JP2004537564A5 - - Google Patents
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- Publication number
- JP2004537564A5 JP2004537564A5 JP2003515500A JP2003515500A JP2004537564A5 JP 2004537564 A5 JP2004537564 A5 JP 2004537564A5 JP 2003515500 A JP2003515500 A JP 2003515500A JP 2003515500 A JP2003515500 A JP 2003515500A JP 2004537564 A5 JP2004537564 A5 JP 2004537564A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- het
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 921
- 125000003118 aryl group Chemical group 0.000 claims 786
- 125000000753 cycloalkyl group Chemical group 0.000 claims 777
- 125000000623 heterocyclic group Chemical group 0.000 claims 301
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 124
- 229910052757 nitrogen Inorganic materials 0.000 claims 124
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 112
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 90
- 125000001424 substituent group Chemical group 0.000 claims 69
- 229910052736 halogen Inorganic materials 0.000 claims 55
- 150000001875 compounds Chemical class 0.000 claims 47
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 45
- 125000001188 haloalkyl group Chemical group 0.000 claims 44
- 150000002367 halogens Chemical class 0.000 claims 43
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 33
- 125000005842 heteroatom Chemical group 0.000 claims 31
- 125000002877 alkyl aryl group Chemical group 0.000 claims 30
- 229910052760 oxygen Inorganic materials 0.000 claims 29
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 28
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 22
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 150000003536 tetrazoles Chemical class 0.000 claims 18
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 13
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 12
- -1 bicycloalkenyl Chemical group 0.000 claims 12
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 9
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 4
- SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 125000003831 tetrazolyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 150000001540 azides Chemical class 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims 3
- 229940091173 hydantoin Drugs 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
- YPWFISCTZQNZAU-UHFFFAOYSA-N Thiane Chemical compound C1CCSCC1 YPWFISCTZQNZAU-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 125000003435 aroyl group Chemical group 0.000 claims 2
- 150000001602 bicycloalkyls Chemical group 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 2
- 239000004305 biphenyl Substances 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 101800001554 RNA-directed RNA polymerase Proteins 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 1
- 229960003805 amantadine Drugs 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000006269 biphenyl-2-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(*)C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30767401P | 2001-07-25 | 2001-07-25 | |
| US33806101P | 2001-12-07 | 2001-12-07 | |
| PCT/CA2002/001128 WO2003010141A2 (en) | 2001-07-25 | 2002-07-18 | Hepatitis c virus polymerase inhibitors with a heterobicyclic structure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009092397A Division JP2009275037A (ja) | 2001-07-25 | 2009-04-06 | ウイルスポリメラーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004537564A JP2004537564A (ja) | 2004-12-16 |
| JP2004537564A5 true JP2004537564A5 (https=) | 2005-12-22 |
| JP4398725B2 JP4398725B2 (ja) | 2010-01-13 |
Family
ID=26975871
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515500A Expired - Fee Related JP4398725B2 (ja) | 2001-07-25 | 2002-07-18 | ウイルスポリメラーゼインヒビター |
| JP2003515499A Expired - Fee Related JP4398241B2 (ja) | 2001-07-25 | 2002-07-18 | ウイルスポリメラーゼインヒビター |
| JP2009048600A Withdrawn JP2009120616A (ja) | 2001-07-25 | 2009-03-02 | ウイルスポリメラーゼインヒビター |
| JP2009092397A Withdrawn JP2009275037A (ja) | 2001-07-25 | 2009-04-06 | ウイルスポリメラーゼインヒビター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515499A Expired - Fee Related JP4398241B2 (ja) | 2001-07-25 | 2002-07-18 | ウイルスポリメラーゼインヒビター |
| JP2009048600A Withdrawn JP2009120616A (ja) | 2001-07-25 | 2009-03-02 | ウイルスポリメラーゼインヒビター |
| JP2009092397A Withdrawn JP2009275037A (ja) | 2001-07-25 | 2009-04-06 | ウイルスポリメラーゼインヒビター |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US7141574B2 (https=) |
| EP (5) | EP2335700A1 (https=) |
| JP (4) | JP4398725B2 (https=) |
| KR (3) | KR100949446B1 (https=) |
| CN (3) | CN102424680A (https=) |
| AR (2) | AR037495A1 (https=) |
| AT (2) | ATE382348T1 (https=) |
| AU (2) | AU2002355150B2 (https=) |
| BR (2) | BR0211477A (https=) |
| CA (2) | CA2449180C (https=) |
| CO (2) | CO5650161A2 (https=) |
| CY (2) | CY1107355T1 (https=) |
| DE (2) | DE60224400T2 (https=) |
| DK (2) | DK1414797T3 (https=) |
| EA (2) | EA007715B1 (https=) |
| ES (2) | ES2299591T3 (https=) |
| HR (3) | HRP20040072B1 (https=) |
| HU (2) | HUP0401784A3 (https=) |
| IL (4) | IL159649A0 (https=) |
| ME (2) | MEP62108A (https=) |
| MX (2) | MXPA04000729A (https=) |
| MY (1) | MY151080A (https=) |
| NO (2) | NO327055B1 (https=) |
| NZ (2) | NZ531267A (https=) |
| PE (1) | PE20030305A1 (https=) |
| PL (2) | PL368357A1 (https=) |
| PT (2) | PT1414441E (https=) |
| RS (3) | RS51083B (https=) |
| SG (1) | SG176999A1 (https=) |
| SI (2) | SI1414797T1 (https=) |
| UA (1) | UA84256C2 (https=) |
| UY (1) | UY27397A1 (https=) |
| WO (2) | WO2003010141A2 (https=) |
Families Citing this family (209)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1470119A4 (en) * | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US7294457B2 (en) * | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| ES2320771T3 (es) | 2003-04-16 | 2009-05-28 | Bristol-Myers Squibb Company | Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c. |
| EP1620094A4 (en) * | 2003-05-06 | 2010-04-28 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
| CA2534649A1 (en) | 2003-08-01 | 2005-02-10 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against flaviviridae |
| WO2005014543A1 (ja) * | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| GB0321003D0 (en) * | 2003-09-09 | 2003-10-08 | Angeletti P Ist Richerche Bio | Compounds, compositions and uses |
| US7112601B2 (en) | 2003-09-11 | 2006-09-26 | Bristol-Myers Squibb Company | Cycloalkyl heterocycles for treating hepatitis C virus |
| RS20060197A (sr) | 2003-09-22 | 2008-09-29 | Boehringer Ingelheim International Gmbh., | Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa |
| CN1882333B (zh) * | 2003-10-07 | 2010-11-10 | 密执安州立大学董事会 | 吲哚抗病毒组合物 |
| GB0323845D0 (en) * | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
| US20050119318A1 (en) * | 2003-10-31 | 2005-06-02 | Hudyma Thomas W. | Inhibitors of HCV replication |
| NZ595000A (en) | 2003-12-22 | 2013-03-28 | Gilead Sciences Inc | Imidazo[4,5-c]pyridine derivative for treating viral infections |
| EP1730167B1 (en) | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Macrocyclic peptides active against the hepatitis c virus |
| HRP20130971T1 (hr) * | 2004-02-20 | 2013-11-08 | Boehringer Ingelheim International Gmbh | Inhibitori virusne polimeraze |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| HRP20090250T1 (hr) | 2004-02-24 | 2009-06-30 | Japan Tobacco | Kondenzirani heterociklički spojevi i njihova upotreba kao inhibitora hcv polimeraze |
| EP1727797B1 (en) | 2004-03-08 | 2012-05-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Process for cross coupling indoles |
| WO2005090302A2 (en) * | 2004-03-16 | 2005-09-29 | Boehringer Ingelheim International Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
| GB0413087D0 (en) | 2004-06-11 | 2004-07-14 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP1771169A1 (en) * | 2004-07-14 | 2007-04-11 | PTC Therapeutics, Inc. | Methods for treating hepatitis c |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| WO2007084413A2 (en) * | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| PE20060569A1 (es) * | 2004-07-16 | 2006-06-22 | Boehringer Ingelheim Int | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
| JP2008507518A (ja) * | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎を治療するためのチエノピリジン |
| BRPI0513811A (pt) | 2004-07-27 | 2008-07-15 | Gilead Sciences Inc | imidazo [4,5-d] pirimidinas, seus usos e processos de preparação |
| RU2387655C2 (ru) * | 2004-08-09 | 2010-04-27 | Бристол-Маерс Сквибб Компани | Ингибиторы репликации вируса гепатита с |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| ZA200705872B (en) * | 2005-01-14 | 2008-09-25 | Genelabs Tecnologies Inc | Indole derivatives for treating viral infections |
| KR20070112165A (ko) * | 2005-02-11 | 2007-11-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
| WO2006094292A2 (en) | 2005-03-02 | 2006-09-08 | Fibrogen, Inc. | Thienopyridine compounds, and methods of use thereof |
| WO2006117306A1 (en) | 2005-05-04 | 2006-11-09 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| BRPI0610283A2 (pt) | 2005-05-13 | 2010-10-19 | Virochem Pharma Inc | composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica |
| MA28394B1 (fr) * | 2005-06-24 | 2007-01-02 | Genelabs Tech Inc | Derives d'heteroaryle pour traitement des virus |
| JP5015154B2 (ja) * | 2005-08-12 | 2012-08-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
| CN102336758A (zh) * | 2005-08-24 | 2012-02-01 | 辉瑞有限公司 | 作为hcv聚合酶抑制剂的化合物及组合物 |
| JP2009523732A (ja) * | 2006-01-13 | 2009-06-25 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｃ型肝炎の治療方法 |
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| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP1981524A2 (en) * | 2006-02-09 | 2008-10-22 | Schering Corporation | Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto |
| JP2009528353A (ja) * | 2006-03-03 | 2009-08-06 | シェーリング コーポレイション | Ｈｃｖのプロテアーゼ阻害剤およびｉｒｅｓ阻害剤の医薬的組み合わせ |
| CN103497184A (zh) | 2006-04-04 | 2014-01-08 | 菲布罗根有限公司 | 作为hif调节剂的吡咯并吡啶和噻唑并吡啶化合物 |
| EP1886685A1 (en) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition |
| RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
| WO2008033464A2 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives for the treatment of disorders of the lipid metabolism |
| WO2008043704A1 (en) | 2006-10-10 | 2008-04-17 | Medivir Ab | Hcv nucleoside inhibitor |
| EP2463389A1 (en) | 2006-10-20 | 2012-06-13 | Innogenetics N.V. | Methodology for analysis of sequence variations within the HCV NS5B genomic region |
| CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
| EP2081922B1 (en) | 2006-12-22 | 2012-02-01 | Schering Corporation | 5,6-Ring annulated indole derivatives and use thereof |
| JP5211068B2 (ja) | 2006-12-22 | 2013-06-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| AU2007339382B2 (en) | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| CN101687789A (zh) * | 2007-02-12 | 2010-03-31 | 因特蒙公司 | C型肝炎病毒复制的新颖抑制剂 |
| US7998951B2 (en) * | 2007-03-05 | 2011-08-16 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
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2003
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2004
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