MA28146A1 - Composes et methodes de traitement et de prevention d'arythmies cardiaques induites par l'exercice physique - Google Patents
Composes et methodes de traitement et de prevention d'arythmies cardiaques induites par l'exercice physiqueInfo
- Publication number
- MA28146A1 MA28146A1 MA28995A MA28995A MA28146A1 MA 28146 A1 MA28146 A1 MA 28146A1 MA 28995 A MA28995 A MA 28995A MA 28995 A MA28995 A MA 28995A MA 28146 A1 MA28146 A1 MA 28146A1
- Authority
- MA
- Morocco
- Prior art keywords
- induced
- methods
- exercise
- preventing
- jtv
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/326—Arrhythmias, e.g. ventricular fibrillation, tachycardia, atrioventricular block, torsade de pointes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Cette invention concerne un procédé visant à limiter ou à prévenir une baisse du niveau de protéines FKBP12.6 liées à RyR2 chez un sujet, une méthode de traitement ou de prévention de l'arythmie cardiaque induite par l'exercice physique chez un sujet, ainsi qu'une méthode de prévention de la mort cardiaque subite induite par l'exercice physique chez un sujet. Cette invention concerne également les utilisations de JTV-519 dans ces méthodes. Cette invention concerne en outre des méthodes permettant d'identifier des agents utilisés pour prévenir la mort cardiaque subite induite par l'exercice physique, ainsi que les agents identifiés par ces méthodes. Cette invention concerne par ailleurs des méthodes de prévention de la mort cardiaque subite induite par l'exercice physique consistant à administrer ces agents. En outre, cette invention concerne des méthodes permettant de synthétiser le JTV-519, le JTV-519 radio marqué et des intermédiaires et dérivés de la 1,4-benzothiazépine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/680,988 US20040229781A1 (en) | 2000-05-10 | 2003-10-07 | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28146A1 true MA28146A1 (fr) | 2006-09-01 |
Family
ID=34465444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28995A MA28146A1 (fr) | 2003-10-07 | 2006-05-02 | Composes et methodes de traitement et de prevention d'arythmies cardiaques induites par l'exercice physique |
Country Status (14)
Country | Link |
---|---|
US (1) | US20040229781A1 (fr) |
EP (1) | EP1684735A4 (fr) |
JP (1) | JP2007507536A (fr) |
KR (1) | KR20060110290A (fr) |
CN (1) | CN100502845C (fr) |
AU (1) | AU2004281672A1 (fr) |
BR (1) | BRPI0415434A (fr) |
CA (1) | CA2541847A1 (fr) |
EA (1) | EA011357B1 (fr) |
MA (1) | MA28146A1 (fr) |
NO (1) | NO20062063L (fr) |
SG (1) | SG147414A1 (fr) |
WO (1) | WO2005037195A2 (fr) |
ZA (1) | ZA200603593B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
EP1784150A4 (fr) * | 2004-09-01 | 2011-05-11 | Nexmed Holdings Inc | Systeme d'administration transdermique d'une composition antiemetique |
US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
WO2008140592A2 (fr) * | 2006-11-29 | 2008-11-20 | Armgo Pharma, Inc. | 1,4-benzothiazépines radioactivement marquées et procédés de criblage de composés qui lient les récepteurs de la ryanodine |
BRPI0908570A2 (pt) * | 2008-03-03 | 2020-08-04 | Les Laboratoires Servier | processo para preparar benzotiazepinas a partir de gama-aminoalquilbenzenos |
US8933129B2 (en) | 2009-04-15 | 2015-01-13 | State Of Oregon By And Through The State Board Of Higher Education On Behalf Of Portland State University | Compounds and methods for modulating activity of calcium release channels |
EP2708535A1 (fr) * | 2012-05-11 | 2014-03-19 | Les Laboratoires Servier | Agents pour le traitement de troubles impliquant la modulation de récepteurs de la ryanodine |
ES2643856B1 (es) | 2016-05-24 | 2018-08-03 | Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea | Triazoles para la regulación de la homeostasis de calcio intracelular |
WO2023091524A1 (fr) * | 2021-11-16 | 2023-05-25 | Armgo Pharma, Inc. | Composés thérapeutiques |
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CA2437021A1 (fr) * | 2001-02-01 | 2002-08-08 | Mochida Pharmaceutical Co., Ltd. | Proteine associee a l'adiponectine |
JP4817514B2 (ja) * | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
CA2440374A1 (fr) * | 2001-03-14 | 2002-09-19 | Takayuki Maruyama | Composition pharmaceutique pour le traitement de la depression comprenant un antagoniste ep1 en tant que principe actif |
US20030054531A1 (en) * | 2001-03-19 | 2003-03-20 | Decode Genetics Ehf, | Human stroke gene |
EP1382604B1 (fr) * | 2001-04-27 | 2005-12-28 | Kirin Beer Kabushiki Kaisha | Derives de quinoline ayant un groupe azolyle et derives de quinazoline |
JP4269052B2 (ja) * | 2001-09-14 | 2009-05-27 | アムジエン・インコーポレーテツド | 連結ビアリール化合物 |
JP2003145746A (ja) * | 2001-11-16 | 2003-05-21 | Seiko Epson Corp | インクジェット記録方法及びインクジェット記録装置 |
WO2003043655A1 (fr) * | 2001-11-19 | 2003-05-30 | Ono Pharmaceutical Co., Ltd. | Remedes pour la frequence urinaire |
US7163952B2 (en) * | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
BR0306643A (pt) * | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
AU2003227433A1 (en) * | 2002-04-26 | 2003-11-10 | Japan Tobacco Inc. | Bar-like article forming device |
JP4113042B2 (ja) * | 2002-05-24 | 2008-07-02 | シチズンホールディングス株式会社 | 表示装置およびカラー表示方法 |
EP1533292B1 (fr) * | 2002-08-30 | 2007-02-14 | Japan Tobacco Inc. | Compose dibenzylamine et utilisation medicinale de ce compose |
US20050032210A1 (en) * | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
WO2004093896A1 (fr) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions constituees d'un inhibiteur selectif de la cyclooxygenase-2 et d'un modulateur des canaux ioniques du potassium destinees au traitement de lesions du systeme nerveux central |
TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
US20050070543A1 (en) * | 2003-07-11 | 2005-03-31 | Pharmacia Corporation | Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ACE inhibitor for the treatment of central nervous system damage |
WO2005013907A2 (fr) * | 2003-08-07 | 2005-02-17 | Japan Tobacco Inc. | Derives de pyrrolo[1,2-b]pyridazine |
US20070010571A1 (en) * | 2003-08-20 | 2007-01-11 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
EP1667643A4 (fr) * | 2003-08-28 | 2008-03-05 | Nitromed Inc | Composes cardiovasculaires nitroses et nitrosyles, compositions et procedes d'utilisation correspondants |
NZ550106A (en) * | 2004-04-22 | 2009-06-26 | Kyowa Hakko Kirin Co Ltd | Transgenic animals and uses thereof |
US7378423B2 (en) * | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
JP3968358B2 (ja) * | 2004-06-30 | 2007-08-29 | 日本電信電話株式会社 | 薄型フラットツイストぺアすきまケーブル及びすきまナビゲータユニット |
CA2571133C (fr) * | 2004-07-15 | 2011-04-19 | Japan Tobacco Inc. | Compose benzamide fusionne et inhibiteur d'activite recepteur vanilloide 1 (vr1) |
AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
-
2003
- 2003-10-07 US US10/680,988 patent/US20040229781A1/en not_active Abandoned
-
2004
- 2004-10-04 AU AU2004281672A patent/AU2004281672A1/en not_active Abandoned
- 2004-10-04 EP EP04794052A patent/EP1684735A4/fr not_active Withdrawn
- 2004-10-04 SG SG200807427-0A patent/SG147414A1/en unknown
- 2004-10-04 CN CNB2004800346080A patent/CN100502845C/zh not_active Expired - Fee Related
- 2004-10-04 KR KR1020067008775A patent/KR20060110290A/ko not_active Application Discontinuation
- 2004-10-04 EA EA200600740A patent/EA011357B1/ru not_active IP Right Cessation
- 2004-10-04 CA CA002541847A patent/CA2541847A1/fr not_active Abandoned
- 2004-10-04 BR BRPI0415434-7A patent/BRPI0415434A/pt not_active IP Right Cessation
- 2004-10-04 JP JP2006534204A patent/JP2007507536A/ja not_active Abandoned
- 2004-10-04 WO PCT/US2004/032550 patent/WO2005037195A2/fr active Application Filing
-
2006
- 2006-05-02 MA MA28995A patent/MA28146A1/fr unknown
- 2006-05-05 ZA ZA200603593A patent/ZA200603593B/xx unknown
- 2006-05-08 NO NO20062063A patent/NO20062063L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SG147414A1 (en) | 2008-11-28 |
WO2005037195A3 (fr) | 2005-12-01 |
WO2005037195A2 (fr) | 2005-04-28 |
EP1684735A4 (fr) | 2009-01-07 |
EA011357B1 (ru) | 2009-02-27 |
ZA200603593B (en) | 2010-10-27 |
EA200600740A1 (ru) | 2006-10-27 |
NO20062063L (no) | 2006-07-07 |
CN100502845C (zh) | 2009-06-24 |
CN1886122A (zh) | 2006-12-27 |
JP2007507536A (ja) | 2007-03-29 |
AU2004281672A1 (en) | 2005-04-28 |
US20040229781A1 (en) | 2004-11-18 |
KR20060110290A (ko) | 2006-10-24 |
BRPI0415434A (pt) | 2006-12-05 |
CA2541847A1 (fr) | 2005-04-28 |
EP1684735A2 (fr) | 2006-08-02 |
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