DE3787573T2 - Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren. - Google Patents

Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren.

Info

Publication number
DE3787573T2
DE3787573T2 DE87305280T DE3787573T DE3787573T2 DE 3787573 T2 DE3787573 T2 DE 3787573T2 DE 87305280 T DE87305280 T DE 87305280T DE 3787573 T DE3787573 T DE 3787573T DE 3787573 T2 DE3787573 T2 DE 3787573T2
Authority
DE
Germany
Prior art keywords
bioadhesive
intra
procedure
drug delivery
extruded film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE87305280T
Other languages
English (en)
Other versions
DE3787573D1 (de
Inventor
Michael Thomas Schiraldi
Martin Monroe Perl
Howard Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Consumer Inc
Original Assignee
Johnson and Johnson Consumer Products Inc
Johnson and Johnson Consumer Companies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson Consumer Products Inc, Johnson and Johnson Consumer Companies LLC filed Critical Johnson and Johnson Consumer Products Inc
Publication of DE3787573D1 publication Critical patent/DE3787573D1/de
Application granted granted Critical
Publication of DE3787573T2 publication Critical patent/DE3787573T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
  • Cosmetics (AREA)
DE87305280T 1986-06-16 1987-06-15 Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren. Expired - Lifetime DE3787573T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/874,904 US4713243A (en) 1986-06-16 1986-06-16 Bioadhesive extruded film for intra-oral drug delivery and process

Publications (2)

Publication Number Publication Date
DE3787573D1 DE3787573D1 (de) 1993-11-04
DE3787573T2 true DE3787573T2 (de) 1994-02-10

Family

ID=25364834

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87305280T Expired - Lifetime DE3787573T2 (de) 1986-06-16 1987-06-15 Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren.

Country Status (13)

Country Link
US (1) US4713243A (de)
EP (1) EP0250187B1 (de)
JP (2) JP2540332B2 (de)
KR (1) KR940011243B1 (de)
AT (1) ATE95058T1 (de)
AU (1) AU7415587A (de)
CA (1) CA1297408C (de)
DE (1) DE3787573T2 (de)
GR (1) GR870935B (de)
IE (1) IE61785B1 (de)
NZ (1) NZ220573A (de)
PH (1) PH24845A (de)
ZA (1) ZA874294B (de)

Families Citing this family (316)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62169723A (ja) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk 徐放化製剤
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
JPH0759496B2 (ja) * 1986-03-25 1995-06-28 ロ−ト製薬株式会社 歯周病治療剤
US5196202A (en) * 1986-09-01 1993-03-23 Teikoku Seiyaku Kabushiki Kaisha Sustained release dosage form
US5213615A (en) * 1986-10-11 1993-05-25 Ivoclar Ag Dental material and method for the control of caries and paradentitis
GB8712518D0 (en) * 1987-05-28 1987-07-01 Univ Belfast Unit-dose film composition
US4808410A (en) * 1987-12-16 1989-02-28 Richardson-Vicks Inc. Pharmaceutical compositions containing dyclonine HC1 and phenol
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
GB8810951D0 (en) * 1988-05-09 1988-06-15 Innovata Biomed Ltd Buccal local anaesthetic
IT1217628B (it) * 1988-05-18 1990-03-30 Neo Abello Spa Forma farmaceutica e supporto per la somministrazione di estratti ellergenici
US5085866A (en) * 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US4992276A (en) * 1988-12-14 1991-02-12 Warner-Lambert Company Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
DK254289D0 (da) * 1989-05-25 1989-05-25 Dumex Ltd As Middel til behandling af svampeinfektioner
US5776493A (en) * 1989-07-14 1998-07-07 Alza Corporation Oral osmotic device for delivery of nystatin with hydrogel driving member
US5021053A (en) * 1989-07-14 1991-06-04 Alza Corporation Oral osmotic device with hydrogel driving member
US5198220A (en) * 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5634943A (en) * 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5147654A (en) * 1990-07-23 1992-09-15 Alza Corporation Oral osmotic device for delivering nicotine
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IL97930A (en) * 1991-04-23 1996-06-18 Perio Prod Ltd Preparations for whitening two controlled release products that contain a super-oxygen compound
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
CA2116115C (en) * 1991-08-23 2000-05-16 Mingchih M. Tseng Sustained-release matrices for dental application
US5906834A (en) * 1992-06-15 1999-05-25 The Gillette Company Color changing matrix as wear indicator
US5340581A (en) 1991-08-23 1994-08-23 Gillette Canada, Inc. Sustained-release matrices for dental application
US5571533A (en) * 1992-02-07 1996-11-05 Recordati, S.A., Chemical And Pharmaceutical Company Controlled-release mucoadhesive pharmaceutical composition for the oral administration of furosemide
US5248310A (en) * 1992-03-27 1993-09-28 Alza Corporation Oral osmotic device with hydrogel driving member
US5512299A (en) * 1992-03-30 1996-04-30 Alza Corporation Method of treating oral inflammatory disease
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
AU679937B2 (en) * 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US5573776A (en) * 1992-12-02 1996-11-12 Alza Corporation Oral osmotic device with hydrogel driving member
US6015844A (en) * 1993-03-22 2000-01-18 Johnson & Johnson Medical, Inc. Composite surgical material
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5489437A (en) * 1993-08-17 1996-02-06 Applied Extrusion Technologies, Inc. Hydrogel products and methods of producing same
AU7568394A (en) * 1993-08-19 1995-03-14 Cygnus Therapeutic Systems Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
US5578315A (en) * 1993-12-01 1996-11-26 Rutgers, The State University Of New Jersey Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
WO1996000072A1 (en) * 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
US5614578A (en) * 1994-10-28 1997-03-25 Alza Corporation Injection-molded dosage form
WO1996025910A1 (en) * 1995-02-23 1996-08-29 Cygnus, Inc. Water-soluble pressure-sensitive mucoadhesive
US5713852A (en) * 1995-06-07 1998-02-03 Alza Corporation Oral dosage and method for treating painful conditions of the oral cavity
CA2184316A1 (en) * 1995-09-12 1997-03-13 Wei-Chi Liao Buccal delivery system for therapeutic agents
US20050152950A1 (en) * 1995-11-13 2005-07-14 Saffran Bruce N. Method and apparatus for macromolecular delivery using a coated membrane
US5906814A (en) * 1995-12-07 1999-05-25 The Andrew Jergens Company Topical film-forming compositions
JP2791317B2 (ja) * 1995-12-26 1998-08-27 株式会社三和化学研究所 多層フィルム製剤
ES2325046T3 (es) * 1996-06-26 2009-08-24 The Board Of Regents, The University Of Texas System Formulacion farmaceutica extruible por fusion en caliente.
US6500777B1 (en) 1996-06-28 2002-12-31 Ethicon, Inc. Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions
US5993787A (en) * 1996-09-13 1999-11-30 Johnson & Johnson Consumer Products, Inc. Composition base for topical therapeutic and cosmetic preparations
SE9603667D0 (sv) * 1996-10-08 1996-10-08 Astra Ab Pharmaceutical compositions
AU769500B2 (en) * 1996-10-18 2004-01-29 Arius Two, Inc. Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5955097A (en) 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
EP1342548B1 (de) * 1996-10-28 2015-12-23 General Mills, Inc. Einbettung und Einkapselung von Teilchen zur kontrollierten Abgabe und eingekapseltes Produkt
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US5879691A (en) 1997-06-06 1999-03-09 The Procter & Gamble Company Delivery system for a tooth whitener using a strip of material having low flexural stiffness
US6045811A (en) * 1997-06-06 2000-04-04 The Procter & Gamble Company Delivery system for an oral care substance using a permanently deformable strip of material
US5894017A (en) * 1997-06-06 1999-04-13 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US20020018754A1 (en) 1999-03-15 2002-02-14 Paul Albert Sagel Shapes for tooth whitening strips
US6096328A (en) * 1997-06-06 2000-08-01 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US6136297A (en) * 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
US5989569A (en) * 1997-06-06 1999-11-23 The Procter & Gamble Company Delivery system for a tooth whitener using a permanently deformable strip of material
US6582708B1 (en) 2000-06-28 2003-06-24 The Procter & Gamble Company Tooth whitening substance
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6123957A (en) * 1997-07-16 2000-09-26 Jernberg; Gary R. Delivery of agents and method for regeneration of periodontal tissues
US6153210A (en) * 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
US20050048102A1 (en) * 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US6072100A (en) * 1998-01-28 2000-06-06 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US5981499A (en) * 1998-02-20 1999-11-09 Atlantic Biomed Corporation Lesion-directed antibiotics in dry dosage forms for the treatment of shallow ulcers of the oral mucosa
US6103266A (en) * 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
WO1999055312A2 (en) * 1998-04-29 1999-11-04 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
DE19856101A1 (de) * 1998-12-04 2000-06-08 Labtec Gmbh Mundhöhlen-Matrixpflaster
WO2000045797A1 (en) * 1999-02-02 2000-08-10 Ortho-Mcneil Pharmaceutical, Inc. Method of manufacture for transdermal matrices
US6319510B1 (en) 1999-04-20 2001-11-20 Alayne Yates Gum pad for delivery of medication to mucosal tissues
AU768471B2 (en) 1999-07-02 2003-12-11 Procter & Gamble Company, The Delivery system for oral care compositions comprising organosiloxane reins using a removable backing strip
DE19954421A1 (de) * 1999-11-12 2001-05-31 Lohmann Therapie Syst Lts Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen
US6432415B1 (en) 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
AU2001249214A1 (en) 2000-03-15 2001-09-24 The Brigham And Women's Hospital, Inc. Suppression of vascular disorders by mucosal administration of heat shock protein peptides
US8652446B2 (en) 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
US6682721B2 (en) * 2000-03-17 2004-01-27 Lg Household & Healthcare Ltd. Patches for teeth whitening
US6689344B2 (en) 2000-03-17 2004-02-10 Lg Household & Healthcare Ltd. Patches for teeth whitening
US7785572B2 (en) * 2000-03-17 2010-08-31 Lg Household And Health Care Ltd. Method and device for teeth whitening using a dry type adhesive
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
JP2003531682A (ja) * 2000-04-28 2003-10-28 フジオメッド インコーポレイテッド ポリ酸及びポリアルキレンオキシドの止血性組成物、並びにその使用方法
DE60122718T2 (de) 2000-06-28 2007-08-23 The Procter & Gamble Company, Cincinnati Strukturen und zusammensetzungen zur erhöhung der stabilität von aktiven peroxiden
CN1182219C (zh) 2000-07-07 2004-12-29 A.V.石化合成托普契夫研究所 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
DE10038571A1 (de) * 2000-08-03 2002-02-14 Knoll Ag Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen
US6756051B1 (en) * 2000-11-15 2004-06-29 Li-Lan H. Chen Bioadhesive, closed-cell foam film, sustained release, delivery devices and methods of making and using same
US6500408B2 (en) 2001-01-27 2002-12-31 Jc Technologies, Inc. Enamel-safe tooth bleach and method for use
EP1236466B1 (de) * 2001-02-28 2011-09-21 Axiomedic Ltd. Feste selbst-haftende Zusammensetzungen zur topischen Behandlung von Störungen der Mundschleimhaut
US8980334B2 (en) 2001-02-28 2015-03-17 Axiomedic Ltd. Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
US6419906B1 (en) * 2001-03-12 2002-07-16 Colgate Palmolive Company Strip for whitening tooth surfaces
US6503486B2 (en) * 2001-03-12 2003-01-07 Colgate Palmolive Company Strip for whitening tooth surfaces
US6514483B2 (en) * 2001-03-12 2003-02-04 Colgate Palmolive Company Strip for whitening tooth surfaces
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
CA2447302C (en) 2001-05-01 2008-07-29 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
DE60233217D1 (de) 2001-05-01 2009-09-17 Corium Internat Inc Hydrogel-zusammensetzungen
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6660292B2 (en) 2001-06-19 2003-12-09 Hf Flavoring Technology Llp Rapidly disintegrating flavored film for precooked foods
US6946142B2 (en) 2001-06-23 2005-09-20 Lg Household & Healthcare Ltd. Multi-layer patches for teeth whitening
WO2003003957A1 (en) * 2001-07-06 2003-01-16 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US6419903B1 (en) * 2001-08-20 2002-07-16 Colgate Palmolive Company Breath freshening film
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
KR20030045473A (ko) * 2001-12-04 2003-06-11 대신제약주식회사 점막부착성을 가지는 의약품 조성물
US20030224090A1 (en) * 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US8623393B2 (en) 2002-04-29 2014-01-07 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US6949240B2 (en) 2002-05-23 2005-09-27 The Procter & Gamble Company Tooth whitening products
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8956160B2 (en) * 2002-07-02 2015-02-17 Ranir, Llc Device and method for delivering an oral care agent
US6921529B2 (en) 2002-07-29 2005-07-26 Joseph C. Maley Treatment modality and method for fungal nail infection
US20040120991A1 (en) * 2002-09-07 2004-06-24 Mars Incorporated Edible films having distinct regions
US20040120903A1 (en) * 2002-09-11 2004-06-24 The Procter & Gamble Company Tooth whitening strips
US20050100515A1 (en) * 2002-09-11 2005-05-12 The Procter & Gamble Company Tooth whitening products
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
DE10252726B4 (de) 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
EA012306B1 (ru) * 2003-01-24 2009-08-28 Магле Холдинг Аб Композиционный материал для доставки через слизистые оболочки
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
US7041311B2 (en) * 2003-02-28 2006-05-09 International Flavors & Fragrances Inc. Preparation for saliva flow
JP2006523703A (ja) * 2003-04-14 2006-10-19 シャイア ラボラトリーズ，インコーポレイテッド 吸収ウィンドウ問題を克服するための、活性剤をバッカルまたは舌下の位置から放出する薬学的組成物
WO2004103328A1 (en) * 2003-04-30 2004-12-02 Icure Pharmaceutical Corporation Patch for tooth whitening
US7306812B2 (en) * 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
EP3210601A1 (de) * 2003-05-28 2017-08-30 MonoSolRX, LLC Polyethylenoxidbasierte folien und daraus hergestellte arzneimittelabgabesysteme
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
US7472655B2 (en) * 2003-07-01 2009-01-06 Lu Hao Leng Table top
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20050036958A1 (en) * 2003-08-13 2005-02-17 Jianxun Feng Dental bleaching
US8815215B2 (en) * 2003-08-15 2014-08-26 Colgate-Palmolive Company Hydrophobic tooth whitening system and methods of use
US20050036957A1 (en) * 2003-08-15 2005-02-17 Michael Prencipe Tooth whitening dental tray and method of use
CA2535846A1 (en) * 2003-08-15 2005-02-24 Qlt Usa, Inc. Adhesive bioerodible transmucosal drug delivery system
US20050069502A1 (en) * 2003-08-15 2005-03-31 Chopra Suman K. Hydrophobic polymer carrier based liquid tooth whitening composition
US20050038181A1 (en) * 2003-08-15 2005-02-17 Colgate-Palmolive Company Silicone polymer based liquid tooth whitening composition
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US7666396B2 (en) * 2003-09-11 2010-02-23 Kimberly-Clark Worldwide, Inc. Single-use moisturizing product
AU2004289222B2 (en) 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
CA2537103C (en) * 2003-11-04 2010-01-19 Shire Laboratories, Inc. Once daily dosage forms of trospium
CN102669810B (zh) 2003-11-07 2014-11-05 美国无烟烟草有限责任公司 烟草组合物
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
KR100462465B1 (ko) * 2003-11-20 2004-12-23 정천수 충방전 겸용잭을 갖는 충전지 케이스구조 및 이에연결되는 방수용 잭플러그
US8529939B2 (en) * 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
AU2004305518A1 (en) * 2003-12-15 2005-07-07 Alexza Pharmaceuticals, Inc. Treatment of breakthrough pain by drug aerosol inhalation
JP4128521B2 (ja) * 2003-12-19 2008-07-30 信越化学工業株式会社 ゲル状シート及びその製造方法
CN102764247B (zh) 2004-01-30 2016-04-20 考里安国际公司 递送活性剂的快速溶解膜
US20070269519A1 (en) * 2004-03-03 2007-11-22 Constantine Georgiades Whitening products
CA2559579A1 (en) * 2004-03-19 2005-09-29 The Tapemark Company Thermoplastic films and methods for making
US20050208108A1 (en) * 2004-03-19 2005-09-22 Jannusch Leonard C Thermoplastic films and methods for making
AU2005235369B2 (en) * 2004-04-22 2010-11-11 Acucort Ab Pharmaceutical compositions for acute glucocorticoid therapy
DE602005015506D1 (de) * 2004-04-28 2009-09-03 Shinetsu Chemical Co Filmzubereitung und Verfahren zu deren Herstelllung
SI1765292T1 (en) 2004-06-12 2018-04-30 Collegium Pharmaceutical, Inc. Formulations of medicines to discourage abuse
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
RU2393877C2 (ru) 2004-08-05 2010-07-10 Кориум Интернэшнл, Инк. Адгезивная композиция
US8899976B2 (en) 2004-09-24 2014-12-02 Align Technology, Inc. Release agent receptacle
US20060099550A1 (en) * 2004-11-10 2006-05-11 Ranir/Dcp Corporation Device and method for delivering an oral care agent
US7766658B2 (en) 2004-11-30 2010-08-03 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US7947508B2 (en) 2004-11-30 2011-05-24 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US20060115785A1 (en) 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
WO2006072946A2 (en) 2005-01-04 2006-07-13 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Hsp60, hsp60 peptides and t cell vaccines for immunomodulation
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
KR100741654B1 (ko) * 2005-02-07 2007-07-23 한웅코텍 주식회사 피부적용 유성 소프트 겔 시트
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
WO2006089082A2 (en) 2005-02-17 2006-08-24 Velcera Pharmaceuticals Transmucosal administration of drug compositions for treating and preventing disorders in animals
DE102005011029A1 (de) * 2005-03-08 2006-09-14 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung für die perorale Applikation mit gesteuerter Freisetzung von Wirkstoffen
WO2006107390A2 (en) 2005-04-04 2006-10-12 Kronos Advanced Technologies, Inc. An electrostatic fluid accelerator for and method of controlling a fluid flow
US20060275369A1 (en) * 2005-06-01 2006-12-07 Cao Group, Inc. Orally Therapeutic Plastics and Devices Formed Therefrom
US8623334B1 (en) 2005-09-29 2014-01-07 Alan J. Wickenhauser Topical anesthetic
US8263047B2 (en) * 2005-09-29 2012-09-11 Wickenhauser Alan J Topical anesthetic for dental procedures
WO2007056142A2 (en) * 2005-11-02 2007-05-18 Theraquest Biosciences, Llc Methods of preventing the serotonin syndrome and compositions for use therefor
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
US9125833B2 (en) * 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
WO2007087452A2 (en) * 2006-01-27 2007-08-02 Theraquest Biosciences, Llc Abuse resistant and extended release formulations and method of use thereof
JP5657206B2 (ja) * 2005-12-21 2015-01-21 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 清浄及び／又は光沢組成物とその使用の方法
US20070154542A1 (en) * 2005-12-30 2007-07-05 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
JP2009523808A (ja) * 2006-01-20 2009-06-25 モノソル アールエックス リミテッド ライアビリティ カンパニー 活性物質の粘膜投与のためのフィルム包帯
EP2010156B1 (de) 2006-03-24 2016-11-16 Auxilium International Holdings, Inc. Stabilisierte zusammensetzungen mit labilen alkalischen wirkstoffen
CN101489756B (zh) 2006-03-24 2013-08-07 奥克思利尤姆国际控股公司 热熔挤出层压材料的制备方法
MX349787B (es) 2006-04-04 2017-08-11 Kg Acquisition Llc Formas de dosis oral que incluyen un agente antiplaqueta y un inhibidor de ácido.
GB0613552D0 (en) * 2006-07-07 2006-08-16 Univ Heriot Watt Resorbable insert
US9682256B2 (en) 2006-07-14 2017-06-20 Colgate-Palmolive Company Methods of making compositions comprising films
EP3067044B1 (de) 2006-07-21 2019-03-27 BioDelivery Sciences International, Inc. Vorrichtungen zur transmukosalen abgabe mit verbesserter aufnahme
AU2007275034A1 (en) * 2006-07-21 2008-01-24 Lab International Srl Hydrophilic abuse deterrent delivery system
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
WO2008028047A2 (en) * 2006-08-30 2008-03-06 Lab International Srl Bioadhesive film drug delivery system
AU2007297697A1 (en) 2006-09-20 2008-03-27 Monosol Rx Llc Edible water-soluble film containing a foam reducing flavoring agent
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
MX2009004789A (es) * 2006-10-31 2009-08-12 Wrigley W M Jun Co Nucleos de liberacion de sabor y su uso en goma de mascar.
CN101754755A (zh) * 2007-02-15 2010-06-23 德尔玛-杨有限公司 促进跨粘膜递送的组合物及方法
DE102007011485A1 (de) * 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
AU2014202362B2 (en) * 2007-10-11 2016-07-14 Philip Morris Products, S.A. Method for delivering nicotine
US20090098192A1 (en) * 2007-10-11 2009-04-16 Fuisz Richard C Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same
KR101564472B1 (ko) * 2007-10-11 2015-10-29 필립모리스 프로덕츠 에스.에이. 무연 담배 제품
US9125434B2 (en) 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
CA2711001A1 (en) 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein-based particles and methods thereof
US8383152B2 (en) 2008-01-25 2013-02-26 Gruenenthal Gmbh Pharmaceutical dosage form
AU2009223061B2 (en) 2008-03-11 2014-10-09 Depomed Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
DE102008014533A1 (de) * 2008-03-15 2009-09-17 Lts Lohmann Therapie-Systeme Ag Gingival-Wafer
HUE030803T2 (en) 2008-05-09 2017-06-28 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form using a spraying step \ t
US8172569B2 (en) 2008-06-12 2012-05-08 Align Technology, Inc. Dental appliance
EP2306981A1 (de) * 2008-06-19 2011-04-13 University Of The Witwatersrand, Johannesburg Transmukosales abgabesystem
EP2293751B1 (de) * 2008-06-23 2018-01-10 BioDelivery Sciences International, Inc. Vorrichtungen zur multidirektionalen schleimhautverabreichung und anwendungsverfahren dafür
GB0812742D0 (en) * 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
EP2387394B1 (de) 2009-01-14 2018-05-02 Corium International, Inc. Transdermale verabreichung von tamsulosin
HUE045444T2 (hu) 2009-03-04 2019-12-30 Regenera Pharma Ltd Polimer mircén kompozíciók
CA2974805C (en) 2009-03-04 2021-11-30 Regenera Pharma Ltd. Therapeutic uses of mastic gum fractions
CN102427782A (zh) * 2009-05-21 2012-04-25 比奥内克斯制药有限公司 双层和单层剂型
AR077420A1 (es) 2009-07-22 2011-08-24 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion para opiaceos sensibles a la oxidacion
EP2456427B1 (de) 2009-07-22 2015-03-04 Grünenthal GmbH Heißschmelzextrudierte retardierte pharmazeutische Darreichungsform
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
EP2504019A2 (de) 2009-11-25 2012-10-03 ArisGen SA Zusammensetzung zur verabreichung über die schleimhaut mit einem komplex aus einem peptid und einer kronenverbindung und/oder einem gegenion
US20110136815A1 (en) 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
EP2531176B1 (de) 2010-02-03 2016-09-07 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels eines extruders
BR112012018523A2 (pt) * 2010-03-26 2019-09-24 Dow Global Technologies Llc película em monocamada ou multicada e processo para produzir uma película extrudada sob fusão
US9572773B2 (en) 2010-04-26 2017-02-21 Novartis A.G. Layered drug delivery device
US20110290694A1 (en) * 2010-05-27 2011-12-01 Monosol Rx, Llc Oral film dosage form having indicia thereon
EP2579844B1 (de) 2010-06-10 2016-02-24 Midatech Ltd. Systeme zur freisetzung von nanopartikeln
DE102010029942A1 (de) * 2010-06-10 2011-12-15 Robert Bosch Gmbh Injektionsnadel
ES2486791T3 (es) 2010-09-02 2014-08-19 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende una sal inorgánica
JP5933553B2 (ja) 2010-09-02 2016-06-15 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング アニオン性ポリマーを含む不正使用抵抗性剤形
DK2613777T3 (da) 2010-09-07 2019-07-01 Regenera Pharma Ltd Sammensætninger omfattende sure ekstrakter af mastiks-gummi
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
WO2012064319A1 (en) 2010-11-08 2012-05-18 Colgate-Palmolive Company Oral compositions containing microaggregates
WO2012082098A1 (en) 2010-12-13 2012-06-21 Colgate-Palmolive Company Oral compositions and method for producing thereof
US20130280184A1 (en) 2010-12-13 2013-10-24 Colgate-Palmolive Company Oral Compositions and Method for Producing Thereof
WO2012082103A1 (en) 2010-12-13 2012-06-21 Colgate-Palmolive Company Oral compositions and method for producing thereof
WO2012104834A1 (en) 2011-02-03 2012-08-09 Pharmedica Ltd. New oral dissolving films for insulin administration, for treating diabetes
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
RS56527B1 (sr) 2011-07-29 2018-02-28 Gruenenthal Gmbh Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
US20140017299A1 (en) * 2011-08-18 2014-01-16 Monosol Rx, Llc Steroid hormone delivery systems and methods of preparing the same
AU2012296346A1 (en) 2011-08-18 2014-04-03 Biodelivery Sciences International, Inc. Abuse-resistant mucoadhesive devices for delivery of buprenorphine
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
EP2838512B1 (de) 2012-04-18 2018-08-22 Grünenthal GmbH Fälschungssichere und dose dumping sichere pharmazeutische darreichungsform
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
BR112015008666B1 (pt) 2012-10-17 2020-04-07 Procter & Gamble produto extensível para tratamento dental e método de aplicação de um ativo para tratamento bucal
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
MX368846B (es) 2013-07-12 2019-10-18 Gruenenthal Gmbh Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo.
CN105531305A (zh) * 2013-09-30 2016-04-27 金伯利-克拉克环球有限公司 具有热活性剂的热塑性制品
EP3073994A1 (de) 2013-11-26 2016-10-05 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
EP2889030A1 (de) 2013-12-30 2015-07-01 Uluru Inc. Steuerung der Erosionsraten von mukoadhäsiven Vorrichtungen mit Lieferung von Wirkstoffen und anderen Verbindungen und Bereitstellung erhöhter und unterschiedlicher therapeutischer Blutwerte
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
AU2015266117A1 (en) 2014-05-26 2016-11-24 Grunenthal Gmbh Multiparticles safeguarded against ethanolic dose-dumping
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
CN107743386A (zh) * 2015-06-05 2018-02-27 荷兰联合利华有限公司 口腔护理装置
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2017085262A1 (en) * 2015-11-19 2017-05-26 Dermtreat Aps A pharmaceutical film composition having improved residence time on the application site
DE102016000541A1 (de) 2016-01-14 2017-07-20 Hofmann & Sommer GmbH und Co.KG Cellulosefaserbasierte Trägermatrices (smartFilms) zur Applikation von Inhaltsstoffen sowie deren Herstellung
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
WO2017192921A1 (en) 2016-05-05 2017-11-09 Monosol Rx, Llc Enhanced delivery epinephrine compositions
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
WO2018226383A1 (en) * 2017-06-07 2018-12-13 Egy-Nano Pharma, Lp Oral prolonged drug delivery platforms
WO2019006122A1 (en) 2017-06-28 2019-01-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education HOT EXTRUSION FOR VAGINAL FILM PHARMACEUTICAL PRODUCTS
DE102017127434A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Taschenförmige oral auflösende Filme mit hoher Wirkstoffbeladung
JP7243301B2 (ja) * 2018-03-15 2023-03-22 大正製薬株式会社 口腔用組成物
GB2575625A (en) 2018-06-22 2020-01-22 Church & Dwight Co Inc Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom
US10758329B1 (en) 2019-08-20 2020-09-01 Raymond L. Wright, III Hydrating mouth guard
CN111249328B (zh) * 2020-03-13 2021-06-25 河南护理职业学院 一种复方口腔溃疡贴膜及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
JPS5620513A (en) * 1979-07-31 1981-02-26 Eisai Co Ltd Sugar-coated tablet containing fat-soluble drug
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
JPS5890507A (ja) * 1981-11-24 1983-05-30 Nippon Soda Co Ltd 粘膜粘着性フイルム製剤の製造方法
JPS59222406A (ja) * 1983-06-01 1984-12-14 Teijin Ltd 歯周疾患治療用製剤及びその製造法
JPS605159A (ja) * 1983-06-24 1985-01-11 ライオン株式会社 医療用バンドの製造方法
KR920010392B1 (ko) * 1984-03-01 1992-11-27 산도즈 아크리엔 게젤샤프트 경피투여용 약학 조성물의 제조방법
JPS62223114A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 徐放性歯周病治療剤

Also Published As

Publication number Publication date
KR940011243B1 (ko) 1994-12-03
DE3787573D1 (de) 1993-11-04
IE61785B1 (en) 1994-11-30
EP0250187A2 (de) 1987-12-23
US4713243A (en) 1987-12-15
CA1297408C (en) 1992-03-17
GR870935B (en) 1987-10-19
ATE95058T1 (de) 1993-10-15
EP0250187A3 (en) 1988-06-01
EP0250187B1 (de) 1993-09-29
JP2540332B2 (ja) 1996-10-02
JPS6319152A (ja) 1988-01-26
ZA874294B (en) 1989-01-25
PH24845A (en) 1990-10-30
KR880000087A (ko) 1988-03-23
JPH08253414A (ja) 1996-10-01
AU7415587A (en) 1987-12-17
NZ220573A (en) 1989-11-28
JP2706064B2 (ja) 1998-01-28
IE871583L (en) 1987-12-16

Similar Documents

Publication Publication Date Title
DE3787573T2 (de) Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren.
US5955097A (en) Pharmaceutical preparation applicable to mucosal surfaces and body tissues
EP0275550B1 (de) Klebeinrichtung zur Anwendung an Körpergewebe
US6103266A (en) Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
EP0641192B1 (de) Einrichtung zur transmucosalen wirkstoffabgabe
EP0973497B1 (de) Pharmazeutisches trägermittel, geeignet zur applikation pharmazeutischer verbindungen auf mucosale öberflächen
US4307717A (en) Sterile improved bandage containing a medicament
CA1245158A (en) Synthetic resin wound dressing and method of treatment using same
US4695464A (en) Sustained release dosage form based on highly plasticized cellulose ether gels
EP0072251B1 (de) Arzneimittel enthaltender verbesserter Verband
US20050048102A1 (en) Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
KR20040039290A (ko) 약물 및 다른 활성 화합물의 제어 투여를 위한 점막접착성침식성 약물 송달 장치
EP0451167A1 (de) Mukoadhäsive bukkale dosiereinrichtung
ATE108650T1 (de) Methode und zusammensetzung zur oralen verabreichung von bioaktiven mitteln zur peyer's flecken.
AU769500B2 (en) Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
ITFI20140116A1 (it) Composizione ad uso odontoiatrico per il trattamento delle tasche paradontali
TH5489EX (th) ฟิล์มอัดรีดยึดติดไบโอสำหรับจ่ายยาภายในช่องปากและกระบวนการ

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN