JP2007507536A5 - - Google Patents

Download PDF

Info

Publication number
JP2007507536A5
JP2007507536A5 JP2006534204A JP2006534204A JP2007507536A5 JP 2007507536 A5 JP2007507536 A5 JP 2007507536A5 JP 2006534204 A JP2006534204 A JP 2006534204A JP 2006534204 A JP2006534204 A JP 2006534204A JP 2007507536 A5 JP2007507536 A5 JP 2007507536A5
Authority
JP
Japan
Prior art keywords
compound
following formula
subject
preparing
defined above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2006534204A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007507536A (ja
Filing date
Publication date
Priority claimed from US10/680,988 external-priority patent/US20040229781A1/en
Application filed filed Critical
Publication of JP2007507536A publication Critical patent/JP2007507536A/ja
Publication of JP2007507536A5 publication Critical patent/JP2007507536A5/ja
Abandoned legal-status Critical Current

Links

JP2006534204A 2003-10-07 2004-10-04 運動誘発性心不整脈の治療及び予防のための化合物及び方法 Abandoned JP2007507536A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/680,988 US20040229781A1 (en) 2000-05-10 2003-10-07 Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
PCT/US2004/032550 WO2005037195A2 (en) 2003-10-07 2004-10-04 Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias

Publications (2)

Publication Number Publication Date
JP2007507536A JP2007507536A (ja) 2007-03-29
JP2007507536A5 true JP2007507536A5 (enExample) 2007-11-22

Family

ID=34465444

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006534204A Abandoned JP2007507536A (ja) 2003-10-07 2004-10-04 運動誘発性心不整脈の治療及び予防のための化合物及び方法

Country Status (14)

Country Link
US (1) US20040229781A1 (enExample)
EP (1) EP1684735A4 (enExample)
JP (1) JP2007507536A (enExample)
KR (1) KR20060110290A (enExample)
CN (1) CN100502845C (enExample)
AU (1) AU2004281672A1 (enExample)
BR (1) BRPI0415434A (enExample)
CA (1) CA2541847A1 (enExample)
EA (1) EA011357B1 (enExample)
MA (1) MA28146A1 (enExample)
NO (1) NO20062063L (enExample)
SG (1) SG147414A1 (enExample)
WO (1) WO2005037195A2 (enExample)
ZA (1) ZA200603593B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
WO2006028863A1 (en) * 2004-09-01 2006-03-16 Nexmed Holdings, Inc. Transdermal antiemesis delivery system, method and composition therefor
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2008140592A2 (en) * 2006-11-29 2008-11-20 Armgo Pharma, Inc. Radioactively labeled 1,4-benzothiazepines and methods of screening for compounds that bind ryanodine receptors
EA028108B1 (ru) * 2008-03-03 2017-10-31 Армго Фарма, Инк. Способ получения бензотиазепинов из гамма-аминоалкилбензолов
WO2010120382A1 (en) * 2009-04-15 2010-10-21 State Of Oregon By And Through The State Board Of Higher Education On Behalf Of Portland State University Compounds and methods for modulating activity of calcium release channels
EP2708535A1 (en) * 2012-05-11 2014-03-19 Les Laboratoires Servier Agents for treating disorders involving modulation of ryanodine receptors
ES2643856B1 (es) 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles para la regulación de la homeostasis de calcio intracelular
EP4433062A4 (en) * 2021-11-16 2025-10-22 Rycarma Therapeutics Inc THERAPEUTIC COMPOUNDS

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1060786A (en) * 1963-10-09 1967-03-08 Wander Ag Dr A Process for the preparation of lactams
EP0150996B1 (en) * 1984-01-27 1988-01-07 Ajinomoto Co., Inc. Manufacture of heptanoic acid derivatives
US4723012A (en) * 1985-03-25 1988-02-02 Japan Tobacco Inc. Desmosine derivatives having a disulfide bond and preparation of artificial antigen using the same
US4841055A (en) * 1985-03-25 1989-06-20 Japan Tobacco Inc. Desmosine derivatives and reagent for preparing artificial antigens
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5124056A (en) * 1987-07-24 1992-06-23 Exxon Chemical Patents Inc. Polymer substituted amido-amine Mannich Base lubricant dispersant additives
JPS6445706A (en) * 1987-08-17 1989-02-20 Sumitomo Electric Industries Production of composite carbon nitride
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
DE58901634D1 (de) * 1988-11-05 1992-07-16 Bayer Ag Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen.
US5223508A (en) * 1988-12-27 1993-06-29 Kirin Beer Kabushiki Kaisha Pyridyl carboximidamide compounds useful in treating blood pressure
EP0446374B1 (en) * 1989-09-30 1996-02-07 Kirin Beer Kabushiki Kaisha Method of producing seedling
KR940000166B1 (ko) * 1989-11-09 1994-01-08 니혼다바고 상교오 가부시기가이샤 신규 글루코사민 유도체 및 이것을 막 구성성분으로서 함유한 리포솜
KR920701200A (ko) * 1990-03-30 1992-08-11 미즈노 시게루 신규의 4h-3,1-벤조옥사진-4-온 유도체
US5517652A (en) * 1990-05-30 1996-05-14 Hitachi, Ltd. Multi-media server for treating multi-media information and communication system empolying the multi-media server
JP2651043B2 (ja) * 1990-07-10 1997-09-10 麒麟麦酒株式会社 ジフェニルメチルピペラジン誘導体
JP2703408B2 (ja) * 1990-12-28 1998-01-26 麒麟麦酒株式会社 １，４‐ベンゾチアゼピン誘導体
DE4102103A1 (de) * 1991-01-25 1992-08-20 Bayer Ag Substituierte benzoxazepine und benzthiazepine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5180720A (en) * 1991-05-03 1993-01-19 G. D. Searle & Co. 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
US5182272A (en) * 1991-05-03 1993-01-26 G. D. Searle & Co. 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
JP3239364B2 (ja) * 1991-10-11 2001-12-17 ウェルファイド株式会社 骨粗鬆症治療薬およびジアゼピン化合物
WO1993013082A1 (en) * 1991-12-20 1993-07-08 G.D. Searle & Co. Substituted dibenzoxazepines or dibenzothiazepines and their use as prostaglandin e2 antagonists
MX9300433A (es) * 1992-01-28 1994-07-29 Kirin Brewery Compuestos de piridincarboximidamina y composiciones farmaceuticas que los contienen.
GB9203347D0 (en) * 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
US5387684A (en) * 1992-03-25 1995-02-07 The Green Cross Corporation Isoindazole compound
US5304644A (en) * 1992-04-15 1994-04-19 G. D. Searle & Co. 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
RU94046317A (ru) * 1992-07-02 1996-10-20 Фудзисава Фармасьютикал Ко. Новое синтетическое промежуточное соединение для получения производных и способы получения производных аминокислот
EP0656356A1 (en) * 1992-08-21 1995-06-07 Japan Tobacco Inc. Dioxacycloalkane compound with renin-inhibiting activity
EP0667866B1 (en) * 1992-11-09 1998-03-11 Knoll AG 1,4-benzothiazepines useful as neurological agents
IL108633A (en) * 1993-02-15 1998-07-15 Wellcome Found History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them
US6897295B1 (en) * 1993-11-10 2005-05-24 Mochida Pharmaceutical Co., Ltd. Antibodies and fragments thereof to Fas ligand and Fas ligand derived polypeptides
JPH08127594A (ja) * 1993-11-10 1996-05-21 Mochida Pharmaceut Co Ltd Ｆａｓ抗原に結合する新規蛋白質およびそれをコードするＤＮＡ
CA2153498A1 (en) * 1993-11-10 1995-05-18 Hidetsura Cho Chroman derivative and medicinal use thereof
JP3914272B2 (ja) * 1993-12-28 2007-05-16 中外製薬株式会社 アドゼベリンをコードする遺伝子
JP2706755B2 (ja) * 1994-02-10 1998-01-28 日本たばこ産業株式会社 新規なベンジルアミノエトキシベンゼン誘導体
DE69535865D1 (de) * 1994-06-15 2008-11-27 Kirin Brewery Transferase und Amylase, Verfahren zur Herstellung dieser Enzyme, ihre Verwendung und kodierende Gene
US6632976B1 (en) * 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
JP3193301B2 (ja) * 1995-09-14 2001-07-30 麒麟麦酒株式会社 生理活性タンパク質ｐ１６０
US5906819A (en) * 1995-11-20 1999-05-25 Kirin Beer Kabushiki Kaisha Rho target protein Rho-kinase
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
WO1998001417A1 (en) * 1996-07-08 1998-01-15 Kirin Beer Kabushiki Kaisha Calcium receptor-active compounds
US5785178A (en) * 1996-11-04 1998-07-28 Minnesota Mining And Manufacturing Co. Packaged photocurable composition
JP4246264B2 (ja) * 1996-12-12 2009-04-02 協和発酵キリン株式会社 新規β１→４Ｎ―アセチルグルコサミニルトランスフェラーゼ、それをコードする遺伝子
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
JP2894445B2 (ja) * 1997-02-12 1999-05-24 日本たばこ産業株式会社 Ｃｅｔｐ活性阻害剤として有効な化合物
JP3521382B2 (ja) * 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) * 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
WO1999018435A1 (en) * 1997-10-08 1999-04-15 International Reagents Corporation Method for analyzing annexin v in urine and use thereof
JP2959765B2 (ja) * 1997-12-12 1999-10-06 日本たばこ産業株式会社 ３−ピペリジル−４−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
US6562618B1 (en) * 1997-12-25 2003-05-13 Japan Tobacco, Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
NZ507760A (en) * 1998-03-26 2002-10-25 Japan Tobacco Inc Amide derivatives and nociceptin antagonists
SK15072000A3 (sk) * 1998-04-10 2001-08-06 Japan Tobacco Inc. Amidové zlúčeniny
EP1085890A1 (en) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Novel sodium channel drugs and uses
AU4930299A (en) * 1998-07-31 2000-02-21 Kirin Beer Kabushiki Kaisha Remedies for neuropathy containing as the active ingredient galectin-1 or its derivatives
DE69929362T2 (de) * 1998-12-28 2006-09-28 Kaneko, Noboru verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION
AU754808B2 (en) * 1999-03-30 2002-11-28 Amgen Fremont Inc. Method for preparing Monoclonal Antibody
AU7097400A (en) * 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1637140B1 (en) * 1999-09-30 2007-04-18 Noboru Kaneko Use of diphenylmethylpiperazine derivatives for the manufacture of a medicament for suppressing the proliferation of fibroblasts
US6568474B2 (en) * 1999-12-20 2003-05-27 Bj Services, Usa Rigless one-trip perforation and gravel pack system and method
WO2001047510A2 (en) * 1999-12-29 2001-07-05 Glaxo Group Limited Methods and compositions related to modulators of annexin and cartilage homeostasis
IL150651A0 (en) * 2000-01-20 2003-02-12 Eisai Co Ltd Nitrogen-containing cyclic compound and pharmaceutical compositions containing the same
US6545170B2 (en) * 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
ES2264444T3 (es) * 2000-05-03 2007-01-01 Astellas Pharma Inc. Composicion farmaceutica que comprende furosemida y conivaptan para el tratamiento de insuficiencia cardiaca congestiva.
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
ATE357257T1 (de) * 2000-07-27 2007-04-15 Pharmacia Corp Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen
MY131964A (en) * 2000-09-15 2007-09-28 Pharmacia Corp 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
AR031129A1 (es) * 2000-09-15 2003-09-10 Pharmacia Corp Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
DE60131456T2 (de) * 2000-11-30 2008-07-10 Medarex, Inc., Milpitas Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern
US6673904B2 (en) * 2000-12-23 2004-01-06 Kirin Beer Kabushiki Kaisha Stem cell growth factor-like polypeptides
CA2437021A1 (en) * 2001-02-01 2002-08-08 Mochida Pharmaceutical Co., Ltd. Adiponectin-associated protein
JP4817514B2 (ja) * 2001-03-09 2011-11-16 協和発酵キリン株式会社 新規動物細胞用ベクターおよびその使用
US7335776B2 (en) * 2001-03-14 2008-02-26 Ono Pharmaceutical Co., Ltd. Remedies for depression containing EP1 antagonist as the active ingredient
US20030054531A1 (en) * 2001-03-19 2003-03-20 Decode Genetics Ehf, Human stroke gene
EP1382604B1 (en) * 2001-04-27 2005-12-28 Kirin Beer Kabushiki Kaisha Quinoline derivative having azolyl group and quinazoline derivative
IL160845A0 (en) * 2001-09-14 2004-08-31 Tularik Inc Linked biaryl compounds
JP2003145746A (ja) * 2001-11-16 2003-05-21 Seiko Epson Corp インクジェット記録方法及びインクジェット記録装置
AU2002354056A1 (en) * 2001-11-19 2003-06-10 Ono Pharmaceutical Co., Ltd. Remedies for urinary frequency
WO2003048140A1 (en) * 2001-12-03 2003-06-12 Japan Tobacco Inc. Azole compound and medicinal use thereof
MXPA04006255A (es) * 2002-01-17 2004-09-27 Pharmacia Corp Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.
JPWO2003090570A1 (ja) * 2002-04-26 2005-08-25 日本たばこ産業株式会社 棒状物品の成形装置
JP4113042B2 (ja) * 2002-05-24 2008-07-02 シチズンホールディングス株式会社 表示装置およびカラー表示方法
US7332514B2 (en) * 2002-08-30 2008-02-19 Japan Tobacco Inc. Dibenzylamine compound and medicinal use thereof
US20050032210A1 (en) * 2003-03-18 2005-02-10 Kirin Beer Kabushiki Kaisha Method of preparing immuno-regulatory dendritic cells and the use thereof
WO2004093896A1 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
US20050070543A1 (en) * 2003-07-11 2005-03-31 Pharmacia Corporation Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ACE inhibitor for the treatment of central nervous system damage
WO2005013907A2 (en) * 2003-08-07 2005-02-17 Japan Tobacco Inc. Pyrrolo[1,2-b]pyridazine derivatives
JP2007502831A (ja) * 2003-08-20 2007-02-15 ニトロメッド インコーポレーティッド ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法
AU2004270161A1 (en) * 2003-08-28 2005-03-17 Nicox S.A. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
US7420099B2 (en) * 2004-04-22 2008-09-02 Kirin Holdings Kabushiki Kaisha Transgenic animals and uses thereof
US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
JP3968358B2 (ja) * 2004-06-30 2007-08-29 日本電信電話株式会社 薄型フラットツイストぺアすきまケーブル及びすきまナビゲータユニット
KR101042490B1 (ko) * 2004-07-15 2011-06-16 니뽄 다바코 산교 가부시키가이샤 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors

Similar Documents

Publication Publication Date Title
Fryer et al. The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P1) and hypertension (S1P3) in rat
JP2005533835A5 (enExample)
CN1277553A (zh) 血管生成促进剂和血管生成增效剂
Lague et al. Exceptional cardiac anoxia tolerance in tilapia (Oreochromis hybrid)
CN101370499A (zh) 治疗认知功能障碍的乙酰胆碱酯酶（ache）抑制剂与5-羟色胺-6（5-ht6）拮抗剂的组合
WO2005094457B1 (en) Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof
EA030333B1 (ru) Способ лечения и/или предотвращения расстройств настроения
Lahat et al. A missense mutation in CASQ2 is associated with autosomal recessive catecholamine‐induced polymorphic ventricular tachycardia in Bedouin families from Israel
Neumann et al. Cardiovascular effects of metoclopramide and domperidone on human 5-HT4-serotonin-receptors in transgenic mice and in human atrial preparations
KR890014114A (ko) 신경이완제 투여와 연관된 추체외로(extrapyramidal) 부작용의 치료방법
CN1094758C (zh) 钙通道的调整
Sherr D1 in G2
JP2009537532A5 (enExample)
JP2005504829A5 (enExample)
JP4836388B2 (ja) ｅＮＯＳ発現に起因する疾患の予防または治療薬
JPWO2002072097A1 (ja) 糖尿病由来虚血性心疾患の治療及び／または予防剤
Chen et al. Cardiac performance in inbred rat genetic models of low and high running capacity
RU2327228C1 (ru) Способ моделирования кардиовазоренальной артериальной гипертензии у крыс
Jaiswal et al. Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart.
TWI666214B (zh) 雙亞硝基鐵錯合物、包含該錯合物之藥學組合物或複合材料及其用途
CN1268395C (zh) 慢性肾脏疾病治疗药物
JP4630989B2 (ja) 心不全症状を呈するゼブラフィッシュ
Baroldi et al. Advances in cardiomyopathies
Wang et al. Parvalbumin isoforms for enhancing cardiac diastolic function
CN86107178A (zh) 用作强心剂的芳酰基噻唑酮的制备方法