CN1711256A - 用于治疗疼痛的4-四唑基-4-苯基哌啶衍生物 - Google Patents
用于治疗疼痛的4-四唑基-4-苯基哌啶衍生物 Download PDFInfo
- Publication number
- CN1711256A CN1711256A CNA2003801035027A CN200380103502A CN1711256A CN 1711256 A CN1711256 A CN 1711256A CN A2003801035027 A CNA2003801035027 A CN A2003801035027A CN 200380103502 A CN200380103502 A CN 200380103502A CN 1711256 A CN1711256 A CN 1711256A
- Authority
- CN
- China
- Prior art keywords
- compound
- tetrazolyl
- alkyl
- pharmaceutically acceptable
- phenylpiperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 208000002193 Pain Diseases 0.000 title claims abstract description 55
- OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title abstract description 283
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- 239000003277 telomerase inhibitor Substances 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- LZNWYQJJBLGYLT-UHFFFAOYSA-N tenoxicam Chemical compound OC=1C=2SC=CC=2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 LZNWYQJJBLGYLT-UHFFFAOYSA-N 0.000 description 1
- 229960005353 testolactone Drugs 0.000 description 1
- BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- WXZSUBHBYQYTNM-WMDJANBXSA-N tetrazomine Chemical compound C=1([C@@H]2CO[C@@H]3[C@H]4C[C@@H](CO)[C@H](N4C)[C@@H](N23)CC=1C=C1)C(OC)=C1NC(=O)C1NCCC[C@H]1O WXZSUBHBYQYTNM-WMDJANBXSA-N 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- XCTYLCDETUVOIP-UHFFFAOYSA-N thiethylperazine Chemical compound C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 XCTYLCDETUVOIP-UHFFFAOYSA-N 0.000 description 1
- 229960004869 thiethylperazine Drugs 0.000 description 1
- VZYCZNZBPPHOFY-UHFFFAOYSA-N thioproperazine Chemical compound C12=CC(S(=O)(=O)N(C)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 VZYCZNZBPPHOFY-UHFFFAOYSA-N 0.000 description 1
- 229960003397 thioproperazine Drugs 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 108010013515 thymopoietin receptor Proteins 0.000 description 1
- PBJUNZJWGZTSKL-MRXNPFEDSA-N tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 description 1
- 229960001918 tiagabine Drugs 0.000 description 1
- 229960005138 tianeptine Drugs 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- 229960001402 tilidine Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 description 1
- 229960003087 tioguanine Drugs 0.000 description 1
- 229950002376 tirapazamine Drugs 0.000 description 1
- QVMPZNRFXAKISM-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=C2[N+]([O-])=NC(=N)N(O)C2=C1 QVMPZNRFXAKISM-UHFFFAOYSA-N 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229950000245 toliprolol Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 229950003873 triciribine Drugs 0.000 description 1
- HOGVTUZUJGHKPL-HTVVRFAVSA-N triciribine Chemical compound C=12C3=NC=NC=1N(C)N=C(N)C2=CN3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O HOGVTUZUJGHKPL-HTVVRFAVSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- IRYJRGCIQBGHIV-UHFFFAOYSA-N trimethadione Chemical compound CN1C(=O)OC(C)(C)C1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 229960004453 trimethadione Drugs 0.000 description 1
- FEZBIKUBAYAZIU-UHFFFAOYSA-N trimethobenzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)NCC=2C=CC(OCCN(C)C)=CC=2)=C1 FEZBIKUBAYAZIU-UHFFFAOYSA-N 0.000 description 1
- 229960004161 trimethobenzamide Drugs 0.000 description 1
- SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
- 229960002431 trimipramine Drugs 0.000 description 1
- ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- FQCQGOZEWWPOKI-UHFFFAOYSA-K trisalicylate-choline Chemical compound [Mg+2].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O FQCQGOZEWWPOKI-UHFFFAOYSA-K 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
- 229950009811 ubenimex Drugs 0.000 description 1
- 229960001055 uracil mustard Drugs 0.000 description 1
- SPDZFJLQFWSJGA-UHFFFAOYSA-N uredepa Chemical compound C1CN1P(=O)(NC(=O)OCC)N1CC1 SPDZFJLQFWSJGA-UHFFFAOYSA-N 0.000 description 1
- 229950006929 uredepa Drugs 0.000 description 1
- AUFUWRKPQLGTGF-FMKGYKFTSA-N uridine triacetate Chemical compound CC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@H](COC(=O)C)O[C@H]1N1C(=O)NC(=O)C=C1 AUFUWRKPQLGTGF-FMKGYKFTSA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- XLQGICHHYYWYIU-UHFFFAOYSA-N veramine Natural products O1C2CC3C4CC=C5CC(O)CCC5(C)C4CC=C3C2(C)C(C)C21CCC(C)CN2 XLQGICHHYYWYIU-UHFFFAOYSA-N 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 description 1
- 229960005318 vigabatrin Drugs 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
- 229960004982 vinblastine sulfate Drugs 0.000 description 1
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
- 229960002110 vincristine sulfate Drugs 0.000 description 1
- 229960005212 vindesine sulfate Drugs 0.000 description 1
- BCXOZISMDZTYHW-IFQBWSDRSA-N vinepidine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@H](C2)CC)N2CCC2=C1NC1=CC=CC=C21 BCXOZISMDZTYHW-IFQBWSDRSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002166 vinorelbine tartrate Drugs 0.000 description 1
- GBABOYUKABKIAF-IWWDSPBFSA-N vinorelbinetartrate Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC(C23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IWWDSPBFSA-N 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- DVPVGSLIUJPOCJ-XXRQFBABSA-N x1j761618a Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 DVPVGSLIUJPOCJ-XXRQFBABSA-N 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960002911 zonisamide Drugs 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
化合物号: | G: | R1: |
AAA | -H | -H |
AAB | -CH2C(O)NH2 | -H |
AAC | -CH2C(O)N(CH3)2 | -H |
AAD | -C(O)CH2NHSO2CH3 | -H |
AAE | -(CH2)2C(O)NH2 | -H |
AAF | -(CH2)2C(O)N(CH3)2 | -H |
AAG | -C(O)(CH2)2NHSO2CH3 | -H |
AAH | -CH2CO2CH3 | -H |
AAI | -CH2CO2CH2CH3 | -H |
AAJ | -(CH2)2CO2CH3 | -H |
AAK | -(CH2)2CO2CH2CH3 | -H |
AAL | -(CH2)3CO2CH3 | -H |
AAM | -(CH2)3CO2CH2CH3 | -H |
AAN | -(CH2)4CO2CH3 | -H |
AAO | -(CH2)4CO2CH2CH3 | -H |
AAP | -CH2SO2NH2 | -H |
AAQ | -CH2SO2N(CH3)2 | -H |
AAR | -(CH2)2NHSO2H | -H |
AAS | -(CH2)2NHSO2CH3 | -H |
AAT | -H | -C(O)NH2 |
AAU | -CH2C(O)NH2 | -C(O)NH2 |
AAV | -CH2C(O)N(CH3)2 | -C(O)NH2 |
AAW | -CH2NHSO2CH3 | -C(O)NH2 |
AAX | -(CH2)2C(O)NH2 | -C(O)NH2 |
AAY | -(CH2)2C(O)N(CH3)2 | -C(O)NH2 |
AAZ | -(CH2)2NHSO2CH3 | -C(O)NH2 |
ABA | -CH2CO2CH3 | -C(O)NH2 |
ABB | -CH2CO2CH2CH3 | -C(O)NH2 |
ABC | -(CH2)2CO2CH3 | -C(O)NH2 |
ABD | -(CH2)2CO2CH2CH3 | -C(O)NH2 |
ABE | -(CH2)3CO2CH3 | -C(O)NH2 |
ABF | -(CH2)3CO2CH2CH3 | -C(O)NH2 |
ABG | -(CH2)4CO2CH3 | -C(O)NH2 |
ABH | -(CH2)4CO2CH2CH3 | -C(O)NH2 |
ABI | -CH2SO2NH2 | -C(O)NH2 |
ABJ | -CH2SO2N(CH3)2 | -C(O)NH2 |
ABK | -(CH2)2NHSO2H | -C(O)NH2 |
ABL | -(CH2)2NHSO2CH3 | -C(O)NH2 |
ABM | -H | -CO2CH3 |
ABN | -CH2C(O)NH2 | -CO2CH3 |
ABO | -CH2C(O)N(CH3)2 | -CO2CH3 |
ABP | -C(O)CH2NHSO2CH3 | -CO2CH3 |
ABQ | -(CH2)2C(O)NH2 | -CO2CH3 |
ABR | -(CH2)2C(O)N(CH3)2 | -CO2CH3 |
ABS | -C(O)(CH2)2NHSO2CH3 | -CO2CH3 |
ABT | -CH2CO2CH3 | -CO2CH3 |
ABU | -CH2CO2CH2CH3 | -CO2CH3 |
ABV | -(CH2)2CO2CH3 | -CO2CH3 |
ABW | -(CH2)2CO2CH2CH3 | -CO2CH3 |
ABX | -(CH2)3CO2CH3 | -CO2CH3 |
ABY | -(CH2)3CO2CH2CH3 | -CO2CH3 |
ABZ | -(CH2)4CO2CH3 | -CO2CH3 |
ACA | -(CH2)4CO2CH2CH3 | -CO2CH3 |
ACB | -CH2SO2NH2 | -CO2CH3 |
ACC | -CH2SO2N(CH3)2 | -CO2CH3 |
ACD | -(CH2)2NHSO2H | -CO2CH3 |
ACE | -(CH2)2NHSO2CH3 | -CO2CH3 |
ACF | -H | -CHO |
ACG | -CH2C(O)NH2 | -CHO |
ACH | -CH2C(O)N(CH3)2 | -CHO |
ACI | -C(O)CH2NHSO2CH3 | -CHO |
ACJ | -(CH2)2C(O)NH2 | -CHO |
ACK | -(CH2)2C(O)N(CH3)2 | -CHO |
ACL | -C(O)(CH2)2NHSO2CH3 | -CHO |
ACM | -CH2CO2CH3 | -CHO |
ACN | -CH2CO2CH2CH3 | -CHO |
ACO | -(CH2)2CO2CH3 | -CHO |
ACP | -(CH2)2CO2CH2CH3 | -CHO |
ACQ | -(CH2)3CO2CH3 | -CHO |
ACR | -(CH2)3CO2CH2CH3 | -CHO |
ACS | -(CH2)4CO2CH3 | -CHO |
ACT | -(CH2)4CO2CH2CH3 | -CHO |
ACU | -CH2SO2NH2 | -CHO |
ACV | -CH2SO2N(CH3)2 | -CHO |
ACW | -(CH2)2NHSO2H | -CHO |
ACX | -(CH2)2NHSO2CH3 | -CHO |
ACY | -H | -CN |
ACZ | -CH2C(O)NH2 | -CN |
ADA | -CH2C(O)N(CH3)2 | -CN |
ADB | -C(O)CH2NHSO2CH3 | -CN |
ADC | -(CH2)2C(O)NHz | -CN |
ADD | -(CH2)2C(O)N(CH3)2 | -CN |
ADE | -C(O)(CH2)2NHSO2CH3 | -CN |
ADF | -CH2CO2CH3 | -CN |
ADG | -CH2CO2CH2CH3 | -CN |
ADH | -(CH2)2CO2CH3 | -CN |
ADI | -(CH2)2CO2CH2CH3 | -CN |
ADJ | -(CH2)3CO2CH3 | -CN |
ADK | -(CH2)3CO2CH2CH3 | -CN |
ADL | -(CH2)4CO2CH3 | -CN |
ADM | -(CH2)4CO2CH2CH3 | -CN |
AND | -CH2SO2NH2 | -CN |
ADO | -CH2SO2N(CH3)2 | -CN |
ADP | -(CH2)2NHSO2H | -CN |
ADQ | -(CH2)2NHSO2CH3 | -CN |
ADR | -H | -CH3 |
ADS | -CH2C(O)NH2 | -CH3 |
ADT | -CH2C(O)N(CH3)2 | -CH3 |
ADU | -C(O)CH2NHSO2CH3 | -CH3 |
ADV | -(CH2)2C(O)NH2 | -CH3 |
ADW | -(CH2)2C(O)N(CH3)2 | -CH3 |
ADX | -C(O)(CH2)2NHSO2CH3 | -CH3 |
ADY | -CH2CO2CH3 | -CH3 |
ADZ | -CH2CO2CH2CH3 | -CH3 |
AEA | -(CH2)2CO2CH3 | -CH3 |
AEB | -(CH2)2CO2CH2CH3 | -CH3 |
AEC | -(CH2)3CO2CH3 | -CH3 |
AED | -(CH2)3CO2CH2CH3 | -CH3 |
AEE | -(CH2)4CO2CH3 | -CH3 |
AEF | -(CH2)4CO2CH2CH3 | -CH3 |
AEG | -CH2SO2NH2 | -CH3 |
AEH | -CH2SO2N(CH3)2 | -CH3 |
AEI | -(CH2)2NHSO2H | -CH3 |
AEJ | -(CH2)2NHSO2CH3 | -CH3 |
AEK | -H | -C(O)NH(CH3) |
AEL | -CH2C(O)NH2 | -C(O)NH(CH3) |
AEM | -CH2C(O)N(CH3)2 | -C(O)NH(CH3) |
AEN | -C(O)CH2NHSO2CH3 | -C(O)NH(CH3) |
AEO | -(CH2)2C(O)NH2 | -C(O)NH(CH3) |
AEP | -(CH2)2C(O)N(CH3)2 | -C(O)NH(CH3) |
AEQ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
AER | -CH2CO2CH3 | -C(O)NH(CH3) |
AES | -CH2CO2CH2CH3 | -C(O)NH(CH3) |
AET | -(CH2)2CO2CH3 | -C(O)NH(CH3) |
AEU | -(CH2)2CO2CH2CH3 | -C(O)NH(CH3) |
AEV | -(CH2)3CO2CH3 | -C(O)NH(CH3) |
AEW | -(CH2)3CO2CH2CH3 | -C(O)NH(CH3) |
AEX | -(CH2)4CO2CH3 | -C(O)NH(CH3) |
化合物号: | G: | R1: |
BAI | -CH2CO2CH2CH3 | -H |
BAJ | -(CH2)2CO2CH3 | -H |
BAK | -(CH2)2CO2CH2CH3 | -H |
BAL | -(CH2)3CO2CH3 | -H |
BAM | -(CH2)3CO2CH2CH3 | -H |
BAN | -(CH2)4CO2CH3 | -H |
BAO | -(CH2)4CO2CH2CH3 | -H |
BAP | -CH2SO2NH2 | -H |
BAQ | -CH2SO2N(CH3)2 | -H |
BAR | -(CH2)2NHSO2H | -H |
BAS | -(CH2)2NHSO2CH3 | -H |
BAT | -H | -C(O)NH2 |
BAU | -CH2C(O)NH2 | -C(O)NH2 |
BAV | -CH2C(O)N(CH3)2 | -C(O)NH2 |
BAW | -C(O)CH2NHSO2CH3 | -C(O)NH2 |
BAX | -(CH2)2C(O)NH2 | -C(O)NH2 |
BAY | -(CH2)2C(O)N(CH3)2 | -C(O)NH2 |
BAZ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH2 |
BBA | -CH2CO2CH3 | -C(O)NH2 |
BBB | -CH2CO2CH2CH3 | -C(O)NH2 |
BBC | -(CH2)2CO2CH3 | -C(O)NH2 |
BBD | -(CH2)2CO2CH2CH3 | -C(O)NH2 |
BBE | -(CH2)3CO2CH3 | -C(O)NH2 |
BBF | -(CH2)3CO2CH2CH3 | -C(O)NH2 |
BBG | -(CH2)4CO2CH3 | -C(O)NH2 |
BBH | -(CH2)4CO2CH2CH3 | -C(O)NH2 |
BBI | -CH2SO2NH2 | -C(O)NH2 |
BBJ | -CH2SO2N(CH3)2 | -C(O)NH2 |
BBK | -(CH2)2NHSO2H | -C(O)NH2 |
BBL | -(CH2)2NHSO2CH3 | -C(O)NH2 |
BBM | -H | -CO2CH3 |
BBN | -CH2C(O)NH2 | -CO2CH3 |
BBO | -CH2C(O)N(CH3)2 | -CO2CH3 |
BBP | -C(O)CH2NHSO2CH3 | -CO2CH3 |
BBQ | -(CH2)2C(O)NH2 | -CO2CH3 |
BBR | -(CH2)2C(O)N(CH3)2 | -CO2CH3 |
BBS | -C(O)(CH2)2NHSO2CH3 | -CO2CH3 |
BBT | -CH2CO2CH3 | -CO2CH3 |
BBU | -CH2CO2CH2CH3 | -CO2CH3 |
BBV | -(CH2)2CO2CH3 | -CO2CH3 |
BBW | -(CH2)2CO2CH2CH3 | -CO2CH3 |
BBX | -(CH2)3CO2CH3 | -CO2CH3 |
BBY | -(CH2)3CO2CH2CH3 | -CO2CH3 |
BBZ | -(CH2)4CO2CH3 | -CO2CH3 |
BCA | -(CH2)4CO2CH2CH3 | -CO2CH3 |
BCB | -CH2SO2NH2 | -CO2CH3 |
BCC | -CH2SO2N(CH3)2 | -CO2CH3 |
BCD | -(CH2)2NHSO2H | -CO2CH3 |
BCE | -(CH2)2NHSO2CH3 | -CO2CH3 |
BCF | -H | -CHO |
BCG | -CH2C(O)NH2 | -CHO |
BCH | -CH2C(O)N(CH3)2 | -CHO |
BCI | -C(O)CH2NHSO2CH3 | -CHO |
BCJ | -(CH2)2C(O)NH2 | -CHO |
BCK | -(CH2)2C(O)N(CH3)2 | -CHO |
BCL | -C(O)(CH2)2NHSO2CH3 | -CHO |
BCM | -CH2CO2CH3 | -CHO |
BCN | -CH2CO2CH2CH3 | -CHO |
BCO | -(CH2)2CO2CH3 | -CHO |
BCP | -(CH2)2CO2CH2CH3 | -CHO |
BCQ | -(CH2)3CO2CH3 | -CHO |
BCR | -(CH2)3CO2CH2CH3 | -CHO |
BCS | -(CH2)4CO2CH3 | -CHO |
BCT | -(CH2)4CO2CH2CH3 | -CHO |
BCU | -CH2SO2NH2 | -CHO |
BCV | -CH2SO2N(CH3)2 | -CHO |
BCW | -(CH2)2NHSO2H | -CHO |
BCX | -(CH2)2NHSO2CH3 | -CHO |
BCY | -H | -CN |
BCZ | -CH2C(O)NH2 | -CN |
BDA | -CH2C(O)N(CH3)2 | -CN |
BDB | -C(O)CH2NHSO2CH3 | -CN |
BDC | -(CH2)2C(O)NH2 | -CN |
BDD | -(CH2)2C(O)N(CH3)2 | -CN |
BDE | -C(O)(CH2)2NHSO2CH3 | -CN |
BDF | -CH2CO2CH3 | -CN |
BDG | -CH2CO2CH2CH3 | -CN |
BDH | -(CH2)2CO2CH3 | -CN |
BDI | -(CH2)2CO2CH2CH3 | -CN |
BDJ | -(CH2)3CO2CH3 | -CN |
BDK | -(CH2)3CO2CH2CH3 | -CN |
BDL | -(CH2)4CO2CH3 | -CN |
BDM | -(CH2)4CO2CH2CH3 | -CN |
BDN | -CH2SO2NH2 | -CN |
BDO | -CH2SO2N(CH3)2 | -CN |
BDP | -(CH2)2NHSO2H | -CN |
BDQ | -(CH2)2NHSO2CH3 | -CN |
BDR | -H | -CH3 |
BDS | -CH2C(O)NH2 | -CH3 |
BDT | -CH2C(O)N(CH3)2 | -CH3 |
BDU | -C(O)CH2NHSO2CH3 | -CH3 |
BDV | -(CH2)2C(O)NH2 | -CH3 |
BDW | -(CH2)2C(O)N(CH3)2 | -CH3 |
BDX | -C(O)(CH2)2NHSO2CH3 | -CH3 |
BDY | -CH2CO2CH3 | -CH3 |
BDZ | -CH2CO2CH2CH3 | -CH3 |
BEA | -(CH2)2CO2CH3 | -CH3 |
BEB | -(CH2)2CO2CH2CH3 | -CH3 |
BEC | -(CH2)3CO2CH3 | -CH3 |
BED | -(CH2)3CO2CH2CH3 | -CH3 |
BEE | -(CH2)4CO2CH3 | -CH3 |
BEF | -(CH2)4CO2CH2CH3 | -CH3 |
BEG | -CH2SO2NH2 | -CH3 |
BEH | -CH2SO2N(CH3)2 | -CH3 |
BEI | -(CH2)2NHSO2H | -CH3 |
BEJ | -(CH2)2NHSO2CH3 | -CH3 |
BEK | -H | -C(O)NH(CH3) |
BEL | -CH2C(O)NH2 | -C(O)NH(CH3) |
BEM | -CH2C(O)N(CH3)2 | -C(O)NH(CH3) |
BEN | -C(O)CH2NHSO2CH3 | -C(O)NH(CH3) |
BEO | -(CH2)2C(O)NH2 | -C(O)NH(CH3) |
BEP | -(CH2)2C(O)N(CH3)2 | -C(O)NH(CH3) |
BEQ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
BER | -CH2CO2CH3 | -C(O)NH(CH3) |
BES | -CH2CO2CH2CH3 | -C(O)NH(CH3) |
BET | -(CH2)2CO2CH3 | -C(O)NH(CH3) |
BEU | -(CH2)2CO2CH2CH3 | -C(O)NH(CH3) |
BEV | -(CH2)3CO2CH3 | -C(O)NH(CH3) |
BEW | -(CH2)3CO2CH2CH3 | -C(O)NH(CH3) |
BEX | -(CH2)4CO2CH3 | -C(O)NH(CH3) |
BEY | -(CH2)4CO2CH2CH3 | -C(O)NH(CH3) |
BEZ | -CH2SO2NH2 | -C(O)NH(CH3) |
BFA | -CH2SO2N(CH3)2 | -C(O)NH(CH3) |
BFB | -(CH2)2NHSO2H | -C(O)NH(CH3) |
化合物号: | G: | R1: |
CAA | -H | -H |
CAB | -CH2C(O)NH2 | -H |
CAC | -CH2C(O)N(CH3)2 | -H |
CAD | -C(O)CH2NHSO2CH3 | -H |
CAE | -(CH2)2C(O)NH2 | -H |
CAF | -(CH2)2C(O)N(CH3)2 | -H |
CAG | -C(O)(CH2)2NHSO2CH3 | -H |
CAH | -CH2CO2CH3 | -H |
CAI | -CH2CO2CH2CH3 | -H |
CAJ | -(CH2)2CO2CH3 | -H |
CAK | -(CH2)2CO2CH2CH3 | -H |
CAL | -(CH2)3CO2CH3 | -H |
CAM | -(CH2)3CO2CH2CH3 | -H |
CAN | -(CH2)4CO2CH3 | -H |
CAO | -(CH2)4CO2CH2CH3 | -H |
CAP | -CH2SO2NH2 | -H |
CAQ | -CH2SO2N(CH3)2 | -H |
CAR | -(CH2)2NHSO2H | -H |
CAS | -(CH2)2NHSO2CH3 | -H |
CAT | -H | -C(O)NH2 |
CAU | -CH2C(O)NH2 | -C(O)NH2 |
CAV | -CH2C(O)N(CH3)2 | -C(O)NH2 |
CAW | -C(O)CH2NHSO2CH3 | -C(O)NH2 |
CAX | -(CH2)2C(O)NH2 | -C(O)NH2 |
CAY | -(CH2)2C(O)N(CH3)2 | -C(O)NH2 |
CAZ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH2 |
CBA | -CH2CO2CH3 | -C(O)NH2 |
CBB | -CH2CO2CH2CH3 | -C(O)NH2 |
CBC | -(CH2)2CO2CH3 | -C(O)NH2 |
CBD | -(CH2)2CO2CH2CH3 | -C(O)NH2 |
CBE | -(CH2)3CO2CH3 | -C(O)NH2 |
CBF | -(CH2)3CO2CH2CH3 | -C(O)NH2 |
CBG | -(CH2)4CO2CH3 | -C(O)NH2 |
CBH | -(CH2)4CO2CH2CH3 | -C(O)NH2 |
CBI | -CH2SO2NH2 | -C(O)NH2 |
CBJ | -CH2SO2N(CH3)2 | -C(O)NH2 |
CBK | -(CH2)2NHSO2H | -C(O)NH2 |
CBL | -(CH2)2NHSO2CH3 | -C(O)NH2 |
CBM | -H | -CO2CH3 |
CBN | -CH2C(O)NH2 | -CO2CH3 |
CBO | -CH2C(O)N(CH3)2 | -CO2CH3 |
CBP | -C(O)CH2NHSO2CH3 | -CO2CH3 |
CBQ | -(CH2)2C(O)NH2 | -CO2CH3 |
CBR | -(CH2)2C(O)N(CH3)2 | -CO2CH3 |
CBS | -C(O)(CH2)2NHSO2CH3 | -CO2CH3 |
CBT | -CH2CO2CH3 | -CO2CH3 |
CBU | -CH2CO2CH2CH3 | -CO2CH3 |
CBV | -(CH2)2CO2CH3 | -CO2CH3 |
CBW | -(CH2)2CO2CH2CH3 | -CO2CH3 |
CBX | -(CH2)3CO2CH3 | -CO2CH3 |
CBY | -(CH2)3CO2CH2CH3 | -CO2CH3 |
CBZ | -(CH2)4CO2CH3 | -CO2CH3 |
CCA | -(CH2)4CO2CH2CH3 | -CO2CH3 |
CCB | -CH2SO2NH2 | -CO2CH3 |
CCC | -CH2SO2N(CH3)2 | -CO2CH3 |
CCD | -(CH2)2NHSO2H | -CO2CH3 |
CCE | -(CH2)2NHSO2CH3 | -CO2CH3 |
CCF | -H | -CHO |
CCG | -CH2C(O)NH2 | -CHO |
CCH | -CH2C(O)N(CH3)2 | -CHO |
CCI | -C(O)CH2NHSO2CH3 | -CHO |
CCJ | -(CH2)2C(O)NH2 | -CHO |
CCK | -(CH2)2C(O)N(CH3)2 | -CHO |
CCL | -C(O)(CH2)2NHSO2CH3 | -CHO |
CCM | -CH2CO2CH3 | -CHO |
CCN | -CH2CO2CH2CH3 | -CHO |
CCO | -(CH2)2CO2CH3 | -CHO |
CCP | -(CH2)2CO2CH2CH3 | -CHO |
CCQ | -(CH2)3CO2CH3 | -CHO |
CCR | -(CH2)3CO2CH2CH3 | -CHO |
CCS | -(CH2)4CO2CH3 | -CHO |
CCT | -(CH2)4CO2CH2CH3 | -CHO |
CCU | -CH2SO2NH2 | -CHO |
CCV | -CH2SO2N(CH3)2 | -CHO |
CCW | -(CH2)2NHSO2H | -CHO |
CCX | -(CH2)2NHSO2CH3 | -CHO |
CCY | -H | -CN |
CCZ | -CH2C(O)NH2 | -CN |
CDA | -CH2C(O)N(CH3)2 | -CN |
CDB | -C(O)CH2NHSO2CH3 | -CN |
CDC | -(CH2)2C(O)NH2 | -CN |
CDD | -(CH2)2C(O)N(CH3)2 | -CN |
CDE | -C(O)(CH2)2NHSO2CH3 | -CN |
CDF | -CH2CO2CH3 | -CN |
CDG | -CH2CO2CH2CH3 | -CN |
CDH | -(CH2)2CO2CH3 | -CN |
CDI | -(CH2)2CO2CH2CH3 | -CN |
CDJ | -(CH2)3CO2CH3 | -CN | |
CDK | -(CH2)3CO2CH2CH3 | -CN | |
CDL | -(CH2)4CO2CH3 | -CN | |
CDM | -(CH2)4CO2CH2CH3 | -CN | |
CDN | -CH2SO2NH2 | -CN | |
CDO | -CH2SO2N(CH3)2 | -CN | |
CDP | -(CH2)2NHSO2H | -CN | |
CDQ | -(CH2)2NHSO2CH3 | -CN | |
CDR | -H | -CH3 | |
CDS | -CH2C(O)NH2 | -CH3 | |
CDT | -CH2C(O)N(CH3)2 | -CH3 | |
CDU | -C(O)CH2NHSO2CH3 | -CH3 | |
CDV | -(CH2)2C(O)NH2 | -CH3 | |
CDW | -(CH2)2C(O)N(CH3)2 | -CH3 | |
CDX | -C(O)(CH2)2NHSO2CH3 | -CH3 | |
CDY | -CH2CO2CH3 | -CH3 | |
CDZ | -CH2CO2CH2CH3 | -CH3 | |
CEA | -(CH2)2CO2CH3 | -CH3 | |
CEB | -(CH2)2CO2CH2CH3 | -CH3 | |
CEC | -(CH2)3CO2CH3 | -CH3 | |
CED | -(CH2)3CO2CH2CH3 | -CH3 | |
CEE | -(CH2)4CO2CH3 | -CH3 | |
CEF | -(CH2)4CO2CH2CH3 | -CH3 | |
CEG | -CH2SO2NH2 | -CH3 | |
CEH | -CH2SO2N(CH3)2 | -CH3 | |
CEI | -(CH2)2NHSO2H | -CH3 | |
CEJ | -(CH2)2NHSO2CH3 | -CH3 | |
CEK | -H | -C(O)NH(CH3) | |
CEL | -CH2C(O)NH2 | -C(O)NH(CH3) | |
CEM | -CH2C(O)N(CH3)2 | -C(O)NH(CH3) | |
CEN | -C(O)CH2NHSO2CH3 | -C(O)NH(CH3) |
CEO | -(CH2)2C(O)NH2 | -C(O)NH(CH3) |
CEP | -(CH2)2C(O)N(CH3)2 | -C(O)NH(CH3) |
CEQ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
CER | -CH2CO2CH3 | -C(O)NH(CH3) |
CES | -CH2CO2CH2CH3 | -C(O)NH(CH3) |
CET | -(CH2)2CO2CH3 | -C(O)NH(CH3) |
CEU | -(CH2)2CO2CH2CH3 | -C(O)NH(CH3) |
CEV | -(CH2)3CO2CH3 | -C(O)NH(CH3) |
CEW | -(CH2)3CO2CH2CH3 | -C(O)NH(CH3) |
CEX | -(CH2)4CO2CH3 | -C(O)NH(CH3) |
CEY | -(CH2)4CO2CH2CH3 | -C(O)NH(CH3) |
CEZ | -CH2SO2NH2 | -C(O)NH(CH3) |
CFA | -CH2SO2N(CH3)2 | -C(O)NH(CH3) |
CFB | -(CH2)2NHSO2H | -C(O)NH(CH3) |
CFC | -(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
CFD | -H | -C(O)N(CH3)2 |
CFE | -CH2C(O)NH2 | -C(O)N(CH3)2 |
CFF | -CH2C(O)N(CH3)2 | -C(O)N(CH3)2 |
CFG | -C(O)CH2NHSO2CH3 | -C(O)N(CH3)2 |
CFH | -(CH2)2C(O)NH2 | -C(O)N(CH3)2 |
CFI | -(CH2)2C(O)N(CH3)2 | -C(O)N(CH3)2 |
CFJ | -C(O)(CH2)2NHSO2CH3 | -C(O)N(CH3)2 |
CFK | -CH2CO2CH3 | -C(O)N(CH3)2 |
CFL | -CH2CO2CH2CH3 | -C(O)N(CH3)2 |
CFM | -(CH2)2CO2CH3 | -C(O)N(CH3)2 |
CFN | -(CH2)2CO2CH2CH3 | -C(O)N(CH3)2 |
CFO | -(CH2)3CO2CH3 | -C(O)N(CH3)2 |
CFP | -(CH2)3CO2CH2CH3 | -C(O)N(CH3)2 |
CFQ | -(CH2)4CO2CH3 | -C(O)N(CH3)2 |
CFR | -(CH2)4CO2CH2CH3 | -C(O)N(CH3)2 |
CFS | -CH2SO2NH2 | -C(O)N(CH3)2 |
化合物号: | G: | R1: |
DAA | -H | -H |
DAB | -CH2C(O)NH2 | -H |
DAC | -CH2C(O)N(CH3)2 | -H |
DAD | -C(O)CH2NHSO2CH3 | -H |
DAE | -(CH2)2C(O)NH2 | -H |
DAF | -(CH2)2C(O)N(CH3)2 | -H |
DAG | -C(O)(CH2)2NHSO2CH3 | -H |
DAH | -CH2CO2CH3 | -H |
DAI | -CH2CO2CH2CH3 | -H |
DAJ | -(CH2)2CO2CH3 | -H |
DAK | -(CH2)2CO2CH2CH3 | -H |
DAL | -(CH2)3CO2CH3 | -H |
DAM | -(CH2)3CO2CH2CH3 | -H |
DAN | -(CH2)4CO2CH3 | -H |
DAO | -(CH2)4CO2CH2CH3 | -H |
DAP | -CH2SO2NH2 | -H |
DAQ | -CH2SO2N(CH3)2 | -H |
DAR | -(CH2)2NHSO2H | -H |
DAS | -(CH2)2NHSO2CH3 | -H |
DAT | -H | -C(O)NH2 |
DAU | -CH2C(O)NH2 | -C(O)NH2 |
DAV | -CH2C(O)N(CH3)2 | -C(O)NH2 |
DAW | -C(O)CH2NHSO2CH3 | -C(O)NH2 |
DAX | -(CH2)2C(O)NH2 | -C(O)NH2 |
DAY | -(CH2)2C(O)N(CH3)2 | -C(O)NH2 |
DAZ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH2 |
DBA | -CH2CO2CH3 | -C(O)NH2 |
DBB | -CH2CO2CH2CH3 | -C(O)NH2 |
DBC | -(CH2)2CO2CH3 | -C(O)NH2 |
DBD | -(CH2)2CO2CH2CH3 | -C(O)NH2 |
DBE | -(CH2)3CO2CH3 | -C(O)NH2 |
DBF | -(CH2)3CO2CH2CH3 | -C(O)NH2 |
DBG | -(CH2)4CO2CH3 | -C(O)NH2 |
DBH | -(CH2)4CO2CH2CH3 | -C(O)NH2 |
DBI | -CH2SO2NH2 | -C(O)NH2 |
DBJ | -CH2SO2N(CH3)2 | -C(O)NH2 |
DBK | -(CH2)2NHSO2H | -C(O)NH2 |
DBL | -(CH2)2NHSO2CH3 | -C(O)NH2 |
DBM | -H | -CO2CH3 |
DBN | -CH2C(O)NH2 | -CO2CH3 |
DBO | -CH2C(O)N(CH3)2 | -CO2CH3 |
DBP | -CH2NHSO2CH3 | -CO2CH3 |
DBQ | -(CH2)2C(O)NH2 | -CO2CH3 |
DBR | -(CH2)2C(O)N(CH3)2 | -CO2CH3 |
DBS | -(CH2)2NHSO2CH3 | -CO2CH3 |
DBT | -CH2CO2CH3 | -CO2CH3 |
DBU | -CH2CO2CH2CH3 | -CO2CH3 |
DBV | -(CH2)2CO2CH3 | -CO2CH3 |
DBW | -(CH2)2CO2CH2CH3 | -CO2CH3 |
DBX | -(CH2)3CO2CH3 | -CO2CH3 |
DBY | -(CH2)3CO2CH2CH3 | -CO2CH3 |
DBZ | -(CH2)4CO2CH3 | -CO2CH3 |
DCA | -(CH2)4CO2CH2CH3 | -CO2CH3 |
DCB | -CH2SO2NH2 | -CO2CH3 |
DCC | -CH2SO2N(CH3)2 | -CO2CH3 |
DCD | -(CH2)2NHSO2H | -CO2CH3 |
DCE | -(CH2)2NHSO2CH3 | -CO2CH3 |
DCF | -H | -CHO |
DCG | -CH2C(O)NH2 | -CHO |
DCH | -CH2C(O)N(CH3)2 | -CHO |
DCI | -C(O)CH2NHSO2CH3 | -CHO |
DCJ | -(CH2)2C(O)NH2 | -CHO |
DCK | -(CH2)2C(O)N(CH3)2 | -CHO |
DCL | -C(O)(CH2)2NHSO2CH3 | -CHO |
DCM | -CH2CO2CH3 | -CHO |
DCN | -CH2CO2CH2CH3 | -CHO |
DCO | -(CH2)2CO2CH3 | -CHO |
DCP | -(CH2)2CO2CH2CH3 | -CHO |
DCQ | -(CH2)3CO2CH3 | -CHO |
DCR | -(CH2)3CO2CH2CH3 | -CHO |
DCS | -(CH2)4CO2CH3 | -CHO |
DCT | -(CH2)4CO2CH2CH3 | -CHO |
DCU | -CH2SO2NH2 | -CHO |
DCV | -CH2SO2N(CH3)2 | -CHO |
DCW | -(CH2)2NHSO2H | -CHO |
DCX | -(CH2)2NHSO2CH3 | -CHO |
DCY | -H | -CN |
DCZ | -CH2C(O)NH2 | -CN |
DDA | -CH2C(O)N(CH3)2 | -CN |
DDB | -C(O)CH2NHSO2CH3 | -CN |
DDC | -(CH2)2C(O)NH2 | -CN |
DDD | -(CH2)2C(O)N(CH3)2 | -CN |
DDE | -C(O)(CH2)2NHSO2CH3 | -CN |
DDF | -CH2CO2CH3 | -CN |
DDG | -CH2CO2CH2CH3 | -CN |
DDH | -(CH2)2CO2CH3 | -CN |
DDI | -(CH2)2CO2CH2CH3 | -CN |
DDJ | -(CH2)3CO2CH3 | -CN |
DDK | -(CH2)3CO2CH2CH3 | -CN |
DDL | -(CH2)4CO2CH3 | -CN |
DDM | -(CH2)4CO2CH2CH3 | -CN |
DDN | -CH2SO2NH2 | -CN |
DDO | -CH2SO2N(CH3)2 | -CN |
DDP | -(CH2)2NHSO2H | -CN |
DDQ | -(CH2)2NHSO2CH3 | -CN |
DDR | -H | -CH3 |
DDS | -CH2C(O)NH2 | -CH3 |
DDT | -CH2C(O)N(CH3)2 | -CH3 |
DDU | -C(O)CH2NHSO2CH3 | -CH3 |
DDV | -(CH2)2C(O)NH2 | -CH3 |
DDW | -(CH2)2C(O)N(CH3)2 | -CH3 |
DDX | -C(O)(CH2)2NHSO2CH3 | -CH3 |
DDY | -CH2CO2CH3 | -CH3 |
DDZ | -CH2CO2CH2CH3 | -CH3 |
DEA | -(CH2)2CO2CH3 | -CH3 |
DEB | -(CH2)2CO2CH2CH3 | -CH3 |
DEC | -(CH2)3CO2CH3 | -CH3 |
DED | -(CH2)3CO2CH2CH3 | -CH3 |
DEE | -(CH2)4CO2CH3 | -CH3 |
DEF | -(CH2)4CO2CH2CH3 | -CH3 |
DEG | -CH2SO2NH2 | -CH3 |
DEH | -CH2SO2N(CH3)2 | -CH3 |
DEI | -(CH2)2NHSO2H | -CH3 |
DEJ | -(CH2)2NHSO2CH3 | -CH3 |
DEK | -H | -C(O)NH(CH3) |
DEL | -CH2C(O)NH2 | -C(O)NH(CH3) |
DEM | -CH2C(O)N(CH3)2 | -C(O)NH(CH3) |
DEN | -C(O)CH2NHSO2CH3 | -C(O)NH(CH3) |
DEO | -(CH2)2C(O)NH2 | -C(O)NH(CH3) |
DEP | -(CH2)2C(O)N(CH3)2 | -C(O)NH(CH3) |
DEQ | -C(O)(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
DER | -CH2CO2CH3 | -C(O)NH(CH3) |
DES | -CH2CO2CH2CH3 | -C(O)NH(CH3) |
DET | -(CH2)2CO2CH3 | -C(O)NH(CH3) |
DEU | -(CH2)2CO2CH2CH3 | -C(O)NH(CH3) |
DEV | -(CH2)3CO2CH3 | -C(O)NH(CH3) |
DEW | -(CH2)3CO2CH2CH3 | -C(O)NH(CH3) |
DEX | -(CH2)4CO2CH3 | -C(O)NH(CH3) |
DEY | -(CH2)4CO2CH2CH3 | -C(O)NH(CH3) |
DEZ | -CH2SO2NH2 | -C(O)NH(CH3) |
DFA | -CH2SO2N(CH3)2 | -C(O)NH(CH3) |
DFB | -(CH2)2NHSO2H | -C(O)NH(CH3) |
DFC | -(CH2)2NHSO2CH3 | -C(O)NH(CH3) |
DFD | -H | -C(O)N(CH3)2 |
DFE | -CH2C(O)NH2 | -C(O)N(CH3)2 |
DFF | -CH2C(O)N(CH3)2 | -C(O)N(CH3)2 |
DFG | -C(O)CH2NHSO2CH3 | -C(O)N(CH3)2 |
DFH | -(CH2)2C(O)NH2 | -C(O)N(CH3)2 |
DFI | -(CH2)2C(O)N(CH3)2 | -C(O)N(CH3)2 |
DFJ | -C(O)(CH2)2NHSO2CH3 | -C(O)N(CH3)2 |
Claims (111)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
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US10/000,000 | 2002-08-01 | ||
US42738102P | 2002-11-18 | 2002-11-18 | |
US60/427,381 | 2002-11-18 | ||
US46027803P | 2003-04-03 | 2003-04-03 | |
US60/460,278 | 2003-04-03 | ||
US48848803P | 2003-07-17 | 2003-07-17 | |
US60/488,488 | 2003-07-17 | ||
US10/714,066 US7202259B2 (en) | 2002-11-18 | 2003-11-13 | Therapeutic agents useful for treating pain |
US10/714,066 | 2003-11-13 |
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CN200910173679A Division CN101648941A (zh) | 2002-11-18 | 2003-11-17 | 用于治疗疼痛的4-四唑基-4-苯基哌啶衍生物 |
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CN1711256A true CN1711256A (zh) | 2005-12-21 |
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CN200910173679A Pending CN101648941A (zh) | 2002-11-18 | 2003-11-17 | 用于治疗疼痛的4-四唑基-4-苯基哌啶衍生物 |
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Country Status (37)
Country | Link |
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US (3) | US7202259B2 (zh) |
EP (2) | EP1803718B1 (zh) |
JP (2) | JP4601429B2 (zh) |
KR (1) | KR20050115221A (zh) |
CN (2) | CN100567288C (zh) |
AP (1) | AP2210A (zh) |
AR (1) | AR047008A1 (zh) |
AT (2) | ATE358674T1 (zh) |
AU (2) | AU2003294313B2 (zh) |
BR (1) | BR0316305A (zh) |
CA (1) | CA2506242C (zh) |
CO (1) | CO5690588A2 (zh) |
CR (2) | CR7877A (zh) |
CY (2) | CY1107682T1 (zh) |
DE (2) | DE60313021T2 (zh) |
DK (2) | DK1803718T3 (zh) |
EA (1) | EA008621B1 (zh) |
EC (1) | ECSP055840A (zh) |
ES (2) | ES2312150T3 (zh) |
GE (1) | GEP20084539B (zh) |
HK (1) | HK1086829A1 (zh) |
IL (1) | IL209352A0 (zh) |
IS (2) | IS2720B (zh) |
MA (1) | MA27565A1 (zh) |
ME (1) | MEP48108A (zh) |
MX (1) | MXPA05004669A (zh) |
MY (1) | MY135647A (zh) |
NI (1) | NI200500087A (zh) |
NO (1) | NO20052894L (zh) |
NZ (2) | NZ572685A (zh) |
OA (1) | OA13010A (zh) |
PT (2) | PT1562932E (zh) |
RS (1) | RS51047B (zh) |
SG (1) | SG165998A1 (zh) |
SI (2) | SI1562932T1 (zh) |
TW (2) | TW200819436A (zh) |
WO (1) | WO2004046132A1 (zh) |
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2003
- 2003-11-13 US US10/714,066 patent/US7202259B2/en active Active
- 2003-11-17 EP EP07006697A patent/EP1803718B1/en not_active Expired - Lifetime
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- 2003-11-17 SI SI200330814T patent/SI1562932T1/sl unknown
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- 2003-11-17 AU AU2003294313A patent/AU2003294313B2/en not_active Ceased
- 2003-11-17 WO PCT/US2003/036742 patent/WO2004046132A1/en active Search and Examination
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- 2003-11-17 CN CNB2003801035027A patent/CN100567288C/zh not_active Expired - Fee Related
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