CN1182219C - 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 - Google Patents
具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 Download PDFInfo
- Publication number
- CN1182219C CN1182219C CNB01815221XA CN01815221A CN1182219C CN 1182219 C CN1182219 C CN 1182219C CN B01815221X A CNB01815221X A CN B01815221XA CN 01815221 A CN01815221 A CN 01815221A CN 1182219 C CN1182219 C CN 1182219C
- Authority
- CN
- China
- Prior art keywords
- composition
- softening agent
- hydrophilic polymer
- poly
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
Abstract
Description
聚合物 | Tg,K | ΔCp,J/gK | ΔCpTg,J/g |
聚二甲基硅氧烷 | 150 | 0.30 | 45.0 |
聚异丁烯 | 200 | 0.40 | 79.6 |
天然橡胶 | 200 | 0.46 | 92.0 |
聚乙烯 | 237 | 0.39 | 92.5 |
PEG-400 | 200 | 0.51 | 101.4 |
双酚聚碳酸酯 | 415 | 0.25 | 103.9 |
聚甲基丙烯酸甲酯 | 385 | 0.29 | 112.8 |
聚(N-乙烯基吡咯烷酮) | 449 | 0.27 | 121.2 |
聚丙烯 | 253 | 0.55 | 139.2 |
聚苯乙烯 | 375 | 0.38 | 141.0 |
聚乙酸乙烯酯 | 305 | 0.50 | 153.4 |
聚对苯二甲酸乙二醇酯 | 340 | 0.49 | 165.7 |
聚氯乙烯 | 355 | 0.63 | 229.9 |
编号 | PVPMw | 组分,重量% | RH,% | 厚度(微米) | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | |
PVP | PEG-400 | ||||||||
1 | 1,000,000 | 64 | 36 | 50 | 130 | 71 | 46.2 | 370 | 混杂 |
2 | 73 | 27 | 39 | 119.0 | 83 | 粘合 | |||
3 | 54 | 46 | 65.2 | 92.6 | 95 | 粘结 | |||
4 | 47 | 53 | 37.2 | 77.2 | 64 | 粘结 | |||
5 | 64 | 36 | 20 | 130 | 69 | 30 | 粘合 | ||
6 | 40 | 73 | 90 | 粘合 | |||||
7 | 65 | 70.5 | 59.1 | 330 | 粘结 | ||||
8 | 80 | 66.2 | 42 | 粘结 | |||||
9 | 90 | 77 | 96.0 | - | 粘结 | ||||
10 | 150,000 | 64 | 36 | 50 | 130 | 82.0 | 15 | 粘结 | |
11 | 8000 | 87.5 | 0 | 粘结 | |||||
12 | 1,000,000 | 64 | 36 | 50 | 250 | 390 | 混杂 | ||
13 | 175 | 390 | 混杂 | ||||||
14 | 119 | 330 | 粘合 | ||||||
15 | 70 | 210 | 粘合 | ||||||
16 | 50 | 185 | 粘合 |
编号 | 增塑剂 | Tg,℃ | Tm,℃ | 组分,重量% | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | |
增塑剂 | PVP | ||||||||
17 | 乙二醇 | -112 | 25 | 75 | n/d | n/d | 123 | 粘合 | |
18 | 36 | 64 | 60 | 62.0 | 142 | 粘合 | |||
19 | 45 | 55 | n/d | n/d | 127±15 | 粘合 | |||
20 | PEG-200 | -70 | n/a | 36 | 64 | 82 | 195 | 粘结 | |
21 | PEG-300 | -70 | n/a | 75 | 110 | 粘合 | |||
22 | PEG-600 | -70 | 16 | 68 | 75.3 | 15 | 粘合 | ||
23 | PEG-1000 | -70 | 39 | 60 | 22.71 | 0 | - | ||
24 | 1,3-丙二醇 | -116 | n/a | 35 | 65 | 55 | 47.9 | 116±10 | 粘合 |
25 | 1,2-丙二醇 | -95 | n/a | 35 | 65 | 42 | 56.5 | 180±20 | 粘合 |
26 | PPG-425 | -68 | n/a | 34 | 66 | 75 | 68.3 | 0 | - |
27 | 1,5-PD | -104 | -12.5 | 43 | 57 | 0 | 47.1 | 0 | - |
28 | 50 | 50 | 55 | 72.6 | 30 | 粘结 | |||
29 | 66.5 | 33.5 | 32.5 | 105.0 | 10 | 粘结 | |||
30 | 2,4-PD | -59 | n/a | 32 | 68 | 02 | 59.7 | 0 | 粘合 |
31 | 49 | 51 | 65.4 | 89.0 | 190 | 粘合 | |||
32 | 65.5 | 34.5 | 39.5 | 140.1 | 0 | 粘结 | |||
33 | 1,6-HD | -99 | 49.1 | 33 | 67 | 27.4 | 29.32 | 0 | - |
34 | 37.6 | 62.4 | 83.1 | 59.6 | 11 | 粘结 | |||
35 | 45 | 55 | 64.6 | 粘结 | |||||
36 | 50 | 50 | 55.6 | 58.6 | 19 | 粘结 | |||
37 | 66.6 | 33.4 | 38.5 | 101.0 | 0 | 粘结 | |||
38 | 2,5-HD | -62 | n/a | 49 | 51 | 65.32 | 76.4 | 26 | 粘合 |
39 | 66 | 34 | 40.1 | 122.2 | 10 | 粘结 | |||
40 | 甘油 | -74 | n/a | 23.4 | 76.6 | 138.1 | 45.92 | - | 粘合 |
41 | 38 | 62 | 70.5 | 85.7 | 850 | 混杂 | |||
42 | 羧基末端的PEG-600 | -49 | 12 | 36 | 64 | 752 | 55.9 | 8.5 | 粘合 |
43 | 50 | 50 | 55 | 112 | 346.5±15 | 粘结 | |||
44 | 丁二酸(SA) | n/d | 188 | 50 | 50 | n/d | 26.1/75.03 | 0/62 | 粘合 |
45 | 丙二酸(MA) | n/d | 135 | 50 | 50 | n/d | 52.5/80.13 | 7.6/71 | 粘合 |
46 | 戊二酸(GA) | n/d | 96 | 50 | 50 | n/d | 129/853 | 0/94 | 粘合 |
47 | 己二酸(AA) | n/d | 152 | TBD | TBD | n/d | 58.1/893 | TBD | 粘合 |
编号 | 聚合物/增塑剂 | 聚合物 | 组分,重量% | RH,% | -ΔTg,K | ΔCpTg,J/g | 剥离力,N/m | 分离方式 | ||
Mw | Tg,℃ | 聚合物 | 增塑剂 | |||||||
48 | PVCap/PEG-400 | 100000 | 165 | 64 | 36 | 40 | 71 | 88.3 | 533 | 混杂(misc.) |
49 | 50 | 363 | 粘结 | |||||||
50 | 60 | 300 | 粘结 | |||||||
51 | 80 | 23 | 粘结 | |||||||
52 | PVCap/PEG-400 | 1000000 | 197 | 64 | 36 | 50 | 81 | 98.0 | 150 | 粘合 |
53 | PVAA/PEG-400 | 1000000 | 64 | 36 | 50 | 397 | 粘合 | |||
54 | PNIPAM/PEG400 | 250000 | 157 | 64 | 36 | 50 | 66 | 89.0 | 230 | 混杂 |
55 | PMAA*/PEG400 | 150000 | 36 | 64 | 50 | - | - | 0 | - | |
56 | 47 | 53 | - | - | 27.5±5 | 粘合 | ||||
57 | 63 | 37 | - | - | 72 | 粘结 | ||||
58 | PAA/PEG400 | 150000 | 47 | 53 | 50 | 51 | 粘合 | |||
59 | PMAA*/1,5PD | 150000 | 36 | 64 | 50 | - | - | 0 | - | |
60 | 50 | 50 | - | - | 22.3 | 粘合 | ||||
61 | Luvisco173/PEG400 | 100000 | 57.5 | 30 | 70 | 50 | 37.1 | 65.9 | 高** | 粘结 |
62 | 36 | 64 | 34.0 | 79.4 | 高** | 粘结 | ||||
63 | Luvisco137/PEG400 | 100000 | 29 | 17 | 83 | 50 | 9.3 | 138.7 | 高** | 粘结 |
64 | 36 | 64 | 24.4 | 180.1 | 高** | 粘结 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
65新烟碱 | PVP-PEG | 1.6 | 150±20 | 106.3±12.0 | ||
66消心痛 | PVP-PEG | 9.6 | 384±48 | 13.0±4.3 | 44±5 | 1.5±0.5 |
67消心痛 | PVCap-PEG | 9.6 | 411±49 | 47.1±5 | ||
68氨基柱头素 | PVP-PEG | 14.3 | 625±20 | 33.7±12.0 | ||
7.6 | 263±10 | |||||
4.0 | 65±5 | |||||
69三硝酸甘油 | PVP-PEG | 7.3 | 160±40 | 12.4±4.0 | 25.6±1.4 | 1.9±0.5 |
1.9 | 45±12 | |||||
70异搏定 | PVP-PEG | 39.1 | 110±20 | 6±2 | 21.4±1.5 | 0.4±0.1 |
24.3 | 110±16 | |||||
13.8 | 95±19 | |||||
3.9 | 78±6 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
71心得安 | PVP-PEG | 13.8 | 118±25 | 26.0±15.0 | 10.6±1.1 | 2.1±0.2 |
7.4 | 79±6 | |||||
72心得安 | PVCap-PEG | 13.8 | 145±30 | 13.0±1.9 | ||
73Silabolin | PVP-PEG | 13.9 | 131±30 | 10.3±0.5 | ||
10.8 | 107±21 | |||||
7.2 | 65±14 | |||||
74Foridone | PVP-PEG | 13.8 | 37.3±4.5 | 4.2±1.5 | ||
10.8 | 34.1±4.0 | |||||
7.4 | 24.8±3.0 | |||||
3.1 | 20.6±1.9 |
药物 | 基材组分 | 基材内的药物含量(%) | 体外释放速率,μg/cm2h | Pm(104)cm/h | Ps(104)cm/h | |
碳化硅 | 人皮肤 | |||||
75氯压定 | PVP-PEG | 7.7 | 26.8±0.8 | 0.75±0.04 | 4.0±1.1 | 0.6±0.2 |
1.4 | 5±2 | 0.78±0.1 | ||||
76金雀花碱 | PVP-PEG | 7.4 | 21±3 | 9.0±4.0 | 3.0±0.5 | 1.3±0.5 |
77Phenazepam | PVP-PEG | 7.4 | 11±2 | 1.4±0.3 | ||
6.8 | 7±2 | |||||
78硝苯吡啶 | PVP-PEG | 15.4 | 19±3 | 1.3±0.2 | ||
79Fluacizin | PVP-PEG | 13.8 | 5±1 | 6±2 | 0.4±0.1 | 0.4±0.1 |
80舒喘宁 | PVP-PEG | 13.8 | 0.10±0.04 | 0.003 | ||
81舒喘宁 | PVCap-PEG | 13.8 | 4.9±1 | 0.4±0.1 | ||
82奎诺溶 | PVP-PEG | 3.0 | n/a | n/a | n/a | n/a |
药物 | 从亲水性基材通过碳化硅输送药物的速率 | 从憎水性基材输送药物的速率 | 憎水性基材的成分 |
氨基柱头素 | 625±20 | 8±1 | 苯乙烯丁二烯橡胶 |
硝酸甘油 | 160±40 | 80±10 | PDMS(NitrodermTTS) |
Silabolin | 131±30 | 16±7 | 苯乙烯丁二烯橡胶 |
心得安 | 118±25 | 56±4 | 苯乙烯丁二烯橡胶 |
氯压定 | 5±2 | 1.6±0.2 | PIB(CatapressTTS) |
Claims (60)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21638600P | 2000-07-07 | 2000-07-07 | |
US60/216386 | 2000-07-07 | ||
US60/216,386 | 2000-07-07 | ||
US84753201A | 2001-05-01 | 2001-05-01 | |
US09/847532 | 2001-05-01 | ||
US09/847,532 | 2001-05-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1452650A CN1452650A (zh) | 2003-10-29 |
CN1182219C true CN1182219C (zh) | 2004-12-29 |
Family
ID=26910962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB01815221XA Expired - Lifetime CN1182219C (zh) | 2000-07-07 | 2001-07-06 | 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6576712B2 (zh) |
EP (1) | EP1299494B1 (zh) |
JP (1) | JP4323797B2 (zh) |
CN (1) | CN1182219C (zh) |
AT (1) | ATE478932T1 (zh) |
AU (2) | AU7323001A (zh) |
CA (1) | CA2415076C (zh) |
DE (1) | DE60142900D1 (zh) |
WO (1) | WO2002004570A2 (zh) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
IT1319210B1 (it) * | 2000-10-13 | 2003-09-26 | Italiano Biochimico Lisapharma | Pellicola per la somministrazione dermica e transdermica di principiattivi. |
FR2815636B1 (fr) * | 2000-10-20 | 2006-02-10 | Lhd Lab Hygiene Dietetique | Nouveaux copolymeres amphiphiles utilisables notamment comme agent emulsionnant |
US7476533B2 (en) | 2002-04-19 | 2009-01-13 | Adhesives Research, Inc. | Diagnostic devices for use in the assaying of biological fluids |
EP1390750B1 (en) * | 2001-04-19 | 2011-03-09 | Adhesives Research, Inc. | Hydrophilic diagnostic devices for use in the assaying of biological fluids |
EP1390084B1 (en) | 2001-05-01 | 2011-03-23 | A.V. Topchiev Institute of Petrochemical Synthesis | Two-phase, water-absorbent bioadhesive composition |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US8541021B2 (en) * | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US20030235549A1 (en) * | 2001-05-01 | 2003-12-25 | Parminder Singh | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8728445B2 (en) | 2001-05-01 | 2014-05-20 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel Compositions |
US20050113510A1 (en) * | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US7651638B2 (en) * | 2002-04-10 | 2010-01-26 | Flexcon Company, Inc. | Hydro-insensitive alternating current responsive composites |
FR2838745B1 (fr) * | 2002-04-17 | 2004-07-09 | Urgo Laboratoires | Emulsions solides a base d'elastomere thermoplastique |
FR2838748B1 (fr) * | 2002-04-17 | 2004-07-09 | Urgo Laboratoires | Nouvelles compositions adhesives thermofusibles hydrophiles |
US8956160B2 (en) * | 2002-07-02 | 2015-02-17 | Ranir, Llc | Device and method for delivering an oral care agent |
US6921529B2 (en) | 2002-07-29 | 2005-07-26 | Joseph C. Maley | Treatment modality and method for fungal nail infection |
US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
US7700707B2 (en) | 2002-10-15 | 2010-04-20 | Exxonmobil Chemical Patents Inc. | Polyolefin adhesive compositions and articles made therefrom |
CA2499951C (en) | 2002-10-15 | 2013-05-28 | Peijun Jiang | Multiple catalyst system for olefin polymerization and polymers produced therefrom |
US7943166B2 (en) | 2003-04-10 | 2011-05-17 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
RU2326893C2 (ru) * | 2003-04-16 | 2008-06-20 | Кориум Интернэшнл | Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними |
US20040247654A1 (en) * | 2003-06-05 | 2004-12-09 | 3M Innovative Properties Company | Hydrophilic adhesives for delivery of herbal medicines |
US9278155B2 (en) * | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
US20070009582A1 (en) * | 2003-10-07 | 2007-01-11 | Madsen Niels J | Composition useful as an adhesive and use of such a composition |
WO2005039499A2 (en) * | 2003-10-24 | 2005-05-06 | Adhesives Research, Inc. | Rapidly disintegrating film |
JP2007509716A (ja) * | 2003-10-29 | 2007-04-19 | ジェンティス インコーポレイテッド | 組織工学用の重合可能なエマルション |
DE10358747A1 (de) * | 2003-12-12 | 2005-07-07 | Lts Lohmann Therapie-Systeme Ag | Darreichungsform basierend auf vernetzten hydrophilen Polymeren |
US20050133384A1 (en) * | 2003-12-19 | 2005-06-23 | 3M Innovative Properties Company | Packaged orthodontic assembly with adhesive precoated appliances |
US20060177487A1 (en) * | 2005-02-07 | 2006-08-10 | Christine Martz | Moisture and lotion retainer |
US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US20050196450A1 (en) * | 2004-03-04 | 2005-09-08 | Elka Touitou | Method and composition for burned skin |
JP2005255801A (ja) * | 2004-03-10 | 2005-09-22 | Nippon Shokubai Co Ltd | ポリエーテル組成物 |
US20050208108A1 (en) * | 2004-03-19 | 2005-09-22 | Jannusch Leonard C | Thermoplastic films and methods for making |
US7166236B2 (en) * | 2004-03-24 | 2007-01-23 | Invista North America S.A.R.L. | Stain-resist compositions |
US20060127468A1 (en) * | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
CN101039706A (zh) | 2004-08-05 | 2007-09-19 | 考里安国际公司 | 粘合剂组合物 |
US20060099550A1 (en) * | 2004-11-10 | 2006-05-11 | Ranir/Dcp Corporation | Device and method for delivering an oral care agent |
US7582330B2 (en) * | 2004-11-24 | 2009-09-01 | 3M Innovative Properties Counsel | Method for making metallic nanostructures |
US7687115B2 (en) * | 2004-11-24 | 2010-03-30 | 3M Innovative Properties Company | Method for making nanostructured surfaces |
US20060110540A1 (en) * | 2004-11-24 | 2006-05-25 | 3M Innovative Properties Company | Method for making nanostructured surfaces |
CA2822643A1 (en) * | 2004-12-21 | 2006-06-29 | Corium International, Inc. | Sustained release tooth whitening formulations and systems |
US7195484B1 (en) | 2005-01-03 | 2007-03-27 | Wagner Eugene C | Oral prosthesis fitment system |
ZA200707492B (en) * | 2005-02-14 | 2009-02-25 | Neurogesx Inc | Device for delivery of TRPV1 agonists |
US20060222690A1 (en) * | 2005-03-30 | 2006-10-05 | Bley Keith R | Low-concentration capsaicin patch and methods for treating neuropathic pain |
JP2006296511A (ja) * | 2005-04-15 | 2006-11-02 | Transcutaneous Technologies Inc | 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ |
JP5243792B2 (ja) * | 2005-06-01 | 2013-07-24 | ニプロパッチ株式会社 | 貼付剤 |
EP1731143B1 (en) * | 2005-06-06 | 2008-11-26 | Nitto Denko Corporation | Percutaneous absorption-type pharmaceutical preparation using a metal chloride, preferably sodium chloride, for preventing cohesive failure |
US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
JPWO2007032446A1 (ja) | 2005-09-15 | 2009-03-19 | Tti・エルビュー株式会社 | ロッド型イオントフォレーシス装置 |
WO2007038028A1 (en) * | 2005-09-28 | 2007-04-05 | Tti Ellebeau, Inc. | Iontophoresis apparatus and method to deliver active agents to biological interfaces |
WO2007041434A2 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue |
US8233954B2 (en) | 2005-09-30 | 2012-07-31 | Nellcor Puritan Bennett Llc | Mucosal sensor for the assessment of tissue and blood constituents and technique for using the same |
US7574256B2 (en) * | 2005-09-30 | 2009-08-11 | Tti Ellebeau, Inc. | Iontophoretic device and method of delivery of active agents to biological interface |
WO2007041323A1 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoretic delivery of vesicle-encapsulated active agents |
US20070232983A1 (en) * | 2005-09-30 | 2007-10-04 | Smith Gregory A | Handheld apparatus to deliver active agents to biological interfaces |
US7718716B2 (en) * | 2005-10-14 | 2010-05-18 | 3M Innovative Properties Company | Chromonic nanoparticles containing bioactive compounds |
US7629027B2 (en) | 2005-10-14 | 2009-12-08 | 3M Innovative Properties Company | Method for making chromonic nanoparticles |
JP5136058B2 (ja) * | 2005-11-01 | 2013-02-06 | 東亞合成株式会社 | 粘接着剤用光硬化型組成物、光硬化型粘接着シート、積層体及び接着シート |
US7807661B2 (en) * | 2005-12-08 | 2010-10-05 | 3M Innovative Properties Company | Silver ion releasing articles and methods of manufacture |
US7601769B2 (en) * | 2005-12-19 | 2009-10-13 | 3M Innovative Peroperties Company | Multilayered chromonic structures |
US20090220614A1 (en) * | 2005-12-19 | 2009-09-03 | The Trustees Of The University Of Pennsylvania | Thermo-Responsive Block Co-Polymers, and Use Thereof |
US8092710B2 (en) * | 2005-12-19 | 2012-01-10 | 3M Innovative Properties Company | Hierarchical chromonic structures |
US7824732B2 (en) * | 2005-12-28 | 2010-11-02 | 3M Innovative Properties Company | Encapsulated chromonic particles |
JP2009522011A (ja) * | 2005-12-30 | 2009-06-11 | Tti・エルビュー株式会社 | 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法 |
JP5173199B2 (ja) * | 2006-01-16 | 2013-03-27 | 株式会社アイ・ティー・オー | 創傷治癒用高分子組成物 |
WO2007123707A1 (en) * | 2006-03-30 | 2007-11-01 | Tti Ellebeau, Inc. | Controlled release membrane and methods of use |
WO2008030497A2 (en) | 2006-09-05 | 2008-03-13 | Tti Ellebeau, Inc. | Transdermal drug delivery systems, devices, and methods using inductive power supplies |
WO2008086341A1 (en) * | 2007-01-09 | 2008-07-17 | Pericor Therapeutics, Inc. | Methods. compositions, and formulations for preventing or reducing adverse effects in a patient |
US20100100064A1 (en) * | 2007-03-07 | 2010-04-22 | Convatec Technologies Inc. | Ostomy devices with mucoadhesives |
US10265265B2 (en) | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
EP2008651A1 (en) | 2007-06-26 | 2008-12-31 | Drug Delivery Solutions Limited | A bioerodible patch |
US8182647B2 (en) | 2007-07-23 | 2012-05-22 | Cohera Medical, Inc. | Hydrophilic biodegradable adhesives |
US8292862B2 (en) | 2007-08-03 | 2012-10-23 | Kimberly-Clark Worldwide, Inc. | Dynamic fitting body adhering absorbent article |
US7947027B2 (en) | 2007-12-28 | 2011-05-24 | Kimberly-Clark Worldwide, Inc. | Body adhering absorbent article |
US8672911B2 (en) | 2007-08-03 | 2014-03-18 | Kimberly-Clark Worldwide, Inc. | Body adhering absorbent article |
US8734413B2 (en) | 2007-08-03 | 2014-05-27 | Kimberly-Clark Worldwide, Inc. | Packaged body adhering absorbent article |
US7947784B2 (en) * | 2007-11-16 | 2011-05-24 | Zimmer, Inc. | Reactive compounding of hydrogels |
US8750978B2 (en) | 2007-12-31 | 2014-06-10 | Covidien Lp | System and sensor for early detection of shock or perfusion failure and technique for using the same |
BRPI0907199A2 (pt) * | 2008-01-10 | 2015-07-14 | Coloplast As | Composição adesiva sensível à pressão compreendendo composto solúvel em água e construção adesiva em camadas e dispositivo médico compreendendo a mesma |
EP2241340B1 (en) * | 2008-01-10 | 2014-07-30 | Alcare Co., Ltd. | Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance |
EP2312998B1 (en) | 2008-07-18 | 2018-12-05 | Flexcon Company, Inc. | High impedance signal detection systems and methods for use in electrocardiogram detection systems |
EP2328989B1 (en) * | 2008-08-06 | 2016-12-28 | Flexcon Company, Inc. | Biomedical sensor system and method of detecting a time varying signal |
WO2010027876A1 (en) * | 2008-08-26 | 2010-03-11 | Hauser Ray L | Substance delivery to skin and other tissues |
US11147722B2 (en) * | 2008-11-10 | 2021-10-19 | Kimberly-Clark Worldwide, Inc. | Absorbent article with a multifunctional acrylate skin-adhesive composition |
AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
US10022468B2 (en) | 2009-02-02 | 2018-07-17 | Kimberly-Clark Worldwide, Inc. | Absorbent articles containing a multifunctional gel |
PL2401027T3 (pl) | 2009-02-26 | 2018-04-30 | The University Of North Carolina At Chapel Hill | Układ do interwencyjnego dostarczania leku |
US8781576B2 (en) | 2009-03-17 | 2014-07-15 | Cardiothrive, Inc. | Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current |
EP2408521B1 (en) | 2009-03-17 | 2014-06-25 | Cardio Thrive, Inc | External defibrillator |
TWI395595B (zh) * | 2009-04-01 | 2013-05-11 | Colgate Palmolive Co | 用於治療牙齒敏感之口腔用組成物及其使用方法與製造 |
US20100272784A1 (en) | 2009-04-28 | 2010-10-28 | 3M Innovative Properties Company | Water-soluble pressure sensitive adhesives |
US8221994B2 (en) * | 2009-09-30 | 2012-07-17 | Cilag Gmbh International | Adhesive composition for use in an immunosensor |
US20110282260A1 (en) * | 2010-04-12 | 2011-11-17 | Genewel Co., Ltd. | Polyurethane Foam Dressing Having Excellent Adhesive Properties and Manufacturing Method Thereof |
JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル, インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
FR2959996B1 (fr) * | 2010-05-11 | 2012-05-11 | Bostik Sa | Hmpsa pour etiquette auto-adhesive decollable |
JP5712523B2 (ja) * | 2010-08-03 | 2015-05-07 | Dic株式会社 | 粘着性有機無機複合体ゲル、及びその製造方法 |
BR112013003216A2 (pt) | 2010-08-12 | 2016-05-17 | Kythera Biopharmaceuticals Inc | composições sintéticas de ácido biliar e métodos |
ES2736256T3 (es) | 2011-03-14 | 2019-12-27 | Drug Delivery Solutions Ltd | Composición oftálmica |
FR2984906B1 (fr) | 2011-12-26 | 2014-02-28 | Bostik Sa | Composition de colle pelable |
KR20150095857A (ko) * | 2012-12-11 | 2015-08-21 | 세키스이 스페셜티 케미칼스 아메리카 엘엘씨 | 개인 관리 어플리케이션들을 위한 pvoh 공중합체들 |
US9616243B2 (en) | 2013-06-14 | 2017-04-11 | Cardiothrive, Inc. | Dynamically adjustable multiphasic defibrillator pulse system and method |
US10279189B2 (en) | 2013-06-14 | 2019-05-07 | Cardiothrive, Inc. | Wearable multiphasic cardioverter defibrillator system and method |
US9656094B2 (en) | 2013-06-14 | 2017-05-23 | Cardiothrive, Inc. | Biphasic or multiphasic pulse generator and method |
US9833630B2 (en) | 2013-06-14 | 2017-12-05 | Cardiothrive, Inc. | Biphasic or multiphasic pulse waveform and method |
US10149973B2 (en) | 2013-06-14 | 2018-12-11 | Cardiothrive, Inc. | Multipart non-uniform patient contact interface and method of use |
US9907970B2 (en) | 2013-06-14 | 2018-03-06 | Cardiothrive, Inc. | Therapeutic system and method using biphasic or multiphasic pulse waveform |
WO2015057244A1 (en) * | 2013-10-18 | 2015-04-23 | Halliburton Energy Srrvices, Inc. | Surface treated lost circulation material |
EP2886578A1 (en) | 2013-12-20 | 2015-06-24 | Nitto Denko Corporation | Hydrophilic skin adhesive |
FR3021973B1 (fr) * | 2014-06-05 | 2016-07-01 | Bostik Sa | Composition de colle pelable |
RU2723602C2 (ru) * | 2015-09-24 | 2020-06-16 | Колопласт А/С | Приспособление для стомы с защитной полоской с оболочкой |
KR102041816B1 (ko) * | 2015-09-25 | 2019-11-07 | 주식회사 엘지화학 | 점착제 조성물 |
CN107629735A (zh) * | 2016-07-19 | 2018-01-26 | 上海暖友实业有限公司 | 医用贴专用热熔压敏胶及其制备方法 |
BR112019013503A2 (pt) | 2016-12-31 | 2020-01-07 | Bioxcel Therapeutics, Inc. | Uso de dexmedetomidina sublingual para o tratamento da agitação |
CN107103130B (zh) * | 2017-04-19 | 2019-08-13 | 中国水利水电科学研究院 | 根据浇筑温度测量值确定有限元计算用浇筑温度的方法 |
US10828500B2 (en) | 2017-12-22 | 2020-11-10 | Cardiothrive, Inc. | External defibrillator |
EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
CN114983981A (zh) | 2018-06-27 | 2022-09-02 | 比奥克斯塞尔医疗股份有限公司 | 含右美托咪定的膜制剂及其制造方法 |
US20200172768A1 (en) * | 2018-12-04 | 2020-06-04 | Adhesives Research, Inc. | Disintegrable thin film adhesive barrier |
CA3145206A1 (en) * | 2019-06-28 | 2020-12-30 | Passport Technologies, Inc. | Transdermal drug delivery patch, drug delivery system and drug delivery method |
MX2022000709A (es) | 2019-07-19 | 2022-05-19 | Bioxcel Therapeutics Inc | Regimenes de tratamiento con dexmedetomidina no sedante. |
CN110964466A (zh) * | 2019-11-25 | 2020-04-07 | 深圳市佳鑫一帆科技有限公司 | 一种胶水制作方法 |
CN114773562B (zh) * | 2022-04-27 | 2023-07-25 | 广东粤港澳大湾区黄埔材料研究院 | 生物功能型单组分医用胶粘剂及其制备方法、应用 |
WO2024025476A1 (en) * | 2022-07-28 | 2024-02-01 | Nanyang Technological University | An electrode with ultralow bioelectronic impedance based on molecule anchoring |
CN115717034B (zh) * | 2022-11-25 | 2024-03-29 | 香港中文大学(深圳) | 基于氢键凝聚物和疏水基团的耐水胶粘剂及其制备方法和应用 |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1576522A (en) | 1977-05-24 | 1980-10-08 | Colorplast International A S | Sealing material for ostomy devices |
US4325851A (en) * | 1980-10-24 | 1982-04-20 | Herman Colon | Water-activatable hot-melt adhesives |
DK147035C (da) | 1980-12-05 | 1984-09-03 | Coloplast As | Hudplade |
US4750482A (en) * | 1982-02-25 | 1988-06-14 | Pfizer Inc. | Hydrophilic, elastomeric, pressure-sensitive adhesive |
US4699146A (en) | 1982-02-25 | 1987-10-13 | Valleylab, Inc. | Hydrophilic, elastomeric, pressure-sensitive adhesive |
JPS59196817A (ja) * | 1983-04-21 | 1984-11-08 | Sekisui Chem Co Ltd | 貼付剤 |
US5364628A (en) | 1985-05-31 | 1994-11-15 | Sandoz Ltd. | Pharmaceutical compositions |
US4593053A (en) | 1984-12-07 | 1986-06-03 | Medtronic, Inc. | Hydrophilic pressure sensitive biomedical adhesive composition |
US4713243A (en) | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
DK154747C (da) | 1986-10-17 | 1989-05-08 | Coloplast As | Bandage med en hudvenlig, vandabsorberende klaebeskive der paa den ene flade er fast forbundet med en ikke-klaebende daekfilm og paa den anden med et aftageligt beskyttelsesdaekke |
SU1459215A1 (ru) * | 1986-12-30 | 1995-11-20 | Всесоюзный Научно-Исследовательский Институт Биотехнологии | Состав полимерной диффузионной матрицы для трансдермального введения лекарственных веществ |
SU1705319A1 (ru) | 1987-10-23 | 1992-01-15 | Всесоюзный Научно-Исследовательский Институт Биотехнологии | Состав полимерной диффузионной матрицы дл трансдермального введени лекарственных веществ |
CA2003808C (en) | 1988-11-28 | 1999-11-09 | Eugene Joseph Sehm | Crosslinked polyacrylic acid |
US5173302A (en) | 1990-09-28 | 1992-12-22 | Medtronic, Inc. | Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs |
US5276079A (en) | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
DK5492A (da) | 1992-01-17 | 1993-07-18 | Coloplast As | Hudpladeprodukt |
DE4219368C2 (de) | 1992-06-12 | 1994-07-28 | Lohmann Gmbh & Co Kg | Elektrisch leitfähige transparente Haftklebefilme, Verfahren zu ihrer Herstellung und Verwendung zur Herstellung biomedizinischer Elektroden |
GR1002418B (el) * | 1992-07-29 | 1996-08-21 | Johnson & Johnson Consumer Products Inc. | Βιοεπισυναπτομενες συνθεσεις θεραπειας και μεθοδοι χρησης. |
US5489624A (en) | 1992-12-01 | 1996-02-06 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
DE4310012A1 (de) | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
US5773490A (en) | 1993-06-24 | 1998-06-30 | Takiron Co., Ltd. | Pressure sensitive adhesive for transdermal absorption formulations |
AU7568394A (en) | 1993-08-19 | 1995-03-14 | Cygnus Therapeutic Systems | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
TW369558B (en) | 1994-01-28 | 1999-09-11 | Minnesota Mining & Mfg | Polymerized microemulsion pressure sensitive adhesive compositions and methods of preparing and using same |
US5780050A (en) | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
US5985990A (en) | 1995-12-29 | 1999-11-16 | 3M Innovative Properties Company | Use of pendant free-radically polymerizable moieties with polar polymers to prepare hydrophilic pressure sensitive adhesive compositions |
US5645855A (en) | 1996-03-13 | 1997-07-08 | Ridge Scientific Enterprises, Inc. | Adhesive compositions including polyvinylpyrrolidone acrylic acid polymers, and polyamines |
DE19653605C2 (de) | 1996-12-20 | 2002-11-28 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems |
DE19653606A1 (de) | 1996-12-20 | 1998-06-25 | Roehm Gmbh | Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher |
-
2001
- 2001-07-06 JP JP2002509427A patent/JP4323797B2/ja not_active Expired - Lifetime
- 2001-07-06 US US09/900,697 patent/US6576712B2/en not_active Ceased
- 2001-07-06 CA CA2415076A patent/CA2415076C/en not_active Expired - Lifetime
- 2001-07-06 AU AU7323001A patent/AU7323001A/xx active Pending
- 2001-07-06 CN CNB01815221XA patent/CN1182219C/zh not_active Expired - Lifetime
- 2001-07-06 AT AT01952486T patent/ATE478932T1/de not_active IP Right Cessation
- 2001-07-06 DE DE60142900T patent/DE60142900D1/de not_active Expired - Lifetime
- 2001-07-06 EP EP01952486A patent/EP1299494B1/en not_active Expired - Lifetime
- 2001-07-06 WO PCT/US2001/021417 patent/WO2002004570A2/en active IP Right Grant
-
2007
- 2007-02-22 AU AU2007200799A patent/AU2007200799B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU2007200799A1 (en) | 2007-03-22 |
EP1299494B1 (en) | 2010-08-25 |
AU7323001A (en) | 2002-01-21 |
CA2415076A1 (en) | 2002-01-17 |
JP2004502857A (ja) | 2004-01-29 |
US6576712B2 (en) | 2003-06-10 |
WO2002004570A2 (en) | 2002-01-17 |
JP4323797B2 (ja) | 2009-09-02 |
CA2415076C (en) | 2010-04-13 |
CN1452650A (zh) | 2003-10-29 |
WO2002004570A3 (en) | 2002-04-18 |
ATE478932T1 (de) | 2010-09-15 |
AU2007200799B2 (en) | 2011-02-03 |
DE60142900D1 (de) | 2010-10-07 |
US20020037977A1 (en) | 2002-03-28 |
EP1299494A2 (en) | 2003-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1182219C (zh) | 具有最佳粘合性能的亲水性压敏性粘合剂的制备方法 | |
RU2286801C2 (ru) | Двухфазные биоадгезионные композиции, абсорбирующие воду | |
RU2326893C2 (ru) | Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними | |
CN100490805C (zh) | 用于经皮传递芬太尼的组合物 | |
CN1098009A (zh) | 用于在皮肤表面或透过皮肤表面传送药物的可挤压组合物 | |
EP2308480A2 (en) | High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications | |
CN1346393A (zh) | 粘合剂 | |
JP2017527540A (ja) | 経皮薬物送達組成物のためのシリコーン含有アクリルポリマー | |
JP2013163820A (ja) | 経皮薬物送達システムにおいて有用な非反応型接着剤 | |
JP5652867B2 (ja) | 医療用粘着剤組成物 | |
JP2009149660A (ja) | 架橋型皮膚用粘着剤 | |
EP1945685B1 (en) | Acrylic polymer-based adhesives | |
WO2012090322A1 (ja) | 貼付剤 | |
USRE45666E1 (en) | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties | |
JPH06145050A (ja) | 貼付剤の製造方法 | |
KR20220034030A (ko) | 아크릴 중합체 및 접착제 조성물 | |
JP2012219044A (ja) | 貼付製剤 | |
JPS63270060A (ja) | 抗菌性粘着部材 | |
JP2012219083A (ja) | 医療用粘着剤組成物およびその製造方法、ならびに、該医療用粘着剤組成物を用いた貼付剤および貼付製剤 | |
JPH0672879A (ja) | アスピリン含有経皮吸収製剤 | |
AU2001273230A1 (en) | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties | |
JP3224582B2 (ja) | 経皮吸収製剤 | |
JPWO2011010556A1 (ja) | 経皮吸収型製剤 | |
JP2647222B2 (ja) | 経皮吸収製剤 | |
JPH09176000A (ja) | 医療用貼付剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CI01 | Publication of corrected invention patent application |
Correction item: Third priority Correct: delete False: [32]2001.05.01[33]US[31]09/847,532 Number: 52 Page: 496 Volume: 20 Correction item: Third inventor Correct: Ann, Tory E., Charlie Kiel False: Ann is Tuoliji E. Charlie Kiel Number: 52 Page: 496 Volume: 20 |
|
CI03 | Correction of invention patent |
Correction item: Third priority Correct: delete False: [32]2001.05.01[33]US[31]09/847,532 Number: 52 Page: The title page Volume: 20 Correction item: Third inventor Correct: Ann, Tory E., Charlie Kiel False: Ann is Tuoliji E. Charlie Kiel Number: 52 Page: The title page Volume: 20 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: THIRD INVENTOR THIRD PRIORITY; FROM: ANJITORIGY E.LIGIER ¢32!2001.5.1 ¢33!US ¢31!09/847,532 TO: ANJITORI E. RICHARD GORE DELETE |
|
ERR | Gazette correction |
Free format text: CORRECT: THIRD INVENTOR THIRD PRIORITY; FROM: ANJITORIGY E.LIGIER ¢32!2001.5.1 ¢33!US ¢31!09/847,532 TO: ANJITORI E. RICHARD GORE DELETE |
|
CX01 | Expiry of patent term |
Granted publication date: 20041229 |
|
CX01 | Expiry of patent term |