JP2004536898A5 - - Google Patents
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- Publication number
- JP2004536898A5 JP2004536898A5 JP2002584987A JP2002584987A JP2004536898A5 JP 2004536898 A5 JP2004536898 A5 JP 2004536898A5 JP 2002584987 A JP2002584987 A JP 2002584987A JP 2002584987 A JP2002584987 A JP 2002584987A JP 2004536898 A5 JP2004536898 A5 JP 2004536898A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- agent
- polymer
- hydrophilic
- hydrogel according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000017 hydrogel Substances 0.000 claims 62
- 229920000642 polymer Polymers 0.000 claims 16
- -1 polyvinylamine Polymers 0.000 claims 14
- 229920001477 hydrophilic polymer Polymers 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 230000000295 complement Effects 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drugs Drugs 0.000 claims 8
- 239000004014 plasticizer Substances 0.000 claims 8
- 230000002209 hydrophobic Effects 0.000 claims 6
- 200000000019 wound Diseases 0.000 claims 6
- 229920002678 cellulose Polymers 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- 229920001515 polyalkylene glycol Polymers 0.000 claims 5
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N Caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 229920002301 Cellulose acetate Polymers 0.000 claims 3
- 229940089114 Drug Delivery Device Drugs 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 3
- 230000003078 antioxidant Effects 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- HKQOBOMRSSHSTC-DIBAFDJWSA-N (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;[(2R,3R,4S,5R,6S)-4,5,6-triacetyloxy-3-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl acetate;[( Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O.CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1.CCC(=O)OC[C@H]1O[C@@H](OC(=O)CC)[C@H](OC(=O)CC)[C@@H](OC(=O)CC)[C@@H]1O[C@H]1[C@H](OC(=O)CC)[C@@H](OC(=O)CC)[C@H](OC(=O)CC)[C@@H](COC(=O)CC)O1 HKQOBOMRSSHSTC-DIBAFDJWSA-N 0.000 claims 2
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N 2-methyl-2-propenoic acid methyl ester Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- 206010003736 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 2
- VUNGHBJEVBKTME-UHFFFAOYSA-N [NH-]C=C Chemical compound [NH-]C=C VUNGHBJEVBKTME-UHFFFAOYSA-N 0.000 claims 2
- UGZICOVULPINFH-UHFFFAOYSA-N acetic acid;butanoic acid Chemical compound CC(O)=O.CCCC(O)=O UGZICOVULPINFH-UHFFFAOYSA-N 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 201000006287 attention deficit hyperactivity disease Diseases 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 239000000812 cholinergic antagonist Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000011347 resin Substances 0.000 claims 2
- 229920005989 resin Polymers 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 239000001069 triethyl citrate Substances 0.000 claims 2
- 235000013769 triethyl citrate Nutrition 0.000 claims 2
- HDDLVZWGOPWKFW-UHFFFAOYSA-N trimethyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound COC(=O)CC(O)(C(=O)OC)CC(=O)OC HDDLVZWGOPWKFW-UHFFFAOYSA-N 0.000 claims 2
- 230000000261 vasodilator Effects 0.000 claims 2
- 239000003071 vasodilator agent Substances 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- OVOUKWFJRHALDD-UHFFFAOYSA-N 2-[2-(2-acetyloxyethoxy)ethoxy]ethyl acetate Chemical compound CC(=O)OCCOCCOCCOC(C)=O OVOUKWFJRHALDD-UHFFFAOYSA-N 0.000 claims 1
- AJMJPGWUPHIMKQ-UHFFFAOYSA-N 2-[2-(2-butanoyloxyethoxy)ethoxy]ethyl butanoate Chemical compound CCCC(=O)OCCOCCOCCOC(=O)CCC AJMJPGWUPHIMKQ-UHFFFAOYSA-N 0.000 claims 1
- AWKXKNCCQLNZDB-UHFFFAOYSA-N 2-[2-(2-propanoyloxyethoxy)ethoxy]ethyl propanoate Chemical compound CCC(=O)OCCOCCOCCOC(=O)CC AWKXKNCCQLNZDB-UHFFFAOYSA-N 0.000 claims 1
- JTXMVXSTHSMVQF-UHFFFAOYSA-N 2-acetyloxyethyl acetate Chemical compound CC(=O)OCCOC(C)=O JTXMVXSTHSMVQF-UHFFFAOYSA-N 0.000 claims 1
- FNJSWIPFHMKRAT-UHFFFAOYSA-M 2-methoxycarbonylbenzoate Chemical compound COC(=O)C1=CC=CC=C1C([O-])=O FNJSWIPFHMKRAT-UHFFFAOYSA-M 0.000 claims 1
- VHOQXEIFYTTXJU-UHFFFAOYSA-N 2-methylbuta-1,3-diene;2-methylprop-1-ene Chemical compound CC(C)=C.CC(=C)C=C VHOQXEIFYTTXJU-UHFFFAOYSA-N 0.000 claims 1
- ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 206010003246 Arthritis Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- SAOKZLXYCUGLFA-UHFFFAOYSA-N Bis(2-ethylhexyl) adipate Chemical compound CCCCC(CC)COC(=O)CCCCC(=O)OCC(CC)CCCC SAOKZLXYCUGLFA-UHFFFAOYSA-N 0.000 claims 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N Bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N Butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 239000004821 Contact adhesive Substances 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 229940030606 DIURETICS Drugs 0.000 claims 1
- YUXIBTJKHLUKBD-UHFFFAOYSA-N Dibutyl succinate Chemical compound CCCCOC(=O)CCC(=O)OCCCC YUXIBTJKHLUKBD-UHFFFAOYSA-N 0.000 claims 1
- VIZORQUEIQEFRT-UHFFFAOYSA-N Diethyl adipate Chemical compound CCOC(=O)CCCCC(=O)OCC VIZORQUEIQEFRT-UHFFFAOYSA-N 0.000 claims 1
- FLKPEMZONWLCSK-UHFFFAOYSA-N Diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 1
- YSAVZVORKRDODB-WDSKDSINSA-N Diethyl tartrate Chemical compound CCOC(=O)[C@@H](O)[C@H](O)C(=O)OCC YSAVZVORKRDODB-WDSKDSINSA-N 0.000 claims 1
- QWDBCIAVABMJPP-UHFFFAOYSA-N Diisopropyl phthalate Chemical compound CC(C)OC(=O)C1=CC=CC=C1C(=O)OC(C)C QWDBCIAVABMJPP-UHFFFAOYSA-N 0.000 claims 1
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical group COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims 1
- 229920002943 EPDM rubber Polymers 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 240000008528 Hevea brasiliensis Species 0.000 claims 1
- 229940088597 Hormone Drugs 0.000 claims 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims 1
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- 229960002715 Nicotine Drugs 0.000 claims 1
- 102000035443 Peptidases Human genes 0.000 claims 1
- 108091005771 Peptidases Proteins 0.000 claims 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims 1
- 229940068918 Polyethylene Glycol 400 Drugs 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920000468 Polystyrene-block-polybutadiene-block-polystyrene Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229940024999 Proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 1
- 239000002174 Styrene-butadiene Substances 0.000 claims 1
- 239000000150 Sympathomimetic Substances 0.000 claims 1
- 229940064707 Sympathomimetics Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- URAYPUMNDPQOKB-UHFFFAOYSA-N Triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 1
- 229960002622 Triacetin Drugs 0.000 claims 1
- STCOOQWBFONSKY-UHFFFAOYSA-N Tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 1
- XZZNDPSIHUTMOC-UHFFFAOYSA-N Triphenyl phosphate Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)(=O)OC1=CC=CC=C1 XZZNDPSIHUTMOC-UHFFFAOYSA-N 0.000 claims 1
- DQEFEBPAPFSJLV-WLTGXWPBSA-N [(2R,3R,4S,5R,6S)-4,5,6-tri(propanoyloxy)-3-[(2S,3R,4S,5R,6R)-3,4,5-tri(propanoyloxy)-6-(propanoyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl propanoate Chemical group CCC(=O)OC[C@H]1O[C@@H](OC(=O)CC)[C@H](OC(=O)CC)[C@@H](OC(=O)CC)[C@@H]1O[C@H]1[C@H](OC(=O)CC)[C@@H](OC(=O)CC)[C@H](OC(=O)CC)[C@@H](COC(=O)CC)O1 DQEFEBPAPFSJLV-WLTGXWPBSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive Effects 0.000 claims 1
- 239000003732 agents acting on the eye Substances 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002269 analeptic agent Substances 0.000 claims 1
- 238000004873 anchoring Methods 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001396 anti-anti-diuretic Effects 0.000 claims 1
- 230000000844 anti-bacterial Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 1
- 230000002460 anti-migraine Effects 0.000 claims 1
- 230000001410 anti-tremor Effects 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 claims 1
- 239000003793 antidiarrheal agent Substances 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003908 antipruritic agent Substances 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 239000002221 antipyretic Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 230000003385 bacteriostatic Effects 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 claims 1
- PDEBQWBBEDBYFI-UHFFFAOYSA-N butanoic acid;ethane-1,2-diol Chemical compound OCCO.CCCC(O)=O.CCCC(O)=O PDEBQWBBEDBYFI-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229920005549 butyl rubber Polymers 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M butyrate Chemical group CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- 230000000271 cardiovascular Effects 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920001727 cellulose butyrate Polymers 0.000 claims 1
- 201000009230 common cold Diseases 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- PCYQQSKDZQTOQG-UHFFFAOYSA-N dibutyl 2,3-dihydroxybutanedioate Chemical compound CCCCOC(=O)C(O)C(O)C(=O)OCCCC PCYQQSKDZQTOQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002097 dibutylsuccinate Drugs 0.000 claims 1
- DKMROQRQHGEIOW-UHFFFAOYSA-N diethyl butanedioate Chemical compound CCOC(=O)CCC(=O)OCC DKMROQRQHGEIOW-UHFFFAOYSA-N 0.000 claims 1
- ONKUXPIBXRRIDU-UHFFFAOYSA-N diethyl decanedioate Chemical compound CCOC(=O)CCCCCCCCC(=O)OCC ONKUXPIBXRRIDU-UHFFFAOYSA-N 0.000 claims 1
- HHECSPXBQJHZAF-UHFFFAOYSA-N dihexyl hexanedioate Chemical compound CCCCCCOC(=O)CCCCC(=O)OCCCCCC HHECSPXBQJHZAF-UHFFFAOYSA-N 0.000 claims 1
- 229960001826 dimethylphthalate Drugs 0.000 claims 1
- VNTXONBESJNLBI-UHFFFAOYSA-N dinonyl decanedioate Chemical compound CCCCCCCCCOC(=O)CCCCCCCCC(=O)OCCCCCCCCC VNTXONBESJNLBI-UHFFFAOYSA-N 0.000 claims 1
- IPKKHRVROFYTEK-UHFFFAOYSA-N dipentyl phthalate Chemical compound CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC IPKKHRVROFYTEK-UHFFFAOYSA-N 0.000 claims 1
- UHGPEWTZABDZCE-UHFFFAOYSA-N dipropyl decanedioate Chemical compound CCCOC(=O)CCCCCCCCC(=O)OCCC UHGPEWTZABDZCE-UHFFFAOYSA-N 0.000 claims 1
- NKOUWLLFHNBUDW-UHFFFAOYSA-N dipropyl hexanedioate Chemical compound CCCOC(=O)CCCCC(=O)OCCC NKOUWLLFHNBUDW-UHFFFAOYSA-N 0.000 claims 1
- MQHNKCZKNAJROC-UHFFFAOYSA-N dipropyl phthalate Chemical compound CCCOC(=O)C1=CC=CC=C1C(=O)OCCC MQHNKCZKNAJROC-UHFFFAOYSA-N 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000000806 elastomer Substances 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- ZANNOFHADGWOLI-UHFFFAOYSA-N ethyl 2-hydroxyacetate Chemical compound CCOC(=O)CO ZANNOFHADGWOLI-UHFFFAOYSA-N 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-M glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 1
- 230000002101 lytic Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 230000000394 mitotic Effects 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 239000003887 narcotic antagonist Substances 0.000 claims 1
- 201000009240 nasopharyngitis Diseases 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 229930015196 nicotine Natural products 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 150000001451 organic peroxides Chemical class 0.000 claims 1
- 230000001769 paralizing Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920001084 poly(chloroprene) Polymers 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920001195 polyisoprene Polymers 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003368 psychostimulant agent Substances 0.000 claims 1
- 230000003014 reinforcing Effects 0.000 claims 1
- 230000000241 respiratory Effects 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 229940116351 sebacate Drugs 0.000 claims 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 claims 1
- 230000000391 smoking Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000003068 static Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000011115 styrene butadiene Substances 0.000 claims 1
- 229920003048 styrene butadiene rubber Polymers 0.000 claims 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 229940086735 succinate Drugs 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 230000001975 sympathomimetic Effects 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 230000002936 tranquilizing Effects 0.000 claims 1
- 239000003204 tranquilizing agent Substances 0.000 claims 1
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N tributyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 1
- AMMPRZCMKXDUNE-UHFFFAOYSA-N trihexyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CCCCCCOC(=O)CC(O)(C(=O)OCCCCCC)CC(=O)OCCCCCC AMMPRZCMKXDUNE-UHFFFAOYSA-N 0.000 claims 1
- WVPGXJOLGGFBCR-UHFFFAOYSA-N trioctyl phosphate Chemical compound CCCCCCCCOP(=O)(OCCCCCCCC)OCCCCCCCC WVPGXJOLGGFBCR-UHFFFAOYSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
Claims (54)
- 不連続疎水性相および親水性相から構成される、ヒドロゲルであって:
(a)該不連続疎水性相は、(i)架橋疎水性ポリマー、(ii)可塑剤、(iii)粘着性付与樹脂、および(iv)任意の抗酸化剤を含有し;そして
(b)該親水性相は、不連続または連続のいずれかである、
ヒドロゲル。 - 前記親水性相が不連続である、請求項1に記載のヒドロゲル。
- 前記親水性相が、水に不溶性の架橋親水性ポリマーから構成される、請求項2に記載のヒドロゲル。
- 水膨潤性ポリマーが、架橋セルロース性ポリマーである、請求項3に記載のヒドロゲル。
- 前記水膨潤性ポリマーが、架橋カルボキシメチルセルロースナトリウムである、請求項4に記載のヒドロゲル。
- 前記親水性相が連続である、請求項1に記載のヒドロゲル。
- 前記親水性相が、(a)8.5未満のpHにおいて水に不溶性の、水膨潤性ポリマー;(b)親水性ポリマーと、該親水性ポリマーに水素結合し得る相補的オリゴマーとのブレンド;および(c)任意の低分子量可塑剤、から構成される、請求項6に記載のヒドロゲル。
- 前記水膨潤性ポリマーが、セルロースエステル組成物を含む、請求項7に記載のヒドロゲル。
- 前記セルロースエステル組成物が、非エステル化セルロース単位、酢酸セルロース単位、および酪酸セルロース単位またはプロピオン酸セルロース単位のいずれかを含む、少なくとも1種のセルロース性ポリマーから構成される、請求項8に記載のヒドロゲル。
- 前記セルロース性ポリマーが、酢酸酪酸セルロースである、請求項9に記載のヒドロゲル。
- 前記セルロース性ポリマーが、酢酸プロピオン酸セルロースである、請求項9に記載のヒドロゲル。
- 前記セルロースエステル組成物が、酢酸酪酸セルロースと酢酸プロピオン酸セルロースとの混合物を含む、請求項9に記載のヒドロゲル。
- 前記水膨潤性ポリマーが、アクリル酸、メタクリル酸、アクリル酸メチル、アクリル酸エチル、メタクリル酸メチル、および/またはメタクリル酸エチルの、ポリマーおよびコポリマーから選択される、請求項7に記載のヒドロゲル。
- 前記水膨潤性ポリマーが、メタクリル酸とメタクリル酸メチルとのコポリマーである、請求項13に記載のヒドロゲル。
- 前記コポリマーが、1:1〜1:2の範囲にある、遊離カルボキシル基対エステル基の比を有する、請求項14に記載のヒドロゲル。
- 前記親水性ポリマーが、ポリ(N−ビニルラクタム)、ポリ(N−ビニルアミド)、ポリ(N−アルキルアクリルアミド)、ポリアクリル酸、ポリメタクリル酸、ポリビニルアルコール、ポリビニルアミン、ならびにこれらのコポリマーおよびブレンドからなる群より選択される、請求項7に記載のヒドロゲル。
- 前記親水性ポリマーが、ポリ(N−ビニルラクタム)、ポリ(N−ビニルアミド)、ポリ(N−アルキルアクリルアミド)、ならびにこれらのコポリマーおよびブレンドからなる群より選択される、請求項16に記載のヒドロゲル。
- 前記親水性ポリマーが、ポリ(N−ビニルラクタム)である、請求項17に記載のヒドロゲル。
- 前記親水性ポリマーが、ポリ(N−ビニルラクタム)ホモポリマーである、請求項18に記載のヒドロゲル。
- 前記ポリ(N−ビニルラクタム)が、ポリビニルピロリドン、ポリビニルカプロラクタム、およびこれらのブレンドからなる群より選択される、請求項18に記載のヒドロゲル。
- 前記ポリ(N−ビニルラクタム)が、ポリビニルピロリドンである、請求項20に記載のヒドロゲル。
- 前記ポリ(N−ビニルラクタム)が、ポリビニルカプロラクタムである、請求項20に記載のヒドロゲル。
- 前記親水性ポリマーが、100,000〜2,000,000の範囲の数平均分子量を有する、請求項7に記載のヒドロゲル。
- 前記親水性ポリマーが、500,000〜1,500,000の範囲の数平均分子量を有する、請求項23に記載のヒドロゲル。
- 前記相補的オリゴマーが、45〜800の範囲の分子量を有する、請求項7に記載のヒドロゲル。
- 前記相補的オリゴマーが、45〜600の範囲の分子量を有する、請求項25に記載のヒドロゲル。
- 前記相補的オリゴマーが、300〜600の範囲の分子量を有する、請求項25に記載のヒドロゲル。
- 前記相補的オリゴマーが、ポリアルコール、モノマー性およびオリゴマー性のアルキレングリコール、ポリアルキレングリコール、カルボキシル末端を有するポリアルキレングリコール、アミノ末端を有するポリアルキレングリコール、エーテルアルコール、アルカンジオールおよび炭酸の二酸からなる群より選択される、請求項25に記載のヒドロゲル。
- 前記相補的オリゴマーが、ポリアルキレングリコールおよびカルボキシル末端を有するポリアルキレングリコールからなる群より選択される、請求項28に記載のヒドロゲル。
- 前記相補的オリゴマーが、ポリエチレングリコールおよびカルボキシル末端を有するポリエチレングリコールからなる群より選択される、請求項29に記載のヒドロゲル。
- 前記相補的オリゴマーが、ポリエチレングリコールである、請求項29に記載のヒドロゲル。
- 前記相補的オリゴマーが、ポリエチレングリコール400である、請求項31に記載のヒドロゲル。
- 前記低分子量の可塑剤が、フタル酸ジアルキル、フタル酸ジシクロアルキル、フタル酸ジアリール、混合アルキル−アリールフタレート、リン酸アルキル、リン酸アリール、クエン酸アルキル、クエン酸エステル、アジピン酸アルキル、酒石酸ジアルキル、セバシン酸ジアルキル、コハク酸ジアルキル、グリコール酸アルキル、グリセロール酸アルキル、グリコールエステル、グリセロールエステル、およびこれらの混合物からなる群より選択される、請求項7に記載のヒドロゲル。
- 前記低分子量可塑剤が、フタル酸ジメチル、フタル酸ジエチル、フタル酸ジプロピル、フタル酸ジ(2−エチルヘキシル)、フタル酸ジイソプロピル、フタル酸ジアミル、フタル酸ジカプリル、リン酸トリブチル、リン酸トリオクチル、リン酸トリクレシル、リン酸トリフェニル、クエン酸トリメチル、クエン酸トリエチル、クエン酸トリブチル、アセチルクエン酸トリエチル、クエン酸トリヘキシル、アジピン酸ジオクチル、アジピン酸ジエチル、アジピン酸ジ(2−メチルエチル)、アジピン酸ジヘキシル、酒石酸ジエチル、酒石酸ジブチル、セバシン酸ジエチル、セバシン酸ジプロピル、セバシン酸ジノニル、コハク酸ジエチル、コハク酸ジブチル、二酢酸グリセロール、三酢酸グリセロール、一乳酸二酢酸グリセロール、メチルフタリルグリコール酸エチル、ブチルフタリルグリコール酸ブチル、二酢酸エチレングリコール、二酪酸エチレングリコール、二酢酸トリエチレングリコール、二酪酸トリエチレングリコール、二プロピオン酸トリエチレングリコール、およびこれらの混合物からなる群より選択される、請求項33に記載のヒドロゲル。
- 前記任意の抗酸化剤が存在する、請求項1に記載のヒドロゲル。
- 前記疎水性ポリマーが、疎水性感圧性接着剤である、請求項1に記載のヒドロゲル。
- 前記疎水性ポリマーが、架橋ブチルゴム、天然ゴム接着剤、ビニルエーテルポリマー、ポリシロキサン、ポリイソプレン、イソブチレン−イソプレンコポリマー、ブタジエンアクリロニトリルゴム、ポリクロロプレン、アタクチックポリプロピレン、エチレン−プロピレン−ジエンターポリマー、およびこれらの組合せからなる群より選択される、請求項1に記載のヒドロゲル。
- 前記可塑剤がエラストマーポリマーである、請求項1に記載のヒドロゲル。
- 前記エラストマーポリマーが、スチレン−イソプレンブロックコポリマー、スチレン−ブタジエンブロックコポリマー、スチレン−イソプレン−スチレンブロックコポリマー、スチレン−ブタジエン−スチレンブロックコポリマー、およびこれらの組合せからなる群より選択されるスチレンベースの可塑剤である、請求項38に記載のヒドロゲル。
- 前記親水性ポリマーが、架橋している、請求項7に記載のヒドロゲル。
- 興奮剤;鎮痛剤;麻酔剤;関節炎治療剤;呼吸用薬物;抗癌剤;抗コリン作用性剤;抗痙攣薬;抗うつ剤;抗糖尿病薬;止瀉薬;駆虫薬;抗ヒスタミン剤;抗高脂血症剤;抗高血圧剤;抗感染薬;抗炎症剤;抗偏頭痛用製剤;制嘔吐剤;抗振せん麻痺薬;鎮痒薬;抗精神病薬;解熱薬;鎮痙薬;抗結核薬;抗潰瘍剤;抗ウイルス剤;抗不安薬;食欲抑制剤;注意欠陥障害用薬物および注意欠陥過活動性障害用薬物;心血管用製剤;中枢神経系刺激薬;咳用製剤および感冒用製剤;利尿薬;遺伝物質;ハーブ治療剤;ホルモン溶解薬;睡眠薬;血糖降下薬;免疫抑制剤;ロイコトリエンインヒビター;有糸分裂インヒビター;筋肉弛緩薬;麻薬アンタゴニスト;ニコチン;栄養剤;眼科用薬物;副交感神経遮断薬;ペプチド薬物;精神刺激剤;鎮静薬;ステロイド;禁煙用薬;交感神経様作用薬;精神安定薬;および血管拡張剤からなる群より選択される活性剤をさらに含有する、請求項1に記載のヒドロゲル。
- 充填剤、保存剤、pH調整剤、柔軟剤、増粘剤、顔料、染料、屈折性粒子、安定化剤、強化剤、および脱粘着性剤からなる群より選択される少なくとも1種の添加剤をさらに含有する、請求項1に記載のヒドロゲル。
- 前記水膨潤性ポリマー、前記低分子量可塑剤、前記親水性ポリマー、および前記相補的オリゴマーの相対量が、前記ヒドロゲルを不透明にしないように選択される、請求項7に記載のヒドロゲル。
- 前記水膨潤性ポリマーが、前記ヒドロゲルの2重量%〜15重量%を占め、前記親水性ポリマーおよび前記相補的オリゴマーが、一緒になって、該ヒドロゲルの17.5重量%〜45重量%を占め、前記低分子量可塑剤が、該ヒドロゲルの2.5重量%〜5.0重量%を占め、そして該親水性ポリマー対該相補的オリゴマーの重量比が、70:30〜40:60の範囲にある、請求項43に記載のヒドロゲル。
- 前記ヒドロゲルを導電性にするための量の、イオン伝導性電解質をさらに含有する、請求項1に記載のヒドロゲル。
- 創傷用包帯であって、身体接触表面を有する身体に面する層と、外向きに面するバッキング層との、積層された複合物を備え、該身体接触表面の少なくとも一部が、請求項1に記載のヒドロゲルから構成される、創傷用包帯。
- 前記身体接触表面全体が、前記ヒドロゲルから構成される、請求項46に記載の創傷用包帯。
- 前記身体に面する層が、皮膚接触接着剤から構成される外周部、および前記ヒドロゲルを含む内側領域を有する、請求項46に記載の創傷用包帯。
- 創傷への適用のための、静菌化合物、殺菌化合物、抗生物質、疼痛緩和剤、局所血管拡張薬、組織治癒増強剤、アミノ酸、タンパク質、タンパク質分解酵素、サイトカイン、およびポリペプチド増殖因子からなる群より選択される活性剤をさらに含む、請求項46に記載の創傷用包帯。
- 薬物レザバ、外向きに面するバッキング層、およびデバイスを身体表面に固定するための手段から構成される、経皮薬物送達デバイスにおいて、改良が、請求項1に記載のヒドロゲルを、該薬物レザバ、該固定手段、またはその両方として使用することを包含する、経皮薬物送達デバイス。
- 前記薬物レザバが、前記固定手段として働く、請求項50に記載の経皮薬物送達デバイス。
- 身体表面への適用のための圧力軽減クッションにおいて、該クッションが、外向きに面するバッキング層、および架橋した感圧性接着剤の身体に面する層から構成され、改良が、請求項40に記載のヒドロゲルを、該架橋した感圧性接着剤として使用することを包含する、圧力軽減クッション。
- 不連続疎水性相および親水性相を有するヒドロゲルフィルムを形成する方法であって、該不連続疎水性相が、疎水性ポリマー、可塑性エラストマー、粘着性付与樹脂、および任意の抗酸化剤を含有し、そして該親水性相が、不連続または連続のいずれかであり、ここで、該方法が、以下:
押出し機を通して、該疎水性相および親水性相の成分を溶融処理して、押出し成形されたヒドロゲルを形成する工程;
該押出し成形されたヒドロゲルを、基材上に配置する工程;ならびに
該ヒドロゲルの層に圧力を付与して、該基材上にヒドロゲルフィルムを形成する工程、を包含する、方法。 - 過酸化水素または有機過酸化物をさらに含む、請求項1に記載のヒドロゲル。
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2002
- 2002-05-01 CA CA002445086A patent/CA2445086C/en not_active Expired - Lifetime
- 2002-05-01 WO PCT/US2002/014260 patent/WO2002087645A1/en active Application Filing
- 2002-05-01 ES ES02766907T patent/ES2331302T3/es not_active Expired - Lifetime
- 2002-05-01 AU AU2002308612A patent/AU2002308612B2/en not_active Expired
- 2002-05-01 AT AT02766907T patent/ATE438418T1/de not_active IP Right Cessation
- 2002-05-01 RU RU2003134633/15A patent/RU2276998C2/ru active
- 2002-05-01 DE DE60233217T patent/DE60233217D1/de not_active Expired - Lifetime
- 2002-05-01 EP EP02766907A patent/EP1390085B1/en not_active Expired - Lifetime
- 2002-05-01 JP JP2002584987A patent/JP4116447B2/ja not_active Expired - Lifetime
- 2002-05-01 US US10/137,664 patent/US8728445B2/en not_active Expired - Lifetime
-
2009
- 2009-06-24 US US12/491,088 patent/US8481059B2/en not_active Expired - Lifetime
-
2013
- 2013-05-10 US US13/892,232 patent/US9259504B2/en not_active Expired - Fee Related
-
2014
- 2014-04-29 US US14/264,983 patent/US10869947B2/en not_active Expired - Lifetime
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