MA27565A1 - Derives de 4-tetrazolyl-4-phenylpiperidine utilises pour le traitement de la douleur - Google Patents
Derives de 4-tetrazolyl-4-phenylpiperidine utilises pour le traitement de la douleurInfo
- Publication number
- MA27565A1 MA27565A1 MA28335A MA28335A MA27565A1 MA 27565 A1 MA27565 A1 MA 27565A1 MA 28335 A MA28335 A MA 28335A MA 28335 A MA28335 A MA 28335A MA 27565 A1 MA27565 A1 MA 27565A1
- Authority
- MA
- Morocco
- Prior art keywords
- tetrazolyl
- treatment
- methods
- phenylpiperidine
- pain
- Prior art date
Links
- OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title abstract 2
- -1 4-tetrazolyl-4-phenylpiperidine compound Chemical class 0.000 abstract 3
- 102000003840 Opioid Receptors Human genes 0.000 abstract 2
- 108090000137 Opioid Receptors Proteins 0.000 abstract 2
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne des composés de 4-tétrazolyl-4-phénylpipéridine, des compositions contenant une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine, ainsi que des procédés pour traiter et prévenir la douleur ou la diarrhée chez un animal. Lesdits procédés consistent à administrer à un animal, nécessitant un tel traitement, une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine. L'invention concerne également des procédés pour stimuler la fonction de récepteurs opioïdes dans une cellule, lesdits procédés consistant à mettre en contact une cellule pouvant exprimer un récepteur opioïde avec une quantité efficace d'un composé de 4-tétrazolyl-4-phénylpipéridine.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42738102P | 2002-11-18 | 2002-11-18 | |
US46027803P | 2003-04-03 | 2003-04-03 | |
US48848803P | 2003-07-17 | 2003-07-17 | |
US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27565A1 true MA27565A1 (fr) | 2005-10-03 |
Family
ID=32777221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28335A MA27565A1 (fr) | 2002-11-18 | 2005-06-13 | Derives de 4-tetrazolyl-4-phenylpiperidine utilises pour le traitement de la douleur |
Country Status (37)
Country | Link |
---|---|
US (3) | US7202259B2 (fr) |
EP (2) | EP1803718B1 (fr) |
JP (2) | JP4601429B2 (fr) |
KR (1) | KR20050115221A (fr) |
CN (2) | CN100567288C (fr) |
AP (1) | AP2210A (fr) |
AR (1) | AR047008A1 (fr) |
AT (2) | ATE358674T1 (fr) |
AU (2) | AU2003294313B2 (fr) |
BR (1) | BR0316305A (fr) |
CA (1) | CA2506242C (fr) |
CO (1) | CO5690588A2 (fr) |
CR (2) | CR7877A (fr) |
CY (2) | CY1107682T1 (fr) |
DE (2) | DE60313021T2 (fr) |
DK (2) | DK1803718T3 (fr) |
EA (1) | EA008621B1 (fr) |
EC (1) | ECSP055840A (fr) |
ES (2) | ES2312150T3 (fr) |
GE (1) | GEP20084539B (fr) |
HK (1) | HK1086829A1 (fr) |
IL (1) | IL209352A0 (fr) |
IS (2) | IS2720B (fr) |
MA (1) | MA27565A1 (fr) |
ME (1) | MEP48108A (fr) |
MX (1) | MXPA05004669A (fr) |
MY (1) | MY135647A (fr) |
NI (1) | NI200500087A (fr) |
NO (1) | NO20052894L (fr) |
NZ (2) | NZ572685A (fr) |
OA (1) | OA13010A (fr) |
PT (2) | PT1562932E (fr) |
RS (1) | RS51047B (fr) |
SG (1) | SG165998A1 (fr) |
SI (2) | SI1562932T1 (fr) |
TW (2) | TW200819436A (fr) |
WO (1) | WO2004046132A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
CA2522529C (fr) | 2003-04-30 | 2015-10-20 | Purdue Pharma L.P. | Forme de dosage transdermique inviolable |
US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
CA2720312A1 (fr) * | 2004-01-30 | 2005-08-18 | Euro-Celtique S.A. | Procedes d'elaboration de composes de 4-tetrazolyl-4-phenylpiperidine |
SE0401656D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
UA91250C2 (en) * | 2005-11-21 | 2010-07-12 | Пердью Фарма Л.П. | 4-oxadiazolyl-piperidine compounds and use thereof |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
CA2810356C (fr) | 2010-09-21 | 2016-06-14 | Purdue Pharma L.P. | Analogues de buprenorphine |
CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
WO2012149334A2 (fr) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Procédés et compositions pour préparer et utiliser des anticorps spécifiques à une conformation |
EP3333156A3 (fr) | 2012-11-09 | 2018-09-26 | Purdue Pharma L.P. | Analogues de benzomorphane et leur utilisation |
JP6317755B2 (ja) | 2012-12-07 | 2018-04-25 | パーデュー、ファーマ、リミテッド、パートナーシップ | オピオイド受容体モジュレーターとしてのブプレノルフィン類似体 |
US8980906B2 (en) | 2012-12-14 | 2015-03-17 | Purdue Pharma L.P. | Pyridonemorphinan analogs and biological activity on opioid receptors |
JP6141444B2 (ja) | 2012-12-14 | 2017-06-07 | パーデュー、ファーマ、リミテッド、パートナーシップ | スピロ環式モルフィナンおよびこれらの使用 |
CA2900023A1 (fr) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Analogues de benzomorphane et leur utilisation |
US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
WO2015097548A1 (fr) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Analogues 7-bêta-alkyle d'orvinols |
US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
EP3087073B1 (fr) | 2013-12-26 | 2018-07-04 | Purdue Pharma LP | Hydantoïnes de morphinane substitués en position 10 |
EP3087079B1 (fr) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés |
AU2014370062A1 (en) | 2013-12-26 | 2016-08-11 | Purdue Pharma L.P. | Ring-contracted morphinans and the use thereof |
EP3086790A4 (fr) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations |
CA2950567A1 (fr) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Morphinanes spirocycliques et utilisation associee |
EP3154972A4 (fr) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Dérivés d'azamophinan et leur utilisation |
MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
JP2019509321A (ja) | 2016-03-22 | 2019-04-04 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 疼痛を処置するための組み合わせ |
PE20190403A1 (es) | 2016-07-29 | 2019-03-13 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata |
US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
MX2023013514A (es) * | 2021-05-21 | 2024-04-02 | Purdue Pharma Lp | Metodos para tratar la cistitis intersticial/sindrome de dolor en la vejiga. |
WO2023250190A1 (fr) * | 2022-06-24 | 2023-12-28 | Purdue Pharma L.P. | Méthodes de traitement ou de prévention du syndrome de la vessie hyperactive |
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-
2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en active Active
- 2003-11-17 EP EP07006697A patent/EP1803718B1/fr not_active Expired - Lifetime
- 2003-11-17 AT AT03789796T patent/ATE358674T1/de active
- 2003-11-17 EP EP03789796A patent/EP1562932B9/fr not_active Expired - Lifetime
- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
- 2003-11-17 ES ES07006697T patent/ES2312150T3/es not_active Expired - Lifetime
- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/fr active Search and Examination
- 2003-11-17 BR BR0316305-9A patent/BR0316305A/pt not_active IP Right Cessation
- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
- 2003-11-17 PT PT03789796T patent/PT1562932E/pt unknown
- 2003-11-17 NZ NZ572685A patent/NZ572685A/en not_active IP Right Cessation
- 2003-11-17 DK DK07006697T patent/DK1803718T3/da active
- 2003-11-17 PT PT07006697T patent/PT1803718E/pt unknown
- 2003-11-17 AT AT07006697T patent/ATE402167T1/de active
- 2003-11-17 EA EA200500726A patent/EA008621B1/ru not_active IP Right Cessation
- 2003-11-17 AP AP2005003297A patent/AP2210A/xx active
- 2003-11-17 RS YUP-2005/0375A patent/RS51047B/sr unknown
- 2003-11-17 CA CA2506242A patent/CA2506242C/fr not_active Expired - Fee Related
- 2003-11-17 ES ES03789796T patent/ES2285235T3/es not_active Expired - Lifetime
- 2003-11-17 NZ NZ540068A patent/NZ540068A/en not_active IP Right Cessation
- 2003-11-17 GE GEAP20038846A patent/GEP20084539B/en unknown
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