MA31761B1 - Nouveaux inhibiteurs de seh et leur utilisation - Google Patents
Nouveaux inhibiteurs de seh et leur utilisationInfo
- Publication number
- MA31761B1 MA31761B1 MA32751A MA32751A MA31761B1 MA 31761 B1 MA31761 B1 MA 31761B1 MA 32751 A MA32751 A MA 32751A MA 32751 A MA32751 A MA 32751A MA 31761 B1 MA31761 B1 MA 31761B1
- Authority
- MA
- Morocco
- Prior art keywords
- seh
- relates
- compounds
- compound
- treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
La présente invention concerne de nouveaux inhibiteurs de seh et leur utilisation dans le traitement de maladies médiées par l'enzyme seh. De façon spécifique, l'invention concerne des composés répondant à la formule i : r1, r2, r5, r6, a, b, y, z, n, et m étant définis ci-après, et des sels pharmaceutiquement acceptables de ces composés. Les composés de l'invention sont des inhibiteurs de seh et peuvent être utilisés dans le traitement de maladies médiées par l'enzyme seh, telles que l'hypertension. Par conséquent, l'invention concerne également des compositions pharmaceutiques contenant un composé de l'invention. L'invention concerne de plus des procédés d'inhibition de seh et le traitement de pathologies y étant associées au moyen d'un composé de l'invention ou d'une composition pharmaceutique contenant un composé de l'invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97915407P | 2007-10-11 | 2007-10-11 | |
PCT/US2008/079517 WO2009049157A1 (fr) | 2007-10-11 | 2008-10-10 | Nouveaux inhibiteurs de seh et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31761B1 true MA31761B1 (fr) | 2010-10-01 |
Family
ID=40549589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32751A MA31761B1 (fr) | 2007-10-11 | 2010-04-08 | Nouveaux inhibiteurs de seh et leur utilisation |
Country Status (29)
Country | Link |
---|---|
US (2) | US8173805B2 (fr) |
EP (1) | EP2214487B1 (fr) |
JP (1) | JP5372943B2 (fr) |
KR (1) | KR101546111B1 (fr) |
CN (1) | CN101896065B (fr) |
AU (1) | AU2008310732B2 (fr) |
BR (1) | BRPI0817542A2 (fr) |
CA (1) | CA2702265C (fr) |
CO (1) | CO6270285A2 (fr) |
CR (1) | CR11423A (fr) |
CY (1) | CY1114865T1 (fr) |
DK (1) | DK2214487T3 (fr) |
DO (1) | DOP2010000101A (fr) |
EA (1) | EA018414B1 (fr) |
ES (1) | ES2445444T3 (fr) |
HK (1) | HK1141211A1 (fr) |
HR (1) | HRP20140105T1 (fr) |
IL (1) | IL204889A (fr) |
MA (1) | MA31761B1 (fr) |
MX (1) | MX2010003942A (fr) |
MY (1) | MY157116A (fr) |
NZ (1) | NZ584471A (fr) |
PL (1) | PL2214487T3 (fr) |
PT (1) | PT2214487E (fr) |
RS (1) | RS53180B (fr) |
SI (1) | SI2214487T1 (fr) |
UA (1) | UA107444C2 (fr) |
WO (1) | WO2009049157A1 (fr) |
ZA (1) | ZA201002465B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008105968A1 (fr) | 2006-11-03 | 2008-09-04 | Smithkline Beecham Corporation | Nouveaux inhibiteurs de seh et utilisation de ces derniers |
WO2009049165A1 (fr) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Inhibiteurs inédits de la seh et leur utilisation |
SI2214487T1 (sl) * | 2007-10-11 | 2014-03-31 | Glaxosmithkline Llc | Novi sEH inhibitorji in njihova uporaba |
FR2948027A1 (fr) | 2009-07-17 | 2011-01-21 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion |
EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
US8809552B2 (en) * | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
WO2015003360A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
WO2015104422A1 (fr) | 2014-01-13 | 2015-07-16 | Basf Se | Composés dihydrothiophène dans la lutte contre des nuisibles invertébrés |
WO2015155129A1 (fr) * | 2014-04-07 | 2015-10-15 | Basf Se | Composé de diaminotriazine |
US10308648B2 (en) | 2014-10-16 | 2019-06-04 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420283A (en) * | 1993-08-02 | 1995-05-30 | Pfizer Inc. | Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide |
CA2348740A1 (fr) * | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Inhibiteurs de la thrombine ou du facteur xa |
US6630478B2 (en) * | 2000-07-07 | 2003-10-07 | Neotherapeutics, Inc. | Methods for treatment of drug-induced peripheral neuropathy |
US6451814B1 (en) * | 2000-07-17 | 2002-09-17 | Wyeth | Heterocyclic β-3 adrenergic receptor agonists |
KR100589032B1 (ko) | 2000-10-20 | 2006-06-14 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
WO2002058736A2 (fr) * | 2000-12-12 | 2002-08-01 | Neotherapetics, Inc. | Utilisation d'analogues de purine a substitution en position 9 et d'autres molecules pour stimuler la neurogenese |
PL210066B1 (pl) * | 2000-12-21 | 2011-11-30 | Vertex Pharma | Związek pirazolowy, kompozycja zawierająca ten związek i jego zastosowania |
MXPA03011681A (es) * | 2001-06-29 | 2004-03-19 | Boehringer Ingelheim Pharma | Uso de inhibidores de epoxido hidrolasa soluble, para tratar enfermedades relacionadas con la enfermedad cardiovascular. |
US20030055249A1 (en) | 2001-07-17 | 2003-03-20 | Fick David B. | Synthesis and methods of use of pyrimidine analogues and derivatives |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
PT1479397E (pt) * | 2002-02-05 | 2011-09-01 | Astellas Pharma Inc | Derivados de 2,4,6-triamino-1,3,5-triazina |
US20040087653A1 (en) | 2002-05-16 | 2004-05-06 | Manning Pamela T. | Methods for the treatment of respiratory diseases and conditions with a selective iNOS inhibitor and a PDE inhibitor and compositions therefor |
EP1464335A3 (fr) | 2003-03-31 | 2007-05-09 | Taisho Pharmaceutical Co. Ltd. | Derivés de quinolines, tetrahydroquinolines et pyrimidines comme antagonistes du MCH |
KR20060032190A (ko) * | 2003-07-02 | 2006-04-14 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널의 조절제로서 유용한 피리미딘 |
WO2005028467A1 (fr) * | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Composes heteroaromatiques et aromatiques a substitution 3,5-diaminopiperidine antibacteriens |
WO2005028438A1 (fr) * | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de piperidine |
GB0401269D0 (en) | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
CA2580838A1 (fr) * | 2004-09-27 | 2006-04-06 | Amgen Inc. | Composes heterocycliques substitues et procedes d'utilisation |
WO2006053109A1 (fr) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Composes heteroaryle |
US20060142572A1 (en) | 2004-12-14 | 2006-06-29 | Gabriel Martinez-Botella | Inhibitors of ERK protein kinase and uses thereof |
CA2608248A1 (fr) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Inhibiteurs de l'epoxyde hydrolase soluble et leurs methodes d'utilisation |
CA2622754A1 (fr) * | 2005-10-07 | 2007-04-19 | Boehringer Ingelheim International Gmbh | Composes de pyridinone ou pyrimidinone n-substitues utiles en tant qu'inhibiteurs d'epoxyde hydrolase soluble |
EP1987004A2 (fr) * | 2006-02-16 | 2008-11-05 | Boehringer Ingelheim International GmbH | Pyridineamides substitués pouvant être employés en tant qu'inhibiteurs d'époxyde hydrolase soluble |
AR059826A1 (es) | 2006-03-13 | 2008-04-30 | Univ California | Inhibidores de urea conformacionalmente restringidos de epoxido hidrolasa soluble |
WO2008105968A1 (fr) * | 2006-11-03 | 2008-09-04 | Smithkline Beecham Corporation | Nouveaux inhibiteurs de seh et utilisation de ces derniers |
SI2214487T1 (sl) | 2007-10-11 | 2014-03-31 | Glaxosmithkline Llc | Novi sEH inhibitorji in njihova uporaba |
WO2009049165A1 (fr) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Inhibiteurs inédits de la seh et leur utilisation |
WO2009049154A1 (fr) | 2007-10-11 | 2009-04-16 | Smithkline Beecham Corporation | Nouveaux inhibiteurs de seh et leur utilisation |
WO2009048154A1 (fr) | 2007-10-12 | 2009-04-16 | Nec Corporation | Dispositif à semi-conducteurs et son procédé de conception |
WO2009070497A1 (fr) | 2007-11-28 | 2009-06-04 | Smithkline Beecham Corporation | Inhibiteurs de ehs et de 11β-hsd1 et leur utilisation |
WO2009073772A1 (fr) | 2007-12-06 | 2009-06-11 | Smithkline Beecham Corporation | Nouveaux inhibiteurs de seh et leur utilisation |
JP2011510998A (ja) * | 2008-01-30 | 2011-04-07 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規sEH阻害剤およびその使用 |
US20100311775A1 (en) * | 2008-01-30 | 2010-12-09 | Smithkline Beecham Corporation | Novel sEH Inhibitors and Their Use |
JP2011510996A (ja) * | 2008-01-30 | 2011-04-07 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規sEH阻害剤およびその使用 |
WO2010011917A1 (fr) | 2008-07-25 | 2010-01-28 | Glaxosmithkline Llc | Inhibiteurs doubles de seh et 11β-hsd1 |
-
2008
- 2008-10-10 SI SI200831142T patent/SI2214487T1/sl unknown
- 2008-10-10 RS RS20140078A patent/RS53180B/en unknown
- 2008-10-10 CA CA2702265A patent/CA2702265C/fr active Active
- 2008-10-10 UA UAA201005720A patent/UA107444C2/uk unknown
- 2008-10-10 PT PT88383146T patent/PT2214487E/pt unknown
- 2008-10-10 AU AU2008310732A patent/AU2008310732B2/en active Active
- 2008-10-10 KR KR1020107010233A patent/KR101546111B1/ko active IP Right Grant
- 2008-10-10 NZ NZ584471A patent/NZ584471A/en unknown
- 2008-10-10 MY MYPI2010001613A patent/MY157116A/en unknown
- 2008-10-10 ES ES08838314.6T patent/ES2445444T3/es active Active
- 2008-10-10 DK DK08838314.6T patent/DK2214487T3/da active
- 2008-10-10 US US12/682,073 patent/US8173805B2/en active Active
- 2008-10-10 WO PCT/US2008/079517 patent/WO2009049157A1/fr active Application Filing
- 2008-10-10 EA EA201070442A patent/EA018414B1/ru not_active IP Right Cessation
- 2008-10-10 EP EP08838314.6A patent/EP2214487B1/fr active Active
- 2008-10-10 PL PL08838314T patent/PL2214487T3/pl unknown
- 2008-10-10 BR BRPI0817542-0A2A patent/BRPI0817542A2/pt active Search and Examination
- 2008-10-10 MX MX2010003942A patent/MX2010003942A/es active IP Right Grant
- 2008-10-10 JP JP2010529081A patent/JP5372943B2/ja active Active
- 2008-10-10 CN CN200880120430XA patent/CN101896065B/zh active Active
-
2010
- 2010-04-06 IL IL204889A patent/IL204889A/en active IP Right Grant
- 2010-04-08 MA MA32751A patent/MA31761B1/fr unknown
- 2010-04-08 ZA ZA2010/02465A patent/ZA201002465B/en unknown
- 2010-04-09 US US12/757,089 patent/US8212032B2/en active Active
- 2010-04-09 DO DO2010000101A patent/DOP2010000101A/es unknown
- 2010-05-06 CO CO10054262A patent/CO6270285A2/es active IP Right Grant
- 2010-05-11 CR CR11423A patent/CR11423A/es unknown
- 2010-08-11 HK HK10107690.6A patent/HK1141211A1/xx unknown
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2014
- 2014-02-05 HR HRP20140105AT patent/HRP20140105T1/hr unknown
- 2014-02-18 CY CY20141100122T patent/CY1114865T1/el unknown
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MA33178B1 (fr) | Pipéridines substituées comme antagonistes de ccr3 | |
TNSN07275A1 (fr) | Derives de triazole substitues, servant d'antagonistes d'ocytocine | |
MA27560A1 (fr) | Nouveaux derives de fluorglycoside heterocycliques, produits pharmaceutiques contenant ces composes et leur utilisation | |
MA31373B1 (fr) | Composes amino-heterocycliques | |
MA33836B1 (fr) | Compositions pharmaceutiques contenant des ligands des récepteurs sigma | |
MA26697A1 (fr) | Composes nouveaux inhibiteurs de gsk-3 et compositions pharmaceutiques les contenant | |
MA27389A1 (fr) | Derives de benzimidazole nouveaux utiles comme agents antiproliferatifs. | |
MA32231B1 (fr) | Composés organiques | |
MA30232B1 (fr) | Inhibiteurs de kinase bases sur l'hydantoine | |
MA31894B1 (fr) | Composes organiques | |
MA30333B1 (fr) | Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete. | |
TNSN07349A1 (fr) | Derives de n-(n-sulfonylaminomethyl) cyclopropanecarboxamide utiles pour le traitement de la douleur | |
MA31766B1 (fr) | Composés organiques | |
MA30652B1 (fr) | Composes organiques | |
MA31873B1 (fr) | Inhibiteurs de la peptide déformylase | |
MA32887B1 (fr) | Aminotetrahydropyranes en tant qu'inhibiteurs de dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete |