JP2020511113A5 - - Google Patents
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- JP2020511113A5 JP2020511113A5 JP2019530389A JP2019530389A JP2020511113A5 JP 2020511113 A5 JP2020511113 A5 JP 2020511113A5 JP 2019530389 A JP2019530389 A JP 2019530389A JP 2019530389 A JP2019530389 A JP 2019530389A JP 2020511113 A5 JP2020511113 A5 JP 2020511113A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- polypeptide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023085495A JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430972P | 2016-12-07 | 2016-12-07 | |
| US62/430,972 | 2016-12-07 | ||
| PCT/EP2017/081818 WO2018104444A1 (en) | 2016-12-07 | 2017-12-07 | Improved serum albumin binding immunoglobulin single variable domains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085495A Division JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511113A JP2020511113A (ja) | 2020-04-16 |
| JP2020511113A5 true JP2020511113A5 (enExample) | 2020-11-19 |
| JP7417421B2 JP7417421B2 (ja) | 2024-01-18 |
Family
ID=60990745
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530389A Active JP7417421B2 (ja) | 2016-12-07 | 2017-12-07 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2023085495A Pending JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A Pending JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085495A Pending JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A Pending JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11414480B2 (enExample) |
| EP (1) | EP3551656A1 (enExample) |
| JP (3) | JP7417421B2 (enExample) |
| KR (3) | KR102616835B1 (enExample) |
| CN (2) | CN110049997B (enExample) |
| AU (2) | AU2017373746B2 (enExample) |
| BR (1) | BR112019011189A2 (enExample) |
| CA (1) | CA3045726A1 (enExample) |
| IL (2) | IL310340A (enExample) |
| MX (3) | MX2019006574A (enExample) |
| RU (2) | RU2022101604A (enExample) |
| WO (1) | WO2018104444A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| PH12022550313A1 (en) * | 2011-06-23 | 2023-01-23 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL310340A (en) * | 2016-12-07 | 2024-03-01 | Ablynx Nv | Improved serum albumin binding immunoglobulin single variable domains |
| EP3565842A1 (en) | 2017-01-06 | 2019-11-13 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
| MX2019008536A (es) * | 2017-01-17 | 2019-09-10 | Ablynx Nv | Aglutinantes de albumina serica mejorados. |
| KR102662499B1 (ko) | 2017-01-17 | 2024-05-02 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합제 |
| JP7312168B2 (ja) | 2017-11-13 | 2023-07-20 | クレッシェンド、バイオロジックス、リミテッド | Ｃｄ１３７に結合するシングルドメイン抗体 |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| WO2020172528A1 (en) * | 2019-02-22 | 2020-08-27 | Anwita Biosciences, Inc. | Albumin binding antibodies and use thereof |
| KR20220008839A (ko) * | 2019-05-15 | 2022-01-21 | 크레센도 바이오로직스 리미티드 | 결합 분자 |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN112409480B (zh) * | 2019-08-20 | 2024-08-27 | 四川科伦博泰生物医药股份有限公司 | 结合血清白蛋白的蛋白及其用途 |
| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| KR20220111313A (ko) | 2019-12-06 | 2022-08-09 | 아블린쓰 엔.브이. | TNFα 및 OX40L을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드 |
| MX2022006880A (es) | 2019-12-06 | 2022-07-11 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa e il-23. |
| TWI861302B (zh) | 2019-12-09 | 2024-11-11 | 比利時商艾伯霖克斯公司 | 包含靶向il-13及tslp之免疫球蛋白單可變域的多肽 |
| EP4126971A1 (en) | 2020-03-30 | 2023-02-08 | Ablynx N.V. | Method for the production and purification of multivalent immunoglobulin single variable domains |
| EP4143329A4 (en) | 2020-04-28 | 2024-10-16 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| MX2023003522A (es) | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| EP4262985A1 (en) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor |
| WO2022129572A1 (en) | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| PH12023500009A1 (en) | 2020-12-18 | 2024-03-11 | Ablynx Nv | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| AU2022217754A1 (en) * | 2021-02-02 | 2023-07-27 | Eli Lilly And Company | Half-life extending moieties and methods of using the same |
| TW202342508A (zh) | 2021-12-17 | 2023-11-01 | 比利時商艾伯霖克斯公司 | 包含靶向ＴＣＲαβ、ＣＤ３３和ＣＤ１２３的免疫球蛋白單可變結構域的多肽 |
| TW202415678A (zh) | 2022-06-14 | 2024-04-16 | 比利時商艾伯霖克斯公司 | 靶向ｔ細胞受體的免疫球蛋白單可變結構域 |
| JP2025526384A (ja) | 2022-07-27 | 2025-08-13 | アブリンクス エン．ヴェー． | 新生児型Ｆｃ受容体の特異的エピトープに結合するポリペプチド |
| WO2024097639A1 (en) * | 2022-10-31 | 2024-05-10 | Modernatx, Inc. | Hsa-binding antibodies and binding proteins and uses thereof |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| WO2024151515A2 (en) | 2023-01-09 | 2024-07-18 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| EP4665755A1 (en) | 2023-02-17 | 2025-12-24 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| AU2024234615A1 (en) | 2023-03-14 | 2025-08-21 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| CN121002685A (zh) | 2023-05-12 | 2025-11-21 | 株式会社Lg新能源 | 包括用于固定堆叠件的外部的带的电极组件和包括该电极组件的二次电池 |
| TW202448951A (zh) | 2023-05-17 | 2024-12-16 | 美商奧迪希治療公司 | 經修飾之單域抗體 |
| CN117986387A (zh) * | 2023-05-31 | 2024-05-07 | 四川大学华西医院 | 一种新型小型化car设计及制备方法和应用 |
| WO2024261235A1 (en) | 2023-06-22 | 2024-12-26 | Ablynx Nv | Chimeric proteins for modulating cytokine receptor activity |
| WO2024261338A1 (en) * | 2023-06-22 | 2024-12-26 | Ablynx Nv | Immunoglobulin single variable domains targeting pd-l1 |
| TW202515917A (zh) | 2023-06-29 | 2025-04-16 | 美商奧迪希治療公司 | 抗trailr2抗原結合蛋白及其用途 |
| WO2025008537A1 (en) | 2023-07-05 | 2025-01-09 | Ablynx Nv | Improved fcrn antagonists for treatment of igg-related diseases and disorders |
| WO2025051767A1 (en) | 2023-09-04 | 2025-03-13 | Sanofi | Polypeptides for use in the treatment of glypican-3-expressing tumours |
| AR133903A1 (es) | 2023-09-22 | 2025-11-12 | Ablynx Nv | Agentes de unión de albúmina bi- y multivalentes |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| TW202530265A (zh) | 2023-10-13 | 2025-08-01 | 美商奧迪希治療公司 | 抗cdh17抗原結合蛋白及其用途 |
| AR134267A1 (es) | 2023-11-08 | 2025-12-17 | Sanofi Sa | Degradador lisosómico basado en cd25 y usos del mismo |
| TW202540188A (zh) | 2023-12-01 | 2025-10-16 | 比利時商艾伯霖克斯公司 | 精準活化的多肽 |
| WO2025133253A2 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based conjugation carriers for intranuclear delivery |
| WO2025133166A1 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based carriers for site-specific amine conjugation |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
| WO2026006708A2 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
| WO2026052756A1 (en) | 2024-09-05 | 2026-03-12 | Ablynx Nv | Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| US6742038B2 (en) | 2000-04-07 | 2004-05-25 | Danger, Inc. | System and method of linking user identification to a subscriber identification module |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP1517921B1 (en) | 2002-06-28 | 2006-06-07 | Domantis Limited | Dual specific ligands with increased serum half-life |
| WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| RU2357974C2 (ru) | 2003-01-10 | 2009-06-10 | Аблинкс Н.В. | Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами |
| WO2006059108A2 (en) | 2004-12-02 | 2006-06-08 | Domantis Limited | ANTI-IL-IRl SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC USES |
| RU2464276C2 (ru) * | 2005-05-18 | 2012-10-20 | Аблинкс Н.В. | Улучшенные нанотела против фактора некроза опухоли-альфа |
| DK2444424T3 (en) | 2005-05-20 | 2018-12-03 | Ablynx Nv | IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS |
| CN101454344A (zh) | 2005-12-01 | 2009-06-10 | 杜门蒂斯有限公司 | 与白细胞介素-1受体1型结合的非竞争性域抗体形式 |
| CA2629850A1 (en) * | 2005-12-01 | 2007-06-07 | Domantis Limited | Competitive domain antibody formats that bind interleukin 1 receptor type 1 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| AU2007209201A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| EP2069402A2 (en) | 2006-09-08 | 2009-06-17 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| AU2008252853B2 (en) | 2007-05-24 | 2011-12-01 | Ablynx N.V. | Amino acid sequences directed against RANK-L and polypeptides comprising the same for the treatment of bone diseases and disorders |
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| AU2009248049B2 (en) | 2008-05-16 | 2015-07-23 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
| LT2334705T (lt) | 2008-09-26 | 2017-03-27 | Ucb Biopharma Sprl | Biologiniai produktai |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| CN102574914A (zh) | 2009-07-16 | 2012-07-11 | 葛兰素集团有限公司 | 改进的抗血清清蛋白结合性单可变区 |
| KR20120092611A (ko) | 2009-09-30 | 2012-08-21 | 글락소 그룹 리미티드 | 연장된 반감기를 갖는 약물 융합체 및 컨쥬게이트 |
| JP2013538566A (ja) * | 2010-08-13 | 2013-10-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 改良された抗血清アルブミン結合変異体 |
| SG188204A1 (en) * | 2010-08-20 | 2013-04-30 | Glaxo Group Ltd | Improved anti-serum albumin binding variants |
| JP2014501515A (ja) * | 2010-12-01 | 2014-01-23 | グラクソ グループ リミテッド | 改良された抗血清アルブミン結合単一可変ドメイン |
| AU2012273928A1 (en) * | 2011-06-23 | 2014-02-06 | Ablynx Nv | Immunoglobulin single variable domains directed against IgE |
| PH12022550313A1 (en) | 2011-06-23 | 2023-01-23 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| EP3466972B1 (en) * | 2011-06-23 | 2026-03-04 | Ablynx NV | Serum albumin binding proteins |
| WO2012174741A1 (en) | 2011-06-24 | 2012-12-27 | Google Inc. | Determining cross-language query suggestion based on query translations |
| PH12014500380A1 (en) | 2011-08-17 | 2022-05-02 | Glaxo Group Ltd | Modified proteins and peptides |
| US20130129727A1 (en) | 2011-11-17 | 2013-05-23 | Nanjingjinsirui Science & Technology Biology Corporation | Methods and systems for increasing protein stability |
| WO2014037419A1 (en) | 2012-09-04 | 2014-03-13 | Vib Vzw | Immunoglobulin single variable domains directed against cd74 and uses derived thereof |
| US20140186365A1 (en) | 2013-01-03 | 2014-07-03 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Antibodies that specifically bind to serum albumin without interfering with albumin's capability to interact with the fcrn |
| WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| HUE050007T2 (hu) | 2014-05-16 | 2020-11-30 | Ablynx Nv | Immunglobulin variábilis domének |
| AU2016209247B2 (en) | 2015-01-21 | 2021-02-25 | Inhibrx Biosciences, Inc. | Non-immunogenic single domain antibodies |
| ES2754427T3 (es) * | 2015-05-13 | 2020-04-17 | Ablynx Nv | Polipéptidos de reclutamiento de células T basados en la reactividad de TCR alfa/beta |
| AU2016360987A1 (en) | 2015-11-27 | 2018-06-07 | Ablynx Nv | Polypeptides inhibiting CD40L |
| IL310340A (en) * | 2016-12-07 | 2024-03-01 | Ablynx Nv | Improved serum albumin binding immunoglobulin single variable domains |
| MX2019008536A (es) * | 2017-01-17 | 2019-09-10 | Ablynx Nv | Aglutinantes de albumina serica mejorados. |
| KR102662499B1 (ko) | 2017-01-17 | 2024-05-02 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합제 |
-
2017
- 2017-12-07 IL IL310340A patent/IL310340A/en unknown
- 2017-12-07 CN CN201780076027.0A patent/CN110049997B/zh active Active
- 2017-12-07 RU RU2022101604A patent/RU2022101604A/ru unknown
- 2017-12-07 BR BR112019011189A patent/BR112019011189A2/pt unknown
- 2017-12-07 CA CA3045726A patent/CA3045726A1/en active Pending
- 2017-12-07 AU AU2017373746A patent/AU2017373746B2/en active Active
- 2017-12-07 CN CN202311111034.3A patent/CN117164710A/zh active Pending
- 2017-12-07 EP EP17829610.9A patent/EP3551656A1/en active Pending
- 2017-12-07 JP JP2019530389A patent/JP7417421B2/ja active Active
- 2017-12-07 RU RU2019120720A patent/RU2765384C2/ru active
- 2017-12-07 KR KR1020197019686A patent/KR102616835B1/ko active Active
- 2017-12-07 MX MX2019006574A patent/MX2019006574A/es unknown
- 2017-12-07 KR KR1020237043751A patent/KR20240001271A/ko not_active Ceased
- 2017-12-07 KR KR1020237014486A patent/KR20230061582A/ko not_active Ceased
- 2017-12-07 IL IL266907A patent/IL266907B2/en unknown
- 2017-12-07 US US16/465,188 patent/US11414480B2/en active Active
- 2017-12-07 WO PCT/EP2017/081818 patent/WO2018104444A1/en not_active Ceased
-
2019
- 2019-06-05 MX MX2023003630A patent/MX2023003630A/es unknown
- 2019-06-05 MX MX2023007520A patent/MX2023007520A/es unknown
-
2022
- 2022-06-29 US US17/852,474 patent/US20230050615A1/en active Pending
-
2023
- 2023-05-24 JP JP2023085495A patent/JP2023109939A/ja active Pending
-
2025
- 2025-01-13 AU AU2025200245A patent/AU2025200245A1/en active Pending
- 2025-06-18 JP JP2025102421A patent/JP2025131869A/ja active Pending
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