JP2007530561A5 - - Google Patents

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JP2007530561A5
JP2007530561A5 JP2007505094A JP2007505094A JP2007530561A5 JP 2007530561 A5 JP2007530561 A5 JP 2007530561A5 JP 2007505094 A JP2007505094 A JP 2007505094A JP 2007505094 A JP2007505094 A JP 2007505094A JP 2007530561 A5 JP2007530561 A5 JP 2007530561A5
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Japan
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alkyl
compound
aryl
alkenyl
patient
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JP2007505094A
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JP5274831B2 (ja
JP2007530561A (ja
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Priority claimed from US10/809,089 external-priority patent/US7718644B2/en
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JP2007505094A 2004-03-25 2005-03-22 リアノジンレセプタ(RyR2)の漏れを標的とする、新規な抗−不整脈性及び心不全用薬剤及びその使用 Expired - Fee Related JP5274831B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/809,089 2004-03-25
US10/809,089 US7718644B2 (en) 2004-01-22 2004-03-25 Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
PCT/US2005/009495 WO2005094457A2 (en) 2004-03-25 2005-03-22 Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012208868A Division JP2012250999A (ja) 2004-03-25 2012-09-21 リアノジンレセプタ(RyR2)の漏れを標的とする、新規な抗−不整脈性及び心不全用薬剤及びその使用

Publications (3)

Publication Number Publication Date
JP2007530561A JP2007530561A (ja) 2007-11-01
JP2007530561A5 true JP2007530561A5 (enExample) 2008-05-08
JP5274831B2 JP5274831B2 (ja) 2013-08-28

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ID=34990842

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007505094A Expired - Fee Related JP5274831B2 (ja) 2004-03-25 2005-03-22 リアノジンレセプタ(RyR2)の漏れを標的とする、新規な抗−不整脈性及び心不全用薬剤及びその使用
JP2012208868A Abandoned JP2012250999A (ja) 2004-03-25 2012-09-21 リアノジンレセプタ(RyR2)の漏れを標的とする、新規な抗−不整脈性及び心不全用薬剤及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012208868A Abandoned JP2012250999A (ja) 2004-03-25 2012-09-21 リアノジンレセプタ(RyR2)の漏れを標的とする、新規な抗−不整脈性及び心不全用薬剤及びその使用

Country Status (25)

Country Link
US (1) US7718644B2 (enExample)
EP (3) EP2127654B1 (enExample)
JP (2) JP5274831B2 (enExample)
KR (2) KR20070041432A (enExample)
CN (2) CN101704799B (enExample)
AU (1) AU2005227907B2 (enExample)
BR (1) BRPI0509199A (enExample)
CA (1) CA2560866A1 (enExample)
CY (1) CY1113426T1 (enExample)
DK (1) DK2163248T3 (enExample)
EA (1) EA015010B1 (enExample)
ES (1) ES2394104T3 (enExample)
GE (1) GEP20115301B (enExample)
HR (1) HRP20120938T1 (enExample)
IL (1) IL178157A (enExample)
MA (1) MA28629B1 (enExample)
NO (1) NO20064843L (enExample)
NZ (1) NZ550750A (enExample)
PL (1) PL2163248T3 (enExample)
PT (1) PT2163248E (enExample)
RS (1) RS52601B (enExample)
SG (1) SG153862A1 (enExample)
SI (1) SI2163248T1 (enExample)
UA (1) UA96914C2 (enExample)
WO (1) WO2005094457A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1961377A4 (en) * 2005-12-14 2009-03-04 Eisai R&D Man Co Ltd METHOD FOR EVALUATING THE QT INTERVAL EXTENSION EFFECT OF AN ELECTROCARDIOGRAM
WO2007127145A2 (en) * 2006-04-25 2007-11-08 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of cardiac arrhythmia in non-human animals
US20110263569A1 (en) * 2007-08-22 2011-10-27 President And Fellows Of Harvard College Ryanodine channel binders and uses thereof
US8618282B2 (en) 2008-03-03 2013-12-31 Les Laboratoires Servier Process for preparing benzothiazepines from gamma-aminoalkylbenzenes
JP4808825B2 (ja) 2009-02-25 2011-11-02 昇 金子 1,4−ベンゾチアゼピン−1−オキシド誘導体、及びそれを用いた医薬組成物
WO2010114562A1 (en) * 2009-04-03 2010-10-07 Sequel Pharmaceuticals, Inc. Improved methods of administration of k201 (jtv-519) (4-[3-{1-(4-benzyl) piperidinyl}propionyl]-7-methoxy 2, 3, 4, 5-tetrahydro-1, 4-benzothiazepine monohydrochloride)
WO2010120382A1 (en) 2009-04-15 2010-10-21 State Of Oregon By And Through The State Board Of Higher Education On Behalf Of Portland State University Compounds and methods for modulating activity of calcium release channels
WO2012019076A1 (en) * 2010-08-06 2012-02-09 The Trustees Of Columbia University In The City Of New York Compositions and methods for preventing and treating cardiac ischemia/reperfusion injury
EP2708535A1 (en) * 2012-05-11 2014-03-19 Les Laboratoires Servier Agents for treating disorders involving modulation of ryanodine receptors
US10786543B2 (en) 2015-09-22 2020-09-29 The Johns Hopkins University P75NTR antagonists and treatment of acute and chronic cardiac disease
US11426415B2 (en) 2017-03-06 2022-08-30 Washington University Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders
CN109010799B (zh) * 2018-07-09 2021-07-06 沣潮医药科技(上海)有限公司 RyR2蛋白或RyR2重组蛋白在制备抗心力衰竭药物中的用途
WO2022246114A2 (en) * 2021-05-20 2022-11-24 Armgo Pharma, Inc. Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof
CN115631871B (zh) * 2022-12-22 2023-03-24 北京大学第三医院(北京大学第三临床医学院) 一种药物相互作用等级的确定方法和装置

Family Cites Families (202)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1060786A (en) * 1963-10-09 1967-03-08 Wander Ag Dr A Process for the preparation of lactams
US3519647A (en) 1966-10-12 1970-07-07 Squibb & Sons Inc 2,3,4,5-tetrahydro-1,5-benzothiazepines
DE3561317D1 (en) * 1984-01-27 1988-02-11 Ajinomoto Kk Manufacture of heptanoic acid derivatives
EP0238700B1 (en) 1986-03-27 1991-01-23 Topy Industries, Limited Carbon monoxide oxidizing catalyst
US4567254A (en) * 1984-09-19 1986-01-28 Kikkoman Corporation Method for preparing N6,8-disubstituted 3',5'-cyclic adenosine monophosphate and salt thereof
US4849535A (en) 1985-02-26 1989-07-18 Ajinomoto Co., Inc. Production of cyclopentenylheptanoic acid derivatives
US4841055A (en) * 1985-03-25 1989-06-20 Japan Tobacco Inc. Desmosine derivatives and reagent for preparing artificial antigens
US4723012A (en) * 1985-03-25 1988-02-02 Japan Tobacco Inc. Desmosine derivatives having a disulfide bond and preparation of artificial antigen using the same
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
JPS63227599A (ja) 1987-03-14 1988-09-21 Kirin Brewery Co Ltd アンスラサイクリン化合物およびその用途
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
DE58901634D1 (de) * 1988-11-05 1992-07-16 Bayer Ag Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen.
DE3837575A1 (de) 1988-11-05 1990-05-10 Bayer Ag Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen
JPH0662567B2 (ja) 1988-12-27 1994-08-17 麒麟麦酒株式会社 ピリジンカルボキシイミダミド誘導体、その製造中間体、製造法および用途
US5223508A (en) * 1988-12-27 1993-06-29 Kirin Beer Kabushiki Kaisha Pyridyl carboximidamide compounds useful in treating blood pressure
US5272164A (en) 1988-12-27 1993-12-21 Kirin Beer Kabushiki Kaisha Carboximidamide derivatives
US5142647A (en) 1989-04-18 1992-08-25 Japan Tobacco, Inc. Magnus measuring apparatus
ES2084706T3 (es) * 1989-09-30 1996-05-16 Kirin Brewery Metodo de produccion de plantones.
US5075293A (en) 1989-10-10 1991-12-24 The Dow Chemical Company ((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides
US5153184A (en) 1989-10-10 1992-10-06 Dowelanco ((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides
KR940000166B1 (ko) * 1989-11-09 1994-01-08 니혼다바고 상교오 가부시기가이샤 신규 글루코사민 유도체 및 이것을 막 구성성분으로서 함유한 리포솜
US4963671A (en) 1989-11-20 1990-10-16 E. R. Squibb & Sons, Inc. Process for resolving chiral intermediates used in making calcium channel blockers
US5214056A (en) * 1989-12-27 1993-05-25 Japan Tobacco Inc. 1,3,2-dioxathiolane oxide derivative
CA2056453A1 (en) * 1990-03-30 1991-10-01 Koji Kobayashi 4h-3, 1-benzoxazin-4-one derivative
JP2651043B2 (ja) * 1990-07-10 1997-09-10 麒麟麦酒株式会社 ジフェニルメチルピペラジン誘導体
US5082847A (en) 1990-07-18 1992-01-21 Syntex (U.S.A.) Inc. Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
US5064810A (en) 1990-09-14 1991-11-12 Jeffrey Askanazi Use of branched chain amino acids to effect diaphragm contractility and fatigue
JP2703408B2 (ja) 1990-12-28 1998-01-26 麒麟麦酒株式会社 1,4‐ベンゾチアゼピン誘導体
DE4102103A1 (de) * 1991-01-25 1992-08-20 Bayer Ag Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5332734A (en) 1991-04-10 1994-07-26 Japan Tobacco, Incorporated Oxazinone derivative
US5182272A (en) * 1991-05-03 1993-01-26 G. D. Searle & Co. 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
US5180720A (en) * 1991-05-03 1993-01-19 G. D. Searle & Co. 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
EP0552372B1 (en) 1991-07-04 1999-06-02 Japan Tobacco Inc. Process for culturing t precursor cell line
JP3239364B2 (ja) * 1991-10-11 2001-12-17 ウェルファイド株式会社 骨粗鬆症治療薬およびジアゼピン化合物
WO1993013082A1 (en) * 1991-12-20 1993-07-08 G.D. Searle & Co. Substituted dibenzoxazepines or dibenzothiazepines and their use as prostaglandin e2 antagonists
MX9300433A (es) * 1992-01-28 1994-07-29 Kirin Brewery Compuestos de piridincarboximidamina y composiciones farmaceuticas que los contienen.
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
JP2667351B2 (ja) 1992-03-24 1997-10-27 麒麟麦酒株式会社 食餌脂質消化吸収阻害剤および飲食品
US5387684A (en) * 1992-03-25 1995-02-07 The Green Cross Corporation Isoindazole compound
JP3093419B2 (ja) 1992-03-30 2000-10-03 麒麟麦酒株式会社 1,4‐ベンゾチアゼピン誘導体
US5304644A (en) * 1992-04-15 1994-04-19 G. D. Searle & Co. 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
US5478832A (en) 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
RU94046317A (ru) 1992-07-02 1996-10-20 Фудзисава Фармасьютикал Ко. Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот
EP0656356A1 (en) * 1992-08-21 1995-06-07 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
US5260286A (en) 1992-10-16 1993-11-09 Japan Tobacco, Inc. 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
JPH08503202A (ja) * 1992-11-09 1996-04-09 ザ ブーツ カンパニー ピーエルシー 治療剤
US5354758A (en) 1992-12-16 1994-10-11 Japan Tobacco Inc. Benzomorphans useful as NMDA receptor antagonists
IL108634A0 (en) 1993-02-15 1994-05-30 Wellcome Found Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them
IL108633A (en) * 1993-02-15 1998-07-15 Wellcome Found History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them
AU683653B2 (en) 1993-04-15 1997-11-20 Kirin Pharma Kabushiki Kaisha Novel sphingoglycolipid and use thereof
US5354747A (en) 1993-06-16 1994-10-11 G. D. Searle & Co. 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5461047A (en) 1993-06-16 1995-10-24 G. D. Searle & Co. 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5824862A (en) 1993-08-19 1998-10-20 Japan Tobacco Inc. DNA encoding ATP-dependent fructose 6-phosphate 1-phosphotransferase originating from plant, recombinant vector containing the same and method for changing sugar content in plant cells under low temperature
FR2709753B1 (fr) 1993-09-09 1995-12-01 Hoechst Lab Nitrates organiques, leur procédé de préparation et leur application comme médicaments.
KR0170534B1 (ko) * 1993-11-10 1999-02-18 미즈노 시게루 크로만 유도체 및 그의 제약학적 용도
JPH08127594A (ja) * 1993-11-10 1996-05-21 Mochida Pharmaceut Co Ltd Fas抗原に結合する新規蛋白質およびそれをコードするDNA
US6897295B1 (en) * 1993-11-10 2005-05-24 Mochida Pharmaceutical Co., Ltd. Antibodies and fragments thereof to Fas ligand and Fas ligand derived polypeptides
JP3914272B2 (ja) * 1993-12-28 2007-05-16 中外製薬株式会社 アドゼベリンをコードする遺伝子
JP2706755B2 (ja) * 1994-02-10 1998-01-28 日本たばこ産業株式会社 新規なベンジルアミノエトキシベンゼン誘導体
US5457182A (en) 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
US5449675A (en) 1994-06-09 1995-09-12 G. D. Searle & Co. Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use
US20040175814A1 (en) 1994-06-15 2004-09-09 Kirin Beer Kubushiki Kaisha Novel transferase and amylase, process for producing the enzymes, use thereof, and gene coding for the same
WO1995034642A1 (en) * 1994-06-15 1995-12-21 Kirin Beer Kabushiki Kaisha Novel transferase and amylase, process for producing the enzymes,use thereof, and gene coding for the same
ZA956647B (en) 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
DE69527505D1 (de) 1994-11-11 2002-08-29 Noboru Kaneko Monoklonaler antikörper gegen antiannexin-v, verfahren zu seiner herstellung und seiner verwendung
WO1996016062A1 (en) 1994-11-18 1996-05-30 Japan Tobacco Inc. Osteoporosis remedy and triazepine compound
DE4445548A1 (de) 1994-12-20 1996-06-27 Bayer Ag Verfahren zur Herstellung von 3-Fluor-4,6-dichlortoluol
AU6470096A (en) * 1995-07-19 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. Fused triazole compounds
US6632976B1 (en) 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
JP3193301B2 (ja) * 1995-09-14 2001-07-30 麒麟麦酒株式会社 生理活性タンパク質p160
US6660837B1 (en) 1995-09-14 2003-12-09 Kirin Beer Kabushiki Kaisha Modified protein derived from protein kinase N
US5906819A (en) * 1995-11-20 1999-05-25 Kirin Beer Kabushiki Kaisha Rho target protein Rho-kinase
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
US6362231B1 (en) 1996-07-08 2002-03-26 Nps Pharmaceuticals, Inc. Calcium receptor active compounds
JP3861187B2 (ja) 1996-08-02 2006-12-20 住友精化株式会社 チアゼピン誘導体の製造方法
US6111072A (en) 1996-08-26 2000-08-29 Kirin Beer Kabushiki Kaisha Rho target protein human mDia and gene encoding same
CN1273586C (zh) * 1996-12-12 2006-09-06 麒麟麦酒株式会社 β1→4N-乙酰葡糖胺基转移酶和编码该酶的基因
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
JP2894445B2 (ja) 1997-02-12 1999-05-24 日本たばこ産業株式会社 Cetp活性阻害剤として有効な化合物
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3885177B2 (ja) 1997-03-26 2007-02-21 大塚製薬株式会社 ヒト遺伝子
US6011036A (en) 1997-04-15 2000-01-04 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
DE19722317C1 (de) 1997-05-28 1998-10-08 Boehringer Ingelheim Int Das Protein des humanen Ryanodinrezeptors vom Typ 3 sowie dafür kodierende DNA-Moleküle
AUPO941497A0 (en) 1997-09-24 1997-10-16 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
JP4431798B2 (ja) 1997-10-08 2010-03-17 昇 金子 尿中のアネキシンvの分析方法及びその利用
GB9724813D0 (en) 1997-11-25 1998-01-21 Univ Nottingham Reducing muscle fatigue
JP2959765B2 (ja) * 1997-12-12 1999-10-06 日本たばこ産業株式会社 3−ピペリジル−4−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
US6562618B1 (en) * 1997-12-25 2003-05-13 Japan Tobacco, Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
US6583157B2 (en) 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
WO1999048492A1 (en) * 1998-03-26 1999-09-30 Japan Tobacco Inc. Amide derivatives and nociceptin antagonists
TR200002904T2 (tr) * 1998-04-10 2001-02-21 Japan Tobacco Inc. Amidin bileşikleri
WO1999064045A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel therapeutic agents for membrane transporters
AU4930299A (en) * 1998-07-31 2000-02-21 Kirin Beer Kabushiki Kaisha Remedies for neuropathy containing as the active ingredient galectin-1 or its derivatives
WO2000016806A1 (en) 1998-09-17 2000-03-30 Nippon Kayaku Kabushiki Kaisha Remedies for photochemotherapy
EP1147772B1 (en) 1998-12-28 2006-01-04 Noboru Kaneko Use of 1,4-benzothiazepine derivatives for the preparation of a medicament FOR the TREATMENT OF ATRIAL FIBRILLATION
WO2000058499A1 (fr) * 1999-03-30 2000-10-05 Japan Tobacco Inc. Procede pour la production d'anticorps monoclonal
WO2000071132A1 (en) 1999-05-19 2000-11-30 Japan Tobacco Inc Use of 1,4-benzothiazepine derivatives as drugs overcoming carcinostatic tolerance
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
AU7097400A (en) * 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
US6683083B1 (en) * 1999-09-30 2004-01-27 Noboru Kaneko Anticancer agents
EP1243582A4 (en) 1999-12-24 2003-06-04 Kirin Brewery CHINOLINE AND CHINAZOLINE DERIVATIVES AND MEDICATIONS CONTAINING THEM
AU2733301A (en) * 1999-12-29 2001-07-09 Glaxo Group Limited Methods and compositions related to modulators of annexin and cartilage homeostasis
WO2001051923A2 (en) 2000-01-14 2001-07-19 Mitokor Screening assays using intramitochondrial calcium
HK1049004A1 (en) 2000-01-20 2003-04-25 Eisai Co., Ltd. Nitrogenous cyclic compounds and pharmaceutical compositions containing the same
US6824973B2 (en) 2000-02-03 2004-11-30 Kirin Beer Kabushiki Kaisha Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide
US6964975B2 (en) 2000-02-18 2005-11-15 Kirin Beer Kabushiki Kaisha Isoxazole and thiazole compounds and use thereof as medicine
ZA200206459B (en) 2000-03-24 2003-08-13 Pharmacia Corp Amidino compound and salts thereof useful as nitric oxide synthase inhibitors.
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US6545170B2 (en) * 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US20060293266A1 (en) 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US6489125B1 (en) 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20030220312A1 (en) 2000-05-11 2003-11-27 G.D. Searle & Co. Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of cardiovascular disorders
CA2409437A1 (en) 2000-05-11 2001-11-22 Pharmacia Corporation Aldosterone antagonist composition for release during aldosterone acrophase
CN101498731A (zh) 2000-05-18 2009-08-05 日本烟草产业株式会社 抗协同刺激信号转导分子ailim的人单克隆抗体及其药物用途
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
EP1316548A4 (en) 2000-07-05 2004-05-19 Ajinomoto Kk ACYLSULFONAMIDE DERIVATIVES
WO2002002101A1 (fr) 2000-07-05 2002-01-10 Ajinomoto Co., Inc. Composes hypoglycemiques
CA2415826A1 (en) * 2000-07-27 2002-02-07 Pharmacia Corporation Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
AR032360A1 (es) 2000-08-01 2003-11-05 Pharmacia Corp Compuesto derivado de acido homoiminopiperidinil hexanoico, composicion farmaceutica que lo comprende y compuestos intermediarios que se usan en su preparacion
AR031129A1 (es) 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR031608A1 (es) 2000-09-15 2003-09-24 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR030741A1 (es) * 2000-09-15 2003-09-03 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-5-heptenoico y - heptinoico utiles como inhibidores de oxido nitrico sintetasa
US6936426B2 (en) * 2000-10-06 2005-08-30 Harbor-Ucla Research And Education Institute Detection of antibody mediated inflammatory auto-immune disorders
ES2405944T3 (es) * 2000-11-30 2013-06-04 Medarex, Inc. Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos zadas
US6673904B2 (en) * 2000-12-23 2004-01-06 Kirin Beer Kabushiki Kaisha Stem cell growth factor-like polypeptides
US6962926B2 (en) 2001-01-31 2005-11-08 Telik, Inc. Antagonist of MCP-1 function, and compositions and methods of use thereof
JPWO2002061076A1 (ja) * 2001-02-01 2004-06-03 持田製薬株式会社 アディポネクチン関連蛋白質
JP4817514B2 (ja) 2001-03-09 2011-11-16 協和発酵キリン株式会社 新規動物細胞用ベクターおよびその使用
JP4175113B2 (ja) 2001-03-14 2008-11-05 小野薬品工業株式会社 Ep1アンタゴニストを有効成分として含有するうつ病の治療剤
US20030054531A1 (en) * 2001-03-19 2003-03-20 Decode Genetics Ehf, Human stroke gene
WO2002078625A2 (en) 2001-03-28 2002-10-10 Pharmacia Corporation Therapeutic combinations for cardiovascular and inflammatory indications
DK1382604T3 (da) * 2001-04-27 2006-04-18 Kirin Brewery Quinolinderivater med en azolylgruppe og quinazolinderivater
JP4230681B2 (ja) 2001-07-06 2009-02-25 株式会社東芝 高耐圧半導体装置
US20030220310A1 (en) 2001-07-27 2003-11-27 Schuh Joseph R. Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
IL160845A0 (en) * 2001-09-14 2004-08-31 Tularik Inc Linked biaryl compounds
JP2003095977A (ja) * 2001-09-21 2003-04-03 Masafumi Yano 筋肉収縮・弛緩機能障害関連疾患の治療又は予防剤
US20030092706A1 (en) * 2001-11-09 2003-05-15 Johannes Barsig Combination
JP4087338B2 (ja) 2001-11-15 2008-05-21 キリンファーマ株式会社 キメラ非ヒト動物
JP2003145746A (ja) * 2001-11-16 2003-05-21 Seiko Epson Corp インクジェット記録方法及びインクジェット記録装置
US20060100195A1 (en) * 2001-11-19 2006-05-11 Takayuki Maruyama Remedies for urinary frequency
CA2469228A1 (en) * 2001-12-03 2003-06-12 Japan Tobacco Inc. Azole compound and medicinal use thereof
WO2003061699A1 (en) 2001-12-27 2003-07-31 Japan Tobacco, Inc. Remedies for allergic diseases
US20040171613A1 (en) 2001-12-27 2004-09-02 Japan Tobacco Inc. Therapeutic agent for non-immediate type allergic diseases
CA2471639A1 (en) * 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
BR0307409A (pt) 2002-02-01 2004-12-28 Dainippon Pharmaceutical Co Compostos de hidrazida de ácido 2-furanocarboxìlico, composições farmacêuticas contendo os mesmos e uso dos mesmos para preparação de um agente preventivo ou terapêutico
US20060233902A1 (en) 2002-02-14 2006-10-19 Kirin Beer Kabushiki Kaisha Compositions and foods for improving lipid metabolism
EP1557099A1 (en) * 2002-04-26 2005-07-27 Japan Tobacco Inc. Bar-like article forming device
AU2003223124A1 (en) 2002-04-26 2003-11-10 Kirin Beer Kabushiki Kaisha Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell or hematopoietic progenitor cell, and dna coding for the same
JP4113042B2 (ja) * 2002-05-24 2008-07-02 シチズンホールディングス株式会社 表示装置およびカラー表示方法
DE10237723A1 (de) 2002-08-17 2004-07-08 Aventis Pharma Deutschland Gmbh Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie
SK2332004A3 (en) * 2002-08-30 2004-12-01 Japan Tobacco Inc Dibenzylamine compound and medicinal use thereof
JP2004103256A (ja) 2002-09-04 2004-04-02 Nippon Chemicon Corp 非常灯
WO2004024717A1 (ja) 2002-09-12 2004-03-25 Kirin Beer Kabushiki Kaisha キナーゼ阻害活性を有するイソキノリン誘導体およびそれを含む医薬
CN1681519A (zh) 2002-09-20 2005-10-12 麒麟麦酒株式会社 含有作为活性成分的α-糖基神经酰胺的丙型肝炎病毒抑制剂
CA2501068C (en) 2002-10-04 2014-12-16 Kirin Beer Kabushiki Kaisha Human artificial chromosome (hac) vector
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2003301894A1 (en) 2002-11-08 2004-06-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
CN1753897A (zh) 2002-11-22 2006-03-29 日本烟草产业株式会社 稠合双环含氮杂环
EP1439221B1 (en) 2002-12-17 2007-01-24 F. Hoffmann-La Roche Ag PDE core construct
AU2004220234C1 (en) 2003-02-13 2013-01-17 Msd K.K. Novel 2-pyridinecarboxamide derivatives
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
TWI220798B (en) 2003-03-07 2004-09-01 Hitachi Cable Light-emitting diode array
WO2004082675A1 (en) 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate
JP5546715B2 (ja) 2003-03-17 2014-07-09 日本たばこ産業株式会社 Cetp阻害剤の医薬組成物
US20040235162A1 (en) 2003-03-18 2004-11-25 Kirin Beer Kabushiki Kaisha Method of preparing immunoregulatory dendritic cells and the use thereof
US20050032210A1 (en) * 2003-03-18 2005-02-10 Kirin Beer Kabushiki Kaisha Method of preparing immuno-regulatory dendritic cells and the use thereof
CL2004000544A1 (es) 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
WO2004085382A1 (ja) 2003-03-27 2004-10-07 Kirin Beer Kabushiki Kaisha 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬
KR20050119201A (ko) 2003-04-09 2005-12-20 니뽄 다바코 산교 가부시키가이샤 5원 헤테로방향족 고리 화합물 및 이의 의약적 용도
US20040229803A1 (en) 2003-04-22 2004-11-18 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of pain, inflammation or inflammation mediated disorders
WO2004093813A2 (en) 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
WO2004093816A2 (en) 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
WO2004093896A1 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合
WO2005016249A2 (en) * 2003-07-11 2005-02-24 Pharmacia Corporation Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ace inhibitor for the treatment of central nervous system damage
US7300932B2 (en) * 2003-08-07 2007-11-27 Japan Tobacco Inc. Pyrrolo[1,2-b]pyridazine derivatives
WO2005018561A2 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
WO2005023183A2 (en) * 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
US20050187221A1 (en) 2003-09-08 2005-08-25 Japan Tobacco Inc. Method of treating ischemia reperfusion injury
US7365075B2 (en) 2003-12-22 2008-04-29 Amgen Inc. Aryl sulfonamide compounds and uses related thereto
US7165879B2 (en) 2004-03-25 2007-01-23 Red Devil Equipment Company Clamp lock apparatus and method for a paint mixer
WO2005104835A2 (en) * 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
EP1743895A4 (en) 2004-04-28 2010-06-16 Aetas Pharma Co Ltd MUSCLE RELIEF ACCELERATOR AND THERAPEUTIC AGENT AGAINST MUSCLE TISSUE DISEASES SUCH AS MUSCLE RELAXATION ERRORS
US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
JP3968358B2 (ja) * 2004-06-30 2007-08-29 日本電信電話株式会社 薄型フラットツイストぺアすきまケーブル及びすきまナビゲータユニット
WO2006006741A1 (ja) * 2004-07-15 2006-01-19 Japan Tobacco Inc. 縮合ベンズアミド化合物及びバニロイド受容体1型(vr1)活性阻害剤
JP2006094849A (ja) 2004-08-30 2006-04-13 Kirin Brewery Co Ltd 相同組換え効率が向上した分化多能性細胞及びその利用
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
US7396829B2 (en) 2005-02-24 2008-07-08 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
AU2006219231B2 (en) 2005-02-28 2010-01-14 Japan Tobacco Inc. Novel aminopyridine compound with Syk inhibitory activity
WO2006098394A1 (ja) 2005-03-14 2006-09-21 Japan Tobacco Inc. 脂質吸収抑制方法および脂質吸収抑制剤
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors

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