 |
针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽
|
|
CN101965362A
(zh)
*
|
2008-03-05 |
2011-02-02 |
埃博灵克斯股份有限公司 |
新型抗原结合二聚体-复合物及其制备方法和应用
|
|
GB0809069D0
(en)
|
2008-05-19 |
2008-06-25 |
Univ Leuven Kath |
Gene signatures
|
|
WO2009124931A2
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Amino acid sequences directed against the notch pathways and uses thereof
|
|
JP2011516603A
(ja)
*
|
2008-04-17 |
2011-05-26 |
アブリンクス エン．ヴェー． |
血清タンパク質と結合することが可能なペプチド、並びにこれを含む化合物、構築物及びポリペプチド
|
|
US8444976B2
(en)
|
2008-07-02 |
2013-05-21 |
Argen-X B.V. |
Antigen binding polypeptides
|
|
LT2334705T
(lt)
|
2008-09-26 |
2017-03-27 |
Ucb Biopharma Sprl |
Biologiniai produktai
|
|
KR20110079693A
(ko)
*
|
2008-10-29 |
2011-07-07 |
와이어쓰 엘엘씨 |
단일 도메인 항원 결합 분자의 정제 방법
|
|
AU2013202856B2
(en)
*
|
2008-10-29 |
2016-02-11 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
EP2362767B1
(en)
|
2008-10-29 |
2017-12-06 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
US9265834B2
(en)
*
|
2009-03-05 |
2016-02-23 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
WO2010100135A1
(en)
|
2009-03-05 |
2010-09-10 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
|
|
AU2010233658B2
(en)
|
2009-04-10 |
2013-11-28 |
Ablynx Nv |
Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders
|
|
AU2010243551B2
(en)
|
2009-04-30 |
2015-03-26 |
Ablynx Nv |
Method for the production of domain antibodies
|
|
EP2438087B1
(en)
|
2009-06-05 |
2017-05-10 |
Ablynx N.V. |
Trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections
|
|
DK2451839T3
(da)
|
2009-07-10 |
2020-07-13 |
Ablynx Nv |
Fremgangsmåde til produktion af variable domæner
|
|
PT2473528E
(pt)
|
2009-09-03 |
2015-03-04 |
Ablynx NV |
Formulações estáveis de polipéptidos e seus usos
|
|
GB201005063D0
(en)
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
|
UY32917A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moléculas de unión a dll-4
|
|
UY32920A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moleculas de unión biespecíficas para la terapia anti-angiogénesis
|
|
WO2011064382A1
(en)
|
2009-11-30 |
2011-06-03 |
Ablynx N.V. |
Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
|
|
RS67588B1
(sr)
|
2009-12-14 |
2026-01-30 |
Ablynx Nv |
Antitela sa pojedinačnim varijabilnim domenom imunoglobulina protiv ox40l, konstrukti i njihova terapijska upotreba
|
|
WO2011083140A1
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
CA2788993A1
(en)
|
2010-02-05 |
2011-08-11 |
Ablynx N.V. |
Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
|
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
|
EP2533761B1
(en)
|
2010-02-11 |
2019-03-27 |
Ablynx N.V. |
Methods and compositions for the preparation of aerosols
|
|
WO2011098518A2
(en)
|
2010-02-11 |
2011-08-18 |
Ablynx Nv |
Delivery of immunoglobulin variable domains and constructs thereof
|
|
AP2012006359A0
(en)
|
2010-03-03 |
2012-08-31 |
Boehringer Ingelheim Int |
Biparatopic abeta binding polypeptides
|
|
US8937164B2
(en)
|
2010-03-26 |
2015-01-20 |
Ablynx N.V. |
Biological materials related to CXCR7
|
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
AU2011254557B2
(en)
|
2010-05-20 |
2015-09-03 |
Ablynx Nv |
Biological materials related to HER3
|
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
|
AU2011277983C1
(en)
*
|
2010-07-16 |
2016-09-29 |
Ablynx Nv |
Modified single domain antigen binding molecules and uses thereof
|
|
US20120225081A1
(en)
|
2010-09-03 |
2012-09-06 |
Boehringer Ingelheim International Gmbh |
Vegf-binding molecules
|
|
US11644471B2
(en)
|
2010-09-30 |
2023-05-09 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
WO2012042026A1
(en)
|
2010-09-30 |
2012-04-05 |
Ablynx Nv |
Biological materials related to c-met
|
|
ES2996232T3
(en)
|
2010-10-29 |
2025-02-12 |
Ablynx Nv |
Method for the production of immunoglobulin single variable domains
|
|
JP5933573B2
(ja)
|
2010-11-08 |
2016-06-15 |
ノバルティス アーゲー |
Ｃｘｃｒ２結合ポリペプチド
|
|
EP2643349B1
(en)
|
2010-11-26 |
2019-09-04 |
Molecular Partners AG |
Designed repeat proteins binding to serum albumin
|
|
WO2012130872A1
(en)
|
2011-03-28 |
2012-10-04 |
Ablynx Nv |
Method for producing solid formulations comprising immunoglobulin single variable domains
|
|
CN106039306A
(zh)
*
|
2011-03-30 |
2016-10-26 |
埃博灵克斯股份有限公司 |
使用针对TNFα的单结构域抗体治疗免疫病症的方法
|
|
US20130078247A1
(en)
|
2011-04-01 |
2013-03-28 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to dii4 and ang2
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
US9534039B2
(en)
|
2011-05-09 |
2017-01-03 |
Ablynx N.V. |
Method for the production of immunoglobulin single variable domains
|
|
CN108329391A
(zh)
|
2011-05-27 |
2018-07-27 |
埃博灵克斯股份有限公司 |
使用rankl结合肽抑制骨质吸收
|
|
AU2012273928A1
(en)
|
2011-06-23 |
2014-02-06 |
Ablynx Nv |
Immunoglobulin single variable domains directed against IgE
|
|
EP4350345A3
(en)
|
2011-06-23 |
2024-07-24 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
|
|
PH12022550313A1
(en)
*
|
2011-06-23 |
2023-01-23 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
EP3466972B1
(en)
|
2011-06-23 |
2026-03-04 |
Ablynx NV |
Serum albumin binding proteins
|
|
RS55775B2
(sr)
|
2011-06-23 |
2022-10-31 |
Ablynx Nv |
Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina
|
|
US10138302B2
(en)
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
|
CA2849409A1
(en)
|
2011-09-23 |
2013-03-28 |
Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa |
Anti-tumor necrosis factor-alpha agents and uses thereof
|
|
CN106046161B
(zh)
|
2011-09-30 |
2019-09-13 |
埃博灵克斯股份有限公司 |
与C-Met相关的生物物质
|
|
US9346884B2
(en)
|
2011-09-30 |
2016-05-24 |
Ablynx N.V. |
Biological materials related to c-Met
|
|
PH12021553014A1
(en)
|
2012-02-27 |
2022-09-05 |
Ablynx Nv |
Cx3cr1-binding polypeptides
|
|
HUE044263T2
(hu)
|
2012-03-30 |
2019-10-28 |
Boehringer Ingelheim Int |
ANG2-kötõ molekulák
|
|
WO2013167883A1
(en)
|
2012-05-07 |
2013-11-14 |
The University Court Of The University Of Aberdeen |
Single domain binding molecule
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
WO2013172967A1
(en)
|
2012-05-17 |
2013-11-21 |
Extend Biosciences, Inc |
Carriers for improved drug delivery
|
|
ES2715279T3
(es)
|
2012-05-24 |
2019-06-03 |
Vib Vzw |
Dominios variables individuales inmunoglobulínicos anti-receptor de manosa de macrófagos para elegir como diana y obtener imágenes in vivo de macrófagos asociados a tumores
|
|
RU2530553C2
(ru)
*
|
2012-11-07 |
2014-10-10 |
Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) |
Рекомбинантное однодоменное антитело, способное специфически связывать фактор некроза опухолей человека, и его производные
|
|
US9315280B2
(en)
*
|
2012-11-20 |
2016-04-19 |
Lockheed Martin Corporation |
Heat pipe with axial wick
|
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
|
CA2894225A1
(fr)
|
2012-12-17 |
2014-06-26 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes
|
|
WO2014111550A1
(en)
|
2013-01-17 |
2014-07-24 |
Glaxosmithkline Intellectual Property Development Limited |
Modified anti-serum albumin binding proteins
|
|
CA2899693C
(en)
|
2013-01-30 |
2023-03-14 |
Vib Vzw |
Novel chimeric polypeptides for screening and drug discovery purposes
|
|
DK2953973T3
(da)
|
2013-02-05 |
2019-08-12 |
Vib Vzw |
Muskarine acetylcholinreceptor-bindemidler og anvendelser deraf
|
|
CA2900912A1
(en)
|
2013-02-13 |
2014-08-21 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Highly galactosylated anti-her2 antibodies and uses thereof
|
|
US20160002330A1
(en)
|
2013-02-13 |
2016-01-07 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Cetuximab with modified glycosylation and uses thereof
|
|
CN105308068A
(zh)
|
2013-02-13 |
2016-02-03 |
法国化学与生物科技实验室 |
高度半乳糖基化的抗TNF-α抗体及其用途
|
|
US9255262B2
(en)
|
2013-03-06 |
2016-02-09 |
Vision Global Holdings Ltd. |
Albumin-binding arginine deminase and the use thereof
|
|
USRE48805E1
(en)
|
2013-03-06 |
2021-11-02 |
Vision Global Holdings Ltd. |
Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
|
|
EP2971166B1
(en)
|
2013-03-14 |
2021-05-19 |
Children's Medical Center Corporation |
Psap peptide for treating cd36 expressing cancers
|
|
JP6499090B2
(ja)
|
2013-03-15 |
2019-04-10 |
ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ |
心血管疾患において使用するための抗マクロファージマンノース受容体単一可変ドメイン
|
|
JP6616284B2
(ja)
|
2013-04-23 |
2019-12-04 |
ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン |
特異的結合分子の人工ライブラリー
|
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
|
WO2015061182A1
(en)
|
2013-10-21 |
2015-04-30 |
Dyax Corp. |
Diagnosis and treatment of autoimmune diseases
|
|
AU2015217846B2
(en)
|
2014-01-30 |
2019-10-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Opioid receptor binding agents and uses thereof
|
|
CA2943445A1
(en)
*
|
2014-03-26 |
2015-10-01 |
Cell Medica Switzerland Ag |
Binding members to tnf alpha
|
|
WO2015164722A1
(en)
|
2014-04-24 |
2015-10-29 |
Immusant, Inc. |
Compositions comprising gluten
|
|
KR20250099289A
(ko)
|
2014-05-16 |
2025-07-01 |
아블린쓰 엔.브이. |
개선된 면역글로불린 가변 도메인
|
|
DK3143403T3
(da)
|
2014-05-16 |
2022-01-17 |
Ablynx Nv |
Fremgangsmåder til påvisning og/eller måling af anti-lægemiddelantistoffer, især behandlingsinducerede anti-lægemiddelantistoffer
|
|
HUE050007T2
(hu)
|
2014-05-16 |
2020-11-30 |
Ablynx Nv |
Immunglobulin variábilis domének
|
|
EP3143164B1
(en)
|
2014-05-16 |
2021-08-11 |
Children's Hospital Medical Center |
Methods for assessing responsiveness to asthma treatment based on vnn-1 expression and promoter methylation
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
|
PT3194976T
(pt)
|
2014-07-22 |
2020-07-03 |
Univ Brussel Vrije |
Métodos para selecionar agentes que estabilizam complexos proteicos
|
|
CA2961774C
(en)
|
2014-10-07 |
2023-05-23 |
Immunomedics, Inc. |
Neoadjuvant use of antibody-drug conjugates
|
|
EP3207048A4
(en)
|
2014-10-17 |
2018-05-30 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
|
US20170267784A1
(en)
|
2014-10-23 |
2017-09-21 |
Singh Molecular Medicine, Llc |
Single domain antibodies directed against intracellular antigens
|
|
HUE057605T2
(hu)
|
2014-10-23 |
2022-06-28 |
Singh Molecular Medicine Llc |
Intracelluláris antigének ellen irányuló egydoménes antitestek
|
|
CA2969463A1
(en)
|
2014-12-09 |
2016-06-16 |
New York University |
Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
|
|
CA2971278C
(en)
|
2014-12-19 |
2023-09-19 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
RS63384B1
(sr)
|
2015-01-08 |
2022-08-31 |
BioNTech SE |
Agonistička sredstva za vezivanje tnf receptora
|
|
WO2016156468A1
(en)
|
2015-03-31 |
2016-10-06 |
Vhsquared Limited |
Polypeptides
|
|
CN107427577A
(zh)
|
2015-03-31 |
2017-12-01 |
韦斯夸尔德有限公司 |
具有蛋白酶可切割接头的肽构建体
|
|
CN107454905B
(zh)
*
|
2015-03-31 |
2023-04-28 |
索里索制药公司 |
多肽
|
|
US9458211B1
(en)
|
2015-04-02 |
2016-10-04 |
Molecular Partners Ag |
Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains
|
|
US9797907B2
(en)
|
2015-04-22 |
2017-10-24 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells
|
|
PL3294319T3
(pl)
|
2015-05-13 |
2024-10-07 |
Ablynx Nv |
Polipeptydy rekrutujące komórki t na podstawie reaktywności cd3
|
|
ES2754427T3
(es)
|
2015-05-13 |
2020-04-17 |
Ablynx Nv |
Polipéptidos de reclutamiento de células T basados en la reactividad de TCR alfa/beta
|
|
ES2889906T3
(es)
|
2015-05-21 |
2022-01-14 |
Harpoon Therapeutics Inc |
Proteínas de unión triespecíficas y usos médicos
|
|
GB201510758D0
(en)
|
2015-06-18 |
2015-08-05 |
Ucb Biopharma Sprl |
Novel TNFa structure for use in therapy
|
|
EP3313519B1
(en)
|
2015-06-29 |
2023-05-31 |
Children's Medical Center Corporation |
Jak-stat inhibitors for the treatment of congenital myopathies
|
|
EP3316885B1
(en)
|
2015-07-01 |
2021-06-23 |
Immunomedics, Inc. |
Antibody-sn-38 immunoconjugates with a cl2a linker
|
|
CA2998611A1
(en)
|
2015-09-14 |
2017-03-23 |
Leukemia Therapeutics, LLC |
Identification of novel diagnostics and therapeutics by modulating rhoh
|
|
TWI746473B
(zh)
|
2015-11-02 |
2021-11-21 |
美商辛分子醫藥有限公司 |
針對細胞內抗原之單域抗體
|
|
NO2768984T3
(enExample)
*
|
2015-11-12 |
2018-06-09 |
|
|
|
LT3374392T
(lt)
|
2015-11-13 |
2022-01-25 |
Ablynx Nv |
Patobulinti serumo albuminą surišantys imunoglobulino kintami domenai
|
|
AU2016353067B2
(en)
*
|
2015-11-13 |
2023-10-05 |
Sanford Research |
Anti-BCMA polypeptides and proteins
|
|
WO2017085172A2
(en)
|
2015-11-18 |
2017-05-26 |
Ablynx Nv |
Improved serum albumin binders
|
|
SG11201804178YA
(en)
|
2015-11-18 |
2018-06-28 |
Merck Sharp & Dohme |
Pd1 and/or lag3 binders
|
|
CR20180279A
(es)
|
2015-11-18 |
2018-08-24 |
Merck Sharp & Dohme |
Enlazadores de ctla4
|
|
KR20180083418A
(ko)
|
2015-11-18 |
2018-07-20 |
머크 샤프 앤드 돔 코포레이션 |
Pd1/ctla4 결합제
|
|
AU2016360987A1
(en)
*
|
2015-11-27 |
2018-06-07 |
Ablynx Nv |
Polypeptides inhibiting CD40L
|
|
LT3383425T
(lt)
|
2015-12-04 |
2020-10-12 |
Boehringer Ingelheim International Gmbh |
Biparatopiniai polipeptidai, veikiantys antagonistiškai wnt signaliniam keliui vėžinėse ląstelėse
|
|
GB201522394D0
(en)
*
|
2015-12-18 |
2016-02-03 |
Ucb Biopharma Sprl |
Antibodies
|
|
DK3411398T3
(da)
|
2016-02-05 |
2024-06-24 |
Orionis Biosciences BV |
Målrettede terapeutiske midler og anvendelse heraf
|
|
US10465003B2
(en)
*
|
2016-02-05 |
2019-11-05 |
Janssen Biotech, Inc. |
Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
|
|
JP7657014B2
(ja)
|
2016-03-07 |
2025-04-04 |
ブイアイビー ブイゼットダブリュー |
Ｃｄ２０結合単一ドメイン抗体
|
|
CA3022697A1
(en)
|
2016-05-02 |
2017-11-09 |
Ablynx Nv |
Treatment of rsv infection
|
|
EP3455245A2
(en)
|
2016-05-13 |
2019-03-20 |
Orionis Biosciences NV |
Therapeutic targeting of non-cellular structures
|
|
PT3461261T
(pt)
|
2016-05-20 |
2025-07-31 |
Harpoon Therapeutics Inc |
Proteínas de ligação ao cd3 de fragmento variável de cadeia única
|
|
CA3024723A1
(en)
|
2016-05-20 |
2017-11-23 |
Robert B. Dubridge |
Single domain serum albumin binding protein
|
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
|
CN109313183B
(zh)
|
2016-06-23 |
2022-10-21 |
埃博灵克斯股份有限公司 |
免疫球蛋白单可变结构域的改进的药代动力学测定
|
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
|
WO2018060453A1
(en)
|
2016-09-30 |
2018-04-05 |
Vhsquared Limited |
Compositions
|
|
CA3043515A1
(en)
|
2016-11-16 |
2018-05-24 |
Ablynx Nv |
T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
|
|
EP3544997A4
(en)
|
2016-11-23 |
2020-07-01 |
Harpoon Therapeutics, Inc. |
PROSTATE SPECIFIC MEMBRANE ANTIGEN BINDING PROTEIN
|
|
KR20190087539A
(ko)
|
2016-11-23 |
2019-07-24 |
하푼 테라퓨틱스, 인크. |
Psma 표적화 삼중특이성 단백질 및 사용 방법
|
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
|
IL310340A
(en)
*
|
2016-12-07 |
2024-03-01 |
Ablynx Nv |
Improved serum albumin binding immunoglobulin single variable domains
|
|
GB201621907D0
(en)
|
2016-12-21 |
2017-02-01 |
Ucb Biopharma Sprl And Sanofi |
Antibody epitope
|
|
CN107674122A
(zh)
*
|
2016-12-28 |
2018-02-09 |
天津天锐生物科技有限公司 |
一种识别人血清白蛋白的单域抗体
|
|
KR102662499B1
(ko)
|
2017-01-17 |
2024-05-02 |
아블린쓰 엔.브이. |
개선된 혈청 알부민 결합제
|
|
MX2019008536A
(es)
|
2017-01-17 |
2019-09-10 |
Ablynx Nv |
Aglutinantes de albumina serica mejorados.
|
|
CA3052523A1
(en)
|
2017-02-06 |
2018-08-09 |
Orionis Biosciences Nv |
Targeted chimeric proteins and uses thereof
|
|
PT3583125T
(pt)
|
2017-02-16 |
2025-04-04 |
Sonnet Biotherapeutics Inc |
Proteínas de fusão ao domínio de ligação à albumina
|
|
KR102616335B1
(ko)
|
2017-02-28 |
2023-12-21 |
브이아이비 브이지더블유 |
경구 단백질 전달을 위한 수단 및 방법
|
|
US11535668B2
(en)
|
2017-02-28 |
2022-12-27 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
|
CN110546506B
(zh)
*
|
2017-03-31 |
2023-04-04 |
埃博灵克斯股份有限公司 |
改进的免疫原性测定法
|
|
WO2018206734A1
(en)
|
2017-05-11 |
2018-11-15 |
Vib Vzw |
Glycosylation of variable immunoglobulin domains
|
|
BR112019023855B1
(pt)
|
2017-05-12 |
2021-11-30 |
Harpoon Therapeutics, Inc |
Proteínas de ligação à mesotelina
|
|
CN115028727A
(zh)
|
2017-05-12 |
2022-09-09 |
哈普恩治疗公司 |
靶向msln的三特异性蛋白质及使用方法
|
|
EP3630816B1
(en)
|
2017-05-31 |
2024-03-20 |
Boehringer Ingelheim International GmbH |
Polypeptides antagonizing wnt signaling in tumor cells
|
|
US11813307B2
(en)
|
2017-06-02 |
2023-11-14 |
Merck Patent Gmbh |
Polypeptides binding ADAMTS5, MMP13 and aggrecan
|
|
WO2018220225A1
(en)
|
2017-06-02 |
2018-12-06 |
Ablynx Nv |
Aggrecan binding immunoglobulins
|
|
BR112019024333A2
(pt)
|
2017-06-02 |
2020-07-28 |
Merck Patent Gmbh |
imunoglobulinas de ligação adamts
|
|
WO2018220235A1
(en)
|
2017-06-02 |
2018-12-06 |
Merck Patent Gmbh |
Mmp13 binding immunoglobulins
|
|
CA3061053A1
(en)
|
2017-06-02 |
2018-12-06 |
Boehringer Ingelheim International Gmbh |
Anti-cancer combination therapy
|
|
GB201710973D0
(en)
|
2017-07-07 |
2017-08-23 |
Avacta Life Sciences Ltd |
Scaffold proteins
|
|
CN111108126B
(zh)
|
2017-07-19 |
2024-04-26 |
非营利性组织佛兰芒综合大学生物技术研究所 |
血清白蛋白结合剂
|
|
WO2019025545A1
(en)
|
2017-08-04 |
2019-02-07 |
Genmab A/S |
BINDING AGENTS BINDING TO PD-L1 AND CD137 AND THEIR USE
|
|
JP7084990B2
(ja)
|
2017-10-13 |
2022-06-15 |
ハープーン セラピューティクス，インク． |
三重特異性タンパク質と使用方法
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
WO2019086548A1
(en)
|
2017-10-31 |
2019-05-09 |
Vib Vzw |
Novel antigen-binding chimeric proteins and methods and uses thereof
|
|
US20210070854A1
(en)
*
|
2017-12-29 |
2021-03-11 |
Board Of Regents, The University Of Texas System |
Antimicrobial nanobodies
|
|
US20200354424A1
(en)
|
2018-01-26 |
2020-11-12 |
Orionis Biosciences, Inc. |
Xcr1 binding agents and uses thereof
|
|
AU2019215440B2
(en)
|
2018-02-05 |
2025-12-04 |
Orionis Biosciences, Inc. |
Fibroblast binding agents and use thereof
|
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
|
WO2019165105A1
(en)
*
|
2018-02-26 |
2019-08-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Ligands of the urokinase receptor and their use in treating, detecting, and imaging cancer
|
|
US11858960B2
(en)
|
2018-03-01 |
2024-01-02 |
Vrije Universiteit Brussel |
Human PD-L1-binding immunoglobulins
|
|
WO2019204634A1
(en)
*
|
2018-04-20 |
2019-10-24 |
Stc. Unm |
Rap1-gtp, rac1-gtp and fms-like tyrosine kinase 3 ligand (flt3-l) as biomarkers for early detection of sepsis
|
|
WO2019222283A1
(en)
|
2018-05-14 |
2019-11-21 |
Harpoon Therapeutics, Inc. |
Binding moiety for conditional activation of immunoglobulin molecules
|
|
CN110613838A
(zh)
*
|
2018-06-19 |
2019-12-27 |
姜石松 |
增强细胞通透性的多肽及其应用
|
|
DE102018122275A1
(de)
*
|
2018-09-12 |
2020-03-12 |
Osram Opto Semiconductors Gmbh |
Lichtemittierendes bauteil und verfahren zum betreiben eines lichtemittierenden bauteils
|
|
US12195544B2
(en)
|
2018-09-21 |
2025-01-14 |
Harpoon Therapeutics, Inc. |
EGFR binding proteins and methods of use
|
|
CN113286817B
(zh)
|
2018-09-25 |
2025-01-28 |
哈普恩治疗公司 |
Dll3结合蛋白及使用方法
|
|
EP3636657A1
(en)
|
2018-10-08 |
2020-04-15 |
Ablynx N.V. |
Chromatography-free antibody purification method
|
|
CN111138537B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
一种抗人血清白蛋白抗体片段、制备方法和应用
|
|
CN111138536B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
抗人血清白蛋白单域抗体的制备及其应用
|
|
CA3118892A1
(en)
|
2018-11-08 |
2020-05-14 |
Orionis Biosciences, Inc. |
Modulation of dendritic cell lineages
|
|
GB201818460D0
(en)
*
|
2018-11-13 |
2018-12-26 |
Crescendo Biologics Ltd |
Single domain antibodies that bind human serum albumin
|
|
CN112830967B
(zh)
*
|
2019-01-10 |
2022-06-24 |
瑞阳(苏州)生物科技有限公司 |
抗hsa单域抗体及其融合蛋白的亲和层析纯化方法
|
|
CN109627334B
(zh)
*
|
2019-01-29 |
2020-07-17 |
康元医疗科技(大连)有限公司 |
一种纳米抗体、以该纳米抗体为配基的吸附剂及其用途
|
|
GB201901306D0
(en)
|
2019-01-30 |
2019-03-20 |
Immunocore Ltd |
Multi-domain binding molecules
|
|
EP3947455A1
(en)
|
2019-03-29 |
2022-02-09 |
Boehringer Ingelheim International GmbH |
Anticancer combination therapy
|
|
JP2022526166A
(ja)
|
2019-03-29 |
2022-05-23 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗癌併用療法
|
|
EP3963329A1
(en)
|
2019-04-29 |
2022-03-09 |
Confo Therapeutics N.V. |
Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
|
|
EP3962599A1
(en)
|
2019-04-30 |
2022-03-09 |
Vib Vzw |
Cystic fibrosis transmembrane conductance regulator stabilizing agents
|
|
US12516128B2
(en)
|
2019-05-14 |
2026-01-06 |
Harpoon Therapeutics, Inc. |
EpCAM binding proteins and methods of use
|
|
WO2020239945A1
(en)
|
2019-05-28 |
2020-12-03 |
Vib Vzw |
Cancer treatment by targeting plexins in the immune compartment
|
|
US12472254B2
(en)
|
2019-05-28 |
2025-11-18 |
Vib Vzw |
CD8+ T-cells lacking plexins and their application in cancer treatment
|
|
CA3138805A1
(en)
|
2019-06-04 |
2020-12-10 |
Johannes Schilling |
Designed ankyrin repeat domain with improved stability
|
|
AU2020296979A1
(en)
|
2019-06-21 |
2022-02-24 |
Sorriso Pharmaceuticals, Inc. |
Polypeptides
|
|
MX2021015761A
(es)
|
2019-06-21 |
2022-04-18 |
Sorriso Pharmaceuticals Inc |
Polipeptidos.
|
|
MX2021015762A
(es)
|
2019-06-21 |
2022-04-18 |
Sorriso Pharmaceuticals Inc |
Composiciones.
|
|
TWI844709B
(zh)
|
2019-07-31 |
2024-06-11 |
美商美國禮來大藥廠 |
鬆弛素(relaxin)類似物及其使用方法
|
|
CN112409480B
(zh)
*
|
2019-08-20 |
2024-08-27 |
四川科伦博泰生物医药股份有限公司 |
结合血清白蛋白的蛋白及其用途
|
|
WO2021039574A1
(ja)
*
|
2019-08-23 |
2021-03-04 |
株式会社カネカ |
Ｏ結合型糖鎖修飾が抑制された重鎖抗体
|
|
CN112480253B
(zh)
|
2019-09-12 |
2022-09-20 |
普米斯生物技术(珠海)有限公司 |
一种抗pd-l1纳米抗体及其衍生物和用途
|
|
CN110642946A
(zh)
*
|
2019-09-30 |
2020-01-03 |
中国药科大学 |
一种人源化纳米抗体及其制备方法
|
|
TW202128775A
(zh)
|
2019-10-16 |
2021-08-01 |
英商阿法克塔生命科學有限公司 |
PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
|
|
WO2021078786A1
(en)
|
2019-10-21 |
2021-04-29 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
|
CN112746331A
(zh)
*
|
2019-10-29 |
2021-05-04 |
安升（上海）医药科技有限公司 |
半衰期延长的药物及其文库、以及制备方法和应用
|
|
BR112022009087A2
(pt)
|
2019-11-11 |
2022-07-26 |
Ibi Ag Innovative Bio Insecticides Ltd |
Nanocorpos para controle de insetos e usos dos mesmos
|
|
CA3158991A1
(en)
|
2019-11-27 |
2021-06-03 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
|
MX2022006880A
(es)
|
2019-12-06 |
2022-07-11 |
Ablynx Nv |
Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa e il-23.
|
|
KR20220111313A
(ko)
*
|
2019-12-06 |
2022-08-09 |
아블린쓰 엔.브이. |
TNFα 및 OX40L을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드
|
|
TWI861302B
(zh)
|
2019-12-09 |
2024-11-11 |
比利時商艾伯霖克斯公司 |
包含靶向il-13及tslp之免疫球蛋白單可變域的多肽
|
|
GB201918279D0
(en)
|
2019-12-12 |
2020-01-29 |
Vib Vzw |
Glycosylated single chain immunoglobulin domains
|
|
CN110988361B
(zh)
*
|
2019-12-13 |
2020-09-18 |
山东民康生物科技有限公司 |
人血清白蛋白去除试剂盒
|
|
EP4077372A1
(en)
|
2019-12-20 |
2022-10-26 |
Vib Vzw |
Nanobody exchange chromatography
|
|
CN112300289B
(zh)
*
|
2019-12-30 |
2022-06-10 |
中国药科大学 |
RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
|
|
ES2992247T3
(es)
|
2020-01-08 |
2024-12-11 |
argenx BV |
Antagonistas del receptor de Fc neonatal humano (FcRn) para el tratamiento de trastornos del pénfigo
|
|
WO2021140205A1
(en)
|
2020-01-10 |
2021-07-15 |
Confo Therapeutics N.V. |
Methods for generating antibodies and antibody fragments and libraries comprising same
|
|
WO2021156490A2
(en)
|
2020-02-06 |
2021-08-12 |
Vib Vzw |
Corona virus binders
|
|
IL295448A
(en)
|
2020-02-21 |
2022-10-01 |
Harpoon Therapeutics Inc |
flt3 binding proteins and methods of use
|
|
EP4110794A1
(en)
|
2020-02-25 |
2023-01-04 |
Vib Vzw |
Leucine-rich repeat kinase 2 allosteric modulators
|
|
CN115698063A
(zh)
*
|
2020-03-06 |
2023-02-03 |
匹兹堡大学联邦高等教育系统 |
血清白蛋白结合纳米抗体组合物以及其使用方法
|
|
WO2021213435A1
(zh)
|
2020-04-22 |
2021-10-28 |
迈威(上海)生物科技股份有限公司 |
一种靶向人程序性死亡配体1(pd-l1)的单可变域抗体及其衍生物
|
|
WO2021229104A1
(en)
|
2020-05-15 |
2021-11-18 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
|
GB202101299D0
(en)
|
2020-06-09 |
2021-03-17 |
Avacta Life Sciences Ltd |
Diagnostic polypetides and methods
|
|
WO2022003156A1
(en)
|
2020-07-02 |
2022-01-06 |
Oncurious Nv |
Ccr8 non-blocking binders
|
|
CN116284374A
(zh)
*
|
2020-08-14 |
2023-06-23 |
上海洛启生物医药技术有限公司 |
非pH依赖性长效型抗血清白蛋白纳米抗体及其应用
|
|
CN114106190B
(zh)
*
|
2020-08-31 |
2025-04-08 |
普米斯生物技术(珠海)有限公司 |
一种抗vegf/pd-l1双特异性抗体及其用途
|
|
WO2022063957A1
(en)
|
2020-09-24 |
2022-03-31 |
Vib Vzw |
Biomarker for anti-tumor therapy
|
|
CA3196737A1
(en)
|
2020-09-24 |
2022-03-31 |
Massimiliano Mazzone |
Combination of p2y6 inhibitors and immune checkpoint inhibitors
|
|
MX2023003522A
(es)
|
2020-09-25 |
2023-04-19 |
Ablynx Nv |
Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l.
|
|
WO2022089435A1
(en)
*
|
2020-10-27 |
2022-05-05 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion proteins of gdf15 and use thereof
|
|
WO2022098743A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
|
|
WO2022098745A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, delivery systems, and methods useful in tumor therapy
|
|
WO2022117569A1
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
|
|
EP4255929A2
(en)
|
2020-12-02 |
2023-10-11 |
Vib Vzw |
An ltbr agonist in combination therapy against cancer
|
|
EP4262985A1
(en)
|
2020-12-18 |
2023-10-25 |
Ablynx N.V. |
Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor
|
|
PH12023500009A1
(en)
|
2020-12-18 |
2024-03-11 |
Ablynx Nv |
T cell recruiting polypeptides based on tcr alpha/beta reactivity
|
|
WO2022129572A1
(en)
|
2020-12-18 |
2022-06-23 |
Ablynx Nv |
Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha
|
|
GB202020502D0
(en)
|
2020-12-23 |
2021-02-03 |
Vib Vzw |
Antibody composistion for treatment of corona virus infection
|
|
WO2022136650A1
(en)
|
2020-12-24 |
2022-06-30 |
Oncurious Nv |
Murine cross-reactive human ccr8 binders
|
|
CA3206124A1
(en)
|
2020-12-24 |
2022-06-30 |
Vib Vzw |
Non-blocking human ccr8 binders
|
|
CA3206304A1
(en)
|
2020-12-24 |
2022-06-30 |
Vib Vzw |
Human ccr8 binders
|
|
CA3207548A1
(en)
|
2021-02-05 |
2022-08-11 |
Xavier Saelens |
Sarbecovirus binders
|
|
CN117794566A
(zh)
|
2021-02-05 |
2024-03-29 |
Vib研究所 |
沙贝病毒结合剂
|
|
CN117241804A
(zh)
|
2021-02-17 |
2023-12-15 |
非营利性组织佛兰芒综合大学生物技术研究所 |
在癌症治疗中slc4a4的抑制
|
|
CA3211270A1
(en)
|
2021-02-19 |
2022-08-25 |
Vib Vzw |
Cation-independent mannose-6-phosphate receptor binders
|
|
WO2022199804A1
(en)
|
2021-03-24 |
2022-09-29 |
Vib Vzw |
Nek6 inhibition to treat als and ftd
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
US20240261446A1
(en)
|
2021-05-17 |
2024-08-08 |
Université de Liège |
Anti-cd38 single domain antibodies in disease monitoring and treatment
|
|
WO2022268993A1
(en)
|
2021-06-23 |
2022-12-29 |
Vib Vzw |
Means and methods for selection of specific binders
|
|
CN117580865A
(zh)
|
2021-06-29 |
2024-02-20 |
山东先声生物制药有限公司 |
Cd16抗体及其应用
|
|
CA3224743A1
(en)
|
2021-07-14 |
2023-01-19 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion polypeptides for metabolic disorders
|
|
CN113527502B
(zh)
*
|
2021-07-20 |
2023-01-17 |
福建医科大学 |
一种用于治疗类风湿性关节炎的纳米抗体重组蛋白
|
|
WO2023006040A1
(zh)
|
2021-07-30 |
2023-02-02 |
江苏先声药业有限公司 |
抗pvrig/抗tigit双特异性抗体和应用
|
|
CA3228014A1
(en)
|
2021-07-30 |
2023-02-16 |
Vib Vzm |
Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
|
|
EP4413038A1
(en)
|
2021-10-07 |
2024-08-14 |
Avacta Life Sciences Limited |
Pd-l1 binding affimers
|
|
EP4412711A1
(en)
|
2021-10-07 |
2024-08-14 |
Avacta Life Sciences Limited |
Serum half-life extended pd-l1 binding polypeptides
|
|
EP4428156A4
(en)
|
2021-12-03 |
2026-03-04 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
ANTI-BCMA NANOBODY AND USE THEREOF
|
|
CN113912730B
(zh)
*
|
2021-12-14 |
2022-03-04 |
北京科诺信诚科技有限公司 |
缓释的抗FcRn抗体或抗原结合片段及其应用
|
|
TW202342508A
(zh)
|
2021-12-17 |
2023-11-01 |
比利時商艾伯霖克斯公司 |
包含靶向ＴＣＲαβ、ＣＤ３３和ＣＤ１２３的免疫球蛋白單可變結構域的多肽
|
|
WO2023125888A1
(zh)
|
2021-12-31 |
2023-07-06 |
山东先声生物制药有限公司 |
一种gprc5d抗体及其应用
|
|
US20250304664A1
(en)
|
2022-01-12 |
2025-10-02 |
Vib Vzw |
Human NTCP Binders For Therapeutic Use And Liver-Specific Targeted Delivery
|
|
WO2023148397A1
(en)
|
2022-02-07 |
2023-08-10 |
Vib Vzw |
Engineered stabilizing aglycosylated fc-regions
|
|
EP4477665A4
(en)
|
2022-02-10 |
2025-08-20 |
Affyxell Therapeutics Co Ltd |
STEFIN A PROTEIN VARIANTS THAT SPECIFICALLY BIND TO CD40L AND THEIR USES
|
|
CN116925215A
(zh)
*
|
2022-03-31 |
2023-10-24 |
普米斯生物技术(珠海)有限公司 |
抗血清白蛋白纳米抗体及其衍生物
|
|
WO2023198848A1
(en)
|
2022-04-13 |
2023-10-19 |
Vib Vzw |
An ltbr agonist in combination therapy against cancer
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
CN119998313A
(zh)
|
2022-05-18 |
2025-05-13 |
Vib研究所 |
沙贝病毒刺突蛋白s2亚基结合剂
|
|
CN115028719B
(zh)
*
|
2022-05-27 |
2023-01-13 |
深圳市人民医院 |
血清白蛋白结合纳米抗体及其制备方法与应用
|
|
CA3258254A1
(en)
|
2022-06-06 |
2025-04-07 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Multi-specific antibody targeting bcma, gprc5d and t cells and application thereof
|
|
TW202415678A
(zh)
|
2022-06-14 |
2024-04-16 |
比利時商艾伯霖克斯公司 |
靶向ｔ細胞受體的免疫球蛋白單可變結構域
|
|
CA3258004A1
(en)
|
2022-06-15 |
2023-12-21 |
argenx BV |
FCRN/HSA BONDING MOLECULES AND METHODS OF USE
|
|
WO2024003873A1
(en)
*
|
2022-06-30 |
2024-01-04 |
Intrexon Actobiotics Nv D/B/A Precigen Actobio |
Single variable domain antibodies against tumor necrosis factor-alpha
|
|
EP4551600A1
(en)
|
2022-07-04 |
2025-05-14 |
Vib Vzw |
Blood-cerebrospinal fluid barrier crossing antibodies
|
|
JP2025526384A
(ja)
|
2022-07-27 |
2025-08-13 |
アブリンクス エン．ヴェー． |
新生児型Ｆｃ受容体の特異的エピトープに結合するポリペプチド
|
|
US20250388663A1
(en)
|
2022-08-17 |
2025-12-25 |
Institut National de la Santé et de la Recherche Médicale |
Improved anti-albumin nanobodies and their uses
|
|
EP4594348A1
(en)
|
2022-09-27 |
2025-08-06 |
Vib Vzw |
Antivirals against human parainfluenza virus
|
|
US12233115B2
(en)
|
2022-09-30 |
2025-02-25 |
Extend Biosciences, Inc. |
Long-acting parathyroid hormone
|
|
WO2024083843A1
(en)
|
2022-10-18 |
2024-04-25 |
Confo Therapeutics N.V. |
Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
|
|
AU2023368748A1
(en)
|
2022-10-28 |
2025-05-08 |
Genor Biopharma Co., Ltd. |
Novel anti-ctla4 antibody
|
|
EP4619156A1
(en)
|
2022-11-15 |
2025-09-24 |
Imec VZW |
Method and system for droplet manipulation
|
|
AR131388A1
(es)
|
2022-12-15 |
2025-03-12 |
Univ Aarhus |
Activación sintética de receptores transmembrana multiméricos
|
|
AR131494A1
(es)
|
2022-12-23 |
2025-03-26 |
Ablynx Nv |
Vehículos de conjugación a base de proteína
|
|
WO2024151515A2
(en)
|
2023-01-09 |
2024-07-18 |
Odyssey Therapeutics, Inc. |
Anti-tnfr2 antigen-binding proteins and uses thereof
|
|
JP2026504873A
(ja)
*
|
2023-01-18 |
2026-02-10 |
ベイジン キューエル バイオファーマシューティカル カンパニー，リミテッド |
融合ポリペプチドの液体医薬組成物およびその使用方法
|
|
CN121002071A
(zh)
|
2023-01-20 |
2025-11-21 |
勃林格殷格翰国际有限公司 |
IL-12 Fc融合蛋白
|
|
EP4655324A1
(en)
|
2023-01-27 |
2025-12-03 |
Vib Vzw |
Cd163-binding conjugates
|
|
WO2024156881A1
(en)
|
2023-01-27 |
2024-08-02 |
Vib Vzw |
CD8b-BINDING POLYPEPTIDES
|
|
EP4665755A1
(en)
|
2023-02-17 |
2025-12-24 |
Ablynx N.V. |
Polypeptides binding to the neonatal fc receptor
|
|
WO2024175787A1
(en)
|
2023-02-24 |
2024-08-29 |
Vrije Universiteit Brussel |
Anti-inflammatory pannexin 1 channel inhibitors
|
|
AU2024234615A1
(en)
|
2023-03-14 |
2025-08-21 |
Odyssey Therapeutics, Inc. |
Anti-cd25 antigen-binding proteins and uses thereof
|
|
EP4680624A1
(en)
|
2023-03-14 |
2026-01-21 |
Aarhus Universitet |
Genetically altered nfr5 receptor kinases
|
|
FR3147278A1
(fr)
|
2023-03-31 |
2024-10-04 |
Avacta Life Sciences Limited |
Polypeptides de liaison au tnfr2 et procedes d'utilisation
|
|
EP4688825A1
(en)
|
2023-03-31 |
2026-02-11 |
AffyXell Therapeutics Co., Ltd. |
Tnfr2 binding polypeptides and methods of use
|
|
CN121358771A
(zh)
|
2023-04-03 |
2026-01-16 |
非营利性组织佛兰芒综合大学生物技术研究所 |
血-脑屏障穿越抗体
|
|
AU2024261810A1
(en)
|
2023-04-24 |
2025-11-13 |
Merck Sharp & Dohme Llc |
Trop2 binders and conjugates thereof
|
|
WO2024231348A1
(en)
|
2023-05-11 |
2024-11-14 |
Vib Vzw |
Slc4a4/nbce1 inhibitors
|
|
TW202448951A
(zh)
|
2023-05-17 |
2024-12-16 |
美商奧迪希治療公司 |
經修飾之單域抗體
|
|
WO2024240162A1
(en)
|
2023-05-23 |
2024-11-28 |
Shanghai Allygen Biologics Co., Ltd. |
Pd-l1 and trop-2 targeting conjugates comprising effector molecules and uses thereof
|
|
WO2024261235A1
(en)
|
2023-06-22 |
2024-12-26 |
Ablynx Nv |
Chimeric proteins for modulating cytokine receptor activity
|
|
WO2024261344A1
(en)
|
2023-06-23 |
2024-12-26 |
Vib Vzw |
Novel binders targeting the multi-drug resistant pathogen acinetobacter baumannii
|
|
TW202515917A
(zh)
|
2023-06-29 |
2025-04-16 |
美商奧迪希治療公司 |
抗trailr2抗原結合蛋白及其用途
|
|
EP4483951A1
(en)
|
2023-06-30 |
2025-01-01 |
Université de Liège |
Single-domain antibody for inhibition of neutrophil elastase activity
|
|
WO2025008537A1
(en)
|
2023-07-05 |
2025-01-09 |
Ablynx Nv |
Improved fcrn antagonists for treatment of igg-related diseases and disorders
|
|
US20250051434A1
(en)
|
2023-08-11 |
2025-02-13 |
Merck Sharp & Dohme Llc |
Monovalent interleukin 12 (il-12) heterodimeric fc proteins
|
|
WO2025051767A1
(en)
|
2023-09-04 |
2025-03-13 |
Sanofi |
Polypeptides for use in the treatment of glypican-3-expressing tumours
|
|
AR133903A1
(es)
|
2023-09-22 |
2025-11-12 |
Ablynx Nv |
Agentes de unión de albúmina bi- y multivalentes
|
|
TW202530265A
(zh)
|
2023-10-13 |
2025-08-01 |
美商奧迪希治療公司 |
抗cdh17抗原結合蛋白及其用途
|
|
WO2025090840A1
(en)
*
|
2023-10-27 |
2025-05-01 |
Rutgers, The State University Of New Jersey |
Antigen binding molecules targeting tnf-alpha
|
|
WO2025093683A1
(en)
|
2023-11-03 |
2025-05-08 |
Neuvasq Biotechnologies Sa |
Wnt7 signaling agonists
|
|
AR134267A1
(es)
|
2023-11-08 |
2025-12-17 |
Sanofi Sa |
Degradador lisosómico basado en cd25 y usos del mismo
|
|
WO2025109176A1
(en)
|
2023-11-22 |
2025-05-30 |
Exevir Bio Bv |
Optimized sarbecovirus spike s2 subunit binders and compositions comprising the same
|
|
TW202540188A
(zh)
|
2023-12-01 |
2025-10-16 |
比利時商艾伯霖克斯公司 |
精準活化的多肽
|
|
WO2025125577A1
(en)
|
2023-12-14 |
2025-06-19 |
Vib Vzw |
Antibodies against influenza b virus
|
|
WO2025133166A1
(en)
|
2023-12-22 |
2025-06-26 |
Ablynx Nv |
Protein-based carriers for site-specific amine conjugation
|
|
WO2025133253A2
(en)
|
2023-12-22 |
2025-06-26 |
Ablynx Nv |
Protein-based conjugation carriers for intranuclear delivery
|
|
US12134635B1
(en)
|
2023-12-29 |
2024-11-05 |
Sonnet BioTherapeutics, Inc. |
Interleukin 18 (IL-18) variants and fusion proteins comprising same
|
|
WO2025147862A1
(zh)
*
|
2024-01-09 |
2025-07-17 |
上海洛启生物医药技术有限公司 |
血清白蛋白结合分子及其应用
|
|
WO2025154058A1
(en)
|
2024-01-21 |
2025-07-24 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect hsp70 nanobodies and uses thereof
|
|
WO2025154056A1
(en)
|
2024-01-21 |
2025-07-24 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect cda nanobodies and uses thereof
|
|
WO2025160546A1
(en)
|
2024-01-26 |
2025-07-31 |
The Johns Hopkins University |
Dendrimer conjugate compositions for intracellular delivery of antibodies and antibody fragments
|
|
WO2025181155A1
(en)
|
2024-02-26 |
2025-09-04 |
Vib Vzw |
Human beta-glucocerebrosidase binders and uses thereof
|
|
GB202403780D0
(en)
|
2024-03-15 |
2024-05-01 |
Avacta Life Sciences Ltd |
Polypeptides and methods for detecting and quantifying small molecules
|
|
WO2025196308A1
(en)
|
2024-03-22 |
2025-09-25 |
Vib Vzw |
Means and methods for displaying fc-containing proteins on cells and selection thereof
|
|
WO2025217240A1
(en)
|
2024-04-10 |
2025-10-16 |
Odyssey Therapeutics, Inc. |
Anti-tnfr2 antigen-binding proteins and uses thereof
|
|
US12459994B2
(en)
|
2024-04-12 |
2025-11-04 |
Paragon Therapeutics, Inc. |
Albumin binding proteins and methods of use
|
|
WO2025219231A1
(en)
|
2024-04-15 |
2025-10-23 |
Vib Vzw |
Computer-implemented means and methods for the de novo design of antibodies targeting a specific epitope
|
|
WO2025255435A2
(en)
|
2024-06-07 |
2025-12-11 |
Odyssey Therapeutics, Inc. |
Antigen-binding proteins against serum albumin and uses thereof
|
|
WO2025255558A2
(en)
|
2024-06-07 |
2025-12-11 |
Odyssey Therapeutics, Inc. |
Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof
|
|
WO2026006708A2
(en)
|
2024-06-27 |
2026-01-02 |
Odyssey Therapeutics, Inc. |
Anti-cd25 antigen-binding proteins and uses thereof
|
|
WO2026006809A1
(en)
|
2024-06-27 |
2026-01-02 |
Odyssey Therapeutics, Inc. |
Multispecific molecules binding tnfr2 and cd25 and uses thereof
|
|
WO2026008665A1
(en)
|
2024-07-01 |
2026-01-08 |
Vib Vzw |
Binders of the pd-1•pd-l1 complex and their use
|
|
WO2026030375A2
(en)
|
2024-07-30 |
2026-02-05 |
Genzyme Corporation |
Lipid nanoparticles and methods of manufacture and use thereof
|
|
WO2026052756A1
(en)
|
2024-09-05 |
2026-03-12 |
Ablynx Nv |
Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof
|